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Combinational Antitumor Strategies Based on the Active Ingredients of Toad Skin and Toad Venom.

A multidrug combination strategy is an important mean to improve the treatment of cancer and is the mainstream scheme of clinical cancer treatment. The active ingredients of traditional Chinese medicine, represented by toad skin and toad venom, have the advantages of high efficiency, low toxicity, wide action and multiple targets and have become ideal targets in combined treatment strategies for tumors in recent years. Toad skin and toad venom are traditional Chinese animal medicines derived from Bufo bufo gargarizans Cantor or Bufo melanostictus Schneider that have shown excellent therapeutic

Clinical Characteristics of Neuropathic Pain and Its Relationship with Cancer in Different Corporal Areas-A Systematic Review.

Background: Neuropathic pain (NP) and cancer are caused by nerve damage due to cancer or treatments such as chemotherapy, radiotherapy, and surgery, with a prevalence that can reach up to 40%. Causes of neuropathic cancer pain (NCP) include direct nerve invasion or compression by the tumor, as well as neural toxicity associated with treatments. This type of pain is classified into several categories, such as plexopathy, radiculopathy, and peripheral neuropathies. Methods: Medline, Web of Science, Google Scholar, CINAHL, and LILACS databases were searched until October 2024. Two authors indepen

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… Patients may experience numbness, hyperalgesia (increased sensitivity to pain), anxiety, allodynia (pain from stimuli that do not normally provoke pain), paresthesia (tingling sensations), depression, and sleep disorders. …

The Value of In Vivo Reflectance Confocal Microscopy as an Assessment Tool in Chemotherapy-Induced Peripheral Neuropathy: A Pilot Study.

BackgroundThere is a lack of standardized objective and reliable assessment tools for chemotherapy-induced peripheral neuropathy (CIPN). In vivo reflectance confocal microscopy (RCM) imaging offers a non-invasive method to identify peripheral neuropathy markers, namely Meissner's corpuscles (MC). This study investigated the feasibility and value of RCM in CIPN.Patients and methodsReflectance confocal microscopy was performed on the fingertip to evaluate MC density in 45 healthy controls and 9 patients with cancer (prior, during, and post-chemotherapy). Quantification was completed by 2 reviewe

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… Thermal hyperalgesia as a marker of oxaliplatin neurotoxicity: a prospective quantified sensory assessment study . Pain 2009 ; 144 ( 3 ): 245 - 252 . 10.1016/j.pain.2009.03.024 . 19457614 66. Wang XS , Shi Q , Dougherty PM , et al. …

The Rationale for Using Neridronate in Musculoskeletal Disorders: From Metabolic Bone Diseases to Musculoskeletal Pain.

Neridronate or ((6-amino-1-hydroxy-1-phosphonohexyl) phosphonic acid) is an amino-bisphosphonate (BP) synthetized in Italy in 1986. Bisphosphonates are molecules with a P-C-P bond in their structure that allows strong and selectively binding to hydroxyapatite (HAP) as well as osteoclasts inhibition through different mechanisms of action. Neridronate was initially used to treat Paget disease of the bone, demonstrating effectiveness in reducing bone turnover markers as well as pain. The interesting molecular properties of neridronate foster its wide use in several other conditions, such as osteo

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… These results were accompanied by evidence of its efficacy in terms of other clinical (resolution of edema, pain at passive motion, allodynia, hyperalgesia, and better QoL) and instrumental (i.e., bone edema reduction and bone scan uptake normalization) findings of algodystrophy. …

Integrative Medicine for Cancer-Related Pain: A Narrative Review.

Cancer-related pain (C-RP) is a prevalent and debilitating concern among patients with cancer, with conventional treatments limited in their ability to provide adequate relief, and by the adverse effects associated with their use. Complementary and integrative medicine (CIM) modalities have been shown to be potentially effective and safe for the treatment of pain and related symptoms, when used in conjunction with conventional medications and under medical supervision. An increasing number of oncology centers provide CIM within their conventional supportive and palliative care service, in an "

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… Fufang Kushen injection inhibits sarcoma growth and tumor-induced hyperalgesia via TRPV1 signaling pathways. Cancer Lett. 2014;355:232–241. doi: 10.1016/j.canlet.2014.08.037. 75. Yanju B., Yang L., Hua B., Hou W., Shi Z., Li W., Li C., Chen C., Liu R., Qin Y., et al. …

Polydatin: Pharmacological Mechanisms, Therapeutic Targets, Biological Activities, and Health Benefits.

Polydatin is a natural potent stilbenoid polyphenol and a resveratrol derivative with improved bioavailability. Polydatin possesses potential biological activities predominantly through the modulation of pivotal signaling pathways involved in inflammation, oxidative stress, and apoptosis. Various imperative biological activities have been suggested for polydatin towards promising therapeutic effects, including anticancer, cardioprotective, anti-diabetic, gastroprotective, hepatoprotective, neuroprotective, anti-microbial, as well as health-promoting roles on the renal system, the respiratory s

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… Polydatin improved mitochondrial function through the Sirt3/Nrf2 axis and, thus, reduced thermal and mechanical hyperalgesia in animal models [ 144 ]. In conclusion, polydatin could be an effective natural compound in the treatment of diabetes and complications related to diabetes. … Mast cell activation leads to the aggravation of pain and hyperalgesia in endometriosis [ 216 ]. In different studies, the effectiveness of palmitoylethanolamide (PEA)/polydatin combination was evaluated on endometriosis. PEA showed anti-inflammatory and inhibitory effects on mast cells. …

Распространение нетрофической боли в многоразовом склерозе - системном обзоре и мета-анализе с использованием алгоритма NeuPSIG.

Множественный склероз (MS) — нейродегенеративное расстройство, часто приводящее к нейропатической боли. Из-за нейродегенеративной природы диагноз нейропатической боли остается сложным. Была разработана система классификации, обеспечивающая обзор диагностической определенности (т.е. возможной, вероятной и определенной). Поскольку ни один из предыдущих обзоров не привел к этому, различия в диагностической определенности, возможно, повлияли на оценки распространенности. Чтобы прояснить этот вопрос, нынешний метаанализ был направлен на оценку распространенности возможной, вероятной и определенной

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… To indicate probable neuropathic pain, pain must also be associated with sensory abnormalities (i.e., clinical signs such as allodynia and/or hyperalgesia) in the same neuroanatomical plausible distribution (Finnerup et al. 2016 ; Schmid et al. 2023 ). …

Alpha-lipoic acid alters the antitumor effect of bortezomib in melanoma cells in vitro.

Bortezomib (BOZ) is a proteasome inhibitor chemotherapeutic agent utilized to treat multiple myeloma and recently offered to cure melanoma. Bortezomib-induced neuropathy is one of the dose-limiting side-effects, which can be treated with antioxidants (e.g. alpha-lipoic acid-ALA and Vitamin B1-vit B1). We hypothesized that these antioxidants may counteract the antitumor activity by disrupting the BOZ-induced pathways (e.g. proteasome inhibition or reactive oxygen species generation). The objectives were: (i) to verify the anti-proliferative effect of BOZ; (ii) to compare the influence of the an

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… The symptoms of BIPN are paresthesia, allodynia, hyperalgesia 11 . These symptoms are usually presented in stocking-and glove-shaped distribution, and thus dose reduction or discontinuation can be required 12 . There have been various supposed theories about the pathogenesis of BIPN. …

Palliative Care and the Management of Common Distressing Symptoms in Advanced Cancer: Pain, Breathlessness, Nausea and Vomiting, and Fatigue.

Good symptom management in oncology is associated with improved patient and family quality of life, greater treatment compliance, and may even offer survival advantages. With population growth and aging, the proportion of patients with multiple symptoms-both related and unrelated to their cancer-is anticipated to increase, supporting calls for a more routine and integrated approach to symptom management. This article presents a summary of the literature for the use of symptom assessment tools and reviews the management of four common and distressing symptoms commonly experienced by people with

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… recommended in international pain guidelines and should be considered an appropriate adjunct to opioids for patients with neuropathic pain. 58 Ketamine has not been shown to be effective for patients with cancer-related neuropathic pain, although it may have a role in a specific subsection of patients with hyperalgesia …

Воспаление и воспаление болезней, маркеры и посредники: роль КПИ в некоторых воспламенительных заболеваниях

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… Inflammatory mediators increase the sensitivity of the tissues to pain (hyperalgesia), and a resultant neurological reflex in response to pain leads to loss of function ( functio laesa ) (Fig. 4.1 ). … Inflammatory mediators enhance the sensitivity of the affected tissues to pain (hyperalgesia), and a resultant neurological reflex in response to pain leads to loss of function ( functio laesa ) of the tissue (Figs. 4.1 , 4.2 , 4.3 , 4.4 , 4.5 , and 4.6 ). Fig. 4.5 Components of inflammation . …

Paeoniflorin Ameliorates BiPN by Reducing IL6 Levels and Regulating PARKIN-Mediated Mitochondrial Autophagy.

BACKGROUND: Bortezomib-induced peripheral neuropathy (BiPN) is a common complication of multiple myeloma (MM) treatment that seriously affects the quality of life of patients. The purpose of the present study was to explore the therapeutic effect of paeoniflorin on BiPN and its possible mechanism. METHODS: ELISA was used to measure the level of interleukin-6 (IL6) in the plasma of MM patients, and bioinformatics analysis was used to predict the mechanism underlying the effect of paeoniflorin on peripheral neuropathy. Cell and animal models of BiPN were constructed to evaluate mitochondrial fu

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… We assessed neuropathy in bortezomib‐treated mice by evaluating mechanical allodynia, thermal hyperalgesia, and conduction velocity. 57 As expected, mice clearly manifested mechanical allodynia after the administration of bortezomib, and paeoniflorin significantly reduced the occurrence of pain and mechanical …

Peripheral Nerves in Cancer: Regulatory Roles and Therapeutic Strategies.

Cancer neuroscience has emerged as a transformative frontier in oncology research, focusing on the interplay between cancer cells and the nervous system. Cancer cells establish tumorspecific neural networks within tumor tissues via neurotrophic hijacking. The nervous system regulates tumor initiation, progression, and metastasis either directly by regulating signal transduction in tumor cells or indirectly by modulating the tumor microenvironment (TME). The positive feedback loop between cancer cells and nerves promotes tumor progression. Deciphering the regulatory role of nerves in tumor prog

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… Sensory neuron‐derived calcitonin gene‐related peptide (CGRP) promotes pain pathogenesis by stimulating vasodilation‐mediated accumulation of proinflammatory factors, which irritate peripheral nociceptors, and induce hyperalgesia and allodynia [ 122 ]. … Anticancer Therapy Based on Pain‐Modulating Molecules Patients with cancer commonly experience cancer‐associated pain at the primary and metastatic sites, which caused by increased perineural infiltration and tumor‐induced hyperalgesia/allodynia. …

Physiological functions and pharmacological targeting of transient receptor potential channels.

Transient receptor potential (TRP) channels represent an extensive and diverse protein family fulfilling salient roles as versatile cellular sensors and effectors. The pivotal role of TRP and related ion channels in sensory processes has been well documented. Over the last few years, a new concept has emerged that TRP proteins control an exceptionally broad spectrum of homeostatic physiological functions such as maintenance of body temperature, blood pressure, transmitter release from neurons, mineral and energy homeostasis, and reproduction. This notion is further supported by more than 20 he

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… TRPC1/4/5 heteromers, particularly TRPC4, are implicated in neurodegeneration 208 and play a role in morphine tolerance and hyperalgesia. 209 TRPC5 is primarily expressed in the brain, 168 , 199 , 210 , 211 where it is associated with neurite growth, neurotransmission, and learning. 61 , 212. , 213. … In diseased states that trigger inflammation, TRPV1 can become strongly sensitized and chiefly mediates inflammatory thermal hyperalgesia and constant pain sensations. 457. , 458. , 459. …

Ethnic differences in pain, function, and catastrophizing in South Florida adults with knee osteoarthritis.

ObjectiveEthnicity is associated with varying reporting of pain, coping mechanisms, and disease severity in patients with knee osteoarthritis (KOA). However, few studies have evaluated its importance in ethnicity, particularly the Hispanic population. This study compares pain intensity (VAS), function (WOMAC), and pain catastrophizing (PCS) between Hispanic (HP) and non-Hispanic White patients (NHWP) stratified by socio-economic status (SES) and osteoarthritis radiographic K-L grade.MethodsA cross-sectional study of patients from a tertiary care clinic between July 2021 and December 2022 was p

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… Ethnic differences in pain, itch and thermal detection in response to topical capsaicin: African Americans display a notably limited hyperalgesia and neurogenic inflammation. Br J Dermatol. 2010;162(5):1023–9. doi: 10.1111/j.1365-2133.2009.09628.x 29. …

Voltage-gated sodium channel as a target for metastatic risk reduction with re-purposed drugs.

ObjectiveTo determine the exact role of sodium channel proteins in migration, invasion and metastasis and understand the possible anti-invasion and anti-metastatic activity of repurposed drugs with voltage gated sodium channel blocking properties.Material and methodsA review of the published medical literature was performed searching for pharmaceuticals used in daily practice, with inhibitory activity on voltage gated sodium channels. For every drug found, the literature was reviewed in order to define if it may act against cancer cells as an anti-invasion and anti-metastatic agent and if it w

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… Pain. 2004 ; 112 ( 1 – 2 ): 131 – 41 . 10.1016/j.pain.2004.08.005 15494193 94 Zhang JL Yang JP Zhang JR : Gabapentin reduces allodynia and hyperalgesia in painful diabetic neuropathy rats by decreasing expression level of Nav1.7 and p-ERK1/2 in DRG neurons. …

Гендерное неравенство в когнитивных расстройствах между неврологическими аутоиммунными расстройствами: систематический обзор.

ВВЕДЕНИЕ: Неврологические аутоиммунные расстройства (НКД) часто переплетаются с когнитивными расстройствами (КИ), что представляет собой многоуровневую проблему как с клиническим пониманием, так и с терапевтическим управлением. Усугубленное бремя NAD и CI не только оказывает значительное влияние на качество жизни пациента (QoL), прогнозы состояния и результаты лечения, но и оказывает несоразмерное воздействие на женщин, которые по своей сути более подвержены автоматическому иммунитету. Этот обзор направлен на изучение гендерных когнитивных недостатков, их основополагающих механизмов и их клини

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… include divided attention, concentration difficulties, set-shifting, memory impairments (short-term, working, and semantic), slowed cognitive processing (commonly referred to as “fibro fog”), and sensory abnormalities such as allodynia (pain from non-painful stimuli like light touch or mild pressure) and hyperalgesia …

Targeting the Endocannabinoidome in Pancreatic Cancer.

Pancreatic Ductal adenocarcinoma (PDAC), the most common malignancy of the pancreas, is an aggressive and lethal form of cancer with a very high mortality rate. High heterogeneity, asymptomatic initial stages and a lack of specific diagnostic markers result in an end-stage diagnosis when the tumour has locally advanced or metastasised. PDAC is resistant to most of the available chemotherapy and radiation therapy treatments, making surgery the most potent curative treatment. The desmoplastic tumour microenvironment contributes to determining PDAC pathophysiology, immune response and therapeutic

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… Peripheral interactions between cannabinoid and opioid receptor agonists in a model of inflammatory mechanical hyperalgesia. Brain Res. Bull. 2016;125:211–217. doi: 10.1016/j.brainresbull.2016.07.009. 101. Singh N.S., Bernier M., Wainer I.W. …

Longitudinal effects of inpatient music therapy dosage on pain intensity and opioid utilization among patients with hematologic or oncologic conditions: a retrospective cohort study.

PurposeSeveral studies support the benefits of music therapy (MT) for improving symptoms within a single session among patients with hematologic/oncologic conditions, but none have examined real-world longitudinal impacts. This study evaluated whether there was a dose-response relationship between MT intervention exposure and longitudinal changes in pain intensity and opioid utilization.MethodsA retrospective electronic health record review was conducted of 283 hospital admissions among adult patients with hematologic/oncologic conditions who received MT and either reported pain ≥ 4/10 on the

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… Patients with SCD face unique pain management challenges due to (1) complex and poorly understood pathophysiology (e.g., vaso-occlusion, inflammation, increased red blood cell adhesion, central sensitization, and opioid-induced hyperalgesia) underlying both acute and chronic pain [ 9 ]; (2) frequent …

Integrated Medicine for Chemotherapy-Induced Peripheral Neuropathy.

Chemotherapy-induced peripheral neuropathy (CIPN) is a common side effect of typical chemotherapeutics among cancer survivors. Despite the recent progress, the effective prevention and treatment strategies for CIPN remain limited. Better understanding of the pathogenesis of CIPN may provide new niches for developing a new ideal therapeutic strategy. This review summarizes the current understanding of CIPN and current recommendations along with completed/active clinical trials and aims to foster translational research to improve the development of effective strategies for managing CIPN.

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… Interaction of transient receptor potential vanilloid 4, integrin, and SRC tyrosine kinase in mechanical hyperalgesia. J. Neurosci. 2008;28:1046–1057. doi: 10.1523/JNEUROSCI.4497-07.2008. 56. Bleyer W.A., Frisby S.A., Oliverio V.T. Uptake and binding of vincristine by murine leukemia cells. …

Impact of physical exercise in cancer survivors during and after antineoplastic treatments.

Cancer patients experience symptoms and adverse effects of treatments that may last even after the end of treatments. Exercise is a safe, non-pharmacological and cost-effective therapy that can provide several health benefits in cancer patient and survivors, reducing cancer symptoms and cancer treatment side effects. The purpose of this review is to describe how the physical exercise is capable to reduce cancer symptoms and cancer treatment side effects. We realized a pragmatic classification of symptoms, dividing them into physical, psychological and psycho-physical aspects. For each symptom

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… Peripheral neuropathy consists commonly in a pure sensory neuropathy, with sensory symptoms (such as tingling, hyperalgesia and allodynia), but sometimes it can cause motor or autonomic symptoms (such as hypotension, constipation and erectile dysfunction). … Neuropathic pain is often accompanied by other symptoms such as paresthesia, hyperalgesia and allodinia localized in the painful area [ 105 ]. …