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50th ESCP Symposium on Clinical Pharmacy, Polypharmacy and ageing - highly individualized, interprofessional, person-centered care : 19–21 October 2022, Prague, Czech Republic

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Cancer Cells Exploit Notch Signaling to Redefine a Supportive Cytokine Milieu.

Notch signaling is a well-known key player in the communication between adjacent cells during organ development, when it controls several processes involved in cell differentiation. Notch-mediated communication may occur through the interaction of Notch receptors with ligands on adjacent cells or by a paracrine/endocrine fashion, through soluble molecules that can mediate the communication between cells at distant sites. Dysregulation of Notch pathway causes a number of disorders, including cancer. Notch hyperactivation may be caused by mutations of Notch-related genes, dysregulated upstream p

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… leukemia | Phase 1/2 | Plerixafor | NCT01435343 ( 272 ) CXCR4 | Refractory acute lymphoblastic leukemia | Phase 1 | Plerixaflor | NCT01319864 ( 273 ) RANKL | Breast cancer | Early phase 1 | Denosumab | NCT02900469 RANKL | Bone metastases | Phase 1 | JMT103 | NCT03550508 TNF1α | Advanced cancer | | Infliximab …

Paraneoplastic Neurological Syndromes: Advances and Future Perspectives in Immunopathogenesis and Management.

Paraneoplastic neurological syndromes (PNSs) are immune-mediated disorders caused by an antitumor response that cross-reacts with the nervous system, leading to severe and often irreversible neurological disability. Once considered exceedingly rare, PNSs are now increasingly recognized owing to the identification of novel neural autoantibodies, wider use of commercial testing, and the emergence of immune checkpoint inhibitor (ICI)-related neurotoxicity that phenotypically overlaps with classic PNS. In this narrative review, we performed a structured search of PubMed/MEDLINE, Scopus, Web of Sci

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… For Grade 3–4 toxicities (severe weakness, encephalitis), permanent discontinuation of the ICI is usually required, along with aggressive immunosuppression (IVIG, PLEX, or stronger agents like infliximab or tocilizumab) [ 83 ]. …

Интегрин α4β7:: патогенные роли в заболеваниях метаболики и воспаления и в терапии перевода.

Интегрин α4β7 является ключевым рецептором сцепления, который является посредником лимфоцита, движущегося к кишечной слизи через взаимодействие с MAdCAM-1, VCAM-1, и фибронектин, тем самым играя центральную роль в иммунной слежке и мукозаловом иммунитете. Появляющиеся данные расширили его функциональный охват за пределы кишечного гомеостаза, с тем чтобы охватить различные подстрекательские и метаболические заболевания. В настоящем обзоре систематически резюмируются структурные характеристики, взаимодействия лигандов и положения о соответствии α.4β7, с акцентом на патогенную роль в провокационн

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… In UC, the GARDENIA trial showed that etrolizumab was not superior to infliximab in achieving the combined primary endpoint of clinical response at week 10 and clinical remission at week 54 (18.6% vs 19.7%, p=0.81). 187 The HIBISCUS I and II trials reported that etrolizumab did not demonstrate superiority …

Устранение неврологических расстройств путем борьбы с нейродегенеративными ассоциированными ферментами: естественные и синтетические молекулы.

Неврологические расстройства, включая нейродегенеративные и нейро-воспалительные заболевания, создают значительные проблемы в области здравоохранения и клинических проблем. Недавние исследования показали, что различные ферменты играют ключевую роль в наступлении и развитии этих расстройств. В этом обзоре изучается терапевтический потенциал адресации этих ферментов естественными и синтетическими молекулами. К таким заболеваниям, как болезнь Альцгеймера, болезнь Паркинсона и множественный склероз, причастны основные ферменты, включая ацетилхолинестеразу, оксидазу моноамина, бета-секретазу, тау к

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… This study reports a severe aggravation of an 18-year-old female patient who had a 1-year history of left-sided ulcerative colitis that was unresponsive to vedolizumab and infliximab. …

Anakinra: efficacy in the management of fever during neutropenia and mucositis in autologous stem cell transplantation (AFFECT-2)-study protocol for a multicenter randomized double-blind placebo-controlled trial.

BACKGROUND: Since decades, fever and infections have been the most important complications of intensive chemotherapy and hematopoietic stem cell transplantation (HSCT) in the treatment of hematologic malignancies. Neutropenia has long been considered to be the most important risk factor for these complications. However, recent studies have shown that not neutropenia, but the development of mucositis is the most important cause of these complications. Currently, limited options for the prevention and treatment of mucositis are available, of which most are only supportive. The pro-inflammatory c

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… Impaired renal function with eGFR < 40 ml/min Received a live vaccine during the 3 months prior to baseline visit Recent use of IL-1 antagonist, such as anakinra, rilonacept, or canakinumab, within 3 months prior to baseline visit Treatment with TNFα-inhibiting agents (such as etanercept, adalimumab, infliximab …

Diabetes mellitus and the skin.

Several dermatoses are routinely associated with diabetes mellitus, especially in patients with chronic disease. This relationship can be easily proven in some skin disorders, but it is not so clear in others. Dermatoses such necrobiosis lipoidica, granuloma annulare, acanthosis nigricans and others are discussed in this text, with an emphasis on proven link with the diabetes or not, disease identification and treatment strategy used to control those dermatoses and diabetes.

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… Treatment usually is not necessary because most of its injuries remit spontaneously within two years. 69 If the lesions become an unpleasant problem, the available options include high-dose topical steroids, intralesional injection of corticosteroids, PUVA, cryotherapy, or drugs such as niacinamide, infliximab …

Forecasting drug utilization and expenditure in a metropolitan health region.

BackgroundNew pharmacological therapies are challenging the healthcare systems, and there is an increasing need to assess their therapeutic value in relation to existing alternatives as well as their potential budget impact. Consequently, new models to introduce drugs in healthcare are urgently needed. In the metropolitan health region of Stockholm, Sweden, a model has been developed including early warning (horizon scanning), forecasting of drug utilization and expenditure, critical drug evaluation as well as structured programs for the introduction and follow-up of new drugs. The aim of this

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… Expenditure has increased rapidly for the treatment of rheumatoid arthritis (RA) due to the introduction of anti-tumor necrosis factor (TNF)-alpha and anti-interleukin (IL)-1 agents (infliximab, adalimumab, etanercept and anakinra). …

Applied information retrieval and multidisciplinary research: new mechanistic hypotheses in complex regional pain syndrome.

BackgroundCollaborative efforts of physicians and basic scientists are often necessary in the investigation of complex disorders. Difficulties can arise, however, when large amounts of information need to reviewed. Advanced information retrieval can be beneficial in combining and reviewing data obtained from the various scientific fields. In this paper, a team of investigators with varying backgrounds has applied advanced information retrieval methods, in the form of text mining and entity relationship tools, to review the current literature, with the intention to generate new insights into th

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… DMSO (Dimethyl sulfoxide), PGE2 (Prostaglandin E2), magnesium, noradrenaline, capsaicin, glucocorticoid, mannitol, pentoxifylline, naproxen, bisphosphonate, verapamil, morphine, ketamine, amitriptyline, clonidine, carbamazepine, nortriptyline, lidocaine, GABA (gamma-aminobutyric acid), ketanserin, infliximab …

От эмпирического лечения к точному вмешательству: библиометрический анализ нейропсихиатрической системной волшебной системы с использованием нескольких баз данных (Erithematosus)2006-2025).

ЦЕЛЬ: Нейропсихиатрическая системная волчанка (NPSLE) представляет собой серьезное и сложное осложнение системного волчанка, которое влияет на принятие диагностических решений и стратегии лечения. Однако временнóе развитие основанных на фактических данных диагностических и терапевтических парадигм, а также сохраняющиеся клинические узкие места не были в полной мере охарактеризованы. МЕТОДЫ: Мы провели всеобъемлющий библиометрический анализ 1,569 Публикации, связанные с ЯИЭ, взяты из &quot; Web of Science Core Collection &quot; и &quot; Scopus &quot; 2006 и 2025. Кроме того, были включены соотв

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… Conversely, from 2013 to 2025, terms related to diagnostic evaluation and pharmacotherapy—such as “diffusion,” “infliximab,” “Montreal Cognitive Assessment,” and “efficacy”—exhibited marked increases in frequency, highlighting the emergence of novel clinical and investigative priorities. …

Геномическая архитектура циркулирующих уровней цитокина указывает на цели лечения иммунных заболеваний.

Циркуляция цитокинес оркестрирует иммунную реакцию и является перспективной целью для лечения иммунных и подстрекательских заболеваний. Изучение генетической архитектуры циркулирующих уровней цитокина могло бы дать ключевые знания о причинно-следственных посредниках в связи с человеческими заболеваниями. Здесь мы провели исследования по общегеномной ассоциации (GWAS) 40 циркуляции цитокинов в мета-анализах 74,783 Люди. Мы обнаружили 359 между уровнями цитокина и вариантами 169 независимых лоси, включая 150 Транс- и 19 Носящая ножи лоси. Интеграция с транскриптивомными данными указывает на ключ

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… In contrast to the TNF blockers infliximab, adalimumab and golimumab, lenercept provides equal inhibitory efficacy for TNF-a and TNF-b 74 , 76 . …

Best of JACC: Case Reports From ACC.23.

This dedicated issue of JACC: Case Reports highlights the top ranked Complex Clinical Cases from the ACC 2023 Scientific Sessions. These cases were reviewed and selected by a committee of peers in the months leading up to the annual meeting. These reviewers were ACC members with no affiliation to the JACC: Case Reports Editorial Board. While the cases were presented at the meeting and included in the formal Abstract Book from ACC, they have not been published elsewhere. These cases illustrate how the ACC can be a place for cardiovascular professionals to come together to learn, grow, and share

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… He had VT recurrence requiring antiarrhythmics, VT ablation, and transition to Infliximab. Given the persistence of arrhythmias, an alternative diagnosis was pursued. A follow-up cMRI suggested a pattern not entirely consistent with iCS and rather consistent with LMNA cardiomyopathy. …

Translating IL-6 biology into effective treatments.

In 1973, IL-6 was identified as a soluble factor that is secreted by T cells and is important for antibody production by B cells. Since its discovery more than 40 years ago, the IL-6 pathway has emerged as a pivotal pathway involved in immune regulation in health and dysregulation in many diseases. Targeting of the IL-6 pathway has led to innovative therapeutic approaches for various rheumatic diseases, such as rheumatoid arthritis, juvenile idiopathic arthritis, adult-onset Still's disease, giant cell arteritis and Takayasu arteritis, as well as other conditions such as Castleman disease and

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… Adalimumab, etanercept, infliximab, certolizumab pegol, golimumab, tocilizumab and abatacept for rheumatoid arthritis not previously treated with DMARDs or after conventional DMARDs only have failed. https://www.nice.org.uk/guidance/TA375 (NICE, 2016). 68. Smolen JS, et al. …

Expert Perspective: Hematologic Malignancies and Vasculitis.

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… Infliximab chimaeric anti‐tumour necrosis factor alpha monoclonal antibody treatment for patients with myelodysplastic syndromes . Br J Haematol 2002 ; 116 ( 2 ): 334 – 337 . 11841434 58 Padron E , Dezern A , Andrade‐Campos M , et al; Myelodysplastic Syndrome Clinical Research Consortium. …

Açai Berry Attenuates Cyclophosphamide-Induced Damage in Genitourinary Axis-Modulating Nrf-2/HO-1 Pathways.

Cyclophosphamide (CYP) is used to treat different malignancies and autoimmune disorders in men. This chemotherapy frequently reduces tumors, which is beneficial, but also causes infertility because of severe oxidative stress, inflammation, and apoptosis in the bladder and testes brought on by its metabolite, acrolein. The goal of this study was to assess the efficacy of a novel food, açai berry, in preventing CYP-induced damage in the bladder and testes.MethodsCYP was administered intraperitoneally once during the experiment at a dose of 200 mg/kg body weight diluted in 10 mL/kg b.w. of water.

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… Role of Etanercept and Infliximab on Nociceptive Changes Induced by the Experimental Model of Fibromyalgia. Int. J. Mol. Sci. 2022;23:6139. doi: 10.3390/ijms23116139. 88. …

Skin manifestations associated with systemic diseases - Part II.

The skin, by reflecting internal processes, externalizes what happens inside the body in many diseases. Thus, the skin, as an organ, extrapolates its functions of protection, barrier and signals the existence of systemic diseases, expanding the importance of the dermatologist beyond the skin surface. Thus, the dermatologist investigates diagnostic hypotheses for conditions related to all systems and refers patients to the appropriate specialty. Combined with examination by a trained eye, the skin, due to its easy access, is still the ideal place for performing biopsies, which often clarify the

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… Metastatic Crohn’s disease despite infliximab therapy. An Bras Dermatol. 2017;92:104–106. doi: 10.1590/abd1806-4841.20175713. 20. Rodrigo L., Beteta-Gorriti V., Alvarez N., Gomez de Castro C., de Dios A., Palacios L., et al. Cutaneous and Mucosal Manifestations Associated with Celiac Disease. …

Aging modulation of the immune system and immunotherapy efficacy in cancer.

Immunosenescence is characterized by immune decline and chronic inflammation. With advancing age, the incidence of tumors increases significantly. Understanding how immunosenescence influences the initiation and progression of tumors, as well as its implications for tumor immunotherapy, has become a matter of urgent importance. This review begins with an analysis of the phenotypic changes and underlying mechanisms associated with immune system and immune cell aging, and further explores the interplay between immunosenescence and tumorigenesis. Evidence indicates that cytokines, cell interactio

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… . | ( 194 ) Infliximab | Colon Cancer | Monoclonal antibody targeting TNF-α; blocks TNF-α/TNFR2 signaling. …

Chronic pruritus: a narrative review.

Chronic pruritus encompasses a manifestation of several cutaneous, allergic, infectious, neurological, psychological, and systemic conditions, whose etiological investigation and therapeutic strategy can be challenging. This comprehensive review aims to enhance the understanding of pruritus by highlighting important elements in its pathogenesis, including keratinocytes, Merkel cells and mast cells, nerve fibers, histaminergic and nonhistaminergic pathways, and the interaction of itch signals with the central nervous system. Diagnostic evaluation of chronic pruritus may require a meticulous app

Drug-Induced Periocular and Ocular Surface Disorders: An EAACI Position Paper.

Various systemic and topical medications can induce ocular and periocular cutaneous adverse effects (AEs), ranging from mild to severe. These AEs may lead to ocular surface (OS) damage and, in some cases, life-threatening complications. Drug-induced ocular adverse reactions are generally classified into two primary categories: toxic reactions and/or allergic hypersensitivity reactions, which can be IgE or non-IgE-mediated. Systemic antibiotics, antivirals, and anticonvulsants can trigger adverse reactions that may involve the OS. Drugs like antihistamines, beta-blockers, antipsychotics, antide

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… Etanercept, infliximab, adalimumab, certolizumab pegol, and golimumab have been approved by the FDA for the treatment of rheumatoid arthritis (RA), inflammatory bowel disease, ankylosing spondylitis, psoriasis, and Behçet's disease. …

IgA Vasculitis (Henoch-Schönlein Purpura): An Update on Treatment.

Objective: IgA vasculitis (IgAV), previously named as Henoch-Schönlein purpura, is the most frequent systemic vasculitis in children. In adults, IgAV is less common although it is associated with more severe disease. In fact, the frequency of glomerulonephritis (referred to as IgAV nephritis) in adults is higher than in children and tends to present more severely, with around 10-30% of those affected eventually progressing to end-stage renal disease. In this review, we describe the pathophysiology, main clinical features, diagnosis of the disease, and latest clinical data regarding IgAV therap

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… The second one is a phase II, modified crossover study examining the efficacy of infliximab, RTX, and tocilizumab in the treatment of refractory non-anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), including IgAV, in both adults and children (the ‘BIOVAS’ trial). …