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Impact of Whole-Body Cryostimulation (WBC) on Hemostatic Parameters in Patients with Multiple Sclerosis.

Background: Multiple sclerosis (MS) involves neuroinflammation, demyelination and hemostatic disturbances linked to blood-brain barrier (BBB) disruption and the resulting neurovascular dysfunction. Whole-body cryostimulation (WBC) is used as an adjunct therapy; however, its influence on coagulation and fibrinolysis remains unclear. This study evaluated the hemostatic effects of a 10-session WBC protocol in MS and non-MS participants. Methods: Seventy-two adults (MS n = 29; non-MS n = 43) underwent 10 consecutive WBC sessions (3 min, -120 °C to -130 °C). Blood samples were collected at baseline…

Walking performance is associated with quality of life and disability in relapsing-remitting multiple sclerosis.

BACKGROUND: Multiple sclerosis (MS) affects the patients physical and psychological state. Despite research, the relationships between quality of life (QoL), disability, and physical activity in MS remain insufficiently understood; this study examines associations in patients with relapsing-remitting multiple sclerosis (RRMS). METHODS: A total of 41 patients with RRMS with an Expanded Disability Status Scale (EDSS) level of 0-5.5 and 20 healthy controls completed the MS Functional Composite (MSFC) test, the RAND-physical component summary (RAND-PCS), the RAND-mental component summary (RAND-MC…

Viral seropositivity in a Brazilian cohort of patients with multiple sclerosis: A retrospective descriptive study.

BACKGROUND: Defining viral serology in multiple sclerosis (MS) patients has become increasingly more relevant, given the potential association between viruses and MS, along with the recent introduction of new immunosuppressive treatments. OBJECTIVES: To describe the frequency of viral seropositivity in a Brazilian cohort of patients with MS and to explore the association of disease-modifying therapies (DMTs) and intravenous pulse therapy (IVPT) with viral serological status. METHODS: This retrospective descriptive study evaluated the seropositivity of ten viral markers in 70 patients with MS…

Поправка: Эпитопа, распространяющаяся в множестве склероза, формируется при пространственной организации иммунной реакции.

[Это исправляет статью DOI: 10.3389- Фимму.2026.1878029]

The Impact of Upper Extremity Rehabilitation on Fatigue in Individuals With Multiple Sclerosis: A Systematic Review.

BACKGROUND: Although numerous interventions have been investigated to alleviate fatigue in people with multiple sclerosis (PwMS), evidence regarding the effects of upper extremity rehabilitation on fatigue remains limited. OBJECTIVE: The objective of this review was to evaluate and synthesize the available evidence on the effects of upper extremity rehabilitation interventions on fatigue in PwMS. METHODS: This review was conducted in accordance with the PRISMA guidelines and was prospectively registered in the PROSPERO database. A systematic search of PubMed, Web of Science, and Scopus was p…

Influence of Antidepressants on the Relationship Between Disease Duration and Depressive Symptoms in Multiple Sclerosis.

OBJECTIVE: Studies have not shown an association between multiple sclerosis (MS) disease duration and depression among people with MS. However, whether antidepressant use influences this possible relationship remains unknown. The authors evaluated whether antidepressant use moderates the association between disease duration and clinically significant depressive symptoms among individuals with MS. METHODS: A consecutive sample of 1,076 adults with MS received psychometric testing during clinical care at a tertiary neuropsychiatry clinic in Toronto from 2020 to 2025. Demographic and disease-rel…

Comorbidities and infectious episodes in multiple sclerosis patients within general practices in the Netherlands.

BACKGROUND: People with multiple sclerosis (PwMS) are at heightened risk of comorbidities and infections, due to the disease's debilitating nature and side effects of disease-modifying therapies (DMT). METHODS: This retrospective case-control study was conducted the Dutch Nivel Primary Care Database from the year 2019, assessing chronic comorbidities and infections in PwMS versus matched controls. The influence of the comorbidity burden (evaluated by the Charlson Comorbidity Index (CCI)) and infections on mortality was evaluated using Cox regression. RESULTS: A higher lifetime prevalence of …

Факторы, связанные с риском падений в людях с множественным склерозом: исследование по контролю за конкретными случаями.

ВВЕДЕНИЕ: Мобильность людей с множественным склерозом (PwMS) существенно ограничена в связи с участием мускулоскелетной системы, что приводит к падению и снижению качества жизни. Цель этого исследования состояла в том, чтобы оценить риск падения (использование шкалы Даунтона) и его связь с прастичностью и другими переменными в PwMS и сравнить его с группой здоровых участников. МЕТОДЫ: Это описательное и перекрестное исследование по наблюдению охватывало 86 тем, разделенных на две группы: случаи (n=41) и меры контроля (n=45). Все участники заполнили испанский вариант шкалы Даунтона.МЕРОПРИЯТИЯ:

Совпадение в аннотации оригинала
INTRODUCTION: The mobility of people with multiple sclerosis (pwMS) is significantly limited due to the involvement of the musculoskeletal system, resulting in falls and a diminished quality of life. This study aimed to assess the risk of falls (utilizing the Downton scale) and its association with spasticity and other variables in pwMS and compare it with a…

Профессиональная реабилитация лиц с множественным склерозом: систематический обзор международных доказательств.

ВВЕДЕНИЕ: Люди с множественным склерозом (ПМС) могут столкнуться с проблемами в своей профессиональной жизни в силу сочетания экологических и индивидуальных факторов. Согласно Escorpizo et al. 2011 Программа профессиональной реабилитации (ПП) направлена на оптимизацию участия в трудовой деятельности, оказание поддержки в обеспечении доступа к рабочим местам, сохранении рабочих мест и возвращении на работу для инвалидов. Однако результаты исследований по VR для PwMS являются неудовлетворительными. Целью этого аналитического обзора является составление карт имеющейся литературы о мероприятиях в

Совпадение в аннотации оригинала
INTRODUCTION: People with multiple sclerosis (pwMS) may encounter challenges in their professional lives, due to a combination of environmental and individual factors. According to Escorpizo et al., 2011 framework, Vocational rehabilitation (VR) aims to optimise job participation, providing support in the job access, retention and in the return to work for p…

Dynamics of choroid plexus volume is associated with the presence and development of fatigue in multiple sclerosis.

BACKGROUND: Immune-mediated processes are implicated in the pathogenesis of fatigue, a common symptom in multiple sclerosis (MS). The choroid plexus (CP) regulates central nervous system (CNS) immune homeostasis and undergoes volumetric modifications possibly contributing to MS-related fatigue. We explored the association between MS-related CP volume changes and fatigue dynamics. METHOD: Eighty-five patients with MS and 68 healthy controls (HC) underwent brain 3T MRI, neurological evaluation and Modified Fatigue Impact Scale (MFIS) at two timepoints (median follow-up=1.4 years). Normalised br…

Leptin as a Potential Modifier of Neuroinflammation: Contrasting Roles in Alzheimer's Disease and Multiple Sclerosis.

The neuroendocrine and immune systems interact bidirectionally through shared ligands and receptors during inflammation, thereby regulating immune responses. Leptin, primarily known for its role in energy metabolism and appetite regulation, also modulates neuroinflammatory pathways. Its receptors are widely expressed on immune cells and contribute to immune mechanisms implicated in the pathogenesis of neuroinflammatory disorders such as multiple sclerosis (MS) and Alzheimer's disease (AD). This review highlights recent advances in understanding leptin's role in immune regulation, with a focus …

Неосознанное отклонение в оценке воздействия лечения на ПИРА при проведении множественных склерозовых клинических испытаний.

Заинтересованность в развитии, независимом от активности рецидива (ИПРА), в качестве конечной точки в многочисленных склерозовых (МС) клинических испытаниях растет. Вместе с тем установленные определения ПИРА могут давать предвзятые оценки воздействия лечения в условиях сокращения рецидивов, вызванных лечением. Мы применяли различные определения ПИРА для объединения данных, полученных в ходе клинических испытаний OPERA I/II (клинические испытания.gov идентификаторы: NCT01247324, NCT01412333). Воздействие обработки на ПИРА в соответствии с различными методами оценивалось по коэффициентам опасно

Совпадение в аннотации оригинала
BACKGROUND: Interest in progression independent of relapse activity (PIRA) as an endpoint in multiple sclerosis (MS) clinical trials is surging. However, established definitions of PIRA may produce biased treatment effect estimates in the presence of a treatment-induced relapse reduction. METHODS: We applied different definitions of PIRA to pooled data from…

Timing and Predictive Value of Clinical Conditions Preceding Multiple Sclerosis in the UK Biobank.

OBJECTIVES: Multiple sclerosis (MS) patients often experience a higher incidence of clinical conditions before diagnosis, suggesting a prodromal phase. However, their predictive value and temporal trajectories remain underexplored. We investigated these aspects using the large UK Biobank's population-based cohort, which provided clinical history through ICD-10 diagnosis codes. METHODS: We assessed associations between 600 clinical conditions and MS risk in 477,421 individuals using Cox models adjusted for demographics, smoking, and MS polygenic risk score (MS-PRS). Statistically significant c…

Characterization of the mechanical changes of adductor muscles in the lower extremities for patients with multiple sclerosis.

BACKGROUND: It is important to know how the mechanical properties of the muscles change in the management of adductor spasticity in patients with Multiple Sclerosis (pwMS). METHODS: This study was conducted by evaluating forty-two pwMS bilaterally. The Modified Ashworth Scale (MAS) was used to determine the hip adductor spasticity level, and pwMS were divided into four groups (MAS0, MAS1, MAS1+, MAS2) regarding the MAS grade. MyotonPro® (Myoton AS, Estonia) was used to determine mechanical properties (tone, stiffness, elasticity) of the muscle from the (i) belly, (ii) musculotendinous, and (i…

A Radiomic Approach to Clinical MRI Refines the Thalamus-Cognition Link in Multiple Sclerosis.

BACKGROUND AND OBJECTIVES: Radiomics extracts imaging features that may not be detectable through conventional volumetric analyses. Given their role in multiple sclerosis (MS), we applied radiomics to thalamic nuclei and examined their associations with cognitive performance. METHODS: A total of 601 individuals were included (342 people with MS-PwMS from two cohorts, and 259 healthy controls-HC). Radiomic features (RF) and volumes were extracted from the whole thalamus, five thalamic nuclei, and the putamen segmented on 3D T1-weighted images. Cognitive performance was assessed using the Symbo…

Utilizing Perceived Fatigability to Identify Cognitive and Mobility Impairments in Aging and Multiple Sclerosis.

BackgroundPerceived fatigability-subjective physical or mental energy depletion within specified activity contexts-is prevalent in aging and neurological conditions. Although the Pittsburgh Fatigability Scale (PFS) is validated for older adults and those with multiple sclerosis (OAMS), its subscale cut-offs and clinical relevance for cognitive and mobility outcomes have not been examined in neurologically affected aging populations.MethodsWe studied 224 older adults (≥60 years): 109 OAMS and 115 controls who completed the PFS, neuropsychological testing, the Short Physical Performance Battery …

Longitudinal changes in cortical cell body and neurite density in people with multiple sclerosis.

Detecting neuroinflammation and neurodegeneration prior to cortical atrophy and subsequent clinical disability in people with multiple sclerosis (MS) has been challenging due to limited sensitivity on MRI. Our aim was to assess longitudinal changes in cortical cell body and neurite density related to lesion formation and atrophy using high-gradient diffusion MRI. In this longitudinal study, nine people with MS underwent 3 T high-gradient diffusion MRI at baseline and follow-up (median 5 years). Intra-soma, intra-neurite and extra-cellular signal fractions and apparent soma radius were estimate…

Декодирование молекулярных и клеточных аспектов множественного склероза: от диагностики до терапевтических стратегий.

Множественный склероз (MS) представляет собой многогранное хроническое нейро-воспалительное состояние центральной нервной системы (CNS), характеризующееся обезвоживанием, глиозом и аксонной деградацией. Несмотря на всеобъемлющее исследование, точная этиология остается неясной и требует сложного взаимодействия между генетическими, эпигенетическими и экологическими переменными. Этот обзор свидетельствует о настоятельной необходимости интеграции новых данных, связывающих генетическую предрасположенность, в частности вариантов HLA-DRB1*15:01 и более 200 не связанных с HLA, с изменяющимися экологич

Совпадение в аннотации оригинала
Multiple sclerosis (MS) is a multifaceted, chronic neuroinflammatory condition of the central nervous system (CNS) marked by demyelination, gliosis, and axonal degradation. Despite the comprehensive investigation, the exact etiology remains unclear, requiring complex interactions among genetic, epigenetic, and environmental variables. This review highlights …

Приобретение сложности реабилитации в условиях множественного склероза в соответствии с резолюцией Всемирной организации здравоохранения.

Всемирная организация здравоохранения (ВОЗ) приняла историческую резолюцию об укреплении реабилитации в системах здравоохранения. В нем содержится призыв к правительствам и заинтересованным сторонам, занимающимся реабилитацией, активизировать процесс реабилитации. Согласно глобальной базе данных о бремени болезней, каждый третий человек во всем мире может воспользоваться услугами по реабилитации. Осуществление резолюции является особенно сложным делом, учитывая сложность нейрореабилитационной работы для людей с НР. Историческая перспектива развития многодисциплинарной реабилитации, включая соз

Регулирование эндосомного комплекса сортировки III связано с нейродегенерацией в прогрессивном множественном склерозе.

Множественный склероз (MS) — хроническое нервно-воспалительное заболевание, которое переходит в стадию необратимого неврологического упадка и широкомасштабного нейродегенерации. Некроптоз — регулируемая форма клеточной смерти, вызванной главным образом некрозом опухоли (TNF), — был связан с нейронной потерей в прогрессивных MS. Как известно, эндосомный сортинговый комплекс, необходимый для транспортных механизмов (ESCRT), который необходим для ремонта плазменной мембраны и незаконного оборота везикла, противодействует некроптозу в ненейральных клетках. В этом исследовании мы изучили, способств

Совпадение в аннотации оригинала
Multiple sclerosis (MS) is a chronic neuroinflammatory disease that progresses to a stage marked by irreversible neurological decline and widespread neurodegeneration. Necroptosis, a regulated form of cell death primarily triggered by tumor necrosis factor (TNF), has been implicated in neuronal loss in progressive MS. The Endosomal Sorting Complex Required f…