Результаты поиска

In vivo characterization of a retinal cellular biomarker of inflammation in multiple sclerosis.

Neuroinflammation plays a central role in the progression of multiple sclerosis (MS). While neuroinflammation contributes to neuronal damage … ients with MS (pwMS) (n = 51) with varying phenotypes: (i) relapsing-remitting MS (RMS) with recent optic neuritis (ON) (<6months) (ON-RMS, N = 31), (ii) RMS without recent ON (N = 12), and (iii) progressive MS (PMS, N = 8). Healthy controls without ocular pathology (N = 9) were recruited. Longitudinal imaging was performed using an AOSLO at 3, 6, and 12 months …

The Leading Causes of Optic Disc Edema Seen in Tertiary Care, Academic Neuro-Ophthalmology Clinics.

BACKGROUND: Optic disc edema (ODE) is one of the most common reasons for referral to a neuro-ophthalmologist. There are various causes that … nterior ischemic optic neuropathy (NAION; 116/654 or 17.4%), non-IIH papilledema (71/654 or 10.9%), optic neuritis (ON; 46/654 or 7.0%), and uveitis (17/654 or 2.6%). When considering female-only patients, the top 3 causes of ODE were IIH, non-IIH papilledema, and NAION. Among male-only patients, the top 3 causes were NAION, IIH, and non-IIH. Among the top 5 cau …

Subnormal visual acuity after compliant amblyopia therapy: residual/refractory amblyopia or co-existing pathology? - a retrospective analysis.

Purpose: To assess the prevalence of alternate etiology/co-existing pathology among patients with amblyopia, and to characterize factors con … s to have amblyopia, but later found to have alternate diagnosis/co-existing pathology. Subclinical optic neuritis (50%, 13 children), and occult macular dystrophy (OMD) (38.4%, 10 children) were the most frequent alternative diagnoses. Children with ametropic amblyopia (8/26, 30.7%) were most frequently misdiagnosed. Risk factors that led to an initial diagnosi …

Radiosurgery for dural carotid-cavernous sinus fistulas: Gamma Knife compared with XKnife radiosurgery.

OBJECT: In the modern era, stereotactic radiosurgery is an important part of the multidisciplinary and multimodality approach used to treat … m, bilateral temporal lobe, and brainstem. Few adverse events occurred, but included 1 patient with optic neuritis (GKS group), 1 intracranial hemorrhage (XKnife group), 1 brainstem edema (XKnife), and 3 temporal lobe radiation edemas (XKnife). CONCLUSIONS: Radiosurgery affords a substantial chance of radiological and clinical improvement in patients with DCCFs …

Pediatric neuromyelitis optica spectrum disorders in Dakar: Insights from a preliminary multicentric case series in Senegal.

AIM: To describe the epidemiological, diagnostic, therapeutic, and outcome aspects of pediatric neuromyelitis optica spectrum disorders (NMOSD) in Dakar, Senegal. METHODS: We conducted a multicenter retrospective and prospective study including patients with pediatric-onset NMOSD (<18 years) diagnosed according to the 2015 Wingerchuk criteria. RESULTS: Over 7 years and 3 months, 8 children (7 females) were included, with a median age at symptom onset of 13.5 years (range 8-17). The main neurological manifestations during the disease course were myelitis (7/8), optic neuritis (5/8), and area …

Pediatric-onset multiple sclerosis in Finland.

INTRODUCTION: Although there are extensive data on multiple sclerosis (MS) in adults, the epidemiology and clinical features of pediatric-on … me from CIS to a diagnosis of MS in those diagnosed before 18 was 6 months. CIS phenotypes included optic neuritis (ON) in 23/73 (32%), acute disseminated encephalomyelitis (ADEM) in 10/73 (14%), transverse myelitis (TM) in 9/73 (12%), internuclear ophthalmoplegia (INO) in 5/73 (7%) and other or undefined monofocal presentations in 15/73 (21%) and multifocal pre …

Pediatric-Onset Neuromyelitis Optica Spectrum Disorder in Isfahan: Insights from a Cross-Sectional Study.

OBJECTIVES: Neuromyelitis optica spectrum disorder (NMOSD) is a rare autoimmune demyelinating disease of the central nervous system. While N … ified. The study cohort had a female-to-male ratio 2.6:1, with the most common onset symptoms being optic neuritis (ON) and transverse myelitis (TM). AQP4-Ab was positive in 66.7% of the patients, with longitudinally extensive transverse myelitis (LETM) being the most common MRI finding. Azathioprine and Rituximab were the most commonly used treatments in patien …

Профиль и полезность серума Цитокина для прогнозирования прогноза в Mielin Oligodendrocyte Glycoprotein Antibody-Associated болезня.

ЦЕЛИ: Охарактеризовать профиль сыворотки цитокина в миелине олигодендроците гликопротеиновых болезней, связанных с антителами (МОГАД), на начальном этапе и в ходе последующих мероприятий и оценить их полезность для прогнозирования рецидивов и инвалидности. МЕТОДЫ: Это ретроспективное многоцентральное когортное исследование охватывало пациентов в возрасте 16 МУГАД 2023 критерии при отборе проб сыворотки на основе базового уровня (≤3 Количество месяцев, прошедших с момента возникновения болезни) и последующих мероприятий≥6 Месяцы от базового уровня), а также возрастные соотношения и время до спа

Совпадение в аннотации оригинала
OBJECTIVES: To characterize the serum cytokine profile in myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) at onset a … = 0.036), IL8 (p = 0.012), and IL18 (p = 0.026) baseline levels compared with those with MS, in non-optic neuritis (ON) presentations. BAFF values increased over time, especially in patients with MOGAD treated with anti-CD20 (p = 0.002). Baseline BAFF, CXCL10, IL10, and IL8 levels correlated with disease severity at MOGAD onset (all p < 0.05). Finally, higher ba …

Случай опрометчивых иллюзий и онемения в качестве первоначального представления множественного склероза.

Множественный склероз (MS) — хроническое аутоиммунное демиелинизирующее заболевание центральной нервной системы (CNS), обычно вызывающее оптический неврит, моторную дисфункцию или сенсорные нарушения. Однако трудноразрешимые икоты в качестве первоначального проявления являются крайне редкими. Раннее распознавание таких нетипичных симптомов имеет решающее значение для своевременного диагностики и вмешательства. A 19-year-old у женщины были неразрешимые икота и прогрессирующая онемение, затронувшая ее правую руку и ствол. Неврологический осмотр выявил слабость верхней части правой конечности, се

Совпадение в аннотации оригинала
Multiple sclerosis (MS) is a chronic autoimmune demyelinating disease of the central nervous system (CNS), commonly presenting with optic neuritis, motor dysfunction, or sensory disturbances. However, intractable hiccups as an initial manifestation are exceedingly rare. Early recognition of such atypical symptoms is crucial for timely diagnosis and intervent…

Impact of Anti-MOG Antibody in Diagnosis of Autoimmune Diseases of the Central Nervous System in Children: A Case Series.

Autoimmune diseases of the central nervous system in children present a significant diagnostic challenge due to their heterogeneous nature. … ted, with 80% classified as ADS and 20% as AE. Within ADS, acute disseminated encephalomyelitis and optic neuritis were the most prevalent at 19%, followed by pediatric-onset multiple sclerosis at 17%, and transverse myelitis at 16%. AE cases were predominantly seropositive (93%), with a vast majority (92%) showing anti-NMDAR antibodies compared with 8% with ant …

Correlation between severe attacks and serum aquaporin-4 antibody titer in neuromyelitis optica spectrum disorder.

Aquaporin 4-immunoglobulin G (AQP4-IgG) specifically targets aquaporin 4 in approximately 80% of Neuromyelitis Optica Spectrum Disorder (NMO … cs and prognoses between the two groups were compared. Patients with AQP4 ( +) exhibited few severe optic neuritis (SON) attacks (false discovery rate [FDR] corrected p < 0.001), a reduced percentage experiencing SON attacks, and a lower incidence of visual disability than patients with AQP4 (+ +). Patients with AQP4 (+ +) and AQP4 ( +) NMOSD exhibited significa …

Epstein-Barr nuclear antigen 1 antibody-based indices are increased in patients with multiple sclerosis.

BACKGROUND: Multiple sclerosis (MS) is a chronic central nervous system (CNS) disease, which is diagnosed by a combination of clinical sympt … tions in serum and CSF of relapsing-remitting (RR)MS patients (n=61) (M:F 28:33, average 40 years), optic neuritis patients (n=26) (M:F 9:17, average 47 years) and healthy controls (HCs) (n=15) (M:F 8:7, average 43 years) were determined by enzyme-linked immunosorbent assay. The obtained EBNA1 IgG levels were compared to factors such as total IgG, albumin concen …

Through the Eyes of Uncertainty: Giant Cell Arteritis and Lyme Neuroborreliosis in a Story of Vision Loss.

Acute vision loss is a prevalent clinical manifestation associated with a broad spectrum of differential diagnoses, encompassing demyelinating diseases, neoplastic processes, autoimmune disorders, and infectious conditions. A rare but noteworthy infectious etiology contributing to acute vision loss is neurological Lyme disease (Lyme neuroborreliosis)-induced optic neuritis. Lyme disease, a vector-borne illness caused by the spirochete Borrelia burgdorferi, has the potential to affect multiple physiological systems and unfolds in three distinct stages. Another significant contributor to acute v…

Serum and Cerebrospinal Fluid Biomarkers in Neuromyelitis Optica Spectrum Disorder and Myelin Oligodendrocyte Glycoprotein Associated Disease.

The term neuromyelitis optica spectrum disorder (NMOSD) describes a group of clinical-MRI syndromes characterized by longitudinally extensive transverse myelitis, optic neuritis, brainstem dysfunction and/or, less commonly, encephalopathy. About 80% of patients harbor antibodies directed against the water channel aquaporin-4 (AQP4-IgG), expressed on astrocytes, which was found to be both a biomarker and a pathogenic cause of NMOSD. More recently, antibodies against myelin oligodendrocyte glycoprotein (MOG-IgG), have been found to be a biomarker of a different entity, termed MOG antibody-associ…

Developmental Eye Movement (DEM) and King-Devick (K-D) Performance in Multiple Sclerosis.

Eye movement disorders have been reported in patients with multiple sclerosis (MS) as saccadic disturbances. Several methods have been described for the assessment of saccades, including the K-D and DEM tests. The performance of these tests also involves attention, language, and other brain areas which have been reported to be altered in MS patients. The aim of the study was to determine how developmental eye movement (DEM) and King-Devick (K-D) tests are affected in MS-patients. It was also to analyze whether a resolved episode of optic neuritis (ON) has a negative influence. Subjects with MS…

Gadolinium-enhanced brain lesions in multiple sclerosis relapse.

OBJECTIVE: To study the clinico-radiological paradox in multiple sclerosis (MS) relapse by analyzing the number and location of gadolinium-e … 1.4% of patients with brainstem-cerebellum symptoms, 57.1% with spinal cord symptoms and 55.5% with optic neuritis (ON). Thirty percent of patients with brain symptoms did not have Gd+ lesions, and only 43.6% of patients had symptomatic Gd+ lesions. The univariate analysis showed a negative correlation between age and the number of Gd+ lesions (p=0.002). CONCLU …

Neuroinflammatory Disease following Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Children.

OBJECTIVE: To describe neurologic, radiologic and laboratory features in children with central nervous system (CNS) inflammatory disease com … cerebellar ataxia, acute disseminated encephalomyelitis, neuromyelitis optica spectrum disorder, or optic neuritis. All patients had a history of SARS-CoV-2 exposure, and all tested positive for circulating antibodies against SARS-CoV-2. At the onset of the neurologic disease, SARS-CoV-2 PCR results (nasopharyngeal swabs) were positive in 8 children. Cerebrospin …

Encephalitis with Extensive Cortical Brain Magnetic Resonance Imaging Changes Secondary to Myelin Oligodendrocyte Glycoprotein Antibody Disease.

BACKGROUND The relatively new autoimmune disorder, anti-myelin oligodendrocyte glycoprotein (MOG) disease is particularly interesting because of its broad range of presentations. This entity's appearance on magnetic resonance imaging (MRI) of the brain often makes identifying this disease a challenging process. Younger patients tend to present with an acute disseminated encephalomyelitis picture, with encephalopathy and multifocal neurological signs, while older patients are more likely to present with optic neuritis. We, however, report an atypical case of a patient who presented with encepha…

Magnetic Resonance Image in Monitor and Diagnosis of Patients with Neuromyelitis Optica.

This study was aimed to investigate the craniocerebral magnetic resonance imaging (MRI) measurement and clinical characteristics of patients with neuromyelitis optica (NMO) and multiple sclerosis (MS). 50 patients with NMO (NMO group) and 50 patients with MS (MS group) were studied. The clinical manifestations, brain injury morphology, MRI signal characteristics, brain distribution characteristics, and related laboratory tests (serum aquaporin 4 [AQP4] antibody) were statistically analyzed. The results showed that the analysis of clinical manifestations of patients revealed that optic neuritis…