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Множественный опыт и предпочтения в области миеломы: исследование смешанных методов лечения пациентов и партнеров по уходу в Соединенных Штатах.

ЦЕЛЬ: Множественная миелома (ММ) характеризуется рецидивом лечения и сопротивлением, что требует принятия последовательных решений о лечении на протяжении всего курса лечения. Для того чтобы понять, каким образом состояние заболеваний и изменение условий лечения влияют на решения, принимаемые пациентами и партнерами по уходу, было проведено исследование по изучению неинтервенционных смешанных методов. ПАТИЕНТЫ И МЕТОДЫ: Пациенты, самоотчитывающиеся MM и партнеры по уходу, были набраны через Гритское сообщество по борьбе с раком, социальные сети и снежные шары для участия в этом исследовании, п

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… 9.4) | 0 | 1 (10.0) | 2 (20.0) Disabled | 12 (37.5) | 8 (66.7) | 2 (20.0) | 2 (20.0) Retired | 12 (37.5) | 3 (25.0) | 4 (40.0) | 5 (50.0) Medical insurance, n (%) d | | | | Commercial through employer | 12 (37.5) | 2 (16.7) | 6 (60.0) | 4 (40.0) Individual commercial | 1 (3.1) | 0 | 0 | 1 (10.0) Medicaid …

Trend Analysis of Medically Related Osteonecrosis of the Jaw in the United States Using US National Inpatient Data From 2016 to 2022.

OBJECTIVES: This study presents a trend analysis of Medication-Related Osteonecrosis of the Jaw (MRONJ) using US National Inpatient Sample (NIS) data from 2016 to 2022, providing insights into its epidemiology, comorbidities, and economics. METHODS: A retrospective cross-sectional analysis was performed using US MRONJ hospital admissions. Prevalence rates were calculated relative to Bisphosphonate patient numbers in the United States and hospital-based denominators. Statistical analyses included two-sample proportion (Z) tests, Cochran-Armitage trend tests, Welch t-tests, and multivariable li

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… Primary payer was grouped as Medicare versus non‐Medicare (Medicaid, private insurance, self‐pay, no charge, and other). …

Descriptive Analysis of Adverse Events Reported for New Multiple Myeloma Medications Using FDA Adverse Event Reporting System (FAERS) Databases from 2015 to 2022.

BackgroundNew multiple myeloma (MM) medications have revolutionized the treatment landscape, but they are also associated with a range of adverse events (AEs). This study aims to provide a comprehensive overview of AEs reported for four new MM medications: daratumumab, ixazomib, elotuzumab, and panobinostat.MethodsThis study uses a descriptive retrospective approach to analyze the FDA Adverse Event Reporting System (FAERS) from 2015 to 2022. It includes variables like medication names, report details, patient demographics, adverse events, and reporter types. The initial dataset consists of ove

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… Alrasheed et al. found that Medicaid claims for daratumumab significantly outnumbered those for ixazomib and elotuzumab. …

Patient characteristics in sepsis-related deaths: prevalence of advanced frailty, comorbidity, and age in a Norwegian hospital trust.

ObjectiveTo examine the prevalence of advanced frailty, comorbidity, and age among sepsis-related deaths in an adult hospital population.MethodsRetrospective chart reviews of deceased adults within a Norwegian hospital trust, with a diagnosis of infection, over 2 years (2018-2019). The likelihood of sepsis-related death was evaluated by clinicians as sepsis-related, possibly sepsis-related, or not sepsis-related.ResultsOf 633 hospital deaths, 179 (28%) were sepsis-related, and 136 (21%) were possibly sepsis-related. Among these 315 patients whose deaths were sepsis-related or possibly sepsis-r

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… Supplemented with other essential medical conditions not included in the CCI (e.g., neuromuscular disease), and definitions for immunosuppression and end-stage conditions applied by Rhee et al . [ 8 ], the latter adapted from Hospice Eligibility Criteria from the Centers for Medicare & Medicaid Services …

Regional, demographic and temporal trends in anemia and malignant cancer-related mortality in U.S. older adults: a nationwide CDC WONDER analysis (1999-2020).

PurposeAnemia and malignancy concurrently contribute to reduced quality of life, treatment intolerance, and increased morbidity and mortality, disproportionately affecting older adults, socioeconomically disadvantaged groups, and minority populations. Despite its clinical importance, national patterns and population-level disparities in the mortality burden associated with this comorbidity remain poorly characterized. This study aims to examine mortality trends associated with concurrent anemia and malignancy in the United States using CDC WONDER (Centers for Disease Control and Prevention Wid

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… Centers for Medicare & Medicaid Services (CMS), National Center for Health Statistics (NCHS) . ICD-10-CM Official Guidelines for Coding and Reporting Fiscal Year 2017 (October 1, 2016 – September 30, 2017). Baltimore (MD: CMS; (2016). …

Describing financial toxicity among cancer patients in different income countries: a systematic review and meta-analysis.

BackgroundThere is limited evidence of financial toxicity (FT) among cancer patients from countries of various income levels. Hence, this study aimed to determine the prevalence of objective and subjective FT and their measurements in relation to cancer treatment.MethodsPubMed, Science Direct, Scopus, and CINAHL databases were searched to find studies that examined FT. There was no limit on the design or setting of the study. Random-effects meta-analysis was utilized to obtain the pooled prevalence of objective FT.ResultsOut of 244 identified studies during the initial screening, only 64 studi

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… . | NA | NA | Patient (OOP), Private insurance, Medicare, Medicaid, and other sources Jagsi et al. 2014 ( 40 ) | USA | Breast cancer | 2005 to 2007 | 1,502 | Median out-of-pocket expenses were ≤$2,000; 17% of respondents reported spending > USD$5,000 | NA | NA | Patient, Health insurance Sharp and Timmons …

Abstracts From JADPRO Live at APSHO 2015.

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… The Oncology Care Model (OCM) was developed by the Center for Medicare and Medicaid Innovation. This is a new payment and delivery system, which is based on quality of care. …

Risk sharing arrangements for pharmaceuticals: potential considerations and recommendations for European payers.

BackgroundThere has been an increase in 'risk sharing' schemes for pharmaceuticals between healthcare institutions and pharmaceutical companies in Europe in recent years as an additional approach to provide continued comprehensive and equitable healthcare. There is though confusion surrounding the terminology as well as concerns with existing schemes.MethodsA literature review was undertaken to identify existing schemes supplemented with additional internal documents or web-based references known to the authors. This was combined with the extensive knowledge of health authority personnel from

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… This is similar to the US Centre for Medicare and Medicaid conditional coverage scheme under which conditions are set for the continued reimbursement of new technologies [ 5 , 34 , 39 ]. …

Machine Learning-Based Prediction of Unplanned Readmission Due to Major Adverse Cardiac Events Among Hospitalized Patients with Blood Cancers.

BackgroundHospitalized patients with blood cancer face an elevated risk for cardiovascular diseases caused by cardiotoxic cancer therapies, which can lead to cardiovascular-related unplanned readmissions.ObjectiveWe aimed to develop a machine learning (ML) model to predict 90-day unplanned readmissions for major adverse cardiovascular events (MACE) in hospitalized patients with blood cancers.DesignA retrospective population-based cohort study.MethodsWe analyzed patients aged ≥18 with blood cancers (leukemia, lymphoma, myeloma) using the Nationwide Readmissions Database. MACE included acute myo

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… IQR) | 7.0 (4.0-15.0) | 9.0 (4.0-18.0) | −0.09 | 9.0 (4.0-18.0) | 9.0 (4.0-4.0) | −0.01 Weekend admission, n (%) | 193 (18.72) | 12 691 (16.71) | 0.05 | 8371 (16.57) | 4513 (17.08) | −0.01 Health insurance, n (%) Medicare | 742 (71.97) | 38 188 (50.30) | 0.46 | 25 437 (50.34) | 13 493 (51.05) | −0.01 Medicaid …

Is the Scope of Costs Considered in Budget Impact Analyses for Anticancer Drugs Rational? A Systematic Review and Comparative Study.

Background: With the increasing disease burden of cancer worldwide, more and more anticancer drugs have been approved in many countries, and the results of budget impact analyses (BIAs) have become important evidence for related reimbursement decisions. Objectives: We systematically reviewed whether BIAs for anticancer drugs consider the scope of costs rationally and compared the results of different cost scopes to provide suggestions for future analyses and decision-making. Methods: Eligible BIAs published in PubMed, Embase, Web of Science, and the Cochrane Library from 2016 to 2021 were iden

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… AA, abiraterone acetate; ADT, androgen deprivation therapy; AE, Adverse events; BRAF, v-Raf murine sarcoma viral oncogene homolog B; BSC, Best supportive care; CRC, Colorectal cancer; CMS, Centers for Medicare & Medicaid Services; CT, Chemotherapy; CDK 4/6, Cyclin-dependent kinase 4 and 6; CRPC, Castration-resistant …

Social relationship challenges perceived by cancer patients and survivors: a qualitative meta-synthesis.

BackgroundA cancer diagnosis can significantly disrupt patients' social lives, leading to strained relationships and increased social isolation. Many encounter uneasy interactions or feel judged by others, amplifying loneliness and a sense of exclusion. While existing research has predominantly focused on clinical outcomes, the social relationship challenges faced by cancer patients have not been fully explored. Consequently, this study aims to synthesize qualitative studies that examine the social relationship experiences of cancer patients and survivors, offering a deeper insight into this i

2022 International Cancer Education Conference Late-Breaking Abstracts

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… While Medicaid is accessible for people with low incomes, many will lack a comparable dental insurance plan. … Utilize low or free out-of-pocket-cost services (Cancer Services Program, Access-A-Ride, Emergency Medicaid, and primary care establishment). …

Residential green spaces and neurodegenerative diseases in middle-aged and older adults: a systematic review and dose-response meta-analysis.

BackgroundThe potential protective role of residential green space against neurodegenerative diseases (NDs) is a topic of growing interest, yet evidence remains inconsistent. This systematic review and meta-analysis aimed to synthesize the current evidence on this association in middle-aged and older adults.MethodsWe searched PubMed, Embase, Web of Science, and the Cochrane Library through March 15, 2025, for observational studies that evaluated the association between objectively measured residential green space and the incidence of NDs in middle-aged and older adults. Risk of bias was assess

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… Aitken 2021 [ 52 ] | America | Centers for Medicare and Medicaid Services(CMS) | 2010–2011 | Cross-sectional | NA | 58.33 | 76.33 | NDVI (ASTER 15 m) | Census Block | NDVI: mean − 0.02 (SD: 0.09); tertiles (ranges): low: −0.4 − 0.06; medium: −0.06, 0.006; high:0.006, 0.429 | 249,405 Medicare benefciaries …

Patient-reported outcome (PRO) instruments used in patients undergoing adoptive cell therapy (ACT) for the treatment of cancer: a systematic review.

IntroductionAdoptive cell therapy (ACT) is a rapidly evolving field. Patient-reported outcomes (PROs) allow patients to report the impact of treatment on their quality of life during and after treatment. The systematic review aims to characterise the breadth of PROs utilised in ACT cancer care and provide guidance for the use of PROs in this patient population in the future.MethodsA systematic search was conducted (MEDLINE, PsycINFO, Embase and CINAHL) in August 2021 by two reviewers. Search terms covered the following: "adoptive cell therapy", "patient-reported outcomes" and "cancer". Studies

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… The Centers for Medicare & Medicaid Services (CMS) panel have also made their own recommendations about the most appropriate tools to use (PROCTCAE [ 51 ], MD Anderson Symptom Inventory [ 60 ], EORTC-QLQ-C30 [ 62 ] and PROMIS [ 48 ]), all of which are flexible questionnaire systems that use item banks …

Overview of nutritional approach in hematopoietic stem cell transplantation: COVID-19 update.

The coronavirus disease 2019 (COVID-19) is caused by the newly discovered SARS-CoV-2. Hematopoietic stem cell transplantation (HSCT) is a high-risk procedure. The novelty of COVID-19 has created more uncertainty during all phases of HSCT. It is thought that HSCT patients taking immunosuppressive agents are more likely to contract COVID-19 than healthy individuals are. Appropriate care precautions should be taken with patients undergoing HSCT to minimize the risk of COVID-19, and appropriate treatment methods must be followed in patients infected with COVID-19. Malnutrition has become a signifi

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… Variation in medicaid coverage for hematopoietic cell transplantation. J Oncol Pract. 2014;10:e196–e200. doi: 10.1200/JOP.2013.001155. 9. Martin-Salces M, de Paz R, Canales MA, Mesejo A, Hernandez-Navarro F. Nutritional recommendations in hematopoietic stem cell transplantation. …

Role of Physical Activity and Cardiac Rehabilitation in Patients Undergoing Hematopoietic Stem Cell Transplantation.

Hematopoietic stem cell transplantation (HSCT) is a standard treatment for several malignancies, and >50,000 HSCT are performed annually worldwide. As survival after HSCT improves, cardiovascular disease and associated risk factors have gained importance as a significant cause of morbidity and mortality in this cohort. In this article, we detail the risk factors for cardiovascular disease and their impact in patients undergoing HSCT. Additionally, we critically review the data on the impact of physical exercise in patients undergoing HSCT. Although limited by significant heterogeneity in metho

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… Centers for Medicare & Medicaid Services Cardiac rehabilitation. https://www.medicare.gov/coverage/cardiac-rehabilitation-programs Available at: Associated Data Supplementary Materials Supplemental Table 1 …

Recent trends in specialty pharma business model.

The recent rise of specialty pharma is attributed to its flexible, versatile, and open business model while the traditional big pharma is facing a challenging time with patent cliff, generic threat, and low research and development (R&D) productivity. These multinational pharmaceutical companies, facing a difficult time, have been systematically externalizing R&D and some even establish their own corporate venture capital so as to diversify with more shots on goal, with the hope of achieving a higher success rate in their compound pipeline. Biologics and clinical Phase II proof-of-concept (POC

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… According to the Centers for Medicare and Medicaid Services, the cost increased from approximately $1 million to as much as $50 million for about 100,000 prescriptions/year. …

Выявление связанных с теплом диагнозов в ходе посещений чрезвычайных служб взрослыми в Чикаго: исследование по всей ассоциации.

Крайняя теплота - это растущая проблема здравоохранения. Несмотря на то, что в ходе предыдущих исследований были изучены ассоциации по вопросам теплоздоровья, их зависимость от ограниченных диагностических и диагностических категорий может упустить из виду или дезклассифицировать связанные с теплом заболевания. Здесь мы провели в Чикаго, штат Иллинойс, исследование теплообщности для оценки диагнозов острого лечения, связанных с экстремальным теплом. Использование 916,904 посещения в целях оказания неотложной медицинской помощи, включая экстренное отделение и встречи по оказанию неотложной меди

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… Because our study period included the transition from ICD-9 to ICD-10 codes (mandated in the US by 1 October 2015), to standardize the diagnoses, we mapped the ICD-9 codes to their corresponding ICD-10 codes using the Centers for Medicare and Medicaid Services General Equivalence Mappings guidance and …

A geriatrician's approach to managing the complex older adult with obesity.

The prevalence of obesity in older adults is rapidly increasing due to the demographic shift occurring globally. Older adults with obesity face health care challenges due to multimorbidity, functional dependency, and disability. This population often has prior history of struggles through weight-loss attempts during the middle years of life. Therefore, weight-loss intervention needs a personalized approach, taking into consideration weight-loss attempts, relapse, and life events, including bariatric surgery, functional limitations, psychosocial status, and current residential environment. Raci

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… In 2011, the Centers for Medicare and Medicaid Services (CMS) approved a behavioral counseling code for intensive behavioral therapy (IBT) to help address obesity among Medicare beneficiaries. …

Scoping Review and Meta-Analysis Suggests that Cannabis Use May Reduce Cancer Risk in the United States.

Introduction:Cannabis smoke contains carcinogens similar to tobacco, in addition to compounds with antitumor activity. Cannabis use reduces the risk of obesity and cannabinoids inhibit chronic inflammation, known causes of cancer. The net effect of Cannabis use on cancer risk is not known. Objective: To examine the association between Cannabis use and cancer risk in the United States. Methods: Identify and analyze published data on cancer risk in Cannabis users. Results: A total of 55 data points, consisting of risk ratios of cancer in Cannabis users and nonusers, were identified from 34 studi

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… Association of medical and adult-use marijuana laws with opioid prescribing for Medicaid enrollees . JAMA Intern Med . 2018 ; 178 : 673 – 679 . 29610827 10.1001/jamainternmed.2018.1007 PMC6145792 12. Carter GT , Flanagan AM , Earleywine M , et al. …