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The Impact of Ketogenic Nutrition on Obesity and Metabolic Health: Mechanisms and Clinical Implications.

The ketogenic diet (KD) has recently gained increasing popularity. This high-fat, adequate-protein, and carbohydrate-poor eating pattern leads to nutritional ketosis. The KD has long been known for its antidiabetic and antiepileptic effects and has been used therapeutically in these contexts. Recently, the KD, due to its effectiveness in inducing weight loss, has also been proposed as a possible approach to treat obesity. Likewise, a KD is currently explored as a supporting element in the treatment of obesity-associated metabolic disorders and certain forms of cancer. Here, we discuss the meta

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… However, these highly processed foods, such as salty snacks and sugar-sweetened beverages, are characterized by a high glycemic index (GI) and deliver quickly absorbed nutrients that cause dopamine-triggered satisfaction and contribute to metabolic health issues and addictive eating behaviors. 26 , 27 … Food and beverage consumption and food addiction among women in the Nurses’ Health Studies. Appetite. 2018;121:186-197. 10.1016/j.appet.2017.10.038 37. Jaworowska A, Blackham T, Davies IG, Stevenson L. Nutritional challenges and health implications of takeaway and fast food. …

Imatinib, sunitinib and pazopanib: From flat-fixed dosing towards a pharmacokinetically guided personalized dose.

Tyrosine kinase inhibitors (TKIs) are anti-cancer drugs that target tyrosine kinases, enzymes that are involved in multiple cellular processes. Currently, multiple oral TKIs have been introduced in the treatment of solid tumours, all administered in a fixed dose, although large interpatient pharmacokinetic (PK) variability is described. For imatinib, sunitinib and pazopanib exposure-treatment outcome (efficacy and toxicity) relationships have been established and therapeutic windows have been defined, therefore dose optimization based on the measured blood concentration, called therapeutic dru

Микробиота и почки в Камеруне работают в автосомных доминирующих полициклических болезнях почек: перекрестное исследование.

Гут дисбиоз патобионтов (Enterobacter, Eschericia и Salmonella) и симбионтов (Bifidobacterium, Lactobacillus и Prevotella) может происходить во время развития хронической болезни почек (CKD). Мы провели оценку связей между репрезентативными симбионтами (Bifidobacterium и Lactobacillus) и патобионтами (Enterobacteriaceae) с функцией почек у лиц с автосомальным доминирующим полициклическим заболеванием почек (ADPKD). МЕТОДЫ: В этом перекрестном исследовании 29 Пациенты ADPKD сравнивались с пациентами 15 контроля в районе действия 2::1 соотношение. Были собраны клинические данные и биологические

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… Group II: meat (beef, pork, poultry), egg, white rice, bread, margarine, mayonnaise, ripe plantains, sugar, alcoholic beverages. …

Вытяжка из листа EGb 761* в качестве образца продукта по концепции процесса.

Часто недооценивается тот факт, что экстракты, получаемые с одного и того же растения, могут существенно различаться по их фитохимическому составу, а также по их фармакокинетическим и фармакодинамическим свойствам, которые лежат в основе их клинической эффективности и безопасности. Специальная экстрактная EGb 761- Это... one из наиболее изученных выдержек растений в мире. В настоящем обзоре, используя этот экстракт в качестве парадигмы, мы рассказываем о том, как климат, район сбора урожая, обработка растительного материала, процесс сушки, экстракционные растворители и детали последующих этапо

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… the cultivar variety, growing environment, manufacturing conditions, and grade (particle size) of the tea leaves, the use of tea bags, including their size and material, the amount of tea and water used, infusion time, and agitation, are all major determinants of the component concentrations of tea beverages … What is commonplace to the vintner, applies even more to the science of phytopharmacology: All beverages sold under the label “wine” should fulfil a modicum of characteristics regarding its manufacturing–which is analogous to the European pharmacopoeia regulations for Ginkgo extract–but not all wines …

Кислотный профиль эритроцитов по множеству склерозов связан с курсами болезней, липидной пероксидацией и диетическим влиянием.

Предыстория/цели: Диетический образ жизни, в частности потребление жирных кислот (FA), может быть полезным для смягчения основных патогенных процессов при множественном склерозе (MS); однако данные по-прежнему являются недостаточными, особенно в том, что касается передачи болезни. Таким образом, цели этого исследования заключались в изучении эритроцитного профиля АУ у пациентов с релапсирующими (RR)MS и прогрессивными (P)MS, а также в изучении вопроса о том, является ли пищевая добавка пищевой добавкой n-3 PUFA может повлиять на профиль FA, в зависимости от хода болезни. Методы: профиль FA был

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… We previously demonstrated that the consumption of nutrients, such as n -3 and polyphenol-rich foods/beverages, could affect the composition of circulatory fatty acids, including PUFAs, in the healthy as well as the subjects at risk of chronic disease [ 13 , 14 , 15 ]. …

Индивидуальные различия в прогнозах в отношении тестостерона и самоконтроля

Способность контролировать сексуальные желания и порывы имеет важнейшее значение для достижения индивидуальной и социальной гармонии. Непринятие мер по регулированию сексуального поведения может привести, в частности, к вмешательству в повседневные жизненные цели, передаче сексуальных заболеваний и нарушению нравственных норм. Двойная модель контроля сексуального реагирования предполагает, что несбалансированность между сексуальным возбуждением и механизмами сексуального сдерживания может привести к регулированию сексуальной дисдукции, объясняя тем самым проблематичное сексуальное поведение. М

Financial Toxicity in Patients With Breast Cancer Treated at Private Medicine Institutions in Brazil.

Financial toxicity (FT) refers to the negative impact of the financial burden of cancer diagnosis and treatment on patients' well-being. With rising global costs of oncologic therapies, diagnostics, and supportive care, FT has become a key concern in cancer care, influencing adherence, quality of life, and outcomes. Breast cancer, given its high prevalence and socioeconomic implications, is notably associated with FT. Beyond direct medical expenses, patients often face income loss and out-of-pocket costs for supportive care, which can significantly affect their therapeutic trajectory. Addressi

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… Receiving sickness benefits/absent from work | 46 | 5.0 Retired | 179 | 19.6 Unemployed | 50 | 5.5 Current smoking habit ( n = 912) | Non‐smoker | 861 | 94.4 Quit smoking within the last 6 months | 16 | 1.8 Smoker | 35 | 3.8 Current alcohol consumption habit ( n = 912) | Does not consume alcoholic beverages …

Существенный потенциал борьбы с миломой вливания зеленого чая и его компонента дигидромиритина.

Множественная миелома (ММ) — фатальная гематологическая порча, характеризующаяся перерастанием моноклонных плазменных клеток. Хотя зеленый чай имеет хорошо задокументированные антивизорные свойства, его специфические последствия для MM по-прежнему плохо характеризуются. Цель этого исследования состояла в изучении антимиеломной активности вливаний четырех репрезентативных зеленых чая и выявлении их эффективных компонентов. Мы обнаружили, что апоптоз клеток MM был вызван зелеными чайными вливаниями в зависимости от концентрации, при этом вливание чая в Билуочун продемонстрировало самую мощную эф

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… Green tea, derived from the fresh leaves of the tea plant ( Camellia sinensis L. ), represents one of the most widely consumed traditional beverages worldwide, particularly popular in Southeast Asian countries. …

Assessing diet as a modifiable risk factor for pesticide exposure.

The effects of pesticides on the general population, largely as a result of dietary exposure, are unclear. Adopting an organic diet appears to be an obvious solution for reducing dietary pesticide exposure and this is supported by biomonitoring studies in children. However, results of research into the effects of organic diets on pesticide exposure are difficult to interpret in light of the many complexities. Therefore future studies must be carefully designed. While biomonitoring can account for differences in overall exposure it cannot necessarily attribute the source. Due diligence must be

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… Dietary exposure from the ingestion of contaminated food (more so than water or other beverages) is considered to be the primary route of exposure for most pesticides although additional environmental exposure is also likely [ 14 – 16 ]. …

The Burden of Cancer, Government Strategic Policies, and Challenges in Pakistan: A Comprehensive Review.

Cancer is a severe condition characterized by uncontrolled cell division and increasing reported mortality and diagnostic cases. In 2040, an estimated 28.4 million cancer cases are expected to happen globally. In 2020, an estimated 19.3 million new cancer cases (18.1 million excluding non-melanoma skin cancer) had been diagnosed worldwide, with around 10.0 million cancer deaths. Breast cancer cases have increased by 2.26 million, lung cancer by 2.21 million, stomach by 1.089 million, liver by 0.96 million, and colon cancer by 1.93 million. Cancer is becoming more prevalent in Pakistan, with 19

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… cancer | References High intake of red meat | Colorectal cancer | ( 89 ) High salted vegetables/food | Gastric cancer | ( 90 ) Ultra-processed food and drinks | Chronic lymphocytic leukemia | ( 91 ) High fat | Breast cancer | ( 92 ) Low vitamin C, E rich foods | Skin cancer | ( 93 ) High alcoholic beverages … People are eating in a new way in terms of global with the rising relative importance of snacks, burgers, pizzas, and fizzy beverages ( 110 ). …

Polyphenolic natural products as photosensitizers for antimicrobial photodynamic therapy: recent advances and future prospects.

Antimicrobial photodynamic therapy (aPDT) has become a potent contender in the fight against microbial infections, especially in the context of the rising antibiotic resistance crisis. Recently, there has been significant interest in polyphenolic natural products as potential photosensitizers (PSs) in aPDT, given their unique chemical structures and inherent antimicrobial properties. Polyphenolic natural products, abundant and readily obtainable from natural sources, are generally regarded as safe and highly compatible with the human body. This comprehensive review focuses on the latest develo

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… It is abundantly found in various fruits and vegetables such as apples, grapes, onions, and tomatoes, as well as beverages such as tea and red wine, nuts and honey, from different plant sources ( 50 , 84 ). … Gallic acid Gallic acid (GA) (3,4,5-trihydroxybenzoic acid), a natural polyphenolic compound, is abundant in various plants, including trees, herbs, fruits, and nuts, as well as processed beverages such as red wine and green tea ( 104 ). …

Routes of administration, reasons for use, and approved indications of medical cannabis in oncology: a scoping review.

INTRODUCTION: Some patients diagnosed with cancer use medical cannabis to self-manage undesirable symptoms, including nausea and pain. To improve patient safety and oncological care quality, the routes of administration for use of medical cannabis, patients' reasons, and prescribed indications must be better understood. METHODS: Based on the Joanna Briggs Institute guidelines, a scoping review was conducted to map the current evidence regarding the use of medical cannabis in oncological settings based on the experiences of patients diagnosed with cancer and their healthcare providers. A searc

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… Edibles Food products or liquid infused with cannabis extract •Brownies, lozenges, cookies, candies, gummies, chocolate bars, cakes, tinctures (cannabis-infused alcohol) and beverages •Have you produced or used edibles containing cannabis to relieve your cancer symptoms? … Edibles | Food products or liquid infused with cannabis extract | •Brownies, lozenges, cookies, candies, gummies, chocolate bars, cakes, tinctures (cannabis-infused alcohol) and beverages | •Have you produced or used edibles containing cannabis to relieve your cancer symptoms? …

Global cancer statistics 2024: GLOBOCAN estimates of incidence and mortality worldwide for 34 cancers in 186 countries.

This article provides updated global cancer statistics for the year 2024 based on the GLOBOCAN estimates of the International Agency for Research on Cancer. The authors describe national cancer incidence and mortality by world region and the Human Development Index and predict the burden in 2050 based on demographic trends. In 2024, an estimated 20.6 million new cancer cases (19.5 million excluding nonmelanoma skin cancer) and 9.8 million deaths (9.7 million excluding nonmelanoma skin cancer) occurred worldwide, equivalent to one in five people developing cancer during their lifetime and one i

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… Although the underlying etiology remains poorly understood, established risk factors include smoking, excess body weight, and diabetes, with limited suggestive evidence for red meat, processed meat, alcohol consumption, and foods and beverages containing fructose and saturated fatty acids. 232 A recent … etiologies. 239 Globally, esophageal squamous cell carcinoma accounts for approximately 84% of all cases and predominates in high‐risk regions, including parts of the regions called central Asian esophageal cancer belt 240 and Eastern Africa’s esophageal cancer corridor , 241 where consumption of very hot beverages …

Advanced Practice Perspectives on Preventing and Managing Tumor Lysis Syndrome and Neutropenia in Chronic Lymphocytic Leukemia.

Tumor lysis syndrome (TLS) and neutropenia are significant toxicities in the treatment of chronic lymphocytic leukemia (CLL). Both TLS and neutropenia can lead to potentially life-threatening complications for patients with chronic lymphocytic leukemia undergoing antineoplastic therapy. This article focuses on diligent risk assessment, prophylaxis, early identification, monitoring, patient education, and prompt intervention for TLS and neutropenia. These are all necessary steps to reduce life-threatening complications. Guidelines are available for risk assessments for both TLS and neutropenia.

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… In the outpatient setting, patients should also limit foods, beverages, and supplements high in potassium, phosphorous, and calcium. It is also important to assess adherence to medication schedules and concomitant medications on an ongoing basis ( Howard et al., 2011 ). …

Bloodstream infections in patients with hematological malignancies: which is more fatal - cancer or resistant pathogens?

BackgroundThe primary objective of this study was to report the incidence of bloodstream infections (BSIs) and clinically or microbiologically proven bacterial or fungal BSIs during neutropenic episodes in patients with hematological malignancies.MethodsIn this retrospective observational study, all patients in the hematology department older than 14 years who developed febrile neutropenia during chemotherapy for hematological cancers were evaluated. Patients were included if they had experienced at least one neutropenic episode between November 2010 and November 2012 due to chemotherapy in th

Efficacy and safety of isatuximab subcutaneous plus carfilzomib and dexamethasone in patients with relapsed/refractory multiple myeloma: results of the Phase 2 study IZALCO.

In the Phase 2 IZALCO study, we evaluated efficacy, patient preference, safety and pharmacokinetics for isatuximab administered SC by an innovative on-body injector (OBI) or manual injection, plus carfilzomib-dexamethasone (Kd) in relapsed/refractory multiple myeloma (RRMM) patients. In Part 1, isatuximab SC was injected manually (cycles 1-6). In Part 2, patients were randomized to isatuximab SC by manual injection (cycles 1-3) followed by OBI administration (cycles 4-6) or to isatuximab OBI (cycles 1-3) followed by manual injection (cycles 4-6). From cycle 7, all patients could choose either

Associations Between Self-Rated Health and Mortality in the Norwegian Women and Cancer (NOWAC) Study.

PurposeWe investigated the association between self-rated health (SRH) and cancer incidence and SRH and all-cause mortality among Norwegian women.Population and methodsWe used data from 110,104 women in the Norwegian Women and Cancer (NOWAC) cohort aged 41-70 years at baseline. We used flexible parametric survival analysis with restricted cubic splines to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) for the association between SRH and mortality in the entire cohort. We employed the same method in a multistate design to assess associations between baseline SRH and 1) cancer

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… They also reported their current weight (kg), height (cm), smoking habits (including smoking status, age at initiation, and average daily numbers of cigarettes smoked at different age intervals), frequency of consumption of specified alcoholic beverages, duration of education, household income, and whether …

Dietary factors and their influence on immunotherapy strategies in oncology: a comprehensive review.

Immunotherapy is emerging as a promising avenue in oncology, gaining increasing importance and offering substantial advantages when compared to chemotherapy or radiotherapy. However, in the context of immunotherapy, there is the potential for the immune system to either support or hinder the administered treatment. This review encompasses recent and pivotal studies that assess the influence of dietary elements, including vitamins, fatty acids, nutrients, small dietary molecules, dietary patterns, and caloric restriction, on the ability to modulate immune responses. Furthermore, the article und

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… Beverages compounds impact on immunotherapies Polyphenolic compounds found in various beverages, including tea, coffee, and red wine, have garnered significant attention for their potential health benefits, including their impact on cancer immunotherapy. …

Antioxidant Intake and Antitumor Therapy: Toward Nutritional Recommendations for Optimal Results.

The role of the induction of oxidative stress as the mechanism of action of many antitumor drugs is acquiring an increasing interest. In such cases, the antitumor therapy success may be conditioned by the antioxidants present in our own body, which can be synthesized de novo (endogenous) or incorporated through the diet and nutritional supplements (exogenous). In this paper, we have reviewed different aspects of antioxidants, including their classification, natural sources, importance in diet, consumption of nutritional supplements, and the impact of antioxidants on health. Moreover, we have f

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… They are rich in polyphenols and also the two most consumed beverages on the planet after water [ 54 , 55 ]. … The total antioxidant content of more than 3100 foods, beverages, spices, herbs and supplements used worldwide. Nutrition Journal. 2010;9(1, article 3) doi: 10.1186/1475-2891-9-3. 42. Cattaneo F., Sayago J. E., Alberto M. R., et al. …

Portable bladder ultrasound: an evidence-based analysis.

OBJECTIVE: The aim of this review was to assess the clinical utility of portable bladder ultrasound. CLINICAL NEED: TARGET POPULATION AND C … y tract infections (UTI), poor mobility, dementia, smoking, obesity, consuming alcohol and caffeine beverages, physical activity, pregnancy, childbirth, forceps and vacuum-assisted births, episiotomy, abdominal resection for colorectal cancer, and hormone replacement therapy. For the purposes of this review, incontinence populations will be stratified into …