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Spatial and temporal disease progression of adult-onset subacute sclerosing panencephalitis.

An adult-onset case of subacute sclerosing panencephalitis with occipitofrontal spread of the infection documented clinically and by MRI is reported. Autopsy revealed numerous intranuclear viral inclusions and widespread demyelination in both frontal lobes. In the occipital lobes where the disease started 5 years previously, inclusions were rare, but degenerative tissue changes were prominent. This case underlines the importance of measles virus migration for the progression of this fatal disorder.

Subretinal lesions in subacute sclerosing panencephalitis.

Subacute sclerosing panencephalitis (SSPE) is a rare progressive neurologic disorder. A 9-year-old boy was seen who had progressive neurocognitive decline, myoclonic jerking of the extremities, and an abnormal result of an electroencephalogram (EEG). Ophthalmoscopic examination revealed multifocal subretinal lesions. The diagnosis of SSPE was made on the basis of the clinical examination and elevated serum and spinal fluid measles titer. We describe subretinal lesions in a patient with SSPE.

Idiopathic corneal endotheliopathy. A report of two cases.

Two male patients had corneal endotheliopathy of unknown origin. In both patients it was characterized by continuously progressing bullous keratopathy preceded by a line of keratic precipitates resembling a rejection line. The disease was progressive and did not respond to intensive corticosteroid therapy. No virus could be isolated from the aqueous humor, and the aqueous-antibody titers to herpes simplex, varicella zoster, and measles viruses were below detection level.

[Successes in the control of childhood droplet infections in the UkrSSR during the 60 years of Soviet government].

Marked achievements in reduction of morbidity and mortality from the main child infections were reached as a result of radical social changes during the years of Soviet power improvement of welfare of the population, science development, proper organization of antiepidemic measures, creation of effective prophylactic preparations and mass immunization. Poliomyelitis is practically wiped out in the Republic, diphtheria incidence fell sharply and whooping cough and measles incidence decreased considerably.

Principles of vaccination and possible development strategies for rational design.

Historically, apart from hygiene, vaccination can be considered as one of the most successful accomplishments of public health in the 20th century. It has lead to some of the greater public health triumphs ever, including the eradication of naturally occurring smallpox and in the control of diseases such as polio. In addition there has been a significant reduction in disease burden imposed by measles, mumps, hepatitis, influenza, diphtheria, haemophilus influenza B and many other infections.

Подводной склероз панэнцефалита в дифференциальном диагностике энцефалита.

Авторы описывают пять случаев субактального склероза панэнцефалита (ССПЕ), выявленных в рамках Калифорнийского проекта по энцефалиту, в которых подчеркивается важность учета ССПЕ при дифференциальном диагностировании энцефалита, особенно среди педиатрических пациентов. В дифференциальной диагностике трех из этих случаев SSE не подозревались до тех пор, пока не были известны результаты тестирования на корь. Диагноз SSE часто не рассматривается врачами из-за его редкости в Соединенных Штатах и неконкретных клинических проявлений на начальном этапе.

Совпадение в аннотации оригинала
The authors describe five cases of subacute sclerosing panencephalitis (SSPE) identified through the California Encephalitis Project that em … tients. SSPE was not suspected in the differential diagnosis of three of the cases until results of measles testing were known. The diagnosis of SSPE is often not considered by clinicians because of its rarity in the United States and the nonspecific clinical manifestations at onset.

[Vaccination in adults].

While immunization programs for children are well accepted in Switzerland, vaccinations of adults are still a problem. This paper deals with indications for vaccinations in adults. While the whole adults population should be immunized (boostered) against diphtheria, poliomyelitis and tetanus, other vaccinations (CEE, hepatitis A, hepatitis B, influenza, measles, mumps, rubella, rabies, varicella) should be administered according to risks at the workplace. Guidelines for vaccination programs in occupational medicine are presented and discussed.

Study of the behaviour of the mumps virus in different cell culture systems.

The Enders reference strain of the mumps virus was cultivated on various systems (chicken embryonated eggs, chicken embryo fibroblast cultures, Vero cell cultures) to develop a model of preparing and controlling the production of the mumps vaccine in Romania. The results have proved that the monolayer of chicken embryo fibroblast is a suitable cell culture system for the multiplication of the mumps virus, and on the Vero cells the virus can be quantified just like the live measles vaccine.

Spontaneous infection or vaccination as cause of acute disseminated encephalomyelitis.

This report describes an approach to determine which of 2 possible etiologies could be responsible for a disease, in this instance acute disseminated encephalomyelitis (ADEM). Information about latency periods was obtained from eighteen reference sources in the literature. Analysis of these data indicate that it would be 9-18 times more likely for ADEM to develop 5 days after a wild virus infection (measles, for example) than 28 days after a vaccination.

Increase of predominantly k-type light chains in the CSF of a case of subacute sclerosing panencephalitis treated with interferon.

The results of a study of the CSF protein pattern in a case of SSPE treated with interferon are reported. An increase in the IgG, IgG index and CNS IgG synthesis values was found during and after the period of treatment. The electrophoretic and IEF patterns show a predominant increase in the L-chain bands, principally k-type, which are anti-measles antibodies. It is suggested that interferon could stimulate some cell clones to synthesize a particular type of L-chains.

In vitro inhibition of subacute sclerosing panencephalitis virus by the antiviral agent ribavirin.

The multiplication in tissue cultures of three isolates of subacute sclerosing panencephalitis virus as well as the Edmonston strain of measles virus was observed to be inhibited by various concentrations of the antiviral agent ribavirin (1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide). The blockage of viral replication by ribavirin could be reversed by the simultaneous addition of equimolar concentrations of either guanosine or adenosine. Expression of virus-specific antigens was greatly reduced in the presence of the antiviral drug.

Differential Demographic and Clinical Characteristics between MMR Vaccinated and Unvaccinated Children in South Korea: A Nationwide Study.

In the context of recent measles outbreaks, substantial factors associated with measles-mumps-rubella (MMR) unvaccination need to be clarified. This study aimed to identify differential demographic and clinical characteristics between MMR vaccinated and unvaccinated groups. We used a large-linked database to identify children born between 2008 and 2016 by combining data from the Korea Immunization Registry Information System and National Health Information database. The MMR vaccination status was ascertained up to the age of 2 to define MMR vaccinated and unvaccinated groups. We conducted a mu…

Uptake of Non-Mandatory Vaccinations in Future Physicians in Italy.

In 2017 in Italy, a number of vaccinations became mandatory or started to be recommended and offered free of charge. In this study, we aimed at assessing the coverage rates for those vaccinations in the pre-mandatory era among students at the School of Medicine of Padua University studying the degree course in medicine and surgery (future physicians) on the basis of the vaccination certificates presented during health surveillance. The vaccinations considered were those against pertussis, rubella, mumps, measles, varicella, Haemophilus influenzae type b (which became mandatory in 2017), pneumo…

Тенденция предотвратимых вакцинами заболеваний в Ираке во время конфликта.

ВВЕДЕНИЕ: Ирак пережил целый ряд конфликтов, экономических санкций и насилия. В целом сектор здравоохранения в Ираке находится в упадке, и службы сталкиваются с постоянной нехваткой вакцин, медикаментов и других предметов снабжения, а доступ населения к основным медицинским услугам становится все более ограниченным. Цель этого исследования заключалась в том, чтобы проиллюстрировать тенденцию заболеваний, поддающихся профилактике с помощью вакцин, в Ираке за последние 17 лет, с тем чтобы получить базовую информацию для оценки бремени заболеваний.МЕТОДЫ: Это исследование основывалось на сборе и

Совпадение в аннотации оригинала
INTRODUCTION: Iraq has passed through a series of successive conflicts, economic sanction and violence. The overall health sector in Iraq ha … d treatment of morbidity data related to vaccine preventable diseases (tuberculosis, poliomyelitis, measles, mumps, rubella, diphtheria, tetanus, pertussis, and hepatitis B) that were registered by the Department of Health Statistics during the years (2000-2016). The incidence rates were plotted on a timeline to define the trend of each disease. Data were …

Current preventive policies and practices against Vaccine-Preventable Diseases and tuberculosis targeted for workers from hospitals of the Sardinia Region, Italy.

INTRODUCTION: Health care Workers are exposed to infectious diseases more than the general population. Many of these infections are preventa … entable diseases and education campaigns about recommended vaccinations for HCWs. Flu, hepatitis B, measles-mumps-rubella, varicella and tuberculosis were the objects of our research. RESULTS: In most of the hospitals, influenza vaccination coverage among HCWs is less than 6%. Hepatitis B antibody assay was performed in all the respondent hospitals but o …

Immunization status of internationally adopted children in Rome, Italy.

AIMS: International adoption medicine is a relatively new specialty in pediatrics that has emerged to address the specific health care needs … ccine-preventable diseases (tetanus, pneumococcus, hepatitis B, hemophilus influenzae type b (Hib), measles), as well as results of screening for HIV, hepatitis C, quantiferon, immunological and nutritional status. RESULTS: For children that had received ≥3 vaccine doses of tetanus, overall protection was 94% of 31 vaccinated children; with 1-2 vaccine d …

Infectious disease burden in Gujarat (2005-2011): comparison of selected infectious disease rates with India.

BACKGROUND: India is known to be endemic to numerous infectious diseases. The infectious disease profile of India is changing due to increas … erature. We chose laboratory cases data for Enteric fever, Cholera, Hepatitis, Dengue, Chikungunya, Measles and Diphtheria in the state since well designed vertical programs do not exist for these diseases. Statistical and GIS analysis was done using appropriate software. RESULTS: Our analysis shows that the existing surveillance system in the state is p …

[Varicella vaccination in Germany. A provisional appraisal in the context of MMR vaccination].

In 2004, a general varicella immunization was introduced in Germany for infants from the age of 11 months, followed by the subsequent recommendation in 2009 of a second vaccine dose. The vaccination is carried out at the same time as the immunization against measles, mumps, and rubella (MMR). Results of the nationwide sentinel surveillance of varicella and herpes zoster implemented by the Varicella Working Group (Arbeitsgemeinschaft Varizellen, AGV) show that the defined goals for varicella immunization (reduction of varicella-related morbidity, complications and hospitalizations) have been re…

Survey of vaccination policies in French healthcare institutions.

OBJECTIVE: The survey was implemented to describe vaccination policies for healthcare professionals in French healthcare institutions. METH … tion to all staff at their annual visit in 100%, 97%, and 62% of cases, respectively. Varicella and measles vaccinations were never suggested in 31% and 17% of cases, respectively. Among respondents, 55% of physicians reported that they had already managed a pertussis epidemic, and 42% a measles epidemic, and in both of these cases an awareness campaigns …

Vaccination coverage of health care personnel working in health care facilities in France: results of a national survey, 2009.

We conducted a national cross-sectional survey to investigate vaccination coverage (VC) in health care personnel (HCP) working in clinics an … .4% for the 10 year booster of the DTP pertussis containing vaccine, 49.7% for at least one dose of measles, 29.9% for varicella and 25.6% for influenza. Hepatitis B VC did not differ neither between HCP working in surgery and HCP in other sectors, nor in surgeons and anaesthesiologists compared to physicians working in medicine. Young HCP were better vac …