Результаты поиска

Genetic susceptibility to multiple sclerosis linked to myelin basic protein gene.

Genetic factors have been implicated in the aetiology of multiple sclerosis (MS), but the genes conferring susceptibility to MS have not bee … del and penetrance 0.05, a maximum LOD score of 3.42 (theta = 0.00) was obtained when patients with optic neuritis and their symptom-free siblings with abnormal MRI findings were classified as "affected". When these subjects were classified as "Нет данных" the maximum LOD scores ranged from 2.99 to 3.25 (theta = 0.00). The results suggest that in this population ge …

Cognitive event-related potentials in multiple sclerosis.

Twenty-three patients with multiple sclerosis (MS) and 1 patient with isolated optic neuritis (mean age 37.5 yrs, average duration of disease 10 yrs) were tested with auditory and visual cognitive event-related potentials (ERPs) using an oddball paradigm. The results were compared with data from 19 age-matched healthy controls. All patients had magnetic resonance imaging (MRI) head scans and 19 had comprehensive neuropsychological testing. The stimulus-related components of the ERPs were normal for nearly all patients, but 10 showed abnormalities of the later cognitive-related components and a…

Patient profiles and disease characteristics of the IMSRN cohort: a multicentre study (2021-2025).

BACKGROUND: Data of Central Nervous System (CNS) demyelinating disorders from India has been published from limited centres. The Indian Mult … 8 (14.03%); acute disseminated encephalomyelitis (ADEM), 76 (1.53%); chronic relapsing inflammatory optic neuritis (CRION), 34 (0.68%); chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS), three (0.06%), and others, 562 (11.29%). The mean (SD) age of the entire cohort at enrolment is 34.62 (12.16) years, at di …

Glaucomatous cupping and raised IOP: sine qua non for glaucoma?

PURPOSE: To present selected cases that highlight the confusions in daily glaucoma practice. METHODS: Four cases with raised or normal intraocular pressure (IOP) and definite glaucomatous cupping were investigated. RESULTS: While raised IOP was found in non-glaucomatous etiologies, IOP was normal in established glaucoma in a young patient. CONCLUSION: Raised IOP and glaucomatous cupping may not be pathognomonic of glaucoma and alternative etiology should be ruled out for appropriate management.

Optical coherence tomography measurements between multiple sclerosis and neuromyelitis optica spectrum disorder: A systematic review and meta-analysis.

BACKGROUND: Multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) are chronic autoimmune demyelinating diseases of the central nervous system (CNS) that frequently present with overlapping features, including optic neuritis (ON). This study aimed to evaluate differences in retinal measurements obtained via optical coherence tomography (OCT) between people with multiple sclerosis (PwMS) and neuromyelitis optica spectrum disorder (PwNMOSD). METHODS: The PubMed/MEDLINE, Embase, Scopus, and Web of Science databases were systematically searched up to February 22, 2025, to iden…

Retinal Layer Thickness for Risk Stratification of Progression Independent of Relapse Activity in Relapsing-Remitting Multiple Sclerosis.

BACKGROUND: Identifying people with relapsing-remitting multiple sclerosis (pwRRMS) at risk of progression independent of relapse activity ( … ds across multimodal assessments, sustained until end of follow-up. Analyses were restricted to non-optic neuritis eyes. Cox hazard models were used to assess the adjusted hazard (aHR) of PIRA with age-adjusted pRNFL or GCIP Z-scores. RESULTS: Out of 220 pwRRMS (age: 38.1 ± 9.9 years), 65 (29.5%) developed PIRA over a follow-up of 2.9 [IQR: 1.6-4.1] years. No a …

Rs10191329 Риск Allee ассоциируется с объявленным атрофией сетчатого слоя в множестве склерозов.

ЦЕЛЬ: Для изучения вопроса о том, связано ли значение rs10191329 в зоне риска аллеле DYSF-ZNF638, которое связано с устойчивостью центральной нервной системы, а не с иммунной патологией, с разбавлением сетчатки, биомаркером нейроаксональных повреждений при повторном склерозе (RMS). МЕТОДЫ: По результатам перспективного исследования мы включили пациентов РМС с ≥ 2 оптическими томографическими сканированием, за исключением глаз с оптическим невритом в период наблюдения. Образцы ДНК были генотипированы с использованием Глобальной скрининговой системы Illuen Infinium-24 и условно исчислены с испол

Совпадение в аннотации оригинала
OBJECTIVE: To investigate whether the rs10191329 risk allele in the DYSF-ZNF638 locus, which is implicated in central nervous system resilie … dy, we included RMS patients with ≥ 2 optical coherence tomography (OCT) scans, excluding eyes with optic neuritis during the observation period. DNA samples were genotyped using the Illumina Infinium Global Screening Array-24 and variants imputed using the Haplotype Reference Consortium panel and Minimac4. Multivariable linear regression models were used to ass …

Разнообразие сетчатки между множественным склерозом и расстройством спектрального спектра нейромиелита: перекрестное исследование с диагностической моделью.

ОКРУЖАЮЩАЯ СРЕДА И ЦЕЛИ: Изменения сетчатки в множественных склерозах (MS) и оптовом расстройстве нейромиелита (NMOSD) остаются неясными, особенно в том, что касается конкретных моделей и масштабов микроваскулярных изменений. Цель этого исследования заключалась в сопоставлении этих изменений и разработке моделей логистической регрессии и машинного обучения с использованием комбинированных микроваскуловых и структурных параметров сетчатки для дифференциации заболеваний. МЕТОДЫ: Пациенты с MS или NMOSD в клинически стабильных фазах прошли стабильную оптическо-согласованную томографию (OCT) и анг

Совпадение в аннотации оригинала
BACKGROUND AND OBJECTIVES: Retinal alterations in multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) remain unclear, … MS patients, 221 NMOSD patients, and 270 age- and sex-matched healthy controls) with 1277 eyes. In optic neuritis (ON) eyes, NMOSD showed significantly lower SVC metrics than MS, whereas in non-ON eyes, MS exhibited more severe microvascular loss (most p < 0.017); correspondingly, EDSS-related SVC decline was steeper in ON eyes of NMOSD but steeper in non-ON ey …

OCT-Based Retina Assessment Reflects Visual Impairment in Multiple Sclerosis.

PURPOSE: To explore the relationship between visual performance and retinal morphology as assessed by optical coherence tomography (OCT), an … < 0.001). The AULCSF showed the strongest correlation with both pRNFL and mGCIPL (P < 0.001), with optic neuritis being a significant contributing factor (P < 0.001). CONCLUSIONS: AULCSF outperformed standard HCVA and LCVA, closely reflecting retinal atrophy. mGCIPL loss showed stronger associations with vision tests and detected neurodegeneration without the …

Corneal Subbasal Nerve Plexus Evaluation by in Vivo Confocal Microscopy in Multiple Sclerosis: A Potential New Biomarker.

Purpose/Aim: Our study aims to evaluate corneal subbasal nerve plexus morphology by in vivo corneal confocal microscopy (CCM) in Multiple Sc … 3.84 to -0.28; p = .027 and -8.70 branches/mm2; 95%CI: -14.69 to -2.71; p = .006, respectively). An optic neuritis (ON) history did not influence CCM parameters.Conclusions: Our results confirm CCM parameters' potential to differentiate MS patients from healthy subjects, not being influenced by a previous ON history. A significant relationship between patient's …

[Transverse myelitis syndrom as a result of neuromyelitis optica spectrum disorders, systemic lupus erythematosus and myasthenia gravis combination].

Neuromyelitis optica spectrum disorders (NMOSD) - autoimmune condition characterized by an inflammatory lesions mainly of the spinal cord with the development of longitudinally extensive transverse myelitis (LETM) and/or involvement of the optic nerve with the development of usually bilateral optical neuritis (ON). In recent years, there has been increased awareness that NMOSD can be combined with other autoimmune diseases, including myasthenia gravis (MG), systemic lupus erythematosus (SLE) et al. The simultaneous presence of several autoimmune diseases in one patient can adversely affect the

No evidence of disease activity is associated with reduced rate of axonal retinal atrophy in MS.

OBJECTIVE: To explore, in a longitudinal study, the usefulness of optical coherence tomography (OCT) in monitoring people with multiple sclerosis (MS) by testing the association between retinal nerve fiber layer (RNFL) thinning and clinical and brain MRI criteria of no evidence of disease activity (NEDA). METHODS: OCT, visual evoked potentials (VEPs), and disability, using the Expanded Disability Status Scale (EDSS), were tested at baseline and after 2 years in 72 patients, 63 with routine yearly brain MRI. RESULTS: Longitudinal mean binocular RNFL thinning, in absence of optic neuritis duri…

Disease-modifying therapies modulate retinal atrophy in multiple sclerosis: A retrospective study.

OBJECTIVE: To retrospectively investigate whether disease-modifying therapies (DMTs) exert differential effects on rates of retinal atrophy … ssessed. Baseline analyses revealed no significant differences between groups in terms of age, sex, optic neuritis history, or follow-up duration. During follow-up, relative to NAT-treated patients, IFNSC- and GA-treated patients exhibited 0.37 μm/y (p < 0.001) and 0.14 μm/y (p = 0.035) faster rates of GCIP thinning, respectively, adjusting for the interval betw …

Retinal damage and vision loss in African American multiple sclerosis patients.

OBJECTIVE: To determine whether African American (AA) multiple sclerosis (MS) patients exhibit more retinal damage and visual impairment com … VA (p = 0.02) and worse LCVA per year of disease duration (p = 0.039). Among patients with an acute optic neuritis (AON) history, AAs had greater loss of HCVA than CA patients (p = 0.012). INTERPRETATION: This multicenter investigation provides objective evidence that AA MS patients exhibit accelerated retinal damage compared to CA MS patients. Self-identified …

Retinal ganglion cell layer volumetric assessment by spectral-domain optical coherence tomography in multiple sclerosis: application of a high-precision manual estimation technique.

BACKGROUND: Neuronal loss in the retina has been demonstrated pathologically in eyes of patients with multiple sclerosis (MS). In vivo, MS e … ting for age and within-patient intereye correlations). Within the MS group, eyes with a history of optic neuritis (ON, n = 4) had significantly lower GCL volumes than MS eyes with no ON history (P < 0.001). In contrast to measures of high-contrast visual acuity (P = 0.14), decreased GCL volumes were associated with worse performance on low-contrast letter acuit …

Optical Coherence Tomography Reveals Distinct Patterns of Retinal Damage in Neuromyelitis Optica and Multiple Sclerosis.

BACKGROUND: Neuromyelitis optica (NMO) and relapsing-remitting multiple sclerosis (RRMS) are difficult to differentiate solely on clinical grounds. Optical coherence tomography (OCT) studies investigating retinal changes in both diseases focused primarily on the retinal nerve fiber layer (RNFL) while rare data are available on deeper intra-retinal layers. OBJECTIVE: To detect different patterns of intra-retinal layer alterations in patients with NMO spectrum disorders (NMOSD) and RRMS with focus on the influence of a previous optic neuritis (ON). METHODS: We applied spectral-domain OCT in ey…

Clinical features and prognosis in ocular toxoplasmosis.

PURPOSE: To evaluate retrospectively the clinical characteristics, complications, and prognosis in patients with ocular toxoplasmosis. PATIENTS AND METHODS: We reviewed the records of 189 patients (243 eyes) with ocular toxoplasmosis who were examined between 1972 and 1999. Color fundus photography and, in some patients, fluorescein angiography and indocyanine green angiography were performed. There were 98 male (52%) and 91 female (48%) patients with a mean age of 22.8 +/- 8.9 years. RESULTS: Of the patients, 140 (74%) had congenital and 49 (26%) had acquired toxoplasmosis. At the initial e

Traumatic optic neuropathy in children: a prospective study.

Fifty children with indirect optic nerve injury were prospectively studied over an 8-year period. They constituted 20% of all patients with optic nerve injury managed on a slightly different protocol. Half of these children were injured due to fall from a height, followed by road traffic accidents in 40% of the cases. Forty-three children had unilateral and 7 children had bilateral visual impairment. Five children had definite history of delayed-onset visual involvement, which ranged from 12 to 72 h following injury. Fifty percent of these children had fractured skulls and 14% had optic canal