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Treatment of osteolytic myelomatosis with mithramycin.

The treatment of rapidly progressive skeletal demineralisation in myelomatosis has been studied with the help of metabolic calcium balance in two patients; In one, osteoporosis accelerated during treatment with melphalan and prednisolone, although he remained normocalcaemic throughout, suggesting that osteoporosis was aggravated by corticosteroid therapy. In the other patient, who was initially hypercalcaemic, conventional treatment produced clinical remission before eventual relapse with more hypercalcaemia and skeletal dissolution. Both patients were then treated with mithramycin alone, and,

A review of selected inherited corneal dystrophies associated with systemic diseases.

The normal transparency of the cornea permits detailed in vivo study of several human pathologic conditions. Many systemic diseases are associated with corneal dystrophies which are manifested by haziness, opacification, crystalline deposition, or discoloration. Although these abnormal states can sometimes be seen grossly, biomicroscopy with slit lamp illumination is necessary for an exact morphologic description. Only precise delineation can lead to an accurate diagnosis of the corneal disorder and thus provide clues for an associatkd systemic disease.

Value of plasma chloride concentration and acid-base status in the differential diagnosis of hyperparathyroidism from other causes of hypercalcaemia.

A study is reported of the estimation of plasma chloride concentration and acid-base status in the differentiation of primary hyperparathyroidism from all other causes of hypercalcaemia. In the two groups of patients studied, all of whom had hypercalcaemia, there was complete separation between the two groups on the basis of plasma chloride concentration and acid-base status. In 16 patients with primary hyperparathyroidism the increase in plasma chloride concentration and associated metabolic acidosis could have been accounted for by the known renal tubular effects of parathyroid hormone. In 1

Calcium Overload in Trisomy 21: An Underrecognized Cause of Persistent Hypercalcaemia - A Case Report.

INTRODUCTION: Calcium overload in trisomy 21 is a rare and underrecognized cause of persistent parathyroid hormone (PTH)-independent hyperca … ith failure to thrive, recurrent vomiting, and nephrocalcinosis in combination with PTH-independent hypercalcemia. Early recognition and initiation of dietary calcium restriction may prevent long-term complications such as chronic kidney disease and prolonged growth impairment.

Delayed Diagnosis of HDR (Hypoparathyroidism, Deafness, and Renal Dysplasia) Syndrome Presenting With Life-Threatening Hypercalcemic Crisis: A Case Report.

Hypoparathyroidism, sensorineural deafness, and renal dysplasia (HDR) syndrome is a rare autosomal dominant disorder caused by pathogenic va … rgency department with altered consciousness, dehydration, and oliguria. Evaluation revealed severe hypercalcemia (20.7 mg/dL) and acute kidney injury on the background of chronic kidney disease (creatinine: 2.98 mg/dL; estimated glomerular filtration rate: 19 mL/minute/1.73 m²). Following urgent hemodialysis and intensive intravenous hydration, serum calcium l …

Assessment of phenotypes in a unique group of RET proto-oncogene Y791F variant carriers in the Polish population.

INTRODUCTION: Among all RET proto-oncogene variants, Y791F has been the most controversial and widely debated with regard to itspathogenicit … t 6after adrenalectomy) was diagnosed with pheochromocytoma. None of the 104 RET Y791F carriers had hypercalcemia. CONCLUSIONS: Based on our results, individuals with the RET Y791F variant do not require enhanced clinical surveillance or prophylactic intervention and should be managed according to general population guidelines, unless additional clinical indic …

Perioperative enhanced recovery after surgery protocols with anterior mediastinal ectopic parathyroid tumor: A case report.

RATIONALE: To summarize the perioperative nursing experience in the successful treatment of anterior mediastinal ectopic parathyroid tumors. PATIENT CONCERNS: A 50-year-old female, who had previously undergone treatment for a parathyroid adenoma for 7 years, was admitted to the hospital because of recurrent pancreatitis, kidney stones, hypercalcemia (2.98 mmol/L), elevated parathyroid hormone levels (299 pg/mL), and an abnormal parathyroid gland discovered in an external hospital examination 2 months prior. DIAGNOSES: Primary hyperparathyroidism secondary to an anterior mediastinal ectopic p…

A unique presentation of an osteolytic chronic lymphocytic leukemia/small lymphocytic lymphoma as a helmet-shaped tumor.

BACKGROUND: Cranial vault lymphomas (CVLs) are rare skull lesions, mostly caused by diffuse large B-cell lymphoma, a subtype of non-Hodgkin … man was admitted to our hospital for the continuation of treatment of CLL/SLL, which presented with hypercalcemia, generalized lymphadenopathy, and osteolytic lesions of Th10, Th11, and L2 vertebrae. An initial head computed tomography (CT) scan, performed due to psychomotor impairment, showed an extensive CVL. Despite therapy, a control CT scan showed progress …

A Case Report of Uterine Dedifferentiated Mesonephric-Like Adenocarcinoma With Comprehensive Molecular Profiling.

Mesonephric-like adenocarcinoma (MLA) of the uterus is a rare, aggressive malignancy of presumed Müllerian origin that was recently included … from a 41-yr-old woman who presented with bilateral ovarian masses, peritoneal carcinomatosis, and hypercalcemia. A diagnosis of small cell carcinoma of the ovary, hypercalcemic type, was initially rendered at an outside institution from an omental biopsy, which only showed the undifferentiated component. The subsequent endometrial curettings performed at our …

Small cell carcinoma of the ovary, hypercalcemic type: a mini review.

Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is a rare and highly aggressive ovarian neoplasm, predominantly affecting you … esents with nonspecific abdominal or pelvic symptoms and is uniquely associated with paraneoplastic hypercalcemia in up to two-thirds of cases. Diagnosis requires a combination of imaging, laboratory evaluation, histopathology, and immunohistochemistry. Treatment is not standardized but typically involves a multimodal approach, including radical surgery and pla …

Проблемы, трудности и запоздалый диагноз множественной миеломы.

Фон: Множественная миелома (ММ) представляет собой разнородную плазменную порчу клеток с неконкретными симптомами и разнородностью болезней на клиническом и биологическом уровнях. Этот неконкретный набор симптомов, включая боль в костях, анемию, почечную недостаточность, гиперкальцемию и нейропатию, может ввести в заблуждение диагноз как хронические или доброкачественные заболевания, что приводит к задержкам в диагностике. Своевременное выявление имеет важнейшее значение для предотвращения повреждения органов и снижения заболеваемости. Методы: В настоящем обзоре мы представляем обзор последней

Совпадение в аннотации оригинала
Background: Multiple myeloma (MM) is a heterogeneous plasma cell malignancy with non-specific symptoms and disease heterogeneity at clinical and biological levels. This non-specific set of symptoms, including bone pain, anemia, renal failure, hypercalcemia, and neuropathy, can mislead diagnosis as chronic or benign conditions, resulting in a delay in diagnos…

PTH Analog Therapy in CKD G4-G5D: Current Evidence and Potential Role of Abaloparatide in Adynamic Bone Disease.

Osteoporosis and fragility fractures are among the most prevalent and clinically significant complications in patients with chronic kidney d … ratide, a selective PTH1 receptor agonist, exerts potent anabolic effects with a lower incidence of hypercalcemia than teriparatide and may offer a favourable safety profile in carefully selected patients. Preliminary data suggest preservation of bone microarchitecture and potential benefits in low-turnover bone disease, although evidence in CKD is still limite …

Molecular basis of symptomatic sporadic primary hyperparathyroidism: New frontiers in pathogenesis.

Primary hyperparathyroidism is a common endocrine disorder characterized by inappropriate elevation of parathyroid hormone and hypercalcemia. While predominantly an asymptomatic disease in Western populations, symptomatic presentations are more prevalent in Eastern countries. The molecular pathogenesis of sporadic PHPT primarily involves genetic and epigenetic alterations leading to abnormal parathyroid cell proliferation and altered calcium sensing mechanism. To date, MEN1 and cyclin D1 are the only established drivers of sporadic PHPT. Somatic MEN1 gene mutations occur in 30-40 % of sporadic…

Severe Headache and Deterioration of Vision in Left Eye in a Chronic Hemodialysis Patient Revealing a Brown Tumor of Sphenoid Sinus.

BACKGROUND/OBJECTIVES: Brown tumors are rare bone lesions associated with hyperparathyroidism, particularly secondary hyperparathyroidism (S … a severe headache, diplopia, and progressive vision loss in her left eye. Laboratory tests revealed hypercalcemia, hypophosphatemia, and elevated parathyroid hormone (PTH) levels, consistent with SHPT. The diagnosis was confirmed through a clinical examination and magnetic resonance imaging (MRI). RESULTS: The clinical examination confirmed decreased visual ac …

Autologous platelet-rich plasma therapy for skin ulceration due to calcific uremic arteriopathy: a case report and review of the literature.

INTRODUCTION: Calcific uremic arteriolopathy (CUA) is a rare, but severe complication primarily affecting end-stage kidney disease (ESKD) pa … no improvement despite medical management for secondary hyperparathyroidism, hyperphosphatemia, and hypercalcemia, experienced progressive wound healing following autologous PRP therapy. The PRP was prepared using a two-step centrifugation process and applied topically after wound debridement. Over five PRP treatment sessions at 5-day intervals within 25 days, …

Advances in the clinical management of parathyroid disorders: report from the 2024 workshop by the ESE educational program on parathyroid disorders.

The present report from the ESE Educational Program on Parathyroid Disorders (PARAT Program) presents recent developments and novelties in t … ry syndromic forms of PHPT, the differentiation between parathyroid-related and unrelated causes of hypercalcemia, and the associated risks for both mother and fetus. Additionally, it addresses the practical aspects of managing pregnant women with HypoPT, aiming to provide practical guidance for clinicians. Clinical vignettes featuring 3 cases illustrate common …

Bisphosphonate Therapy and the Occurrence of the Hungry Bone Syndrome After Surgery for Primary Hyperparathyroidism.

OBJECTIVE: Hungry bone syndrome (HBS), marked by severe and persistent hypocalcemia, frequently occurs after parathyroidectomy for primary h … ue to bisphosphonate treatment, either in the overall cohort or in patients with moderate to severe hypercalcemia (calcium level ≥ 12 mg/dL) (odds ratio: 3.4, 95% CI: 0.5-22.7, p=0.191; odds ratio: 15.0, 95% CI: 0.6-383.9, p=0.102, respectively). CONCLUSION: Preoperative bisphosphonate therapy does not prevent the development of HBS following parathyroidectomy …