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Adolescent health behaviors, family socioeconomic status and health as risk factors for tendon ruptures in adulthood: a longitudinal study.

INTRODUCTION: The incidence of tendon ruptures has increased in recent years highlighting the need of better understanding their causes and prevention strategies. This study aims to investigate the influence of adolescent health behaviors (smoking, alcohol use, physical activity), health (self-reported chronic disease, overweight), and family socioeconomic status (SES) (parental occupational status and educational level) on later tendon ruptures until middle age in Finnish adolescents. MATERIALS AND METHODS: The baseline data were surveys gathered biennially in 1981-1997 (the Adolescent Healt…

The impact of obesity and its related underlying diseases on cytokine release syndrome and the efficacy of CAR-T therapy in treating B-cell malignancies.

Chimeric Antigen Receptor T-cell (CAR-T) therapy has revolutionized treatment for relapsed/refractory B-cell malignancies, including B-cell … es and clinical outcomes. The median BMI was 21.91 (IQR 19.265-24.365). Among the patients, 32 were overweight, and only one had a BMI over 30. Severe CRS occurred in 16 patients, with a higher proportion in those with obesity or related conditions (10.4% vs. 3.5%, p = 0.01). Hyperlipidemia significantly increased the risk of severe CRS (OR = 3.730, CI [1.20 …

Association between gestational weight gain and perinatal outcomes among women with gestational diabetes mellitus.

OBJECTIVE: This study identifies the optimal gestational weight gain (GWG) range for women with gestational diabetes mellitus (GDM) in singl … ng and validation sets (7:3 ratio) and classified by pre-pregnancy BMI: underweight, normal weight, overweight, and obese. Logistic regression in the training set was conducted to determine optimal GWG for each group, and examined the relationship between adverse outcomes and the Institute of Medicine(IOM), Chinese nutrition society(CNS), and study-derived ( …

Fetal exposure to gestational diabetes severity and postnatal infant feeding in the first year of life associated with preadolescent obesity: a prospective cohort.

OBJECTIVE: This study sought to evaluate the distinct impact of fetal exposure to gestational diabetes (GDM) severity, as well as the impact of infant breastfeeding (BF) and sugary beverage intake, on preadolescent overweight and obesity, accounting for other established risk factors. METHODS: This analysis included 850 mother-infant dyads exposed to GDM who reported monthly infant BF duration and intensity, as well as sugary beverage intake (sugar-sweetened beverages [SSB] and 100% fruit juice [FJ]) during the first year of life, BMI measured at ages 6 to 11 years, and GDM severity variables…

Elevated Body Mass Index in Patients Undergoing Stand-alone Anterior and Lateral Lumbar Interbody Fusion: Complications, Hospital Length of Stay, and Cost.

STUDY DESIGN: Retrospective cohort study. OBJECTIVE: This study aims to evaluate the impact of body mass index (BMI) on postoperative outcomes following anterior, extreme lateral, and oblique lumbar interbody fusion (A/X/OLIF). BACKGROUND: Obesity is an increasingly common comorbidity among spine surgery patients, potentially leading to elevated postoperative complications. Little is known about the safety of A/X/OLIF approaches in overweight and obese patients. MATERIALS AND METHODS: The PearlDiver database was queried to identify all adults who underwent single-level A/X/OLIF. Patients we…

Comparison of Vitamin D Deficiency among Obese and Normal Children of Bangladesh.

Obesity is a risk factor for vitamin D deficiency (VDD) with limited data on their association with Bangladeshi children. The aim of this study was to compare vitamin D levels and the status among obese, overweight and normal-weight children. This cross-sectional study was performed in the Obesity Clinic, Department of Endocrinology, Bangladesh Medical University hospital, Bangladesh from May 2020 to August 2021 and included 100 children of 10-17 years [age-matched 50 children with normal BMI, 22 with overweight and 28 with obesity: 14.0 (12.0-17.0) vs. 12.50 (10.0-16.25) vs. 12.50 (11.0-14.0)…

Glucagon-Like Peptide-1 Receptor Agonists and Gastrointestinal Adverse Events: A Systematic Review and Meta-Analysis.

BACKGROUND & AIMS: Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are widely used for glycemic control or weight management in patients with type 2 diabetes mellitus or overweight/obesity. However, there are concerns regarding their association with serious gastrointestinal adverse events, although findings have been inconsistent. METHODS: We systematically searched 5 databases for placebo-controlled randomized controlled trials assessing GLP-1RAs in patients with type 2 diabetes mellitus, overweight/obesity, or metabolic dysfunction-associated steatohepatitis/metabolic dysfunction-asso…

[Effect of body mass index on the efficacy of acupuncture for discogenic sciatica: a secondary analysis of a multicenter randomized controlled trial].

OBJECTIVE: To explore the effect of body mass index (BMI) on the efficacy of acupuncture for discogenic sciatica. METHODS: A secondary anal … group were further divided into two subgroups according to BMI: normal body type (BMI<24 kg/m2) and overweight/obese type (BMI≥24 kg/m2). Visual analogue scale (VAS) score for leg pain and Oswestry disability index (ODI) score were recorded before and after treatment in the two BMI subgroups. The interaction between BMI and treatment method was also analyzed …

Индекс массы тела не связан с реакцией на аутологическую трансплантацию стволовых клеток у лиц с множественным склерозом.

Множественный склероз (MS) является хроническим аутоиммунным расстройством, которое подрывает центральную нервную систему; он характеризуется воспалением, обезвоживанием и нейронным дегенерацией. Сложная этиология включает генетические, экологические и жизненные факторы, при этом намечаются исследования, в которых подчеркивается важность питания, в частности индекса массы тела, для развития заболеваний. Несмотря на то, что БМИ связано с другими нейродегенеративными условиями, его конкретное воздействие на НР остается неясным.ЦЕЛЬ: Цель настоящего исследования заключается в анализе связи между

Совпадение в аннотации оригинала
BACKGROUND: Multiple sclerosis (MS) is a chronic autoimmune disorder that compromises the central nervous system; it is characterized by inf … n May 2015 and June 2023. Patients were classified into BMI categories: underweight, normal weight, overweight, and obese. Response to HSCT was assessed by changes in the Expanded Disability Status Scale (EDSS), 3- and 12-months post-transplant. A positive response was defined as EDSS stabilization or improvement. RESULTS: The cohort included 16 underweight …

Associations between body mass index and all-cause mortality among individuals with psoriasis: results from the NHANES database retrospective cohort study.

BACKGROUND: Previous findings imply a potential positive association between BMI and all-cause mortality in individuals with psoriasis, yet direct evidence remains absent. This study aimed to fill this gap. METHODS: We utilized data from the National Health and Nutrition Examination Survey (NHANES) for the periods 2003-2006 and 2009-2014. Participants' BMI was categorized as lean (<25), overweight (25 ≤ BMI < 30), and obese (BMI ≥ 30). Psoriasis status was determined through self-reporting. The main outcome measured was all-cause mortality up to December 2019. We accounted for multiple covari…

The Interactive Effects of Sedentary Time, Physical Activity, and Fat Mass on Insulin Resistance in the Young Population.

CONTEXT: Recent evidence in 9-year-old children with overweight/obesity followed up for 7 years until late adolescence concluded that increased physical activity (PA) decreased the risk of high fasting glucose, low insulin sensitivity, and secretion. However, whether this effect persists until young adulthood is unknown. OBJECTIVE: This observational study examined the effects of cumulative sedentary time (ST), light PA (LPA), and moderate to vigorous (MVPA) on glucose, insulin, and homeostatic model assessment for insulin resistance (HOMA-IR) in 11-year-old children followed up for 13 years …

Impact of BMI on serum 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D with calcifediol supplementation in young adults: a longitudinal study.

BACKGROUND: High body mass index (BMI) is a risk factor for vitamin D deficiency. The rise in serum 25-hydroxyvitamin D [25(OH)D] concentrations following cholecalciferol supplementation is suboptimal, owing to adipose tissue sequestration and/or volumetric dilution. Calcifediol is a proven potent oral alternative for vitamin D supplementation, but whether BMI adversely affects its efficacy in raising 25(OH)D concentrations, is not well known. MATERIAL AND METHODS: Adults with serum concentrations of 25(OH)D < 30 ng/mL were recruited and stratified as normal, overweight, or obese using WHO cr…

Assessment of correlation between lipid ratios and body mass index in patients with type 2 diabetes mellitus in Sarajevo, Bosnia and Herzegovina.

Objective. Studies that have evaluated correlation between body mass index (BMI) and novel lipid indices such as triglycerides (TG)/high-den … lations were determined by Spearman's test. Results. In a total sample of T2DM patients, 41.0% were overweight and 44.4% were obese. In the control group, 51.5% of subjects were overweight and 25.0% were obese. In T2DM group, a significant correlation was observed between BMI and HDL-C, LDL-C, TG/HDL, TC/HDL-C, and LDL-C/HDL-C ratios. In the control group, t …

Perinatal depression and adverse child growth outcomes in low-income and middle-income countries (LMICs): A systematic review and meta-analysis.

Perinatal depression (PND), which encompasses the antepartum and postpartum depression (APD and PPD), is a neglected crisis in low-income an … dies that reported four types of adverse child growth outcomes (stunting, wasting, underweight, and overweight/obesity) in children younger than 5 years. We assessed the quality using the Newcastle Ottawa Scale and pooled risk ratios (RRs) and odds ratios (ORs) between PND and each adverse growth outcome using random-effects models. In total, 27 studies met …

Women's Improvements in Cardiorespiratory Fitness Following Cardiac Rehabilitation Differ by Body Mass Index Category.

BACKGROUND: Improving women's cardiovascular outcomes requires optimizing cardiorespiratory fitness (CRF), as higher CRF predicts improved m … metabolic equivalents (METs). Women were categorized by baseline BMI: normal = 18.5 to 24.9 kg/m2, overweight = 25.0 to 29.9 kg/m2, and obese ≥ 30 kg/m2. Mixed analysis of covariance (ANCOVA) was performed to evaluate the impact of BMI classification on ΔMETs at 12 weeks. RESULTS: Data from 1313 women (mean age = 62 ± 11 years) were analyzed. Results from …

Relationship between maternal obesity and first-trimester TSH in women with negative anti-TPO antibodies.

OBJECTIVE: Obesity is associated with increased thyroid-stimulating hormone (TSH) in non-pregnant subjects, but this phenomenon has not been … itivity and mean UtA-PI were collected. RESULTS: A total of 1693 women had normal weight, 435 were overweight and 140 were obese. Maternal age, ANA/ENA positivity, history of autoimmune diseases and familiar history of thyroid diseases were similar in the three groups. TSH was significantly higher in obese women (1.8 (IQR: 1.4-2.4) mU/L) when compared to no …

Association between blood lipid levels in early pregnancy and urinary organophosphate metabolites in the Japan Environment and Children's Study.

BACKGROUND: High low-density lipoprotein cholesterol levels (LDL-C) during pregnancy have been associated with adverse pregnancy and offspri … gression under a Bayesian paradigm. These analyses were repeated in underweight, normal-weight, and overweight participants. RESULTS: DEP, DMP, and DMTP were detected in >50 % of the participants. Multiple linear regression analyses did not show associations between LDL-C and these dialkylphosphates. Stratified analyses showed a positive association between …

Genome-wide association study of metabolic dysfunction-associated fatty liver disease in a Korean population.

Genome-wide association studies have identified several genetic variants associated with nonalcoholic fatty liver disease. To emphasize meta … lly, we categorized participants into three groups, no MAFLD, metabolic dysfunction (MD)-MAFLD, and overweight/obese-MAFLD. After adjusting for age, sex, and principal component scores, rs738409 [risk allele G] and rs3810622 [risk allele T], located in the PNPLA3 gene, showed significant associations with MAFLD (P-values, discovery set = 1.60 × 10-15 and 4.8 …

One-year anthropometric follow-up of South African preterm infants in kangaroo mother care: Which early-life factors predict malnutrition?

BACKGROUND: Preterm infants often have poor short- and long-term growth. Kangaroo mother care supports short-term growth, but longer-term ou … MI-for-age [BMIZ]) and rates of underweight (WAZ < -2), stunting (LAZ < -2), wasting (WLZ < -2) and overweight (BMIZ> + 2). Multiple regression analysis was used to investigate associations between maternal/infant characteristics and rates of underweight, stunting, wasting and overweight. RESULTS: At 1 year, compared with AGA infants (n = 210), SGA infants …

The Reproducibility and Reliability of Insulin Sensitivity and Secretion Indices in Children and Adolescents.

CONTEXT: Insulin sensitivity and secretion indices can be useful tools in understanding insulin homeostasis in children at risk for diabetes. There have been few studies examining the reproducibility of these measures in pediatrics. OBJECTIVE: To determine whether fasting or oral glucose tolerance test (OGTT)-derived insulin measures would be more reproducible and whether there would be differences based on weight, sex, race, and pubertal status. DESIGN: Observational study. SETTING: Clinical research unit. PATIENTS OR OTHER PARTICIPANTS: Two hundred fifty-seven overweight/obese (BMI ≥ 85t…