Результаты поиска

Временная тенденция изменения национального и субнационального бремени раковых заболеваний, обусловленная факторами риска в Иране 1990 в адрес 2021:: Результаты глобального исследования бремени болезней 2021.

Рак является одной из главных причин смерти в мире и в Иране. Однако исследований, посвященных изучению тенденций, связанных с факторами риска возникновения раковых заболеваний в Иране, недостаточно. В этом исследовании мы представляем оценки возможного воздействия раковых заболеваний на национальном и субнациональном уровнях в Иране. 1990 в адрес 2021. МЕТОДЫ: В рамках данного исследования использовались данные, полученные от Глобального центра по проблемам заболеваемости (ГБЗ) 2021 Исследование, проведенное для оценки потерянных лет жизни, связанных с раком, лет жизни с инвалидностью, лет жи

Совпадение в полном тексте источника
… Iran enacted the Sugar-Sweetened Beverages (SSBs) taxation program in 2013, which was revised in 2021, imposing a 16% and 36% tax on domestic and imported SSBs, respectively; however, household expenditure on SSBs has not declined in Iran despite taxation [ 31 ]. … Situation analysis of sugar‑sweetened beverages taxation in Eastern Mediterranean Region. Eur J Public Health. 2023;32(1):1. 33. Farhood B, Geraily G, Alizadeh A. Incidence and Mortality of Various Cancers in Iran and Compare to Other Countries: A Review Article. …

BLAB2CancerKD: a knowledge graph database focusing on the association between lactic acid bacteria and cancer, but beyond.

In a broad sense, lactic acid bacteria (LAB) is a general term for Gram-positive bacteria that can produce lactic acid by utilizing fermentable carbohydrates. It is widely used in essential fields such as industry, agriculture, animal husbandry and medicine. At the same time, LAB are closely related to human health. They can regulate human intestinal flora and improve gastrointestinal function and body immunity. Cancer, a disease in which some cells grow out of control and spread to other body parts, is one of the leading causes of human death worldwide. In recent years, the potential of LAB i

Совпадение в полном тексте источника
… Meanwhile, we also focus on biomedical concepts such as analytical, diagnostic and therapeutic techniques and equipment category, phenomena and processes category and technology and food and beverages category, unlabeled by PubTator. … Other related entities We describe BLAB2CancerKD as ‘beyond’ because it also contains concepts such as gene, chemical, cell line, phenomena and process, technology and food and beverages, analytical, diagnostic and therapeutic techniques and equipment, etc. …

Design and Rationale of Prolonged Nightly Fasting for Multiple Myeloma Prevention (PROFAST): Protocol for a Randomized Controlled Pilot Trial.

BACKGROUND: Obesity is an established, modifiable risk factor of multiple myeloma (MM); yet, no lifestyle interventions are routinely recommended for patients with overweight or obesity with MM precursor conditions. Prolonged nightly fasting is a simple, practical dietary regimen supported by research, suggesting that the synchronization of feeding-fasting timing with sleep-wake cycles favorably affects metabolic pathways implicated in MM. We describe the design and rationale of a randomized controlled pilot trial evaluating the efficacy of a regular, prolonged nighttime fasting schedule among

Совпадение в полном тексте источника
… The overnight fasting period is defined as the longest interval of time overnight in which no calorie-containing foods or beverages are consumed. … To maximize acceptability and adherence to the intervention protocol, participants are allowed to consume noncaloric beverages including water, plain coffee, plain tea, zero-calorie sodas, and calorie-free sweeteners. …

Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017.

BACKGROUND: The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017 comparative risk assessment (CRA) is a comprehensive approach to risk factor quantification that offers a useful tool for synthesising evidence on risks and risk-outcome associations. With each annual GBD study, we update the GBD CRA to incorporate improved methods, new risks and risk-outcome pairs, and new data on risk exposure levels and risk-outcome associations. METHODS: We used the CRA framework developed for previous iterations of GBD to estimate levels and trends in exposure, attributable deaths, and

Совпадение в полном тексте источника
… | Average daily consumption of beverages with ≥50 kcal per 226·8 g serving, including carbonated beverages, sodas, energy drinks, fruit drinks, but excluding 100% fruit and vegetable juices | Consumption of sugar-sweetened beverages 0–5 g per day | 13·0% | 16·1% | 26·9% 3 | | Diet low in fibre | Average … In past cycles of GBD, given the strength of the causal relationship between sugar-sweetened beverage intake and BMI compared with the association between sugar-sweetened beverages and disease endpoints, we estimated the disease burden of high intake of sugar-sweetened beverages through its effect on …

Xanthohumol: Mechanistic Actions and Emerging Evidence as a Multi-Target Natural Nutraceutical.

BACKGROUND: Xanthohumol (XN), a prenylated chalcone flavonoid derived from hops (Humulus lupulus), is increasingly recognized as a highly pleiotropic natural compound. OBJECTIVE: We aimed to structure XN's mechanistic hierarchy with emerging translational relevance across disease areas. METHODS: We performed a comprehensive and integrative literature review of XN for its biological and translational effects across cancer, metabolic, neurological, cardiovascular, hepatic, renal, and dermatological disorders. RESULTS: Mechanistically, XN exerts diverse bioactivities by inhibiting major pro-on

Совпадение в полном тексте источника
… In a controlled crossover study using an XN-containing beverage, daily intake in the range of 6–24 mg reduced biomarkers of oxidative DNA damage and DNA strand breaks induced by dietary carcinogens, consistent with chemoprotective mechanisms observed in preclinical models [ 11 ]. … Acute crossover studies in healthy adults demonstrated that beverages or extracts providing approximately 0.125 mg XN attenuated ex vivo cytokine production (IL-1β, IL-6, and TNF-α) and dampened Toll-like receptor 4 signaling in peripheral blood mononuclear cells following bacterial stimulation [ 3 , …

Mobile phone messaging for preventive health care.

BACKGROUND: Preventive health care promotes health and prevents disease or injuries by addressing factors that lead to the onset of a diseas … id not have a statistically significant effect on physical activity, consumption of sugar-sweetened beverages or screen time.For the secondary outcome of acceptability, there was very low quality evidence from one study that user evaluation of the intervention was similar between groups. There was moderate quality evidence from one study of no difference in …

Taxation of unprocessed sugar or sugar-added foods for reducing their consumption and preventing obesity or other adverse health outcomes.

BACKGROUND: Global prevalence of overweight and obesity are alarming. For tackling this public health problem, preventive public health and … sugar threshold value. The intervention includes co-interventions: the taxation of sugar-sweetened beverages (SSBs) and of foods high in salt or caffeine. The study provides evidence on the effect of taxing foods exceeding a specific sugar threshold value on the consumption of sugar-added foods. After implementation of the Hungarian public health product t …

Chemosensory Changes from Cancer Treatment and Their Effects on Patients' Food Behavior: A Scoping Review.

Individuals undergoing treatment for cancer can experience changes in taste or smell that are often assumed to affect constructs related to food behavior, although this relationship is rarely measured directly. To ascertain the extent to which measured changes in taste and smell during and after cancer treatment affect food behavior, we conducted a scoping review and completed a comparative analysis for studies that met our criteria, which were: they directly measured cancer patients' (a) psychophysical response to taste and/or olfactory stimuli, and (b) food behavior (including food enjoyment

Совпадение в полном тексте источника
… However, the intensity and hedonic response of suprathreshold stimuli has been associated with the intake of a variety of foods and beverages [ 67 , 68 , 78 , 79 ]. … Allelic variation in TAS2R bitter receptor genes associates with variation in sensations from and ingestive behaviors toward common bitter beverages in adults Chem. Senses 2011 36 311 319 10.1093/chemse/bjq132 21163912 PMC3038275 66. Hayes J.E. Feeney E.L. Allen A.L. …

Evaluation of Exposure to Toluene and Xylene in Gasoline Station Workers.

The main volatile organic compounds found at gasoline stations are benzene, toluene, ethylbenzene, and xylene isomers (BTEX). They cause several harmful effects on human health. Regulatory Norm 7 (1978) provides that, in Brazil, biological monitoring of toluene and xylene is carried out by measuring the urinary metabolites hippuric acid (HA) and methylhippuric acid (MHA), respectively. The objective of this study was to assess the exposure to toluene and xylene and to identify related signs and symptoms in gasoline station workers. A cross-sectional epidemiological study was conducted with wor

Совпадение в полном тексте источника
… Statistical Analysis Initially, descriptive statistics were performed for the following variables: sex, tobacco consumption, alcoholic beverages, processed food consumption, and length of stay in the current job. … However, the consumption of alcoholic beverages was reported in all groups as well as daily consumption of industrialized food. All groups reported practicing the profession for up to 9 years. …

Randomized Study of enterade® to Reduce Diarrhea in Patients Receiving High-Dose Chemotherapy and Autologous Hematopoietic Stem Cell Transplantation.

High-dose chemotherapy frequently causes injury to the gastrointestinal mucosa, resulting in diarrhea. The purpose of the current study was to assess the tolerability and efficacy of enterade® in reducing ≥ grade 2 diarrhea (G2D) in association with high-dose melphalan followed by autologous stem cell transplantation (ASCT). We conducted a prospective, double blinded, multi-center trial in which 114 subjects were randomized to receive enterade® or placebo twice daily during the transplant hospitalization. Gastrointestinal toxicities (nausea, vomiting, oral mucositis and dysphagia) resulted in

Large-Scale Plasma Proteomics and Genetic Integration Uncover Novel Biological Pathways in Male Pattern Baldness.

Male pattern baldness (MPB) is a highly prevalent condition with a complex, poorly understood molecular basis that limits therapeutic innovation. This study aimed to bridge the gap between statistical genetic associations and biological function by identifying and prioritizing causal proteins and pathways involved in MPB. Using data from 24,069 men in the UK Biobank, we performed a proteome-wide association study of 2911 plasma proteins with self-reported MPB severity via multivariable ordinal logistic regression, adjusting for age, Body Mass Index (BMI), ethnicity, lifestyle, socioeconomic fa

Совпадение в полном тексте источника
… Total alcohol consumption was calculated based on self-reported weekly or monthly intake of various beverages. … Standard units of alcohol were assigned as follows: 2 units (16 g) per pint of beer/cider, 1.5 units (12 g) per glass of wine or other alcoholic beverages, and 1 unit (8 g) per measure of spirits. …

Phytochemicals in Cancer Treatment and Cancer Prevention-Review on Epidemiological Data and Clinical Trials.

Phytochemicals are a non-nutritive substances that are present in plants and contribute significantly to their flavor and color. These biologically active compounds are classified into five major groups, namely phenolics, carotenoids, organosulfur compounds, nitrogen-containing compounds, and alkaloids, and are known for their potential health benefits in the prevention of various diseases, including cancer. The purpose of this review article is to explore the potential therapeutic benefits of the dietary phytochemicals, such as flavonoids, phenolic acids, phytosterols, carotenoids, and stilbe

Совпадение в полном тексте источника
… Introduction Phytochemicals are non-nutritive substances found in plants that contribute significantly to the flavor and color of the plants, as well as the beverages derived from them. They are also being studied for their potential health benefits [ 1 , 2 ]. … Fruits (particularly citrus and berries), nuts, and vegetables (such as tomatoes, cabbage, onions, and beans), as well as beverages, such as tea, tisanes (herbal teas), and red wine, are excellent sources of dietary flavonoids. …

Adjuvant Properties of Caffeic Acid in Cancer Treatment.

Caffeic acid (CA) is a polyphenol belonging to the phenylpropanoid family, commonly found in plants and vegetables. It was first identified by Hlasiwetz in 1867 as a breakdown product of caffetannic acid. CA is biosynthesized from the amino acids tyrosine or phenylalanine through specific enzyme-catalyzed reactions. Extensive research since its discovery has revealed various health benefits associated with CA, including its antioxidant, anti-inflammatory, and anticancer properties. These effects are attributed to its ability to modulate several pathways, such as inhibiting NFkB, STAT3, and ERK

Совпадение в полном тексте источника
… Natural Sources with High Content of CA CA is abundantly present in a wide range of plant-derived foods, including fruits, vegetables, and certain beverages. … Quantitation of volatiles and nonvolatile acids in an extract from coffee beverages: Correlation with antioxidant activity. J. Agric. Food Chem. 2006;54:6054–6058. doi: 10.1021/jf060460x. 23. Mattila P., Kumpulainen J. …

Polyphenols: Chemoprevention and therapeutic potentials in hematological malignancies.

Polyphenols are one of the largest plant-derived natural product and they play an important role in plants' defense as well as in human health and disease. A number of them are pleiotropic molecules and have been shown to regulate signaling pathways, immune response and cell growth and proliferation which all play a role in cancer development. Hematological malignancies on the other hand, are cancers of the blood. While current therapies are efficacious, they are usually expensive and with unwanted side effects. Thus, the search for newer less toxic agents. Polyphenols have been reported to po

Совпадение в полном тексте источника
… Flavonoids Flavonoids are a large class of polyphenolic secondary metabolites found in fruits, grains, vegetables, flowers, and certain beverages. … They are well-distributed in most plants including many species that are consumed as food or processed into beverages. They are abundant in fruits, vegetables, cereals, legumes, soybeans, coffee, and tea ( 77 , 78 ). …

The Global Obesity Epidemic: Epidemiology, Health Burden and Policy Priorities.

The global prevalence of obesity has more than tripled since 1975, now affecting nearly one billion adults and over 170 million children and adolescents. In 2025, The Lancet Diabetes & Endocrinology Commission on Clinical Obesity redefined obesity as a chronic, multisystem disease characterised by excess adiposity leading to organ dysfunction, distinguishing between preclinical obesity (excess adiposity without end-organ injury) and clinical obesity (manifest metabolic or structural complications). This framework moves beyond reliance on BMI, acknowledging that ectopic fat deposition in the li

Совпадение в полном тексте источника
… On an international level, the WHO’s Global Action Plan on NCDs and the 2022 Acceleration Plan to STOP Obesity promote systemic interventions, such as urban design for activity and subsidised healthy diets. 102 Taxes on sugar-sweetened beverages and UPFs, for example in the Philippines, are projected … Basto-Abreu A Torres-Alvarez R Barrientos-Gutierrez T Estimated reduction in obesity prevalence and costs of a 20% and 30% ad valorem excise tax to sugar-sweetened beverages in Brazil: a modeling study. PLOS Med 2024 21 e1004399 10.1371/journal.pmed.1004399 39018346 PMC11253955 26. …

Lifestyle considerations in multiple myeloma.

As the prognosis for multiple myeloma (MM) has significantly improved and patients remain on therapy longer, there is a need for supportive care interventions to optimize patient quality of life (QOL) and functional status over the course of cancer treatment. MM is characterized by a significant symptom burden and a relatively lower QOL compared to other cancers. This review evaluates the role of healthy lifestyle behaviors in improving both the physical functioning and psychological well-being of the MM population. We (1) describe the current literature on physical activity, weight management

Совпадение в полном тексте источника
… This association was seen across different alcoholic beverages such as beer, wine, and liquor and did not differ when adjusted for smoking status, BMI, or education. … resistance training, at least two times per week [ 8 ] • Incorporate strength training exercises at least 2 days per week Body composition and diet [ 46 , 48 ] | • Achieve and maintain a healthy weight (BMI between 18.5 and 25 kg/m 2 ) • If overweight or obese, limit consumption of high-calorie foods and beverages …

Health management program: factors influencing completion of therapy with high-dose interferon alfa-2b for high-risk melanoma.

The goal of the 1-year observational, multicentre, open-label study reported here was to identify factors influencing adherence to high-dose interferon alfa-2b adjuvant therapy in patients at high risk of recurrence following surgical excision of malignant melanoma. The study was carried out in 23 tertiary-care centres across Canada.The 225 patients enrolled in the study all had malignant melanoma that was surgically excised and that required adjuvant treatment with interferon alfa-2b. Of these patients, 64% were men. Mean age was 51.7 years. All patients received interferon alfa-2b treatment

Совпадение в полном тексте источника
… The most common beverages were water (54.2%), juice (21.6%), tea (6.2%), and milk (4.0%). Abstention from alcohol consumption was reported by 96.4% of the patients. …

Use of bisphosphonates in prostate cancer: Current status.

Bisphosphonates are a relatively newer class of drugs which have been used for the prevention of skeletal related complications of age related osteoporosis or metastatic disease from carcinoma breast or multiple myeloma. Their role in the management of prostate cancer is still under evolution. We hereby review the ongoing and some published randomized trials to define the role of bisphosphonates in various stages of prostate cancer.

Совпадение в полном тексте источника
… Typically, absorption ranges from 0.7% to 3% of an oral dose and is significantly reduced in the presence of calcium, other divalent cations or food or beverages other than plain water. Bisphosphonates are not metabolized. …

Целые пищевые рационы на основе растений являются практически осуществимыми при автоматическом воздействии на организм человека и связаны с модификацией микробиома в зависимости от дозы.

Целые пищевые рационы, основанные на кратком планете, могут представлять собой целенаправленный подход к смягчению последствий нарушения микробиома и улучшению последствий для пациентов, проходящих аутологическую трансплантацию гематопоиетических клеток (auto-HCT) в случае множественной миеломы, в которой кишечный дисбиоз связан с более низким уровнем выживаемости. Мы провели одностороннее клиническое испытание в нашем центре, в ходе которого участники прошли автоHCT (n = 22) получили свежее, заранее подготовленное, растительное питание 5 Недели, охватывающие кондиционирование, нейтрализацию и

Совпадение в полном тексте источника
… Importantly, dietary records show that alcohol intake in this cohort was largely derived from condiments within the study meals (eg, wine vinegars, vanilla), not from beverage consumption, as no alcoholic beverages were reported. …

Упражнения и питание в гематологических заболеваниях: свидетельства перевода и новые меры вмешательства.

Пациенты, страдающие гематологическими микроорганизмами, включая лейкемию, лимфому и миелому, живут дольше из - за прогресса в лечении. Тем не менее такое лечение часто приводит к токсичным последствиям, влияющим на качество жизни пациентов (QoL). Хотя мероприятия, связанные с образом жизни, такие, как упражнение и питание, приносят пользу, снижая риск заболевания раком и улучшая результаты лечения твердых опухолей, их применение в гематологических опухолей по-прежнему недостаточно изучено. В настоящем описательном обзоре рассматриваются текущие данные о роли физических упражнений и питания в

Совпадение в полном тексте источника
… Follow-up Study risk (HR, 1.16; 95% CI, 1.02-1.32 per standard deviation increase). 19 Additional observational studies support inverse associations between the intake of fruits, vegetables, whole grains, cruciferous vegetables, and fish with risk of MGUS and multiple myeloma, whereas sugar-sweetened beverages … guidance should align with established ACS, American Institute for Cancer Research/World Cancer Research Fund, and American College of Lifestyle Medicine recommendations supporting diets rich in fruits, vegetables, legumes, and whole grains, with reduced intake of processed foods and sugar-sweetened beverages …