Результаты поиска

Massive intra-abdominal irrigation fluid extravasation causing respiratory compromise and compressive hepatopathy during biportal lumbar foraminal endoscopic surgery: a case report.

INTRODUCTION: Biportal endoscopic spinal surgery is increasingly adopted as a minimally invasive technique with favorable clinical outcomes. … cidosis (pH 7.1). Laboratory findings indicated acute hepatic injury with markedly elevated alanine transaminases (peak ALT 1129 IU/L). Hounsfield unit measurements suggested simple irrigation fluid rather than hemorrhage. A large volume of intra-abdominal fluid was evacuated through percutaneous drainage and diuretic therapy, resulting in rapid clinical improv …

Sustained Correction of Hereditary Antithrombin Deficiency in Mice by AAV8-Mediated Gene Delivery.

BACKGROUND: Mutations in antithrombin (SERPINC1) lead to the hereditary antithrombin deficiency. Conventional therapies for hereditary antit … mice were 60%, 60%, 70% and 60%, respectively. After AAV injection, transient elevations in hepatic transaminases and cytokines were observed in mice during a short-term period. CONCLUSIONS: Our study demonstrates that AAV8-hSERPINC1 gene delivery resulted in durable AT expression, sustained blood hypercoagulation state correction, thereby rescuing thrombophil …

Co-infection of Hepatitis A and E With Atypical Manifestation: A Case Report.

Hepatitis A virus (HAV) and hepatitis E virus (HEV) are common causes of acute viral hepatitis in developing countries where inadequate sani … r disease. Laboratory investigations demonstrated significant hyperbilirubinemia and elevated liver transaminases. Serological testing confirmed acute HAV and HEV co-infection with positive anti-HAV IgM and anti-HEV IgM antibodies. Abdominal ultrasonography showed a normal-sized liver with altered echogenicity and a characteristic "starry sky" appearance, along …

People living with HIV co-infected with HBV at the Nkembo Outpatient Treatment Center, Gabon: prevalence and associated factors.

BACKGROUND: Hepatitis B virus (HBV) is a global public health problem that affects many people, including people living with HIV (PLHIV). In … I: 7.9-13.8). Alcohol intake (adjusted odds ratio (aOR) = 2.1, 95% CI:1.2-3.4, p = 0.006), elevated transaminases (aOR = 3.1, 95% CI:1.8-4.8, p = 0.0001), CD4 + count less than 200 cells/mm3 (aOR = 3.6, 95% CI: 2.2-5.8, p = 0.0001), HIV viral load greater than 1,000 copies/mL (aOR = 2.5, 95% CI: 1.4-4.4, p = 0.001), and being unvaccinated (aOR = 2.2 95% CI: 1.2 …

First-in-Human Safety, Tolerability, Efficacy, and Pharmacokinetics of Pegfosimer Manganese (SN132D) for Contrast-Enhanced MRI of Breast Cancer.

OBJECTIVES: The primary objective of the first-in-human (FIH) study was to evaluate the safety and tolerability of the manganese (Mn)-based … nificant changes in the safety laboratory parameters were reported, except for transiently elevated transaminases observed at the end of the infusion. Clinically relevant low-background MRI scans for clinical visualization of primary breast tumor, liver, and pancreas were obtained at the expanded dose level. Pegfosimer manganese has an initial plasma half-life …

Therapeutic application of EUS-guided intraportal autologous bone marrow transplantation for decompensated liver cirrhosis.

BACKGROUND AND AIMS: To compare the efficacy and safety of different treatment regimens for decompensated liver cirrhosis (DLC), focusing on … up and PEV group that received ABMT showed different degrees of improvement in routine blood tests, transaminases, albumin levels, Child-Pugh scores, and coagulation function compared with the conventional treatment group, the clinical symptoms were relieved, with no apparent adverse reactions. The EUS-POV group was more effective than the PEV group in improvin …

Trimetazidine mitigates methotrexate-induced liver damage: Insights From biochemical, histological, and in silico analyses.

This study aimed at generating preliminary evidence for the potential utility of repurposing the clinically approved anti-ischemic drug trimetazidine (TMZ) against methotrexate (MTX)-induced hepatotoxicity. In this study, rats received MTX (30 mg/kg) with or without TMZ pretreatment (20 mg/kg). MTX caused a 2.7-3.6-fold increase in serum transaminases, while TMZ pretreatment caused a 37%-40% reduction. Regarding oxidative markers, MTX significantly suppressed the antioxidant glutathione (GSH) levels by 37% and elevated malondialdehyde (MDA) levels by 29%, while TMZ boosted GSH levels by 40% an…

Age-Specific Clinical and Laboratory Features and Renal Involvement in Children with MIS-C: A Single Tertiary Centre Experience from Vojvodina.

Backgrounds and Objectives: Multisystem Inflammatory Syndrome in Children (MIS-C) is a rare but potentially severe complication of SARS-CoV- … ns. The 3-6-year age group was characterized by the presence of rash, hypoalbuminemia, and elevated transaminases. The 7-12-year age group showed the highest rate of organ dysfunction. In adolescents (13-18 years), neurological symptoms, the highest BMI values, the greatest prevalence of comorbidities, leukopenia, lymphopenia, and elevated GGT levels were obser …

The use of ELF in predicting liver fibrosis prevalence and fibrosis progression in the general population.

BACKGROUND AND AIMS: The enhanced liver fibrosis (ELF) test has good discrimination performance in detecting advanced liver fibrosis. The ch … (OR 1.72, p = 0.049), and it did not predict fibrosis progression in either sex. Although elevated transaminases were associated with eELF, in most individuals with eELF they were within reference limits. Increased CLivD scores correlated with baseline and the change of ELF values over the 10-year follow-up independent of baseline ELF (p < 0.001). CONCLUSIONS …

Conventional vs. DEB vs. DSM: Which technique for palliative TACE in intermediate-stage HCC? Results on 70 patients in terms of efficacy and tolerance.

PURPOSE: This study aims to compare palliative cTACE, DEB-TACE and DSM-TACE in patients affected by HCC in intermediate BCLC stage in terms … . Patients treated with DSM-TACE showed significantly better tolerance, considering post-procedural transaminases and INR values together with clinical adverse events occurrence monitored up to 7 days. There were no differences in post-procedural complications and no major complications occurred. CONCLUSIONS: In this study, in patients with intermediate-stage …

Increase the sensitivity of terahertz liquid detection using a triple attenuated total reflection probe.

The B-cell maturation antigen (BCMA)-targeting bispecific T-cell engager pavurutamab (AMG 701) directs the cytotoxic T-cell response toward … patients had dose-limiting toxicities, which included cytokine release syndrome (CRS) and increased transaminases; none of which occurred at the RP2D. The most frequently reported treatment-emergent adverse events included CRS (74.4%), anemia (61.0%), neutropenia (47.1%), and hypophosphatemia (45.3%). Grade ≥3 infections were noted in 60 patients (34.9%). The o …

Liver involvement in Gaucher disease type I: a retrospective single-center study from Ukraine.

BACKGROUND: Gaucher disease (GD) type I is a rare lysosomal storage disorder characterized by systemic manifestations including hepatospleno … of patients with GD type I. Despite liver enlargement, only 2.4% of patients demonstrated elevated transaminases, and no hyperbilirubinemia was reported, indicating preserved hepatic function. Additional liver pathology (steatosis, fibrosis, hemangiomatosis, cysts, or cholecystitis) was present in 45% of cases. A strong correlation was identified between the d …

Procyanidin B2 mitigates methotrexate-induced hepatic pyroptosis by suppressing TLR4/NF-κB and caspase-3/GSDME pathways.

Methotrexate (MTX), a potent chemotherapeutic and immunosuppressive agent, is widely used for cancer and autoimmune diseases. MTX-induced he … gside MTX. The results revealed that MTX-induced hepatic injury was evidenced by elevation in serum transaminases. This elevation was accompanied by hepatic oxidative stress due to an imbalance in oxidative/antioxidant markers, specifically elevated malondialdehyde (MDA) and decreased glutathione (GSH) levels and superoxide dismutase (SOD) activity. The inflamm …

Hepatic Form of Dihydrolipoamide Dehydrogenase Deficiency (DLDD): Phenotypic Spectrum, Laboratory Findings, and Therapeutic Approaches in 52 Patients.

Dihydrolipoamide dehydrogenase deficiency (MIM 246900/DLDD) is an autosomal recessive mitochondrial disease with three clinical subgroups. The hepatic form leads to recurrent metabolic decompensations often accompanied by elevated levels of liver transaminases (ELT) in blood, sometimes progressing to acute liver failure (ALF). Genetically, it is linked to the p.G229C variant in the DLD gene, which has been reported in the Ashkenazi Jewish and Arabic population. In this study, we analyzed phenotypic diversity, therapeutic management, and outcome in novel symptomatic individuals with hepatic DLD…

Valacyclovir-induced neurotoxicity and nephrotoxicity in an elderly patient with a history of nephrectomy: a case report.

BACKGROUND: Valacyclovir is a prodrug of acyclovir, both of which are commonly used in the treatment of varicella zoster and herpes simplex viruses. Its mechanism as a guanosine analog antiviral inhibits DNA polymerase via chain termination. It has selective action in infected cells with minimal effect on host cells, lending to fewer side effects, and is a well-tolerated medication often chosen for its better oral bioavailability over acyclovir. Its side effect profile includes thrombotic thrombocytopenic purpura (TTP), gastrointestinal symptoms such as nausea, and increased transaminases. Com…

Сопоставимость, безопасность и стойкость на этапе III клинических испытаний при множественном склерозе.

СВЯЗЬ МЕЖДУ коморбидностью и снижением стойкости к лечению различных видов склероза (MS) с целью изменения заболеваний (DMT). Имеется ограниченная информация о связи совместимости с результатами в области безопасности. Цель исследования состояла в том, чтобы оценить связь между совместимостью и результатами в области безопасности и стойкостью. Мы провели two- метаанализ данных об отдельных участниках, полученных в ходе клинических испытаний на этапе III МНТ. Индивидуальные совпадающие и совпадающие нагрузки, определяемые как сумма всех совпадающих факторов (n=15), были осмотрены. Были проанали

Совпадение в аннотации оригинала
BACKGROUND: Associations between comorbidity and reduced persistence to disease-modifying therapies (DMTs) in multiple sclerosis (MS) have b … cific AEs of interest, including infection; treatment-emergent autoimmune disease; cancer; elevated transaminases and lymphopenia. We also examined any early trial discontinuation. RESULTS: We included 17 clinical trials representing 16 794 MS participants. Over a 2-year follow-up, the pooled proportion of AEs was 64% (95% CI 59.4% to 68.9%) and the majority w …

The influence of acute lifestyle changes on NAFLD evolution in a multicentre cohort: a matter of body composition.

BACKGROUND: Unhealthy lifestyles represent a key element fueling Non-alcoholic fatty liver disease (NAFLD) onset and worsening. We aimed to … oprotein, triglycerides, glucose, insulin, homeostatic model assessment for insulin resistance, and transaminases worsened during the lockdown (glucose: p = 0.0007; p < 0.0001 for the others). Moreover, NAFLD fibrosis score, liver stiffness, and controlled attenuation parameter were also impaired during the same period (p < 0.0001 for all). The bioelectrical im …

A free-living, walking-based, exercise programme, with exercise timed relative to breakfast, to improve metabolic health in people living with overweight and obesity: A feasibility study.

Optimising the timing of food intake relative to exercise may maximise the effectiveness of free-living exercise programmes on improvements … 24-hour continuous glucose monitoring, serum biochemistry including HbA1c, lipid profile and liver transaminases. Exercise adherence (FASTED: 93±4%, FED: 95±5%) and compliance (FASTED: 85±10%, FED: 88±10%) was high in both groups, and participants described exercise monitoring, programme structure and support as facilitators to this. Body mass, BMI, waist-to-h …

Adult-Onset Still's Disease (AOSD)-On the Basis of Own Cases.

INTRODUCTION: Adult-onset Still's disease (AOSD) is a rare chronic autoinflammatory condition characterized by a spiking fever, arthritis, a … , a sharp decrease in the number of leukocytes and thrombocytes, a further increase in the level of transaminases and ferritin, significant hepatosplenomegaly, lymphadenopathy, symptoms of the central nervous system (CNS), disseminated intravascular coagulation (DIC) and hemophagocytosis in the bone marrow. This study aimed to evaluate the course of AOSD, which …

CLINICAL PROFILE OF EXPANDED DENGUE SYNDROME IN CHILDREN.

The objective is to study the clinical profile and outcome of expanded dengue syndrome (EDS) in children. We conducted a retrospective cohor … significantly anemic and had leukocytosis, hyperkalemia, azotemia, hyperbilirubinemia, raised serum transaminases and fluid-refractory shock than their non-EDS counterparts. Children with EDS had a trend toward higher mortality (P = 0.07) and the survivors had a longer duration of hospital stay (5 days vs. 4 days in non-EDS, P = 0.001). In conclusion, we observ …