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Global, regional, and national burden of 12 mental disorders in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019.

BACKGROUND: The mental disorders included in the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 were depressive diso … life expectancy to estimate YLLs. Deaths and YLLs could be calculated only for anorexia nervosa and bulimia nervosa, since these were the only mental disorders identified as underlying causes of death in GBD 2019. FINDINGS: Between 1990 and 2019, the global number of DALYs due to mental disorders increased from 80·8 million (95% uncertainty interval [UI] …

Eating disorders and oral health: a matched case-control study.

The aim was to compare the oral health status of patients with eating disorders (EDs), with sex- and age-matched controls, with a view to identify self-reported and clinical parameters that might alert the dental healthcare professional to the possibility of EDs. All patients who entered outpatient treatment in an ED clinic during a 12-month period were invited to participate. Of 65 ED patients who started psychiatric/medical treatment, 54 agreed to participate. Eating disorder patients and controls answered a questionnaire and underwent dental clinical examinations. Multivariate analysis iden

Relevance Index Regional Variation by Each Disease and Its Essential Medical Field: A Retrospective Data Analysis From 2016-2020 in Korea.

BackgroundTo precisely build a healthcare delivery system at regional levels, local patients' healthcare service utilization patterns must be examined. Hence, this study utilized trend analysis of the relevance index of each disease of each essential medical service field at the municipal and provincial levels.MethodsThis study analyzed customized databases released by the National Health Insurance Service from 2016-2020. Diseases defined in the Korean National Burden of Disease (KNBD) study were categorized into the following essential medical service fields: trauma care, cardiocerebrovascula

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… In the mental health field, apart from addiction-related diseases, bulimia nervosa (0.0%) and autism (57.1%) showed low relevance index values. … | 80.0 | 81.9 | 78.3 | 77.8 167 | Obsessive-compulsive disorder | 66.7 | 71.4 | 71.4 | 80.0 | 73.9 168 | Post-traumatic stress disorder | 76.0 | 76.9 | 80.0 | 66.7 | 75.0 169 | Other anxiety disorder | 82.3 | 83.2 | 82.6 | 81.8 | 80.8 170 | Anorexia nervosa | 69.2 | 71.4 | 75.0 | 66.7 | 88.1 171 | Bulimia …

The Multifaceted Nature of GLP-1: Molecular Mechanisms and Signaling Pathways in Metabolic and Neurodegenerative Diseases.

The aim of this article is to present the current state of knowledge regarding the use of GLP-1 agonists in the treatment of type 2 diabetes, obesity, and other potential clinical indications, including neurodegenerative conditions. The article describes the characteristics of the diseases discussed, with particular emphasis on the pathophysiological mechanisms and the impact of metabolic disorders on the course of the diseases. In addition, the specific role of GLP-1 receptor agonists and their mechanisms of action leading to improved clinical outcomes were discussed, including their impact o

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… In addition, binge eating may also co-occur with bulimia. GLP-1 receptor agonists in the hypothalamus act on POMC/CART and NPY/AgRP neurons, enhancing satiety signals and suppressing appetite, with the simultaneous involvement of serotonin pathways. … Current data and evidence suggest that GLP-1 receptor agonists may be a promising alternative to pharmacotherapy in bulimia and other psychiatric disorders whose underlying causes include both appetite regulation disorders and behavioral aspects related to eating control [ 123 ]. …

[Comorbidity between eating disorders and mood disorders: review].

OBJECTIVE: Comorbidity between eating disorders (ED) and mood disorders is a major issue when evaluating and treating patients with anorexia nervosa (AN) or bulimia nervosa (BN). In the literature, estimated comorbidity rates of mood disorders in subjects with ED differ widely across studies. Obviously, it is difficult to compare results from various sources because of differences in methods of assessment of depressive symptoms and in diagnostic criteria for both ED and mood disorders. Furthermore, few studies have included control groups, and, since mood disorders are among the most frequent …

Updating Disability Weights for Measurement of Healthy Life Expectancy and Disability-adjusted Life Year in Korea.

BackgroundThe present study aimed to update the methodology to estimate cause-specific disability weight (DW) for the calculation of disability adjusted life year (DALY) and health-adjusted life expectancy (HALE) based on the opinion of medical professional experts. Furthermore, the study also aimed to compare and assess the size of DW according to two analytical methods and estimate the most valid DW from the perspective of years lost due to disability and HALE estimation.MethodsA self-administered web-based survey was conducted ranking five causes of disease. A total of 901 participants star

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… 0.437 194 | Major depressive disorder (severe) | 0.570 | 0.392 | 0.668 | 0.527 195 | Dysthymia | 0.229 | 0.271 | 0.243 | 0.334 196 | Bipolar disorder | 0.499 | 0.361 | 0.536 | 0.450 197 | Anxiety disorders | 0.308 | 0.294 | 0.317 | 0.359 198 | Anorexia nervosa | 0.361 | 0.311 | 0.249 | 0.336 199 | Bulimia … For example, the DWs for ‘anorexia nervosa’ and ‘bulimia nervosa’ were 0.224 and 0.223 in the GBD 2013 study, 12 respectively, but 0.420 and 0.392 in the most recent KNBD study, 18 respectively. …

The 2024 Saudi Pharmacotherapy Didactic Curriculum Toolkit: A Modified Delphi Study.

BACKGROUND: Several pharmacy schools in Saudi Arabia (S.A.) refer to the American College of Clinical Pharmacy (ACCP) pharmacotherapy toolkit in developing their pharmacotherapy curriculum. However, the ACCP toolkit does not specifically address the healthcare needs of the Saudi population. A tailored pharmacotherapy curriculum that offers graduates the essential competencies to better serve the nation's needs is warranted. This study aims to develop a population-centered didactic pharmacotherapy toolkit for the Saudi population to assist pharmacy schools in designing pharmacotherapy course co

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… Bipolar disorder (e.g., mania, bipolar depression, maintenance therapy) 2 Delirium/acute agitation (non-critically ill patients) 2 Obsessive-compulsive disorders 2 Schizophrenia 2 Trauma- and stressor-related disorders (e.g., posttraumatic stress disorder) 3 Eating disorders (e.g., anorexia nervosa, bulimia … disorder (e.g., mania, bipolar depression, maintenance therapy) 2 | Delirium/acute agitation (non-critically ill patients) 2 | Obsessive-compulsive disorders 2 | Schizophrenia 2 | Trauma- and stressor-related disorders (e.g., posttraumatic stress disorder) 3 | Eating disorders (e.g., anorexia nervosa, bulimia …

Налтрексон для острого управления навязчивыми сексуальными и одержимыми симптомами у пациента с неевроразвитым расстройством.

Навязчивое сексуальное расстройство (CSBD) характеризуется постоянной сложностью контроля за сексуальными желаниями и поведением, связанным с явными расстройствами или расстройствами. Данные, основанные на населении, свидетельствуют о том, что ~8.6% , взрослых американцев испытывают трудности, связанные с борьбой с сексуальными желаниями, чувствами и поведением, в то время как крупные международные исследования в области скрининга показывают, что ~5% ОСББ может подвергаться высокому риску, однако лишь меньшинство обращается за лечением. Диагностическая классификация по-прежнему сопряжена с тру

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… Additionally, 20% experience moderate to severe depression, 21% have had an adjustment disorder at some time, and 6% have been diagnosed with bulimia nervosa (as compared to only 0.3% prevalence in the total US population) [ 11 , 14 ]. …

Romosuzumab used to treat a 29-year-old patient with anorexia nervosa related osteoporosis - A case report.

Osteoporosis and decreased bone density is a frequent complication of anorexia nervosa (AN). As of yet, there have been no studies of accomplished treatment of AN-related osteoporosis with romosuzumab, a monoclonal antibody to sclerostin. We report the first case of a premenopausal, 29-year old patient in Switzerland with decreased bone density and osteoporotic fractures due to anorexia nervosa, who completed the treatment with romosuzumab. There was a significant increase in bone mineral density (BMD) after 12 months of therapy. No serious side effects were reported. To date, only bisphosphon

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… Fractures in patients with anorexia nervosa, bulimia nervosa, and other eating disorders-a nationwide register study. Int. J. Eat. Disord. 2002 doi: 10.1002/eat.10101. Zipfel S., Giel K.E., Bulik C.M., Hay P., Schmidt U. Anorexia nervosa: aetiology, assessment, and treatment. …

Adverse outcomes in patients with a diagnosis of an eating disorder: primary care cohort study with linked secondary care and mortality records.

OBJECTIVE: To examine the short and long term adverse physical and mental health outcomes, all cause mortality, and natural and unnatural de … to 20 comparators without an eating disorder (n=493 001). Disorders examined were anorexia nervosa, bulimia nervosa, binge eating disorder, and all other types combined. MAIN OUTCOME MEASURES: Physical health conditions, mental health conditions, and mortality (all cause and cause specific). Hazard ratios and cumulative incidences were calculated to comp …

[Sociodemographic profiles, addictive and mental comorbidity in cannabis users in an outpatient specific setting].

CONTEXT: In the 1990s, cannabis consumption in France increased considerably. So, in 10 years, the number of adolescents reporting regular c … and post-traumatic stress disorder (5%). The prevalence of schizophrenia was 4%. The prevalence of bulimia was 4% and no anorexia. Women are more likely to report an affective disorder (64% versus 41%; p=0.04) or a post-traumatic stress disorder (17% versus 0%; p<0.001) in the last 12 months. The prevalence of family history for psychiatric disorders was …

Характеристики самоидентифицированных сексуальных азартных игроков в клинике азартных заболеваний.

Фон и цели Исследования сексуального зависимости процветали в последний десятилетний период, стимулированные развитием большого количества онлайн-сексуальных активностей. Несмотря на накопление исследований, однако, доказательства, собранные в клинических образцах людей, ищущих лечение, остаются редкими. Целью этого исследования было описать характеристики (социodemографические, сексуальные привычки и сопутствующие заболевания) самоназначенных «сексуальных зависимых». Методы Образец составлял 72 пациента, обратившихся в поликлинический центр лечения по поводу своих сексуальных поведений. Данны

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… 64.4  Suicide risk 41.7 52.4  Hypomanic disorder 0  Dysthymia 0  Generalized anxiety disorder 33.3 100  Social phobia 41.7 93.3  Agoraphobia 18.1 83.3  Panic disorder 16.7 75  Obsessive–compulsive disorder 16.7 66.7  Post-traumatic stress disorder 5.6 100  Psychotic syndrome 2.8 50  Anorexia 1.4 100  Bulimia …

Теоретический опыт в множестве склерозов: функциональные неврологические симптомы, недовольство изображением тела и расстройство пищевой практики. Обзор описательной части.

Множественный склероз (MS) — хроническое заболевание центральной нервной системы, связанное с целым рядом физических, когнитивных и психологических трудностей. Помимо классических неврологических симптомов, нарушения физического опыта, включая функциональные неврологические симптомы, соматизацию, расстройства, связанные с изображением тела, и расстройство питания, представляют собой недооцененный, но клинически значимый аспект болезни. В настоящем докладе обобщаются данные, полученные от взрослого и педиатрического населения, с уделением особого внимания частому соучастию этих нарушений в рабо

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… These behaviors may represent subclinical manifestations or may meet DSM-5-TR criteria for formal eating disorders (such as anorexia nervosa, bulimia nervosa, or binge-eating disorder), and can negatively affect both physical and mental health ( American Psychiatric Association, 2022 ; Conceição and … They reported that 21% of participants had a lifetime diagnosis of an eating disorder, including 12.4% with anorexia nervosa, 9.5% with bulimia nervosa, and 1.5% with binge-eating disorder, while an additional 27.6% were considered at risk of developing an eating disorder. …

A rapid and systematic review of the clinical effectiveness and cost-effectiveness of orlistat in the management of obesity.

BACKGROUND: The prevalence of obesity in developed societies is increasing. Obesity is associated with an increased risk of co-morbidity, in … ol and blood pressure. Studies recruiting people with eating disorders such as anorexia nervosa and bulimia nervosa were excluded. METHODS - PROCESS OF STUDY SELECTION: Assessment of titles and abstracts was performed independently by two reviewers. If either reviewer considered a reference to be relevant, the full paper was retrieved. Full papers were as …

Clinical and Therapeutic Implications of Male Obesity.

The prevalence of obesity, a disorder linked to numerous comorbidities and metabolic complications, has recently increased dramatically worldwide and is highly prevalent in men, even at a young age. Compared to female patients, men with obesity more frequently have delayed diagnosis, higher severity of obesity, increased mortality rate, and only a minority of obese male patients are successfully treated, including with bariatric surgery. The aim of this review was to present the current state of knowledge about the clinical and therapeutic implications of obesity diagnosed in males.

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… It may also result in future eating disorders in the form of anorexia nervosa or bulimia nervosa [ 26 ]. Research shows that androgens are not as closely associated with increased depression in chronic stress states as female sex hormones are [ 27 , 28 ]. … Moreover, androgens do not induce eating disorders, such as anorexia nervosa or bulimia nervosa, in contrast to estrogens, which display such effects, hence the rare occurrence of eating disorders in males [ 29 ]. …

European Guidelines for Obesity Management in Adults.

Obesity is a chronic metabolic disease characterised by an increase of body fat stores. It is a gateway to ill health, and it has become one of the leading causes of disability and death, affecting not only adults but also children and adolescents worldwide. In clinical practice, the body fatness is estimated by BMI, and the accumulation of intra-abdominal fat (marker for higher metabolic and cardiovascular disease risk) can be assessed by waist circumference. Complex interactions between biological, behavioural, social and environmental factors are involved in regulation of energy balance and

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… History Taking – Ethnicity – Family history – Dietary habits – Physical activity frequency and nature – Eating pattern and possible presence of an eating disorder (binge eating disorder, night eating syndrome, bulimia) – Presence of depression and other mood disorders – Other determinants, e.g … dysgeusia Bupropione/ naltrexone | FDA & EMA approved | DA/NE reuptake inhibitor(B) opioid antagonist (N) | 8/90 mg tb 2 tb bid | 4.8% 1 year stop if <%5 weight loss at 12 weeks | fetal toxicity, increased seizure risk, glaucoma, hepatoxicity | uncontrolled hypertension, seizure, anorexia nervosa / bulimia …

Плазма и вицеральный орган Kynurenin Metabolites Коррелат в Multical Sclerosis Cuprizon Animal Model.

Модель нескольких склерозов (MS) капризона (CPZ) является прекрасной для изучения молекулярных различий, связанных с ущербом, причиненным отравлением. Метаболические различия в кинуреньиновом пути (КП) разложения триптофана (TRP) наблюдаются как в MS, так и в модели мыши CPZ. Наша цель состояла в том, чтобы проанализировать кинуреньин, серотонин и индоловые пути деградации ТРП на периферии, в нейродегенеративных процессах воспаления. В нашем исследовании мыши питались 0,2% токсина CPZ в течение 5 недель. Мы изучили метаболиты на трех путях разрушения ТРП в моче, плазме и соответствующих висцер

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… Abnormalities in the metabolic pathways of TRP degradation were also reported in some diseases, such as irritable bowel syndrome, chronic kidney disease, obesity, and anorexia nervosa or bulimia, among others [ 83 ]. …

Antiobesity Medications for Older Adults-the New, the Good, the Bad, and the Unknown.

OBJECTIVE: Obesity affects 42% of older adults, with rates continuing to rise. This a complex condition influenced by non-modifiable as well as modifiable risk factors. The disease can be treated through modifications to diet, physical activity, and behavior and more recently through antiobesity medications (AOMs) and surgery. Treatment must be tailored to individual needs due to age-related metabolic and physiological changes. This review aimed to identify the suitability of seven FDA-approved AOMs in the treatment of obesity in older adults. METHODS: A review of AOMs was performed, focusing

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… . | In patients with uncontrolled hypertension, seizure disorders, anorexia nervosa or bulimia. | In patients with MEN2a and MEN2b, history of pancreatitis, T1DM, gastroparesis, family history of medullary thyroid cancer, Cr Cl < 30, eGFR < 30 | In patients with MEN2a and MEN2b, history of pancreatitis … While less common among older adults, we generally avoid GLP1‐RAs and GLP1‐RA/GIPs with inadequate food intake, malnutrition, or eating disorders such as anorexia and or bulimia. …

Abstracts of the 5(th) Cachexia Conference, Barcelona, Spain, December 5-8, 2009.

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Cancer during a pandemic: A psychosocial telehealth intervention for young adults.

The SARS-II COVID-19 pandemic has posed pronounced global health threats and prompted assorted transformations in societal engagement and clinical service delivery. For cancer survivors, many of whom are immune-compromised, these pandemic-related health threats pose greater challenges, warranting extra precautions within everyday living. Young adult (YA) cancer survivors already confront many unique physical and emotional challenges specific to their demographic. Already comfortable with assorted technologies, the pandemic presented an opportunity to provide telehealth intervention that target

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… Severe eating disorders; as evidenced by an ICD-10 code in the medical record such as anorexia nervosa or bulimia within the past year or revealed during patient interview 7. Must have experienced health-related anxiety and/or distress in last 3 months | 7. …