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Exploring cancer care needs for Latinx adults: a qualitative evaluation.

PurposeLatinx adults with cancer, as compared with non-Latinx White adults, are diagnosed with more advanced stages and experience worse quality of life. Identifying barriers in cancer care among low-income Latinx adults is crucial to designing and implementing culturally appropriate interventions. The objective of this study was to explore the specific barriers encountered by Latinx adults after a cancer diagnosis and perspectives on the use of community health workers (CHWs) to address these barriers.MethodsWe conducted semi-structured qualitative interviews with low-income Latinx adults wit

The feasibility of a Bayesian network model to assess the probability of simultaneous symptoms in patients with advanced cancer.

Although patients with advanced cancer often experience multiple symptoms simultaneously, clinicians usually focus on symptoms that are volunteered by patients during regular history-taking. We aimed to evaluate the feasibility of a Bayesian network (BN) model to predict the presence of simultaneous symptoms, based on the presence of other symptoms. Our goal is to help clinicians prioritize which symptoms to assess. Patient-reported severity of 11 symptoms (scale 0-10) was measured using an adapted Edmonton Symptom Assessment Scale (ESAS) in a national cross-sectional survey among advanced can

Longitudinal Collection of Patient-Reported Outcomes and Activity Data during CAR-T Therapy: Feasibility, Acceptability, and Data Visualization.

Background: Clinicians must closely monitor patients for toxicities after chimeric antigen receptor T-cell therapy (CAR-T). Patient-reported … cated acceptability. Preliminary data patterns suggested that participants with better treatment response (vs. progressive disease) had a higher toxicity burden. Conclusions: Longitudinal PRO and activity data collection was feasible and acceptable. Data collected on a larger scale may be used to specify risk prediction models to identify predictors of …

Assessing and Management of Neurotoxicity After CAR-T Therapy in Diffuse Large B-Cell Lymphoma.

Chimeric antigen receptor T-cell (CAR-T) therapy represents the most important advances in cancer immunotherapy, especially in hematological malignancies such as B-cell lymphomas. CAR-T cell therapy has significant activity in poor risk B-cell lymphomas. CAR-T cell therapy is associated with potentially life-threatening toxicities such as cytokine release syndrome (CRS) and neurotoxicity (NT). While CRS pathophysiology and management are well established, the understanding and treatment of NT continues to develop. All current CAR-T products approved for DLBCL have been associated with NT with

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… needed to rule out other causes, such as intracranial hemorrhage or lymphoma involvement of the CNS. 11 , 20 , 24 , 28 In some cases, patients with moderate to severe neurotoxicity might show patchy T2 hyperintensities throughout the white matter or T2 hyperintensities in the bilateral thalami, dorsal pons …

eCross-cultural adaptation of the spine oncology-specific SOSGOQ2.0 questionnaire to German language and the assessment of its validity and reliability in the clinical setting.

BackgroundThe recently developed Spine Oncology Study Group Outcomes Questionnaire (SOSGOQ2.0) was proven a valid and reliable instrument me … questionnaire in total score and by domain was confirmed (range of deviation 4.4 to 9.0%). Good responsiveness for the domains Physical Functioning (P ConclusionsAccording to our results, the cross-cultural adapted questionnaire is a reliable and valid tool to measure HRQOL in German speaking patients with spinal malignancies. Especially the domains P …

Multiple Myeloma Outpatient Transplant Program in the Era of Novel Agents: State-of-the-Art.

Multiple myeloma (MM) is the most common indication for autologous stem cell transplantation (ASCT), and outpatient models have been widely developed in this setting. Although numerous studies have demonstrated the safety and feasibility of outpatient ASCT, it is not a routine procedure. Stringent guidelines for patient selection and clinical management, including functional status, caregiver support, and psychological aspects, are essential to identify eligible patients. However, there is still no general agreement on these criteria. Quality of life data are limited and contradictory. There i

The Oncolytic Virotherapy Era in Cancer Management: Prospects of Applying H-1 Parvovirus to Treat Blood and Solid Cancers.

Non-Hodgkin lymphoma (NHL) and leukemia are among the most common cancers worldwide. While the treatment of NHL/leukemia of B-cell origin has much progressed with the introduction of targeted therapies, few treatment standards have been established for T-NHL/leukemia. As presentation in both B- and T-NHL/leukemia patients is often aggressive and as prognosis for relapsed disease is especially dismal, this cancer entity poses major challenges and requires innovative therapeutic approaches. In clinical trials, oncolytic viruses (OVs) have been used against refractory multiple myeloma (MM). In pr

Improving management of patients with advanced cancer.

Development of bone metastases in patients with advanced cancer is associated with skeletal-related events (SREs) such as pathologic fractur … hly infusion visit allows a dedicated team of healthcare professionals to regularly assess SREs, response to therapy, adverse events (AEs), QOL, and adherence to oral medications and supplements. The continuity of care that occurs during the monthly infusion visit provides oncology nurses with an opportunity to educate patients about effective strategi …

Omega-3 Fatty Acids and Cancer Cell Cytotoxicity: Implications for Multi-Targeted Cancer Therapy.

Cancer is a major disease worldwide. Despite progress in cancer therapy, conventional cytotoxic therapies lead to unsatisfactory long-term survival, mainly related to development of drug resistance by tumor cells and toxicity towards normal cells. n-3 polyunsaturated fatty acids (PUFAs), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), can exert anti-neoplastic activity by inducing apoptotic cell death in human cancer cells either alone or in combination with conventional therapies. Indeed, n-3 PUFAs potentially increase the sensitivity of tumor cells to conventional therapies, poss

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… Giros A., Grzybowski M., Sohn V.R., Pons E., Fernandez-Morales J., Xicola R.M., Sethi P., Grzybowski J., Goel A., et al. Regulation of colorectal cancer cell apoptosis by the n-3 polyunsaturated fatty acids Docosahexaenoic and Eicosapentaenoic. Cancer Prev. …

Targeting large middle molecules: Clinical implications of expanded hemodialysis in hemodialysis care.

End-stage kidney disease (ESKD) presents a major clinical burden, with maintenance hemodialysis (HD) patients facing high cardiovascular mortality and impaired quality of life (QoL). Despite advances from low-flux to high-flux HD and the introduction of hemodiafiltration (HDF), clearance of large middle molecules (LMMs >25 kDa) remains inadequate. These molecules contribute to inflammation, oxidative stress, atherogenesis, and mineral-bone disorders, all of which worsen patient outcomes. Expanded hemodialysis (HDx), utilizing medium cutoff membranes, represents a novel approach that combines d

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… Maduell F, Moreso F, Pons M, Ramos R, Mora-Macià J, Carreras J, et al. High-efficiency postdilution online hemodiafiltration reduces all-cause mortality in hemodialysis patients. J Am Soc Nephrol. 2013;24:487–97. doi: 10.1681/ASN.2012080875. 44. …

Risk Factors for Adverse Outcomes in Cancer Patients With Sepsis.

BACKGROUND: Cancer and its various treatment modalities increase susceptibility to the development of sepsis. Because of the complex relationship between sepsis and cancer, we aimed to study the differences in risk factors and outcomes of sepsis in patients with cancer (SCa) compared to patients without cancer (SnoCa). METHODS: A retrospective cohort analysis of all adult patients who received care for sepsis in an urban tertiary healthcare center was conducted. Risk factors and outcomes were compared between the SCa and SnoCa groups. RESULTS: SCa group (n = 310) was older than SnoCa group (

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… Oncol 2021 44 10 505 511 10.1097/COC.0000000000000859 34342290 6 Xiang MJ Chen GL Impact of cancer on mortality rates in patients with sepsis: a meta-analysis and meta-regression of current studies World J Clin Cases 2022 10 21 7386 7396 10.12998/wjcc.v10.i21.7386 36157986 PMC9353912 7 Lemiale V Pons …

Интерпретация вирусных ассоциаций по нейродегенеративным болезням.

Вирусные инфекции связаны с множественным склерозом (MS), болезнью Альцгеймера (AD), болезнью Паркинсона (PD) и амиотропическим боковым склерозом (ALS), но ассоциации могут отражать различные связи с процессом заболевания. В настоящем обзоре анализируются данные, свидетельствующие о наличии вирусных заболеваний в связи с началом болезни, модификацией установленных заболеваний, дисфункциональным вирусным контролем в качестве вторичных заболеваний или методов лечения и случайным обнаружением. Самые убедительные временные данные касаются вируса Эпштейн-Барр (ЭБВ) и MS. Перспективные данные указыв

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… Lapeyre L., Piret J., Rhéaume C., Pons V., Uyar O., Préfontaine P., Rivest S., Boivin G. Herpes simplex virus 1 infection does not increase amyloid-β pathology in APP/PS1 mice. J. Alzheimer’s Dis. 2024;97:171–178. doi: 10.3233/jad-230746. 34. …

Psychometric Properties of the Persian Self-Advocacy in Cancer Survivorship Scale (SACS-P) in Iran.

BackgroundSelf-advocacy is crucial for cancer patients, as it allows them to express their needs and engage in treatment decisions. This skill enhances the quality of care and life satisfaction. Accurately measuring self-advocacy and supporting patients with lower skills is essential to improving treatment outcomes and promoting patient-centered care. Accurate measurement of self-advocacy is vital for identifying patients with lower skills and providing support to enhance treatment outcomes and patient-centered care. This study aimed to investigate the psychometric properties of the Persian ve

Euthanasia as a safeguard for living: Anticipation and incurable cancer in a Colombian context.

This article builds on years of ethnographic conversations I sustained with my father, 89, who lives in Colombia. Soon after getting diagnosed with an incurable Multiple Myeloma-a cancer known for unleashing prolonged and painful agonies-he withdrew from oncology treatments and secured access to euthanasia (assisted-dying) on his own, bypassing medico-insurance guidelines created to regulate this medical practice and prevent abuses. Eight years after withdrawing treatments, my dad is still alive. His case shines a light on how securing access to euthanasia may have had unintended therapeutic e

Переписка MRI и NTMS с EDS в рамках многоразового склероза: продольное исследование последующей деятельности.

ЦЕЛИ: С учетом характеристик множественного склероза (МС) и его воздействия на моторную недостаточность цель настоящего исследования заключается в оценке функциональной целостности кортикоспинального тракта путем изучения моторных возможностей (МЭП), оценок, полученных в рамках расширенной шкалы инвалидности (EDSS), числа случаев поражения магнитными резонансными изображениями (MRI), а также психологического и физического состояния, о котором сообщают пациенты с повторно излучающими MS (RRMS). МЕТОДЫ: 23 Темы ОРУ (RMS)17 в последующей деятельности) кортикоспинальный тракт для верхних и нижних

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OBJECTIVES: Considering the characteristics of multiple sclerosis (MS) disease and its impact on motor disability, this study aims to assess … RPRETATION: RRMS subjects with altered MEP latency findings (prolonged MEP latency or absent MEP response) compared to subjects with non-altered MEP latency findings, had higher EDSS scores in lower extremity muscles as well as a higher number of lesions in the corpus callosum. This is the first longitudinal nTMS study to perform four-limb cortical map …

Mitigating Doxorubicin-Induced Cardiotoxicity through Quercetin Intervention: An Experimental Study in Rats.

Doxorubicin (DOX) is an effective anticancer drug, but its use is limited by dose-dependent heart toxicity. Quercetin is a natural antioxidant frequently studied for its beneficial properties. Moreover, a wide range of dietary supplements are available for human use. This in vivo study aimed to explore the potential cardioprotective effects of quercetin in chronic DOX treatment. A total of 32 Wistar rats were randomly divided into four groups: control, DOX, DOX/Q-50, and DOX/Q-100, treated with saline, 2.5 mg/kg body-weight DOX, 2.5 mg/kg body-weight DOX + 50 mg quercetin, and 2.5 mg/kg body-w

Assessing the impact of digital patient monitoring on health outcomes and healthcare resource usage in addition to the feasibility of its combination with at-home treatment, in participants receiving systemic anticancer treatment in clinical practice: protocol for an interventional, open-label, multicountry platform study (ORIGAMA).

IntroductionDigital patient monitoring (DPM) tools can enable more effective clinical care and improved patient outcomes in cancer. However, their broad adoption requires ease of use and demonstration of real-world clinical utility/impact. ORIGAMA (MO42720) is an interventional, open-label, multicountry platform study investigating the clinical utility of DPM tools and specific treatments. ORIGAMA will begin with two cohorts that aim to assess the impact of the atezolizumab-specific Roche DPM Module (hosted on the Kaiku Health DPM platform (Helsinki, Finland)) on health outcomes and healthcare

Financial toxicity following surgical treatment for colorectal cancer: a cross-sectional study.

PurposeFinancial toxicity has become a global public health issue. The purpose of the study is to investigate and analyze the influencing factors of financial toxicity in patients with non-metastatic colorectal cancer.MethodsA convenient sample of 250 patients with stage I-III colorectal cancer was investigated in the study. They completed a set of questionnaires, including the Comprehensive Score for Financial Toxicity questionnaire, the Perceived Social Support Scale, and the Hospital Anxiety and Depression Scale. Univariate and multivariate linear regression were performed to investigate th

Tapentadol: A Review of Experimental Pharmacology Studies, Clinical Trials, and Recent Findings.

Tapentadol is an analgesic compound that acts centrally to attenuate pain. Previous studies have shown that tapentadol has dual mechanisms of action as a mu-opioid receptor agonist and noradrenaline re-uptake inhibition. Therefore, tapentadol provides a great advantage over classic opioids in pain management from nociceptive to neuropathic. Cumulative evidence from in vitro data suggests that tapentadol effect of norepinephrine re-uptake could be a new target that overcomes other classic opioids in chronic neuropathic pain. Compared to tramadol and other opioids, tapentadol is associated with

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… In addition, tissues were obtained from the rat hypothalamus to test NE uptake and medulla oblongata and pons to test 5HT uptake. Ki values were 0.48 µM and 2.37 µM for NE and 5HT, respectively. 28 Thus, tapentadol showed more specificity and selectivity toward NE than 5HT. …

A scoping review examining the integration of exercise services in clinical oncology settings.

BackgroundAddressing questions surrounding the feasibility of embedding exercise service units in clinical oncology settings is imperative for developing a sustainable exercise-oncology clinical pathway. We examined available literature and offered practical recommendations to support evidence-based practice, policymaking, and further investigations.MethodsFour thousand eight hundred sixty-three unique records identified in Embase, CINAHL, MEDLINE, Web of Science Core Collection, and ProQuest (Health and Medicine) were screened for studies that recruited cancer patients, assessed the co-locati