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Alcohol Consumption and Autoimmune Diseases.

Alcohol is the second-most misused substance after tobacco. It has been identified as a causal factor in more than 200 diseases and 5.3% of all deaths and is associated with significant behavioral, social, and economic difficulties. As alcohol consumption may modulate the immune system's regulatory mechanisms to avoid attacking the body's tissues, it has been proven to play a dichotomic role in autoimmune diseases (ADs) based on the quantity of consumption. In this review, we report updated evidence on the role of alcohol in ADs, with a focus on alcohol addiction and the human biological immun

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… Different types of alcoholic beverages may have varying effects. … In particular, alcohol intake was found to protect against the development of autoimmune hypothyroidism, independently of sex or the type of alcoholic beverage (wine versus beer) [ 59 ]. …

Lifestyle clusters and bone mineral density in Chinese adults: a cross-sectional study with cluster analysis.

BACKGROUND: Osteoporosis is a major global public health challenge, with lifestyle as a key modifiable factor. This study aimed to examine associations between lifestyle patterns and bone mineral density (BMD) in Chinese adults. METHODS: In this cross-sectional, multi-center study, 5,324 adults from Beijing (2016-2020) with complete lifestyle questionnaires were analyzed (lumbar spine BMD available for 4,028; hip BMD available for 4,654). Each of eight lifestyle variables was residualized on age and sex before k-means clustering (k = 3) categorized participants into three groups: office/menta

Alcohol consumption, drinking patterns and cancer incidence in an Australian cohort of 226,162 participants aged 45 years and over.

BackgroundAlthough overall alcohol consumption is known to increase the risk of a number of cancers internationally, evidence for Australia and evidence regarding the pattern of drinking and cancer risk is limited.MethodsAdjusted hazard ratios (HR) and 95% confidence intervals (CI) for cancer risk in relation to overall alcohol consumption (drinks/week) and pattern of drinking were calculated using Cox proportional hazard regressions for 226,162 participants aged ≥45 years (2006-2009) in the 45 and Up Study, an Australian prospective cohort study. Incident primary cancer cases were ascertained

Корреляции неточностей в сообщении о поглощении энергии среди лиц с множественным склерозом.

Лица с множественным склерозом (МС) заинтересованы в рационе питания в качестве второго подхода к лечению заболеваний. В этом исследовании были изучены потенциальные переменные, которые соотносятся с неточностью данных о самопоглощении энергии (ЭИ) у взрослых с МЗ. МЕТОДЫ: Twenty-eight Число завершенных участников two назначений в рамках системы Организации 14-day b) период, который включал стандартный протокол с двойной маркировкой воды (ДЛВ) для оценки общих расходов на энергию (ПЭЭ). Участники сообщили о том, что они используют автоматизированную систему самоуправления 24 h (ASA24) Инструме

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… Briefly, the ASA24 website is equipped with a series of steps to capture all food and beverages consumed during the previous 24 h period. …

Lifestyle Factors in Cancer Survivorship: Where We Are and Where We Are Headed.

Advances in early detection and curative therapies have led to an increased number of cancer survivors over the last twenty years. With this population comes the need to evaluate the late and long term effects of cancer treatment and develop recommendations about how to optimally care for these survivors. Lifestyle factors (diet, body weight, physical activity, and smoking) have been linked to a higher risk of many medical comorbidities (cardiovascular, metabolic, etc.). There is increasing evidence linking these factors to the risk of developing cancer and likely cancer-related outcomes. This

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… This should be achieved through limitation in the consumption of high-calorie foods and beverages and increased physical activity [ 18 ]. Limiting portion sizes, especially of energy-dense foods, is an important weight loss strategy [ 46 ]. … If overweight or obese, limit consumption of high-calorie foods and beverages and increase physical activity to promote weight loss. | Achieve a dietary pattern that is high in vegetables, fruits, and whole grains. …

Dietary patterns among individuals with plasma cell disorders- opportunities for targeted interventions.

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FASTINA - protocol for a randomised feasibility trial of time-restricted eating to improve response to multiple myeloma therapy.

Multiple myeloma (MM) is an incurable plasma cell malignancy with relapses and diminishing response durations. Preclinical studies suggest that time-restricted eating (TRE)-related metabolic changes may enhance chemosensitivity by exploiting cancer cell vulnerabilities to nutrient deprivation. Clinical data in solid tumours remain limited and heterogeneous, mainly supporting feasibility and possible toxicity reduction rather than definitive efficacy. While efficacy has been explored in breast cancer patients, there is a lack of data for haematological patients, including MM. FASTINA (Fasting i

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… Outside the designated 8 h window, patients abstain from foods or caloric beverages. Non-caloric fluids are allowed during fasting hours. Adherence is defined as maintaining the 16 h fasting goal on at least 80% of days, with minor deviations permitted. …

A Comparison of the Clinical Effectiveness Between Low-Dose Strong Opioids and Non-Steroidal Anti-Inflammatory Drugs in the Treatment of Mild Cancer Pain: A Randomized Trial.

ObjectiveThe present study aims to explore the effectiveness and safety of low-dose strong opioids compared with non-steroidal anti-inflammatory drugs (NSAIDs) in the treatment of mild cancer pain.MethodsFrom September 2016 to September 2018, 66 patients with a malignant tumor and mild cancer pain admitted to the Department of Oncology of Dalian Fifth People's Hospital were divided into the group A (treated with ibuprofen sustained-release tablets for pain relief) and the group B (treated with oxycodone hydrochloride sustained-release tablets for pain relief). After 7 days of treatment, the pa

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… Those with an increased risk of GI tract toxicity: patients aged >60 years, with peptic ulcer or history of alcohol abuse (3 or more alcoholic beverages per day), patients with vital organ dysfunction (including hepatic failure), patients on long-term high-dose NSAIDs, on a combination of steroids, or …

Cancer and Obesity: An Obesity Medicine Association (OMA) Clinical Practice Statement (CPS) 2022.

BackgroundThis Obesity Medicine Association (OMA) Clinical Practice Statement (CPS) provides an overview of cancer and increased body fat.MethodsThe scientific information for this CPS is based upon published scientific citations, clinical perspectives of OMA authors, and peer review by the Obesity Medicine Association leadership.ResultsTopics include the increased risk of cancers among patients with obesity, cancer risk factor population-attributable fractions, genetic and epigenetic links between obesity and cancer, adiposopathic and mechanistic processes accounting for increased cancer risk

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… . | Beyond their effects on body fat accumulation, foods that may increase the risk of cancer include processed meats, meats cooked at high temperature, and simple carbohydrates including sugar-sweetened beverages [ 27 ]. … Sugar-sweetened beverage and sugar consumption and colorectal cancer incidence and mortality according to anatomic subsite. Am J Clin Nutr. 2022 Jun 7;115(6):1481–1489. doi: 10.1093/ajcn/nqac040. PMID: 35470384; PMCID: PMC9170474. 28. …

Средиземное питание и риск множественных склерозов: перспективное когортное исследование.

Несмотря на то, что, согласно сообщениям, присоединение к средиземноморскому рациону питания обратно связано с риском нейродегенеративного заболевания, нет уверенности в том, что эта схема рациона питания также позволит снизить риск множественных склерозов (МС). Мы проанализировали данные, полученные от 41,428 - участники шведского Национального марша Корта. Поступление в рацион питания оценивалось на базовом уровне в 1997 с использованием вопросника о частотности пищевых продуктов. Счёт средиземноморского диета был проанализирован в цифровом выражении (диапазон: 0-9) и категорично (низкий, ср

Hospitalization rates for complications due to systemic therapy in the United States.

The aim of this study was to estimate the trends and burdens associated with systemic therapy-related hospitalizations, using nationally representative data. National Inpatient Sample data from 2005 to 2016 was used to identify systemic therapy-related complications using ICD-9 and ICD-10 external causes-of-injury codes. The primary outcome was hospitalization rates, while secondary outcomes were cost and in-hospital mortality. Overall, there were 443,222,223 hospitalizations during the study period, of which 2,419,722 were due to complications of systemic therapy. The average annual percentag

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… This could be due to complications such as mucositis, common in these patients, limiting their ability to consume food and beverages, as well as destruction of the lining of the gastrointestinal tract, limiting the absorption of fluids and electrolytes 23 . …

Novel Investigations of Flavonoids as Chemopreventive Agents for Hepatocellular Carcinoma.

We would like to highlight the application of natural products to hepatocellular carcinoma (HCC). We will focus on the natural products known as flavonoids, which target this disease at different stages of hepatocarcinogenesis. In spite of the use of chemotherapy and radiotherapy in treating HCC, patients with HCC still face poor prognosis because of the nature of multidrug resistance and toxicity derived from chemotherapy and radiotherapy. Flavonoids can be found in many vegetables, fruits, and herbal medicines that exert their different anticancer effects via different intracellular signalin

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… The flavonoids are a group of plant secondary metabolites that comprise diverse classes of polyphenolic compounds found in fruits, vegetables, roots, stems, flowers, and beans, as well as beverages such as tea and wine, which can be ingested daily. … The corresponding signal pathways and flavonoids are mapped in Figure 3 and summarized in Tables 1 – 7 , respectively. 2.1. (−)-Epi-gallocatechin-3-gallate Tea is the most widely consumed beverage worldwide; furthermore, green tea is sold on a large scale, in part, due to its chemotherapeutic value …

A rare primary pericardial DLBCL masquerading as an unexplained malignant pleural effusion in an elderly woman: A case report.

IntroductionPrimary cardiac lymphoma (PCL) is an extremely rare and fatal heart neoplasm. Primary cardiac non-Hodgkin lymphoma (NHL) is uncommon, considering the rarity of pericardial diffuse large B-cell lymphoma (DLBCL) with advanced pleural metastasis.Case presentationWe reported an 86-year-old female with primary pericardial DLBCL diagnosed initially by pleural effusion cytology. The chest imaging study revealed multiple pericardial lobulated infiltrative masses and epicardial invasion. Subsequently, she underwent an emergent pericardial window with a pericardial mass biopsy. The final his

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… She denied a history of socializing alcoholic beverages or using illegal drug. She was no any drug allergies and/or adverse reactions, or addiction. She did not report any B symptoms. There was no history of smoking, chewing betel nut, occupation, or travel in the past three months. …

EANM guidelines on the use of [18F]FDG PET/CT in diagnosis, staging, prognostication, therapy assessment, and restaging of plasma cell disorders.

We provide updated guidance and standards for the indication, acquisition, and interpretation of [18F]FDG PET/CT for plasma cell disorders. Procedures and characteristics are reported and different scenarios for the clinical use of [18F]FDG PET/CT are discussed. This document provides clinicians and technicians with the best available evidence to support the implementation of [18F]FDG PET/CT imaging in routine practice and future research.

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… A few relevant points are discussed below: Patients without diabetes are advised to abstain from eating any food, simple sugars, or beverages, except for plain (unflavored) water, for a minimum of 4 hours prior to the commencement of the [18F]FDG PET/CT scan (relative to the [18F]FDG injection time). … Coffee or caffeinated beverages are not recommended because even if “sugarless” they may contain traces of simple carbohydrates and have the potential to induce excitant effects; this may also be the case for “sugar-free” beverages. …

NTP toxicology and carcinogenesis studies of trans-cinnamaldehyde (CAS No. 14371-10-9) in F344/N rats and B6C3F1 mice (feed studies).

UNLABELLED: Cinnamaldehyde is used in foods, beverages, medical products, perfumes, cosmetics, soaps, detergents, creams, and lotions. Cinnamaldehyde has been used as a filtering agent and a rubber reinforcing agent and is used as a brightener in electroplating processes, as an animal repellent, as an insect attractant, and as an antifungal agent. trans-cinnamaldehyde was nominated for study by the Food and Drug Administration based on its widespread use as a flavor and fragrance ingredient and its structural similarity to cinnamyl anthranilate and 3,4,5-trimethoxy cinnamaldehyde, two known ro…

Food fortification with multiple micronutrients: impact on health outcomes in general population.

BACKGROUND: Vitamins and minerals are essential for growth and maintenance of a healthy body, and have a role in the functioning of almost e … included staple foods, such as rice and flour; dairy products, including milk and yogurt; non-dairy beverages; biscuits; spreads; and salt. Fourteen of the studies were fully commercially funded, 13 had partial-commercial funding, 14 had non-commercial funding and two studies did not specify the source of funding. We rated all the evidence as of low to very …

The Impact of an Embedded Oncology Pharmacist in an Outpatient Oncology Center in the Treatment of Hematologic Malignancies.

BackgroundThe growing demand for clinicians in the ambulatory oncology setting to reduce fragmentation of care and improve patient outcomes represents a need for oncology pharmacists as advanced practitioners in the provision of direct patient-centered care. These provisions can include supportive care management, drug-drug interaction evaluation, and selection of appropriate chemotherapy regimens to reduce physician workload in a cost-effective manner, while increasing physician and patient satisfaction. However, robust data are currently lacking to support the impact of pharmacists in the am

The expenditures related to the use of antifungal drugs in patients with hematological cancers: a cost analysis.

ObjectiveThe aim of this study is to analyze the expenditures related to the use of antifungal drugs in patients with hematological malignancies.MethodsIn this retrospective study, the expenditures related to use of antifungal drugs for treatment of invasive fungal infections in patients with hematological malignancies between November 2010 and November 2012 were analyzed. Expenditures of antifungal drugs were calculated by converting the price billed to the Republic of Turkey Social Security Institution per patient using the US dollar ($) exchange rate.ResultsWe retrospectively analyzed the e

Epigallocatechin-3-Gallate Therapeutic Potential in Cancer: Mechanism of Action and Clinical Implications.

Cellular signaling pathways involved in the maintenance of the equilibrium between cell proliferation and apoptosis have emerged as rational targets that can be exploited in the prevention and treatment of cancer. Epigallocatechin-3-gallate (EGCG) is the most abundant phenolic compound found in green tea. It has been shown to regulate multiple crucial cellular signaling pathways, including those mediated by EGFR, JAK-STAT, MAPKs, NF-κB, PI3K-AKT-mTOR, and others. Deregulation of the abovementioned pathways is involved in the pathophysiology of cancer. It has been demonstrated that EGCG may exe

Nutrition-specific interventions for preventing and controlling anaemia throughout the life cycle: an overview of systematic reviews.

BACKGROUND: Anaemia is a prevalent health problem worldwide. Some types are preventable or controllable with iron supplementation (pills or drops), fortification (sprinkles or powders containing iron added to food) or improvements to dietary diversity and quality (e.g. education or counselling). OBJECTIVES: To summarise the evidence from systematic reviews regarding the benefits or harms of nutrition-specific interventions for preventing and controlling anaemia in anaemic or non-anaemic, apparently healthy populations throughout the life cycle. METHODS: In August 2020, we searched MEDLINE, E