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Recommendations for epidemiologic and phenotypic research in polycystic ovary syndrome: an androgen excess and PCOS society resource.

STUDY QUESTION: What are the best practices for undertaking epidemiologic and phenotypic studies in polycystic ovary syndrome (PCOS)? SUMMARY ANSWER: Best practices for the undertaking of epidemiologic and phenotypic studies in PCOS are outlined. WHAT IS KNOWN ALREADY: Currently methodologies used for studies of PCOS epidemiology and phenotypes vary widely, and the comparability of studies is low, reducing the ability to harmonize studies. STUDY DESIGN, SIZE, DURATION: The Androgen Excess and PCOS (AE-PCOS) Society established a Task Force to draft a research resource for epidemiologic and

VP3.15, двойной ингибитор GSK-3β/PDE7, уменьшает рост опухоли глиобластомы, изменяя микроопухоль в контексте PTEN дикой природы.

Глиобластома (ГБ) — неизлечимый рак мозга, и необходимо срочно определить эффективные методы лечения. Это может быть достигнуто либо путем идентификации новых молекул, либо путем переочистки наркотиков. Для определения терапевтического потенциала известных ингибиторов GSK-3β и/или PDE7 в GB был проведен анализ наркотиков с использованием модели глиомы Дрософила меланогастера. VP3.15, двойной ингибитор с противовоспалительными и нейрозащитными функциями при множественном склерозе, был выбран для дальнейшего изучения. VP3.15 продемонстрировал высокую антиопухоль против панели клеток человека и м

Artificial Intelligence in the Management of Hereditary and Acquired Hemophilia: From Genomics to Treatment Optimization.

Hemophilia, an X-linked bleeding disorder, is characterized by a deficiency in coagulation factors. It manifests as spontaneous bleeding, leading to severe complications if not properly managed. In contrast, acquired hemophilia is an autoimmune condition marked by the development of inhibitory antibodies against coagulation factors. Both forms present significant diagnostic and therapeutic challenges, highlighting the need for advanced genetic, molecular, laboratory, and clinical assessments. Recent advances in artificial intelligence have opened new avenues for the management of hemophilia. M

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… The diagnosis is confirmed by measuring factor VIII levels in hemophilia A and factor IX levels in hemophilia B. … Confirmatory testing includes measurement of factor VIII activity and inhibitor titration. …

Heyde Syndrome Unveiled: A Case Report with Current Literature Review and Molecular Insights.

Heyde syndrome, marked by aortic stenosis, gastrointestinal bleeding from angiodysplasia, and acquired von Willebrand syndrome, is often underreported. Shear stress from a narrowed aortic valve degrades von Willebrand factor multimers, leading to angiodysplasia formation and von Willebrand factor deficiency. This case report aims to raise clinician awareness of Heyde syndrome, its complexity, and the need for a multidisciplinary approach. We present a 75-year-old man with aortic stenosis, gastrointestinal bleeding from angiodysplasia, and acquired von Willebrand syndrome type 2A. The patient w

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… Mutations in the F8 gene, related to factor VIII, are associated with Type 2N VWD [ 32 ]. … Desmopressin rapidly stimulates the release of VWF and factor VIII from endothelial cells, achieving this effect within 1–2 h. Monitoring VWF and factor VIII levels is essential to prevent tachyphylaxis. …

Natural orifice surgery on thyroid gland: totally transoral video-assisted thyroidectomy (TOVAT): report of first experimental results of a new surgical method.

BACKGROUND: Neck surgery is one of the newest fields of application of minimally invasive surgery. The technique of minimally invasive video-assisted thyroidectomy (MIVAT) developed by Miccoli [1] is the method that has so far become most widespread. Limiting factors of this method include the bothersome 20-mm cervical incision and consequently the specimen size to remove. Several papers describing an access outside the front neck region have been published. Such approaches are via the chest, axillary, a combined axillary bilateral breast, or a bilateral axillary breast approach [2-5]. The dev

Роль мозжечка в множестве проблем со склерозом и инвалидностью.

Фон: Усталость является распространенным и изнурительным симптомом у людей с множественным склерозом (PwMS), что существенно снижает качество жизни. В то время как мозжечок традиционно ассоциируется с управлением мотором, появляющиеся данные указывают на его участие в когнитивных, эмоциональных и интеграционных функциях. Цель этого исследования заключалась в изучении взаимосвязи между компонентами усталости (физической, когнитивной и психосоциальной), клинической инвалидностью и мозговыми структурными изменениями в ПМС, полученными с помощью магнитного резонансного изображения (MRI). Методы: У

Recent advances in use of fresh frozen plasma, cryoprecipitate, immunoglobulins, and clotting factors for transfusion support in patients with hematologic disease.

Hematologic diseases include a broad range of acquired and congenital disorders, many of which affect plasma proteins that control hemostasis and immune responses. Therapeutic interventions for these disorders include transfusion of plasma, cryoprecipitate, immunoglobulins, or convalescent plasma-containing therapeutic antibodies from patients recovering from infectious diseases, as well as concentrated pro- or anticoagulant factors. This review will focus on recent advances in the uses of plasma and its derivatives for patients with acquired and congenital hematologic disorders.

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… There are more than 30 active gene therapy trials for Factor VIII and IX replacement currently listed at clinicaltrials.gov. … Additionally, a unique alternative to factor replacement has emerged for Factor VIII: emicizumab, a bispecific chimeric monoclonal antibody, will mimic the cofactor activity of Factor VIII by co-locating Factor IXa and Factor X to catalyze clot formation [102] , [103] , [104] . …

Объяснение когнитивной функции при множественном склерозе через сети элементов серых и белых веществ: совместный независимый анализ компонентов.

Когнитивное повреждение (CI) при множественном склерозе (MS) лишь частично объясняется показателями объема всего мозга, однако независимый анализ компонентов (ICA) может вычислить региональные модели ущерба серым веществом (GM) или белым веществом (WM), которые более тесно связаны с CI. Патология в ГМ и WM происходит параллельно, и, таким образом, модели могут охватывать и то, и другое. В ходе этого исследования была проведена оценка того, лучше ли объяснена когнитивная функция совместной ИКА ГМ и WM по сравнению с одиночной ISA. 89 человек с MS прошли когнитивное тестирование и магнитно-резон

Severe Disc degeneration is associated with lower caudal subendplate hounsfield unit values in degenerative lumbar spinal stenosis.

STUDY DESIGN: Retrospective radiological analysis OBJECTIVE: To analyze the distribution of computed tomography (CT)-based Hounsfield unit (HU) values of lumbar vertebrae and explore the correlation between HU values and the modified Pfirrmann grades in patients with degenerative lumbar spinal stenosis (DLSS). METHOD: A total of 82 DLSS patients were divided into two gender-based groups for this retrospective analysis. Demographic data, including age, gender, body mass index, medical history, smoking status, operative levels, bone turnover markers (BTMs), and bone metabolism indicators, of al

Association between pacifier use and breast-feeding, sudden infant death syndrome, infection and dental malocclusion.

OBJECTIVE: To critically review all literature related to pacifier use for full-term healthy infants and young children. The specific review questions addressed are: What is the evidence of adverse and/or positive outcomes of pacifier use in infancy and childhood in relation to each of the following subtopics: • breast-feeding; • sudden infant death syndrome; • infection; • dental malocclusion. INCLUSION CRITERIA: Specific criteria were used to determine which studies would be included in the review: (i) the types of participants; (ii) the types of research design; and (iii) the types of outc

Reimagination in art and science: Seeing the familiar in a new light and creating new things that didn't exist before.

Many groundbreaking works in art and science owe their origins to the creative spark ignited by reimagination-the process whereby artists and scientists reinterpret and reframe past and existing knowledge, envisioning it in a new context that reveals new possibilities. Artistic and scientific innovation originating from reimagination brings to mind William Faulkner's famous line, "The past is never dead. It's not even past." [W. Faulkner, Requiem for a Nun (1)].

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… Such approaches involved the use of plasma replacement and/or plasma-derived Factor VIII concentrates for which many treated patients developed hepatitis, HIV, and/or neutralizing antibodies to Factor VIII. Moreover, bleeding was poorly controlled. … The awardees’ bispecific antibody, the first bispecific IgG approved by the FDA for therapeutic use in 2017, has virtually eliminated the bleeding in hemophilia A patients, even in those with Factor VIII antibodies. …

BEVA primary care clinical guidelines: Diagnosis and management of equine pituitary pars intermedia dysfunction.

BACKGROUND: Pituitary pars intermedia dysfunction (PPID) is a prevalent, age-related chronic disorder in equids. Diagnosis of PPID can be challenging because of its broad spectrum of clinical presentations and disparate published diagnostic criteria, and there are limited available treatment options. OBJECTIVES: To develop evidence-based primary care guidelines for the diagnosis and treatment of equine PPID based on the available literature. STUDY DESIGN: Evidence-based clinical guideline using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) framework. METHODS

Hematology

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… . ↑ INR, ↑ PTT, ↓ fibrinogen (although it can be normal or even elevated in acute phase), ↑ D-dimers, ↓ factor VIII (in contrast to liver diseases, which have normal factor VIII). … also serves as carrier for factor VIII. …

Preventing and Repairing Myeloma Bone Disease by Combining Conventional Antiresorptive Treatment With a Bone Anabolic Agent in Murine Models.

Multiple myeloma is a plasma cell malignancy, which develops in the bone marrow and frequently leads to severe bone destruction. Current antiresorptive therapies to treat the bone disease do little to repair damaged bone; therefore, new treatment strategies incorporating bone anabolic therapies are urgently required. We hypothesized that combination therapy using the standard of care antiresorptive zoledronic acid (Zol) with a bone anabolic (anti-TGFβ/1D11) would be more effective at treating myeloma-induced bone disease than Zol therapy alone. JJN3 myeloma-bearing mice (n = 8/group) treated w

Clinical Efficacy of a Novel Therapeutic Principle, Anakoinosis.

Classic tumor therapy, consisting of cytotoxic agents and/or targeted therapy, has not overcome therapeutic limitations like poor risk genetic parameters, genetic heterogeneity at different metastatic sites or the problem of undruggable targets. Here we summarize data and trials principally following a completely different treatment concept tackling systems biologic processes: the principle of communicative reprogramming of tumor tissues, i.e., anakoinosis (ancient greek for communication), aims at establishing novel communicative behavior of tumor tissue, the hosting organ and organism via re

Leukoencephalopathy During Daratumumab-Based Therapy: A Case Series of Two Patients with Multiple Myeloma.

Leukoencephalopathy in the setting of multiple myeloma (MM) is a rare demyelinating condition, with few reported cases in literature. Daratumumab is a CD38 targeted monoclonal antibody that has been widely used for the management of MM. In the absence of central nervous system (CNS) disease, many medication-induced leukoencephalopathy cases reported with MM, including daratumumab-induced, are associated with progressive multifocal leukoencephalopathy (PML) and John Cunningham (JC) virus. Currently, there are no reported cases of daratumumab-induced leukoencephalopathy among patients without CN

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… Of note, a coagulopathy panel was performed on May 24, 2021, and he was found to have an elevated factor VIII level of 269%. … VIII level of 277% Elevated serum factor VIII level of 269% LP results Elevated myelin basic protein; negative JCV Elevated myelin basic protein; negative JCV; positive oligoclonal bands; lymphocytic pleocytosis with elevated protein Effect of discontinuation of daratumumab Unable to assess (patient …

Acquired Factor X Deficiency without Amyloidosis Presenting with Massive Hematuria: A Case Report and Review of the Literature.

Acquired factor X deficiency is a rare diagnosis, especially without the association of other co-existing conditions such as amyloidosis. The authors report the case of a 34-year-old male with severe frank hematuria found to have markedly prolonged prothrombin time and activated partial thromboplastin time. A mixing study showed correction utilizing normal plasma and a coagulation panel testing revealed decreased factor X activity. The patient was treated with multiple blood transfusions, fresh frozen plasma, high-dose pulse steroids, and rituximab. The patient's condition improved during his

Isolated cranial nerve disorder as presenting sign in multiple sclerosis: optic nerve versus "the others".

BACKGROUND: The prevalence of cranial nerve involvement in Multiple Sclerosis (MS) varies across studies. It has been speculated that first presentation of disease with cranial nerve involvement - except for optic neuritis - may be associated with milder progression. AIM: This study compares the clinical outcome of patients with MS in a 4-year follow-up of patients with initial symptoms of optic neuritis (ON) versus those with other cranial nerve (OCN) involvement. MATERIALS AND METHODS: Retrospective analysis of MS patient database of a tertiary referral university MS center. We included tr

Thrombotic risk in hepatitis C: Interplay between hepatic dysfunction, viral-driven inflammation, and cardiovascular consequences.

Hepatitis C virus (HCV) infection, traditionally regarded as a hepatotropic disease, is increasingly recognized as a systemic condition with significant thrombotic implications. Chronic HCV induces a persistent proinflammatory and prothrombotic state that substantially elevates the risk of both venous and arterial events. Mechanistically, HCV drives endothelial dysfunction, enhances platelet activation, disrupts coagulation and fibrinolytic balance, and promotes immune-mediated vascular injury through cryoglobulinemia and chronic systemic inflammation. Clinical manifestations range from portal

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… In cirrhosis, reduced activity of several procoagulant factors is offset by increased levels of factor VIII, synthesized by liver sinusoidal endothelial cells, along with decreased concentrations of natural anticoagulants. … Additionally, the studies would evaluate longitudinal changes in key coagulation biomarkers, including factor VIII, protein C, von Willebrand factor, and D-dimer levels. …

Множественная миелома у людей трудоспособного возраста в Германии, Польше и Чехии: результаты качественного исследования.

ЦЕЛЬ: Цель исследования состояла в том, чтобы понять опыт взрослых трудоспособного возраста с миеломой и их партнерами/членами семьи, проживающими в Германии, Чешской Республике и Польше. МЕТОДЫ: КОНСУЛЬТАТИВНЫЕ СООБРАЖЕНИЯ 36 взрослых трудоспособного возраста, живущих с миеломой, и three Члены семьи. Данные были собраны в период с мая по октябрь 2022. К данным был применен тематический анализ. Результаты: Описано медицинское обслуживание и государственная поддержка в каждой стране. Степень участия в трудовой деятельности зависит от бремени симптомов пациентов, потребностей в лечении, государс