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Fracture Risk Evaluation of Trochlear Groove Depth in Toy and Small-Breed Dogs Under Gait-Based Loading: A Finite Element and Fatigue Analysis Study.

This study evaluated fracture risk associated with varying trochlear groove depth-to-patellar thickness (D/T) ratios in toy and small-breed dogs using finite element analysis and cadaveric mechanical testing. Finite element models derived from computed tomography data of a 4.5-kg toy poodle were adjusted to simulate D/T ratios ranging from 0.5 to 2.0 and analyzed for von Mises stress, principal strain, safety factor, and fatigue life under standing, trotting, and jumping conditions. Increasing D/T ratios led to progressive rises in stress and compressive strain, with the safety factor falling …

Оптимизированное назначение упражнений для уменьшения онкологической усталости у выживших после первичного лечения у женщин с раком молочной железы: систематический обзор и доза-ответный сетевой мета-анализ.

ОБЪЕКТ: Психофизиологический стресс у пациентов с онкологическими заболеваниями (CRF) значительно снижает качество жизни у выживших после рака молочной железы. Хотя физические упражнения рекомендуются в клинических руководствах для уменьшения CRF, эффективные и оптимальные дозы остаются неопределёнными. Настоящее исследование направлено на изучение зависимости дозы упражнений от CRF у выживших после рака молочной железы. МЕТОДЫ: Доза упражнений рассчитывалась как произведение продолжительности, частоты и интенсивности, выраженная в метаболических эквивалентах минут в неделю (METs-min/неделя),

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BACKGROUND: Cancer-related fatigue (CRF) significantly impairs the quality of life in breast cancer survivors. Although exercise is recommended in clinical guidelines to alleviate CRF, the effective and optimal doses remain uncertain. This study aims to examine the dose-response relationship of different exercise modalities with CRF in breast cancer survivor…

Baseline pain, fatigue, and sleep quality predict 12-week pain improvement in inflammatory arthritis: retrospective real-world analysis of a digital health application cohort.

Despite advances in pharmacotherapy, many patients with inflammatory arthritis (IA) experience residual pain even in remission. Digital heal … ncluded baseline demographics, diagnosis, disease duration, and psychosocial and lifestyle factors: fatigue (Brief Fatigue Inventory, BFI), psychological distress (Patient Health Questionnaire, PHQ-4), sleep and diet quality, physical activity, social support, and app engagement. Multivariable logistic regression and Random Forest models were fitted; non- …

Psychometric validation of PROMIS-Fatigue-MS-8a and MSIS-29v2 questionnaires in relapsing multiple sclerosis participants enrolled in a phase 2 trial of frexalimab.

BACKGROUND: There are limited psychometric studies conducted using the Patient-Reported Outcomes Measurement Information System Adult Short Form-Fatigue-Multiple Sclerosis 8a (PROMIS-Fatigue-MS-8a) and Multiple Sclerosis Impact Scale-29 version 2 (MSIS-29v2) questionnaires. METHODS: Data were collected from a phase 2 trial (NCT04879628) investigating frexalimab in adults with relapsing multiple sclerosis (RMS). Reliability, convergent validity, construct validity, and sensitivity to change were assessed on PROMIS-Fatigue-MS-8a and MSIS-29v2 using Cronbach's alpha coefficient, intraclass corre…

Fatigue after COVID-19 in occupationally exposed workers: prevalence, severity and associated risk factors in a cross-sectional analysis of a multicentre registry study.

OBJECTIVES: As fatigue is among the most frequent manifestations of post-COVID syndrome (PCS), this study aimed to assess the prevalence and severity of cognitive and physical fatigue after occupational SARS-CoV-2 infection and to identify sociodemographic, clinical and occupational predictors of fatigue severity. DESIGN: Cross-sectional analysis of a multicentre prospective registry. SETTING: Six German Social Accident Insurance hospitals distributed across Germany, providing standardised post-COVID assessments for individuals with persistent symptoms following occupational SARS-CoV-2 infec…

Effects of kinesio tape on countermovement jump kinetic variables in physically active females with flat feet before and after fatigue: a randomized controlled trial.

BACKGROUND: Flatfoot, characterized by a reduced medial longitudinal arch, alters lower-limb biomechanics and affects vertical ground reaction force (vGRF) during dynamic tasks like jumping. Kinesio taping (KT) is often used to support foot posture; however, its efficacy under high-load conditions-such as jumping, which increases arch stress, and fatigue, which reduces muscular support-remains unclear. METHODS: This double-blind randomized controlled trial included 46 physically active females with flexible flat feet (arch height ratio < 0.221), assigned to KT or sham groups. Participants per…

Randomized controlled trial investigating the effect of a Baduanjin exercise plus nutrition programme on cancer-related fatigue in elderly lung cancer patients receiving chemotherapy.

OBJECTIVE: The purpose of this study was to evaluate the benefits of the Baduanjin exercise and nutrition intervention on Cancer-related fatigue (CRF) in elderly lung cancer patients undergoing chemotherapy. METHODS: 96 elderly patients suffering from lung cancer and undergoing chemotherapy were enlisted and randomly assigned to the control group, the exercise group, and the exercise plus nutrition group. Primary and secondary endpoints were assessed at baseline, week 6, and week 12, including Brief Fatigue Inventory (BFI) scores, Pittsburgh Sleep Quality Index (PSQI) scores, grip strength, a…

Effects of psychosocial factors on Swedish waste collectors musculoskeletal pain through the mediating roles of occupational fatigue and physical demands: a structural equation model.

BACKGROUND: Musculoskeletal pain is waste collectors' most common non-fatal and disabling health problem. However, research on how psychosocial factors affect musculoskeletal pain via physical and psychosocial pathways is limited. This study aimed to examine the effects of leadership quality, social support, and job demands on musculoskeletal pain among Swedish waste collectors. In addition, the mediating roles of physical demands and occupational fatigue and their chain mediation were also examined. METHODS: A 2015 cross-sectional survey of all Swedish waste collectors utilized validated sca…

Towards vitality: a longitudinal pilot study with a cognitive bias modification e-health intervention (VitalMe) to reduce fatigue in patients with chronic kidney disease.

BACKGROUND: This longitudinal pilot trial investigated the effects of novel Cognitive Bias Modification (CBM) training targeting fatigue on cognitive biases, fatigue, vitality, and fatigue-related behaviour in people with chronic kidney disease (CKD). METHODS: Thirty patients were alternately allocated to a week of CBM training with either attentional bias modification (ABM) or self-identity bias modification (SIBM), followed by a second week with the trainings combined. Twenty-two participants (12 pre-dialysis, 10 dialysis) completed the study, where cognitive biases and self-reported outcom…

Psychometric Properties of Patient-Reported Outcomes Measurement Information Systems (PROMIS) Computer Adaptive Test (CAT) - Fatigue in Individuals Receiving Chronic Hemodialysis Therapy: A Secondary Analysis.

The purpose of this secondary analysis was to report the psychometric properties of the Patient-Reported Out comes Measurement Information Systems (PROMIS) Computer Adaptive Test (CAT) - Fatigue in individuals receiving hemodialysis (HD) treatment. Measures included Piper Fatigue Scale-12, Six-Minute Walk Test, PROMIS CAT-Fatigue, and Charlson Comorbidity Index. English-speaking adults older than 18 years, cognitively intact, receiving two to three times weekly HD treatment were included. A total of 86 individuals (M = 61.7 years, SD = 13.81), predominantly males (58.1%), and African American …

Effect of one session of hyperbaric oxygen (2.5 ATA for 60 min) after moderate-intensity exercise on fatigue: a single-blind crossover randomized trial.

OBJECTIVES: Although insufficient delivery of oxygen may be a factor in physical and perceived fatigue, the relationship between exposure to hyperbaric oxygen (HBO) and recovery from perceived fatigue remains unexplained. The purpose of this single-blind study was to investigate the effects of exposure to HBO after long-duration, medium-intensity training on recovery from perceived fatigue. METHODS: Fatigue was induced in nine male university students (mean age: 21.3 years) using an ergometer exercise bike at a moderate intensity of 75% of their maximum heart rate for 60 min. Post-workout, th…

Efficacy of 8-week oral iron supplementation on fatigue and physical capacity in young women with iron deficiency anemia: An uncontrolled pilot clinical trial.

This study aims to investigate the effect of 8 weeks of ferrous sulfate supplementation (160 mg elemental iron/day) on fatigue and physical performance in young women with iron deficiency anemia (IDA). In this uncontrolled pilot clinical trial, twenty-three women with IDA aged between 18 and 30 years participated in this study. Aerobic fitness, muscle strength and muscle endurance were performed to evaluate physical capacities. Moreover, the multidimensional fatigue inventory (MFI-20) was used to assess general, physical, and mental fatigue, reduced activity and motivation. Due to multiple com…

The Relationship Between Sex, Fatigue, and Post-Concussion Symptoms Differs Between Those With Mild Traumatic Brain Injury Versus Trauma Control and Healthy Control Participants.

OBJECTIVE: Sex, fatigue and subjective sleep disruption have been shown to be associated with poor subjective recovery after mild traumatic brain injury (mTBI). This study aimed to determine whether the relationship between these factors and post-concussion symptom (PCS) reporting are unique to individuals who have incurred an mTBI. Setting, Participants, Design and Main Measures: In this observational study, a group of 208 pre-morbidly healthy adults was assessed with measures of fatigue (Multi-dimensional Fatigue Inventory), subjective sleep disturbance (Pittsburgh Sleep Quality Index), depr…

Greater fatigue, disturbed sleep, persistent memory problems, and reduced CD4+ T cell and B cell percentages in adults with a history of methamphetamine dependence.

Methamphetamine (MA) dependence is associated with immunotoxicity and high rates of neuropsychiatric impairments that persist into remission … low cytometry. Results suggest that early remission from MA dependence is associated with increased fatigue and persistent sleep and prospective and retrospective memory problems, along with reduced B and CD4+ T cell percentages, compared to the CTL group. Preliminary findings support the hypothesis that the immune system modulates the sleep impairments a …

Digital cognitive behavioural self-management programme for fatigue, pain, and faecal incontinence in inflammatory bowel disease (IBD-BOOST): a multicentre, parallel, randomised controlled trial.

BACKGROUND: Fatigue, pain, and faecal urgency or incontinence are common, debilitating symptoms in inflammatory bowel disease (IBD). We developed IBD-BOOST, a digital, interactive, facilitator-supported, self-management intervention, and aimed to assess its effects compared with care as usual in relieving these symptoms and improving quality of life. METHODS: This multicentre, parallel, randomised controlled trial was conducted online in the UK, with allocation concealment maintained. Participants aged 18 years or older with IBD who rated the impact of fatigue, pain, and faecal urgency or inc…

Exploratory study on autoantibodies to arginine-rich human peptides mimicking Epstein-Barr virus in women with post-COVID and myalgic encephalomyelitis/chronic fatigue syndrome.

INTRODUCTION: Epstein-Barr virus (EBV) infection is a well-established trigger and risk factor for both myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and post-COVID syndrome (PCS). In previous studies, we identified elevated IgG responses to arginine-rich (poly-R) sequences within the EBV nuclear antigens EBNA4 and EBNA6 in post-infectious ME/CFS (piME/CFS). Building on these findings, this exploratory study examines IgG reactivity to poly-R-containing EBV-derived peptides and homologous human peptides in women with PCS and ME/CFS. METHODS: IgG reactivity to poly-R containing pe…

Распространение EBV, HHV6, HCMV, HADV, SARS-COV-2 и Autoanticbodies to Type I Interferon в Sputum от Myalgic Encephalomyelit/Chronic Fatig cиндрома.

В миальгическом энцефаломиелите/хроническом синдроме усталости (ME/CFS) и синдроме после SARS-COV-2 также называют длинным синдромом COVID. В этом исследовании были исследованы потенциальные механизмы, лежащие в основе такого истощения. Во-первых, вирусная нагрузка вируса Эпштейн-Барр (EBV), аденовируса человека (HAdV), цитомегаловируса человека (HCMV), герпесвируса человека 6 (HHV6) и острого острого острого дыхательного синдрома коронавируса 2 (SARS-COV-2) была определена в пробах слюны (n = 29), полученных от пациентов ME/CFS (n = 13), здорового контроля (n = 10), контроля за здоровьем пожи

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An exhausted antiviral immune response is observed in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and post-SARS-CoV-2 syndrome, also termed long COVID. In this study, potential mechanisms behind this exhaustion were investigated. First, the viral load of Epstein-Barr virus (EBV), human adenovirus (HAdV), human cytomegalovirus (HCMV), human he…

Effects of Mindfulness-Based Cancer Recovery training on anxiety, depression, post-traumatic stress disorder, and cancer-related fatigue in breast neoplasm patients undergoing chemotherapy.

RATIONALE: Mindfulness-Based Cancer Recovery (MBCR) program is a group course training for cancer patients that combines cancer knowledge an … ss-Based Cancer Recovery on anxiety, depression, post-traumatic stress disorder, and cancer-related fatigue in breast neoplasm patients, to provide a practical basis for improving the physical and mental health of breast cancer patients. INTERVENTION: In this study, 80 patients with chemotherapy-stage breast neoplasm attending the oncology department of …

Effects of different intervention methods on psychological anxiety, stress, and fatigue among healthcare workers during COVID-19 pandemic: a systematic review and meta-analysis.

OBJECTIVE: This study aimed to explore the treatment effects of various intervention methods on the stress, anxiety, and fatigue of medical workers during the 2019 Coronavirus Disease (COVID-19) pandemic. MATERIALS AND METHODS: We conducted computer searches in both Chinese and English databases including China National Knowledge Infrastructure (CNKI), Wanfang Data Knowledge Service Platform (Wang Fang), VIP Chinese Journal Service Platform (VIP), Web of Science, Embase, PubMed, Cochrane Library, Scopus, and ScienceDirect to include prospective randomized controlled studies (Prospective RCT) …

Dose-dependent effects of gamma radiation sterilization on the collagen matrix of human cortical bone allograft and its influence on fatigue crack propagation resistance.

Fatigue crack propagation resistance and high-cycle S-N fatigue life of cortical bone allograft tissue are both negatively impacted in a radiation dose-dependent manner from 0 to 25 kGy. The standard radiation sterilization dose of 25-35 kGy has been shown to induce cleavage of collagen molecules into smaller peptides and accumulation of stable crosslinks within the collagen matrix, suggesting that these mechanisms may influence radiation-induced losses in cyclic fracture resistance. The objective of this study was to determine the radiation dose-dependency of collagen chain fragmentation and …