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Anti-nuclear antibodies in patients with suspicion of neuromyelitis optica spectrum disorder: Frequency and significance.

BACKGROUD & OBJECTIVES: Neuromyelitis Optica spectrum disorder (NMOSD) is an autoimmune inflammatory disease involving optic nerves and spinal cord. The association of NMOSD with anti-nuclear antibodies and autoimmune disorders has been reported. This study was conducted to determine frequency of anti-nuclear antibodies (ANA) in patients with NMOSD and to observe for the development of symptoms related to autoimmune disorders on follow up. METHODOLOGY: After approval from Institutional Review Board, this cross-sectional study was conducted at Immunology Department, Shifa International Hospita

Partial Versus Complete Cholecystectomy: A Propensity Score-Matched Analysis of Complications.

INTRODUCTION: Partial cholecystectomy is increasingly performed for complex gallbladder disease, yet comparative outcomes data remain limite … ensity matching. These findings provide evidence-based information for surgical decision-making and informed consent discussions.

Access to early-phase oncology trials: Trajectories and outcomes of more than 26,000 patients referred to a high-volume phase I unit.

BACKGROUND: Early-phase oncology trials (EPT) are a mandatory step in anticancer drug development, providing early access to innovative ther … Among 26,394 patients referred for EPT, 13,713 (52%) were evaluated in consultation and 5847 signed informed consent for an EPT (22%). Overall, 4769 unique patients received at least one dose of experimental treatment (18%), corresponding to 5438 inclusions. Patients were recruited across France, but distance from the unit did not influence TTF. The therapeutic la …

Probiotic and Prebiotic Supplementation for Gastrointestinal Discomfort in Chronic Spinal Cord Injury (PRO-GIDSCI): A Randomized Controlled Crossover Trial Protocol.

BACKGROUND: Gastrointestinal discomfort affects up to 70% of individuals with spinal cord injury (SCI), largely due to gut dysbiosis caused … Version 2.0). The study is registered at ClinicalTrials.gov (ID: NCT06870331, 02.04.2025). Written informed consent will be obtained from all participants involved in the study.

Impact of Continuing Medical Education on Family Physicians' Knowledge and Clinical Decision-Making Regarding Intermittent Fasting in Type 2 Diabetes.

AIMS/BACKGROUND: Intermittent fasting (IF) is increasingly adopted by patients with type 2 diabetes mellitus (T2DM), often without adequate … ore and after each session. A total of 180 participants who completed both assessments and provided informed consent were included in the final analysis. RESULTS: The educational intervention produced a statistically significant increase in total knowledge scores (median [interquartile range, IQR]: 12.0 [10.0-15.25] vs. 18.0 [15.25-19.0], Z = -9.17, p < 0.001, r …

Identification of biomarkers associated with enhanced survival in lung cancer patients undergoing immune checkpoint inhibitor treatment.

INTRODUCTION: Immunotherapy has revolutionized lung cancer treatment but has a relatively low response rate. Identification of predictive bi … dvanced stage (III and IV) lung cancer, treated with ICIs and who signed the OncoLifeS data-biobank informed consent were included. We conducted univariate and multivariable Cox-regression analyses to identify blood-based biomarkers associated with PFS and OS (adjusted for PD-L1 expression, ECOG performance status, cancer stage, treatment line, type of treatment, …

Urethral Closure Mechanism Caused by Prostate Rotation During Abdominal Pressure in Men: A Dynamic Magnetic Resonance Imaging Study.

OBJECTIVES: To elucidate the urethral closure mechanism during abdominal pressure in men, we investigated changes in pelvic anatomy during a … . CLINICAL TRIAL REGISTRATION: Not applicable. This study was conducted prospectively with written informed consent and institutional ethical approval; however, it was not designed as a clinical trial because it was a non-interventional observational study in which a specialized MRI protocol was added to standard clinical imaging without any therapeutic intervent …

Integrating Nutrition and Physical Activity into the EXEMIG/01 Interdisciplinary Model for Chronic and High-Frequency Migraine.

Background: Migraine (MIG) management guidelines support a comprehensive approach combining medication, therapeutic patient education (TPE), … ty, and independent walking ability. Exclusion criteria include contraindications to PA and lack of informed consent. Participants will be randomized to standard care (SC) or an intervention group receiving TPE plus three months of supervised exercise (EXE). All participants will receive an informational brochure with nutritional tips (included in SC) and undergo: …

Preoperative stress markers as predictors of postoperative neuropsychological disorders in cardiac surgery patients: protocol for a single-centre prospective observational study (CAVALIR).

INTRODUCTION: Postoperative neuropsychological disorders including delirium, cognitive dysfunction and emotional distress are common after c … sity Giessen (Ref.: 54/24) and is conducted in accordance with the Declaration of Helsinki. Written informed consent will be obtained from the patients. Results will be disseminated through peer-reviewed publications and scientific conferences. TRIAL REGISTRATION NUMBER: Prospectively registered with the German Clinical Trials Register (DRKS00035318).

Delayed diagnosis of ectopic ACTH-secreting tumors following transsphenoidal surgery for presumed MRI-negative Cushing's disease: implications for long-term surveillance.

PURPOSE: To determine the long-term diagnostic outcomes of rigorously defined magnetic resonance imaging (MRI)-negative ACTH-dependent Cushi … ic lesion was identified by radiological or functional imaging in any case. TSS was performed after informed consent, but no tumor was identified intraoperatively or on pathological examination. During follow-up, ectopic tumors were detected approximately 2 years after surgery in three patients (pulmonary, adrenal, and pancreatic neuroendocrine tumors), whereas a …

Functional Aerobic Capacity and Quality of Life in Patients with Heart Failure by Body Mass Index Category and Different Body Mass Index.

OBJECTIVE: Improved survival has been described in obese patients with heart failure (HF). However, whether this survival advantage is accom … acity was also assessed. The ethics committee approved the study, and all patients provided written informed consent. RESULTS: A total of 170 patients with HF were admitted; most were men. Arterial hypertension was more frequent in the obese group 33(84.6%) P = .032. Obese patients had higher waist circumference (103.9 ± 10.66 cm) and body fat (34.44 ± 7.33%; P < …

More than a moment: Evolving decisions among eligible volunteers in phase 1 COVID-19 vaccine trials.

Phase 1 vaccine trials rely on healthy participants who accept uncertainty with limited or no personal health benefit. Why people join and w … andemic circumstances. Future trials should anticipate changing contexts, communicate clearly about informed consent and data integrity when standard-of-care vaccines emerge, and incorporate flexible trial adaptations.

Токсичность CAR-T, биконкретных антител и антителных соединений в Множественной миеломе: практический подход к уменьшению рисков и управлению ими.

Антигены созревания B-клеток (BCMA), группа рецепторов с белковым сцеплением C 5 Член группы D (GPRC5D) под руководством иммунотерапии, продуктов химерика антигенного рецептора Т-клестера (CAR-T), лиц, занимающихся деятельностью в двух конкретных Т-клетках (BsAbs), и лиц, занимающихся антителными препаратами (ADC), изменил управление MM. В настоящее время их внедрение выходит за рамки высших центров после внесения изменений в УЛХ для обеспечения безопасности CAR-T и быстрого внедрения недр, пригодных для общинной доставки. Поэтому врачи, находящиеся вне специализированных центров, должны быть

Совпадение в аннотации оригинала
B-cell maturation antigen (BCMA), G protein-coupled receptor class C group 5 member D (GPRC5D)-directed immunotherapies, chimeric antigen re … be conversant with the full toxicity spectrum, including rare but high-consequence events, both for informed consent and for the work-up of post-therapy complications. In this narrative review, we report on the published literature around toxicities of approved and investigational BCMA- and GPRC5D-directed therapies, drawing on pivotal trial data, real-world cohor …

Bilateral Cochlear Implantation in a Child With Galloway-Mowat Syndrome: A Case Report.

BACKGROUND This report describes the surgical management and early auditory outcomes of bilateral cochlear implantation in a child with Galloway-Mowat syndrome (GAMOS). To the best of our knowledge, this is the first reported case of such surgery. GAMOS is an exceedingly rare genetic disorder characterized by microcephaly, early onset of steroid-resistant nephrotic syndrome, and brain anomalies. It is inherited in an autosomal recessive pattern and has a genetically heterogeneous basis. CASE REPORT We report the case of a young boy diagnosed with GAMOS who had profound bilateral deafness, cere

Superimposed intraoperative neuromonitoring for epidermoid cyst: Two-dimensional operative video.

BACKGROUND: Intraoperative neuromonitoring (IONM) is critical for preserving cranial nerve function during cerebellopontine angle (CPA) tumo … ranial nerve preservation. Ethics committee approval was obtained, and the patient provided written informed consent for participation, surgical video, and publication.

Gene variants associated with pediatric-onset erythromelalgia: Mendelian and rare-variant association analyses.

INTRODUCTION: Erythromelalgia is a descriptive term for burning pain and erythema in distal extremities, often worsened by heat and improved by cold. Inherited erythromelalgia has been primarily linked to gain-of-function variants in SCN9A, encoding voltage-gated sodium channel NaV1.7. However, approximately 65% to 85% of patients with erythromelalgia do not have pathogenic SCN9A variants. OBJECTIVES: The objective of this study was to uncover and assess gene variants potentially associated with pediatric-onset erythromelalgia. METHODS: With IRB approval and informed consent, probands and fa…

Priorities for public health preparedness for psychedelics: education, workforce readiness, and strategic information needs in a rapidly changing landscape.

Use of psychedelic substances is increasing across unregulated, state-regulated, research, ceremonial/religious, and medical settings in the … ing. Workforce considerations include defining core competencies, clarifying ethical boundaries and informed consent, establishing training and technical assistance infrastructure, strengthening capacity across the behavioral health workforce, and preparing providers to respond to patients using psychedelics outside regulated systems. Strategic information priorit …

Efficacy of iodine-131-metaiodobenzylguanidine therapy for multiple endocrine neoplasia type 2A-associated metastatic pheochromocytoma: case report and literature review.

Malignant transformation in multiple endocrine neoplasia type 2 (MEN2)-associated pheochromocytoma is rare, and there have been few reports … owth. The malignant potential of MEN2A-associated pheochromocytoma emphasizes the need for accurate informed consent, especially when performing partial adrenalectomy. While 131I-MIBG therapy appears promising, its efficacy requires further assessment due to the limited number of reported cases of MEN2A-associated metastatic pheochromocytoma.

Diagnostic yield and safety of probe-based confocal laser endomicroscopy-guided pleural biopsy via semirigid thoracoscope in diagnosing patients with unknown pleural effusion: a protocol for a multicentre, randomised controlled trial (COLLABORATION-I).

INTRODUCTION: Semirigid thoracoscopy plays an important role in the diagnosis of pleural diseases. However, its diagnostic performance remai … roval was obtained from the China-Japan Friendship Hospital Ethics Committee (2025-KY-018). Written informed consent will be obtained from all the participants. The findings will be disseminated through journal publications and conference presentations. TRIAL REGISTRATION NUMBER: NCT06741839.

Design and Baseline Data of the Guangzhou Child and Adolescent High Myopia Study.

PURPOSE: To establish a longitudinal, school-based cohort to investigate physiological and pathological ocular changes and identify associat … oved by the Ethics Committee of Zhongshan Ophthalmic Centre (approval number: 2017KYPJ100). Written informed consent is obtained from all participants and their guardians. Generalized estimating equations and mixed-effect models assess ocular changes and associations with environmental and biometric factors. RESULTS: 1,331 participants were enrolled at baseline ( …