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Microwave ablation combined with cementoplasty under real-time temperature monitoring in the treatment of 82 patients with recurrent spinal metastases after radiotherapy.

BackgroundThe spine is the most frequently affected part of the skeletal system to metastatic tumors. External radiotherapy is considered the first-line standard of care for these patients with spine metastases. Recurrent spinal metastases after radiotherapy cannot be treated with further radiotherapy within a short period of time, making treatment difficult. We aimed to evaluate the effectiveness and safety of MWA combined with cementoplasty in the treatment of spinal metastases after radiotherapy under real-time temperature monitoring.MethodsIn this retrospective study, 82 patients with 115

Changes in bone turnover markers in patients without bone metastases receiving immune checkpoint inhibitors: An exploratory analysis.

Immune checkpoint inhibitors (ICIs) has revolutionized the treatment of different advanced solid tumors, but most patients develop severe immune-related adverse events (irAEs). Although a bi-directional crosstalk between bone and immune systems is widely described, the effect of ICIs on the skeleton is poorly investigated. Here, we analyze the changes in plasma levels of type I collagen C-terminal telopeptide (CTX-I) and N-terminal propeptide of type I procollagen (PINP), reference makers of bone turnover, in patients treated with ICIs and their association with clinical outcome. A series of 4

Initiation of maintenance hemodialysis through central venous catheters: study of patients' perceptions based on a structured questionnaire.

BackgroundDespite well-publicized suggestions to utilize arteriovenous fistulae and grafts to initiate hemodialysis, too many patients in the United States start dialysis via central venous catheters despite their well-known association with increased morbidity, mortality, and cost.MethodsTo determine the reasons for this high rate of catheter use, and, ultimately, ways to reduce it, we developed a questionnaire designed to determine where in the process of patient care the process to fistula or graft placement was not completed, thus requiring the use of central venous catheters. The question

Доклад о деле: реактивные Т-клетки большие гранулальные лимфоциты в костном мозге пациента с повторной/охлажденной множественной миеломой, получающего теклистамб.

Лечение Т-клеток для лечения повторной/реактивной (R/R) множественной миеломы (MM) может привести к нейтропенсии с сопутствующими инфекциями или без них, что может ограничить лечение и эффективность. Мы представляем случай пациента с пента-классом R/R MM, который, принимая теклистамб, развивал стойкую или умеренную нейтрализацию с сопутствующими инфекциями. Обзор ее костного мозга подтвердил уничтожение злокачественных плазменных клеток, но цитометрия потока выявила увеличение содержания крупных гранулированных лимфоцитов (T-LGL). После дальнейшего анализа было установлено, что Т-ЛГЛ являются

Вторичные деформации врождённых расщелин нёба у детей: комплексная диагностика и выбор методов лечения

В этой статье будет рассмотрена оценка и лечение детей с вторичными деформациями врождённых расщелин нёба по мере её распространения в полости рта и носа. Вторичными деформациями рассмотрена не только ороназальные фистулы, но и недостаточное прикрепление, расщепление мышц мягкого нёба, либо с покрытием слизистой оболочкой (нормальная анатомия ротового и носового слизистого), либо без покрытия (расщелины) на различных участках первичного и вторичного нёба. Фистулы мягкого нёба, не влияющие на функциональную недостаточность, не требуют коррекции. Вторичные деформации, на которых образуются трещи

Неучтенная роль экгасомов в когнитивно-моторной нейрореабилитации: систематический обзор.

Эксгармии — это новые инструменты когнитивно-моторной нейрореабилитации, но их воздействие на взрослых с неврологическими условиями еще недостаточно изучено. В рамках этого систематического обзора были изучены исследования, полученные из PubMed, Scopus, Embase и Web of Science, с оценкой воздействия экзотомов на двигательные и когнитивные результаты. К числу приемлемых исследований относятся случайные контролируемые испытания (РСТ), не связанные с РСТС и экспериментальные проекты. Протокол был зарегистрирован на сайте ПРОСПЕРО (CRD420250655053) и составлен в соответствии с руководящими принцип

Using Genomic Data in Personalized Oncology Medicine: An Exploratory Expert-Elicitation Study with Narrative Regulatory Mapping of Regulations, Implementations, and Challenges in Saudi Arabia.

BACKGROUND/OBJECTIVES: Personalized medicine represents a transformative approach to healthcare in Saudi Arabia. However, a significant research gap exists regarding the specific regulatory, implementation, and practical challenges of integrating genomic data into personalized oncology care in the Saudi context. We aimed to conduct an exploratory assessment of the current regulatory landscape, practices, and challenges related to genomic data use in personalized oncology in Saudi Arabia and to identify regulatory and practical gaps, propose actionable solutions, and outline future directions f

Широкие повреждения обода являются новым патологическим и визуализированным биомаркером для быстрого развития заболеваний в множестве склерозов.

Текущее несколько методов лечения склероза (MS) сокращают активность рецидивов, но оказывают ограниченное воздействие на прогрессию заболеваний. Клинические испытания, ориентированные на прогресс, часто не дают результатов из-за недостаточного понимания его основополагающих механизмов. В этом исследовании анализировалась клинически хорошо известная когорта вскрытия MS из банка мозга Негерланда (186 человек), из которого мы отобрали доноров, проявляющих противоположные траектории заболеваний медленных и быстрых темпов развития. Мы провели обширную непредвзятую гистологию и пространственную тран

Effective Targeting of Melanoma Cells by Combination of Mcl-1 and Bcl-2/Bcl-xL/Bcl-w Inhibitors.

Recent advances in melanoma therapy have significantly improved the prognosis of metastasized melanoma. However, large therapeutic gaps remain that need to be closed by new strategies. Antiapoptotic Bcl-2 proteins critically contribute to apoptosis deficiency and therapy resistance. They can be targeted by BH3 mimetics, small molecule antagonists that mimic the Bcl-2 homology domain 3 (BH3) of proapoptotic BH3-only proteins. By applying in vitro experiments, we aimed to obtain an overview of the possible suitability of BH3 mimetics for future melanoma therapy. Thus, we investigated the effects

New players in the landscape of renal cell carcinoma bone metastasis and therapeutic opportunities.

Approximately one-third of advanced renal cell carcinoma (RCC) patients develop osteolytic bone metastases, leading to skeletal complications. In this review, we first provide a comprehensive perspective of seminal studies on bone metastasis of RCC describing the main molecular modulators and growth factor signaling pathways most important for the RCC-stimulated osteoclast-mediated bone destruction. We next focus on newer developments revealing with in-depth details, the bidirectional interplay between renal cancer cells and the immune and stromal microenvironment that can through epigenetic r

The Missing Link: Integrating Interventional Pain Management in the Era of Multimodal Oncology.

Cancer-related pain (CrP) is one of the most frequent and debilitating issues that affect the quality of life of patients with cancer. Systemic analgesics, particularly opioids, have been the cornerstone of pain management. However, the following shortcomings of the mentioned therapies, such as side effects, tolerance, and inadequate relief in refractory cases, make implementing a more complete, multimodal treatment plan necessary. Interventional pain management (IPM) uses specific invasive procedures, with different degree of invasiveness, such as nerve blocks, neurolysis, neuromodulation, an

Palliative care of proximal femur metastatic disease and osteolytic lesions: results following surgical and radiation treatment.

BACKGROUND: Femoral bone metastases (FBM) or lesions (FBL) can lead to loss of mobility and independence due to skeletal-related events (SRE), e.g. pain, deformity and pathological fractures. Aim of this study was to analyze effects of radiotherapy and surgery, different surgical techniques and complications on disease-specific survival (DSS). METHODS: Patients who underwent palliative therapy for FBM or FBL between 2014 and 2020 were retrospectively analyzed. Chi-square test was used to detect intergroup differences. Survival was calculated using Kaplan-Meier method, Cox regression and compa

A geriatrician's approach to managing the complex older adult with obesity.

The prevalence of obesity in older adults is rapidly increasing due to the demographic shift occurring globally. Older adults with obesity face health care challenges due to multimorbidity, functional dependency, and disability. This population often has prior history of struggles through weight-loss attempts during the middle years of life. Therefore, weight-loss intervention needs a personalized approach, taking into consideration weight-loss attempts, relapse, and life events, including bariatric surgery, functional limitations, psychosocial status, and current residential environment. Raci

Impact of the COVID-19 pandemic on the diagnosis and treatment of onco-hematologic patients: a discussion paper.

We do not know the precise figure for solid organ tumors diagnosed each year in Spain and it is therefore difficult to calculate whether there has been a decrease in cancer diagnoses as a consequence of the pandemic. Some indirect data suggest that the pandemic has worsened the stage at which some non-hematological neoplasms are diagnosed. Despite the lack of robust evidence, oncology patients seem more likely to have a poor outcome when they contract COVID-19. The antibody response to infection in cancer patients will be fundamentally conditioned by the type of neoplasia present, the treatmen

A Novel Paradigm for Targeting Challenging Targets: Advancing Technologies and Future Directions of Molecular Glue Degraders.

Molecular glue degraders (MGDs) constitute a class of innovative therapeutic agents within the field of targeted protein degradation (TPD). In contrast to proteolysis-targeting chimeras (PROTACs), MGDs induce protein degradation by stabilizing the interaction between an E3 ubiquitin ligase and a target protein. They typically exhibit favorable drug-like characteristics, including lower molecular weight and enhanced bioavailability. Although their discovery was historically serendipitous, recent advances in high-throughput screening, bioinformatics, and artificial intelligence are enabling more

Совпадение в полном тексте источника
… On 10 October 2025, the team led by Lai and Pei from the Center for Quantitative Biology at the Academy for Advanced Interdisciplinary Studies, Peking University, systematically compiled and organized MG-PDB, the most comprehensive dataset of molecular glue ternary complex structures to date. …

Integrating Academic and Community Cancer Care and Research through Multidisciplinary Oncology Pathways for Value-Based Care: A Review and the City of Hope Experience.

As the US transitions from volume- to value-based cancer care, many cancer centers and community groups have joined to share resources to deliver measurable, high-quality cancer care and clinical research with the associated high patient satisfaction, provider satisfaction, and practice health at optimal costs that are the hallmarks of value-based care. Multidisciplinary oncology care pathways are essential components of value-based care and their payment metrics. Oncology pathways are evidence-based, standardized but personalizable care plans to guide cancer care. Pathways have been developed

Библиометрический анализ исследований по проблемам инвалидности в Саудовской Аравии: меняющиеся тенденции, тематическое картирование и пробелы.

ЦЕЛИ: Определение ключевых тенденций и влиятельных авторов и учреждений, составление тематических карт и определение последних изменений и пробелов в исследованиях по проблемам инвалидности в Саудовской Аравии. МЕТОДЫ: Исследование было начато в июне 2024 года, и данные были проанализированы в июле 2024 года в Аль-Ахсе, Саудовская Аравия. В ходе анализа использовались библиометрические методы, такие, как библиометрическое сцепление и тематическое картирование с использованием VOSviewer и RStudio с пакетом Bibliometrix. Результаты: Библиометрический анализ выявил в общей сложности 3080 публикац

Cross-cultural translation and adaptation of Functional Assessment of Cancer Therapy - Multiple Myeloma tool - MM1 and LEU3 - for Portuguese.

OBJECTIVE: To describe of the translation from English to Portuguese and adaption process of subitems of the Functional Assessment of Cancer Therapy - Multiple Myeloma. METHODS: In the first phase, translations from English into Portuguese of two subitems of Functional Assessment of Cancer Therapy - Multiple Myeloma were performed. Subsequently, a consensus and back translation were conducted, and, finally, translation and back translations were reviewed by four independent bilingual experts. In the second phase, the translated subitems were applied, along with a questionnaire, to 10 native P

The role of postoperative radiation and coordination of care in patients with metastatic bone disease of the appendicular skeleton.

Metastatic bone disease affects approximately 300,000 people in the United States, and the burden is rising. These patients experience significant morbidity and decreased survival. The management of these patients requires coordinated care among a multidisciplinary team of physicians, including orthopaedic surgeons. This article reviews the role of radiation therapy after orthopaedic stabilization of impending or realized pathologic extremity fractures. Orthopaedic surgeons have an opportunity to benefit patients with metastatic bone disease by referring them for consideration of post-operativ

Доклад по делу: Цитовосстановительная хирургия как терапевтическая попытка лечения внематочной плазматомы.

ВВЕДЕНИЕ: Множественная миелома представляет собой гематологическую порчу, основанную на патологическом моноклональном распространении плазменных клеток, которое обычно происходит в костном мозге. Известные аспекты его симптоматологии включают анемию, почечную недостаточность, гиперкалкемию, остеолитические повреждения костей и потенциальные последствия амилоидоза. Диагностика носит мультимодальный характер и опирается на лабораторные и визуальные методы традиционной радиологии и ядерной медицины. Тогда лечение является достоянием гематолога-онколога. One форма этого заболевания представляет с