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Питание N-6 Полиненасыщенное содержание жира в кислоте и здоровье мозга у взрослых людей среднего и старшего возраста.

ПАФА играет важную роль в возникновении и развитии нейродегенеративных заболеваний. С тех пор, как нейрозащитные эффекты n-3 ПУФА получил широкую поддержку, роль n-6 ПУФА по-прежнему обсуждается, а их основополагающие механизмы до сих пор не в полной мере понятны. В этом исследовании 169,295 Участники из Биобанка Соединенного Королевства были включены для анализа связей между питанием n-6 Поступление ПУФА и нейродегенеративные заболевания с использованием моделей коксовой регрессии с полной корректировкой для потенциальных сомнителей. Кроме того, для оценки воздействия различных моделей линейн

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… From 2009 to 2021, participants were asked to complete the questionnaire up to five times, detailing their consumption of 206 food items and 32 beverages within the past 24 h. …

Amelioration of the cyclophosphamide induced genotoxic damage in mice by the ethanolic extract of Equisetum arvense.

In the present study, we evaluated the potential of the plant E. arvense against the cytotoxic and mutagenic effects induced by cyclophosphamide (chemotherapeutic agent) in the bone marrow cells of mice using the Chromosome assay (CA) and Mitotic index (MI) in vivo as the biomarkers. The study was performed following 3 protocols: pre-treatment, simultaneous treatment and post-treatment with the ethanolic extract of the plant. The results demonstrated that the plant extract was not cytotoxic and mutagenic and has a protective effect against the mutagenicity induced by cyclophosphamide in pre, s

Turmeric and Its Major Compound Curcumin on Health: Bioactive Effects and Safety Profiles for Food, Pharmaceutical, Biotechnological and Medicinal Applications.

Curcumin, a yellow polyphenolic pigment from the Curcuma longa L. (turmeric) rhizome, has been used for centuries for culinary and food coloring purposes, and as an ingredient for various medicinal preparations, widely used in Ayurveda and Chinese medicine. In recent decades, their biological activities have been extensively studied. Thus, this review aims to offer an in-depth discussion of curcumin applications for food and biotechnological industries, and on health promotion and disease prevention, with particular emphasis on its antioxidant, anti-inflammatory, neuroprotective, anticancer, h

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… It is mainly used in dairy products, beverages, cereals, mustard, food concentrates, pickles, sausages, confectionery, ice cream, and meat, fish, eggs, and bakery products ( Lakshmi, 2014 ; Solymosi et al., 2015 ). …

Tumor angiogenesis as a target for dietary cancer prevention.

Between 2000 and 2050, the number of new cancer patients diagnosed annually is expected to double, with an accompanying increase in treatment costs of more than $80 billion over just the next decade. Efficacious strategies for cancer prevention will therefore be vital for improving patients' quality of life and reducing healthcare costs. Judah Folkman first proposed antiangiogenesis as a strategy for preventing dormant microtumors from progressing to invasive cancer. Although antiangiogenic drugs are now available for many advanced malignancies (colorectal, lung, breast, kidney, liver, brain,

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… They are also responsible for the astringent taste of certain foods and beverages [ 233 ]. Among their natural roles is protection against predation [ 234 ]. Anthocyanins and proanthocyanidins share steps in the flavonoid biosynthetic pathway. …

Более широкие соображения в отношении интеграции медицинских и стоматологических данных

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… an infectious disease that can be spread to a child by sharing spoons, for example, May not know the potential value of chewing gum with Xylitol, May not fully grasp the importance of good oral health hygiene habits, May not grasp the consequences of a child consuming quantities of sugared foods or beverages … , May have difficulty controlling the child’s consumption of sugared foods or beverages in or out of the home, May not realize the consequences of chronic use of sugared medications, May not know the potential for systemic spread of disease from a toothache, or for liver damage due to overuse of acetaminophen …

Targeting Autophagy with Natural Products as a Potential Therapeutic Approach for Cancer.

Macro-autophagy (autophagy) is a highly conserved eukaryotic intracellular process of self-digestion caused by lysosomes on demand, which is upregulated as a survival strategy upon exposure to various stressors, such as metabolic insults, cytotoxic drugs, and alcohol abuse. Paradoxically, autophagy dysfunction also contributes to cancer and aging. It is well known that regulating autophagy by targeting specific regulatory molecules in its machinery can modulate multiple disease processes. Therefore, autophagy represents a significant pharmacological target for drug development and therapeutic

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… Coffee and Tea: (−)-epigallocatechin-3-gallate (EGCG), Catechin and Epicatechin Coffee and tea are the most consumed beverages worldwide, and have an impressive impact on the economies of the countries that produce them. … Tea made from the leaves of the plant Camellia sinensis is a popular beverage [ 220 ]. …

Euthanasia and physician-assisted suicide not meeting due care criteria in the Netherlands: a qualitative review of review committee judgements.

UNLABELLED: ObjectivesTo assess how Dutch regional euthanasia review committees (RTE) apply the euthanasia and physician-assisted suicide (EAS) due care criteria in cases where the criteria are judged not to have been met ('due care not met' (DCNM)) and to evaluate how the criteria function to set limits in Dutch EAS practice. DESIGN: A qualitative review using directed content analysis of DCNM cases in the Netherlands from 2012 to 2016 published on the RTE website (https://www.euthanasiecommissie.nl/) as of 31 January 2017. RESULTS: Of 33 DCNM cases identified (occurring 2012-2016), 32 case

Регулирование пациентов с реанимированными/реферантными миеломами, лечившимися с Талкетамабом: основные моменты из точки зрения фармацевтов.

Talquetamab — семейство рецепторов с белковым белком в классе G. 5 член D (GPRC5D) и CD3-targeting bi специфическая антитела с > 71% :: общее реагирование пациентов с рецидивной или рефрактной множественной миеломой, three другие виды наркотиков. GPRC5D сильно отражается на клетках миэломы, а также некоторое выражение в обычных волосатых фолликах, коже и языке. Его уникальное выражение на этих нормальных тканях приводит к явной структуре неблагоприятных явлений (АЭ), как это было отмечено на этапе I/II. MonumenTAL-1 суд. GPRC5D-related АО включали оральные побочные эффекты (например, дисгейсия

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… Eating or drinking should be avoided immediately after use of rinses and patients with dry mouth should avoid hot beverages. Sour citrus fruits or candies can be taken before a meal to potentially stimulate the taste buds. …

A qualitative study on patients' and their support persons' preferences for receiving one longer consultation or two shorter consultations when being informed about allogeneic hematopoietic stem cell transplantation.

BackgroundAllogeneic hematopoietic stem cell transplantation (alloHSCT) is the only potentially curative treatment option for many patients with hematological disorders but it includes a significant risk of mortality and long-term morbidity. Many patients and their support persons feel overwhelmed when being informed about alloHSCT and may benefit from improvements in consultation style and timing.AimsTo explore, qualitatively, in a sample of hematological cancer patients and their support persons, their preferences for receiving one longer consultation or two shorter consultations when being

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… They highlighted that the room where patients and support persons spend their break in-between two consultations should convey a neutral atmosphere and allow for the consumption of beverages. …

Extraskeletal benefits and risks of calcium, vitamin D and anti-osteoporosis medications.

UnlabelledDrugs used for the prevention and the treatment of osteoporosis exert various favourable and unfavourable extra-skeletal effects whose importance is increasingly recognized notably for treatment selection.IntroductionThe therapeutic armamentarium for the prevention and the treatment of osteoporosis is increasingly large, and possible extra-skeletal effects of available drugs could influence the choice of a particular compound.MethodsThe present document is the result of a national consensus, based on a systematic and critical review of the literature.ResultsObservational research has

Curcumin Formulations for Better Bioavailability: What We Learned from Clinical Trials Thus Far?

Curcumin has been credited with a wide spectrum of pharmacological properties for the prevention and treatment of several chronic diseases such as arthritis, autoimmune diseases, cancer, cardiovascular diseases, diabetes, hemoglobinopathies, hypertension, infectious diseases, inflammation, metabolic syndrome, neurological diseases, obesity, and skin diseases. However, due to its weak solubility and bioavailability, it has limited potential as an oral medication. Numerous factors including low water solubility, poor intestinal permeability, instability at alkaline pH, and fast metabolism contri

Effectiveness of bilingual health education on obesity and dietary behaviors in Mongolian adolescents: a six-month intervention study.

BackgroundObesity among adolescents has become a global public health concern. Previous studies have shown that multidimensional interventions, such as school-based programs, health education, and guidance on diet and physical activity, effectively improve obesity in adolescents. However, there is a lack of research on bilingual health education interventions in minority language environments in rural and pastoral areas of China. Based on a 2023 field survey of students from three Mongolian middle schools in Ar Horqin Banner, Chifeng City, Inner Mongolia, this study evaluated the effect of a 6

Diet-driven microbiome changes and physical activity in cancer patients.

Exploring the role of the gut microbiome in oncology is gaining more attention, mainly due to its ability to shape the immune system in cancer patients. A well-balanced microbial composition forms a symbiotic relationship with the host organism. Mounting evidence supports the potential of modifiable lifestyle factors, such as diet and physical activity, in restoring intestinal dysbiosis related to cancer development and treatment. In this Minireview, we describe the host-microbiome interplay following different dietary patterns, including a high-fat diet, fiber-rich diet, diet rich in rice and

Harnessing the Potential of Enzymes as Inhaled Therapeutics in Respiratory Tract Diseases: A Review of the Literature.

Respiratory tract diseases (RTDs) are a global cause of mortality and affect patient well-being and quality of life. Specifically, there is a high unmet need concerning respiratory tract infections (RTIs) due to limitations of vaccines and increased antibiotic resistance. Enzyme therapeutics, and in particular plant-based enzymes, represent an underutilised resource in drug development warranting further attention. This literature review aims to summarise the current state of enzyme therapeutics in medical applications, with a focus on their potential to improve outcomes in RTDs, including RTI

Alcohol use, intentions to reduce consumption, and perceived motivations and barriers among cancer survivors.

PurposeTo characterize alcohol use patterns, awareness of alcohol's oncologic risks, and efforts and intentions to reduce consumption among cancer survivors in New Hampshire and Vermont.MethodsCross-sectional survey of 471 cancer survivors aged ≥21 years enrolled in two state-wide, online panels. Participants reported their current or former alcohol use, completed the Alcohol Use Disorders Identification (AUDIT), and replied to a series of items regarding any efforts to reduce consumption and related motivations and barriers.ResultsAmong 471 survivors, 34.2% of which had an alcohol-related can

Изменчивость генотипов кассавы (Manihot Escelenta [Cranz]) для состава питания в юго-западной Эфиопии.

В ходе исследования было использовано в общей сложности 100 Генотипы кассавы, полученные из МИТА, Нигерия (биофортифицированные генотипы), и собранные на месте земли Эфиопии, сохранены в Центре сельскохозяйственных исследований Джиммы. Таким образом, понимание изменчивости состава рациона питания может служить ориентиром для будущего генетического совершенствования и поддерживать развитие питательных разновидностей маниоки. Цель этого исследования заключалась в оценке изменчивости генотипов кассавы на основе их анализа состава питательных веществ. Анализ различий (АНОВА) выявил весьма значител

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… Also, its production is intended for human consumption, sources of income and industrial production of starch, flour, beverages, animal feeds, biofuels and textiles, contributing to its global importance 6 . …

Pilot clinical and pharmacokinetic study of Δ9-Tetrahydrocannabinol (THC)/Cannabidiol (CBD) nanoparticle oro-buccal spray in patients with advanced cancer experiencing uncontrolled pain.

This pilot study aimed to assess the safety, tolerability, pharmacokinetics and exploratory analgesic effect of a novel water-soluble oro-buccal nanoparticle spray of a cannabis-based medicine (MDCNS-01) in patients with advanced incurable malignancy with unrelieved pain from opioid analgesic. The study was a non-blinded single arm 2 stage study. Stage I was a single escalating dose (n = 5) [2.5 mg Δ9-THC and 2.5 mg CBD) versus a 3-fold escalated dose. Stage II was an up-titrated dose in patients with advanced cancers and intractable pain (n = 25). During Stage I with an increased cannabis-bas

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… Patients were also informed that they should not consume food, beverages (for at least 60 minutes before or after using the spray) or speak during the administration process of the cannabis-based medicine. …

Естественные модули вкуса и микробиомеозная поддержка в области питания для иммунотерапии-ассоциированной дисгеусии: перевод для оказания помощи в лечении рака.

Дисгейсия является клинической, но по-прежнему недостаточно стандартизированной токсичностью для лечения рака. В эпоху иммунотерапии расстройства вкуса становятся все более актуальными для пациентов, получающих ингибиторы на иммунных контрольно-пропускных пунктах, химерик антигенные рецепторы (CAR) T-клеток и T-перенаправленные антитела, с группой G-белковых рецепторов C 5 - лечение в множестве миэлома, осуществляемое под руководством члена D (GPRC5D), представляет собой особенно поучительную модель с высокой нагрузкой. Мы провели структурированный критический обзор с картированием доказательс

Adherence to the World Cancer Research Fund/American Institute for Cancer Research recommendations for cancer prevention in adolescent and young adult (AYA) cancer survivors: results from the SURVAYA study.

PurposeFor adolescent and young adult (AYA) cancer survivors with a good prognosis, having a healthy lifestyle prevents morbidity and mortality after treatment. The aim of this study was to investigate the prevalence of (un)healthy lifestyle behaviors and related determinants in AYA cancer survivors.MethodsA population-based, cross-sectional study was performed among long-term (5-20 years) AYA cancer survivors (18-39 years old at diagnosis) registered within the Netherlands Cancer Registry. Self-reported questionnaires data about health behaviors were used to calculate the 2018 World Cancer Re

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… We did not include food groups overlapping with other score components such as processed meats and sugar-sweetened beverages. …

Multidisciplinary Progress in Obesity Research.

Obesity is a chronic disease that endangers human health. In recent years, the phenomenon of obesity has become more and more common, and it has become a global epidemic. Obesity is closely associated with many adverse metabolic changes and diseases, such as insulin resistance, type 2 diabetes mellitus, coronary heart disease, nervous system diseases and some malignant tumors, which have caused a huge burden on the country's medical finance. In most countries of the world, the incidence of cancer caused by obesity is increasing year on year. Diabetes associated with obesity can lead to seconda

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… The current passive overconsumption of energy-dense, nutrient-poor foods and beverages has been identified as a major driver of the obesity epidemic [ 7 , 18 ]. Decreased physical activity due to modern lifestyles is also an important contributor [ 19 ]. …