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Curcumin Formulations for Better Bioavailability: What We Learned from Clinical Trials Thus Far?

Curcumin has been credited with a wide spectrum of pharmacological properties for the prevention and treatment of several chronic diseases such as arthritis, autoimmune diseases, cancer, cardiovascular diseases, diabetes, hemoglobinopathies, hypertension, infectious diseases, inflammation, metabolic syndrome, neurological diseases, obesity, and skin diseases. However, due to its weak solubility and bioavailability, it has limited potential as an oral medication. Numerous factors including low water solubility, poor intestinal permeability, instability at alkaline pH, and fast metabolism contri

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… 130 ) CUC-1 | 300 mg solution of curcumin | ( 129 ) CuraMed | 552–578 mg of BCM-95 extracted in ethanol 99% (v/v) and 100% ethyl acetate +49–52 mg volatile oil from C. longa containing 22–23.4 mg aromatic turmerone + inactive excipients (120–140 mg) including phosphatidyl choline, medium chain TGs, glycerol …

ESICM LIVES 2016: part two : Milan, Italy. 1–5 October 2016

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… Energy dysfunction also correlated with concomitant pathological elevations of glutamate and glycerol, that were more pronounced in hyperemic than normal pCT (LPR 54 ± 12 vs. 42 ± 7 and glycerol 157 ± 76 vs. 95 ± 41 μmol/L, both p < 0.01; glutamate 38 ± 52 vs. 26 ± 24 μmol/L, p = 0.18, t -test for comparisons …

Targeting inflammation as cancer therapy.

Inflammation has accompanied human beings since the emergence of wounds and infections. In the past decades, numerous efforts have been undertaken to explore the potential role of inflammation in cancer, from tumor development, invasion, and metastasis to the resistance of tumors to treatment. Inflammation-targeted agents not only demonstrate the potential to suppress cancer development, but also to improve the efficacy of other therapeutic modalities. In this review, we describe the highly dynamic and complex inflammatory tumor microenvironment, with discussion on key inflammation mediators i

Экстракорпоральное обнаружение биомаркеров и патогенов в слюне: всеобъемлющий, панорамный обзор.

Человеческая слюна представляет собой разнородную жидкость с сложным составом, которая содержит антитела, белки и вирусы, что делает ее применимой в клинической диагностике. Анализ проб слюны имеет несколько преимуществ по сравнению с другими биофильтрами, включая неинвазивную и простую процедуру сбора для эксторального обнаружения. Диагностика биомаркеров или патогенов в слюне может осуществляться различными методами: масс-спектрометрией, ПЦР, ЭЛИСА, электрохимическими и оптическими методами, такими, как флуоресцентная, SPR и SERS. Раннее обнаружение раковых и других биомаркеров заболеваний,

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… Another widely used approach involves modifying electrodes with hydrophilic anti-fouling coatings such as polyethylene glycol, zwitterionic polymers, or other types of synthetic polymers such as poly(hydroxyfunctional acrylates), poly(2-oxazoline)s, poly(vinylpyrrolidone), poly(glycerol) [ 366 , 367 …

Natural anti-cancer products: insights from herbal medicine.

Herbal medicine exhibits a broad spectrum of potent anti-cancer properties, including the enhancement of tumor immune responses, reversal of multidrug resistance, regulation of autophagy and ferroptosis, as well as anti-proliferative, pro-apoptotic, and anti-metastatic effects. This review systematically explores recent advances (primarily documented since 2019) in research on key anti-cancer compounds derived from herbal medicine, such as apigenin, artemisinin, berberine, curcumin, emodin, epigallocatechin gallate (EGCG), ginsenosides, icariin, resveratrol, silibinin, triptolide, and ursolic

Colorectal Cancer at the Crossroads: The Good, the Bad, and the Future of Platinum-Based Drugs.

Colorectal cancer (CRC) remains a significant global health challenge, ranking third in incidence and second in mortality among cancers worldwide. This review addresses the complex landscape of CRC, focusing on incidence, mortality trends, preventive strategies, and the evolving therapeutic approaches, particularly highlighting the role of platinum-based drugs like oxaliplatin (OXP). It also underscores the increasing burden of CRC, with factors such as westernized diets, aging populations, and genetic predispositions contributing to its prevalence. Therapeutically, early detection greatly enh

Mucosal-Associated Invariant T Cells in Health and Disease.

Mucosal-associated invariant T (MAIT) cells are a population of evolutionarily conserved, unconventional innate-like T lymphocytes that are restricted by major histocompatibility complex Class I-related (MR1) molecules. They can be activated either in a T-cell receptor-MR1- or cytokine-dependent manner. Activated MAIT cells play crucial roles in maintaining homeostasis and the fine regulation of the immune system. This review presents a systematic exploration of the development, biological characteristics, and multiple effects of MAIT cells in health and various diseases. In healthy individual

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… During Mtb infection, MA can be esterified to glycerol (Gro‐MM), glucose (GMM), or trehalose (TMM) and presented by CD1b to activate GEM T cells. The conserved TCR within GEM‐T cells can respond to Mtb infection via clonal expansion and the secretion of antimycobacterial cytokines [ 177 ]. …

NF-κB in biology and targeted therapy: new insights and translational implications.

NF-κB signaling has been discovered for nearly 40 years. Initially, NF-κB signaling was identified as a pivotal pathway in mediating inflammatory responses. However, with extensive and in-depth investigations, researchers have discovered that its role can be expanded to a variety of signaling mechanisms, biological processes, human diseases, and treatment options. In this review, we first scrutinize the research process of NF-κB signaling, and summarize the composition, activation, and regulatory mechanism of NF-κB signaling. We investigate the interaction of NF-κB signaling with other importa

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… 73 ZAP-70 phosphorylates the activating linker for the activation of T cells (LAT), which promotes the recruitment of multiple junction proteins and effector molecules including phospholipase C γ1 (PLCγ1) and the formation of the LAT signalosome complex. 74 PLCγ1 catalyzes the synthesis of diester glycerol …

Biomarkers in Stress Related Diseases/Disorders: Diagnostic, Prognostic, and Therapeutic Values.

Various internal and external factors negatively affect the homeostatic equilibrium of organisms at the molecular to the whole-body level, inducing the so-called state of stress. Stress affects an organism's welfare status and induces energy-consuming mechanisms to combat the subsequent ill effects; thus, the individual may be immunocompromised, making them vulnerable to pathogens. The information presented here has been extensively reviewed, compiled, and analyzed from authenticated published resources available on Medline, PubMed, PubMed Central, Science Direct, and other scientific database

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… Similarly, biomarkers for health and function of liver (ketone bodies, central metabolism, ALAT, ASAT, ALP, GGT, CRP, TG, liver IR index, liver IS index), pancreas (disposition index, C-peptide, insulin, glucagon, HOMA-B), kidney (creatinine, Asp, Glu, Orn, urea, albumin), adipose tissue (glycerol, NEFA …

Metabolic reprogramming and therapeutic resistance in primary and metastatic breast cancer.

Metabolic alterations, a hallmark of cancer, enable tumor cells to adapt to their environment by modulating glucose, lipid, and amino acid metabolism, which fuels rapid growth and contributes to treatment resistance. In primary breast cancer, metabolic shifts such as the Warburg effect and enhanced lipid synthesis are closely linked to chemotherapy failure. Similarly, metastatic lesions often display distinct metabolic profiles that not only sustain tumor growth but also confer resistance to targeted therapies and immunotherapies. The review emphasizes two major aspects: the mechanisms driving

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… Moreover, Tm can utilize glucose to synthesize glycogen and convert fatty acids and glycerol into triglycerides for energy storage, enabling them to generate a rapid protective immune response when encountering pathogens again [ 144 ].Current research mainly focuses on CTLs and helper T cells, and the …

Всемирный конгресс молекулярного воображения 2022.

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Plant-Derived Natural Products in Cancer Research: Extraction, Mechanism of Action, and Drug Formulation.

Cancer is one of the main causes of death globally and considered as a major challenge for the public health system. The high toxicity and the lack of selectivity of conventional anticancer therapies make the search for alternative treatments a priority. In this review, we describe the main plant-derived natural products used as anticancer agents. Natural sources, extraction methods, anticancer mechanisms, clinical studies, and pharmaceutical formulation are discussed in this review. Studies covered by this review should provide a solid foundation for researchers and physicians to enhance basi

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… Other nanoparticle formulations of curcumin include glycerol monooleate and pluronic F127 curcumin loaded nanoparticles [ 419 ], and curcumin-loaded zinc oxide (ZnO) nanoparticles [ 420 ]. 3.1.2. …

The leptomeninges as a critical organ for normal CNS development and function: First patient and public involved systematic review of arachnoiditis (chronic meningitis).

BACKGROUND & IMPORTANCE: This patient and public-involved systematic review originally focused on arachnoiditis, a supposedly rare "iatrogenic chronic meningitis" causing permanent neurologic damage and intractable pain. We sought to prove disease existence, causation, symptoms, and inform future directions. After 63 terms for the same pathology were found, the study was renamed Diseases of the Leptomeninges (DLMs). We present results that nullify traditional clinical thinking about DLMs, answer study questions, and create a unified path forward. METHODS: The prospective PRISMA protocol is pu

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9th Trends in Medical Mycology Held on 11-14 October 2019, Nice, France, Organized under the Auspices of EORTC-IDG and ECMM.

Dear Friends and Colleagues,It is a great honor and pleasure for us to invite you cordially to participate in the 9th Congress on Trends in Medical Mycology (TIMM-9) [...].

Abstracts of the 19th International Congress on Neuromuscular Diseases 7th – 11th July 2026

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Landscape of small nucleic acid therapeutics: moving from the bench to the clinic as next-generation medicines.

The ability of small nucleic acids to modulate gene expression via a range of processes has been widely explored. Compared with conventional treatments, small nucleic acid therapeutics have the potential to achieve long-lasting or even curative effects via gene editing. As a result of recent technological advances, efficient small nucleic acid delivery for therapeutic and biomedical applications has been achieved, accelerating their clinical translation. Here, we review the increasing number of small nucleic acid therapeutic classes and the most common chemical modifications and delivery platf

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… SLNs are spherical nanoparticles composed of biodegradable physiological lipids and surfactants with a drug-containing solid lipid core, and thus they are less toxic than other nanodelivery systems. 244 The melting points of the employed lipids, such as monostearin, stearyl alcohol, stearic acid, glycerol …

Navigating the landscape of protein folding and proteostasis: from molecular chaperones to therapeutic innovations.

Protein folding is a fundamental process ensuring that polypeptide chains acquire the correct three-dimensional structures required for biological function. This complex journey from nascent polypeptides to mature proteins is tightly regulated by the cellular proteostasis network-an integrated system of molecular chaperones, folding enzymes, and degradation machineries. Disruptions in this network lead to dysproteostasis, a pathological state implicated in a growing list of human diseases, including neurodegenerative disorders, metabolic syndromes, and cancer. In this review, we provide a comp

ESCP 36th European Symposium on Clinical Pharmacy ‘Implementing Clinical Pharmacy in Community and Hospital Settings: Sharing the Experience’, Istanbul, Turkey 25–27 October 2007; Abstracts

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… Arnaud 1 1 Clinical Pharmacy, 2 Geriatry, Bichat Claude Bernard Hospital, Paris, France Background and Objective : To evaluate a new medical device Aequasyal ® , a mixture of oxidized glycerol triesters (TGO) in oral dryness of old patients in palliative care. …

Tumor biomarkers for diagnosis, prognosis and targeted therapy.

Tumor biomarkers, the substances which are produced by tumors or the body's responses to tumors during tumorigenesis and progression, have been demonstrated to possess critical and encouraging value in screening and early diagnosis, prognosis prediction, recurrence detection, and therapeutic efficacy monitoring of cancers. Over the past decades, continuous progress has been made in exploring and discovering novel, sensitive, specific, and accurate tumor biomarkers, which has significantly promoted personalized medicine and improved the outcomes of cancer patients, especially advances in molecu