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Dengue fever scoring system: new strategy for the early detection of acute dengue virus infection in Taiwan.

BACKGROUND/PURPOSE: Dengue fever is an important public health problem in Southern Taiwan. The purpose of this study was to develop a dengue scoring system using a three-stage process, which may be used as a guidance tool for the early diagnosis of dengue fever. METHODS: A retrospective study was conducted to identify factors useful for the early diagnosis of dengue fever. We assessed the clinical and laboratory features of 89 adult patients with dengue from 2002 to 2004 at a community-based hospital. They were compared with 14 patients with scrub typhus, 104 with Q fever, and 35 with murine …

Comparison of PanBio dengue duo enzyme-linked immunosorbent assay (ELISA) and MRL dengue fever virus immunoglobulin M capture ELISA for diagnosis of dengue virus infections in Southeast Asia.

The performances of the MRL dengue fever virus immunoglobulin M (IgM) capture enzyme-linked immunosorbent assay (ELISA) and the PanBio Dengue Duo IgM capture and IgG capture ELISA were compared. Eighty sera from patients with dengue virus infections, 24 sera from patients with Japanese encephalitis (JE), and 78 sera from patients with nonflavivirus infections, such as malaria, typhoid, leptospirosis, and scrub typhus, were used. The MRL test showed superior sensitivity for dengue virus infections (94 versus 89%), while the PanBio test showed superior specificity for JE (79 versus 25%) and othe…

Effectiveness of Montelukast in Reducing the Risk of Severe Dengue in Dengue Fever Patients: An Evidence-Based Case Report.

BACKGROUND: Dengue fever continues to spread worldwide, particularly in tropical regions. Some patients with dengue fever may progress to severe dengue, which is associated with significantly higher morbidity and mortality. Despite this, no definitive treatment has been found to prevent its progression. Montelukast, a leukotriene receptor antagonist, has shown potential in reducing plasma leakage, a key factor in the pathophysiology of severe dengue. Therefore, this study aimed to evaluate the effectiveness of montelukast in reducing the risk of severe dengue. METHODS: A systematic literature…

Localized Inflammation in Dengue Vaccine-Induced Skin Rash Is Not Associated with Continuous Presence of Dengue Virus Genome.

Vaccination with the tetravalent live-attenuated dengue virus (DENV) vaccines TV003 and TV005 causes a mild, relatively localized erythematous maculopapular skin rash in most dengue-naïve vaccinees. Human challenge model DENV strains, DENV2Δ30 and DENV3Δ30, trigger a confluent skin rash over most of the body in most unvaccinated participants. To determine the etiology of these rashes, we performed in situ hybridization for DENV genome and assessed cellular infiltration by H&E staining in skin biopsies from humans infected with live-attenuated dengue vaccine DENV2Δ30 or DENV3Δ30 challenge strai…

Association of total and dengue-specific IgE levels in the sera with dengue virus inhibition and antibody-dependent enhancement.

Dengue, caused by the dengue virus (DENV), poses a significant global health challenge. Effective vaccines and treatments for dengue are lacking due to gaps in understanding its pathogenesis and mechanisms in severe cases. This study investigates the role of immunoglobulin E (IgE) in dengue, focusing on its potential association with virus neutralization and antibody-dependent enhancement (ADE) in DENV replication. Serum samples were obtained from dengue-positive (dengue-IgG positive), SLE (dengue-IgG negative), and control (dengue-IgG and SLE-negative) individuals. SLE sera were included as a…

Dengue virus serotype did not contribute to clinical severity or mortality in Taiwan's largest dengue outbreak in 2015.

BACKGROUND: Dengue virus serotype 2 (DENV-2) was the major serotype in the 2015 dengue outbreak in Taiwan, while DENV-1 and DENV-3 were dominant between 2005 and 2014. We aimed to investigate whether DENV-2 contributed to disease severity and mortality in the outbreak in Kaohsiung city, Taiwan. METHODS: We collected serum samples from dengue patients to detect the presence of DENV and determine the serotypes by using quantitative reverse transcription-polymerase chain reaction. Our cohorts comprised 105 DENV-1-infected cases and 1,550 DENV-2-infected cases. Demographic data, DENV serotype, an…

Evidence of dengue virus in eviscerated specimens of panophthalmitis secondary to dengue fever: A possible cause-effect phenomenon.

PURPOSE: To report a retrospective series of three cases of infectious panophthalmitis post-dengue fever with ex vivo confirmation of dengue virusribonucleic acid (RNA) in the tissues of the eye. METHODS: Four eyes of three patients, who were diagnosed with panophthalmitis following dengue fever and who underwent evisceration, were included. All demographic and clinical data were recorded. The eviscerated samples were subjected to direct microscopy, culture for bacteria, fungi, and parasites, and molecular virology (dengue virus [DENV] NS1-specific reverse transcription loop-mediated isotherm…

[Spatial autocorrelation of dengue cases and molecular biological characteristics of envelope gene of dengue virus in Guangzhou, 2019].

Objective: Analyze epidemiological situation of dengue fever,and survey impacts of four serotypes dengue viruses in Guangzhou, 2019. Methods: Information of patients was collected in Notifiable Infectious Disease Report System (NIDRS). Spatial autocorrelation of dengue cases was evaluated using ArcGIS version 10.2. Serum samples were tested by real-time PCR. Virus strains were isolated from positive sera. Then E gene was sequenced. Phylogenetic trees were including PhyMLsoftwarev 3.1. Results: A total of 1 655 dengue cases, consisted of 1 382 local cases and 273 imported cases, was confirmed i…

Gall Bladder Wall Thickening in Dengue Fever - Aid in Labelling Dengue Hemorrhagic Fever and a Marker of Severity.

Introduction Dengue fever is a mosquito-borne viral disease spread by the bite of the Aedes aegypti mosquito. Dengue epidemics have contributed to a great economic burden, especially in South-East Asia. This study aimed to determine gall bladder wall thickness (GBWT) in patients with dengue fever, assess its sensitivity and specificity to identify dengue hemorrhagic fever, and also compare gall bladder wall thickening (GWBT) with platelets, hematocrit, and leucocyte count. Materials and methods This prospective observational study was conducted in the dengue ward of Benazir Bhutto Hospital, Ra…

Trends of fluid requirement in dengue fever and dengue haemorrhagic fever: a single centre experience in Sri Lanka.

BACKGROUND: Meticulous fluid management is the mainstay of treatment in dengue fever that is currently governed by consensus guidelines rather than by strong research evidence. To examine this issue we audited the fluid requirement of a cohort of adult patients with dengue fever (DF) and dengue haemorrhagic fever (DHF) in a tertiary care clinical setting. RESULTS: This retrospective cohort study was conducted from July 2012 to January 2013 in Teaching Hospital, Peradeniya, Sri Lanka. Adult patients with confirmed dengue infection managed according to the national and WHO guidelines were inclu…

Challenges in dengue fever in the elderly: atypical presentation and risk of severe dengue and hospital-acquired infection [corrected].

BACKGROUND/METHODS: To better understand dengue fever in the elderly, we compared clinical features, World Health Organization (WHO) dengue classification and outcomes between adult (<60) and elderly (≥60) dengue patients. We explored the impact of co-morbidity and hospital-acquired infection (HAI) on clinical outcomes in the elderly. All patients managed at the Communicable Disease Centre, Singapore, between 2005 and 2008 with positive dengue polymerase chain reaction (PCR) or who fulfilled WHO 1997 or 2009 probable dengue criteria with positive dengue IgM were included. RESULTS: Of the 6989…

Острый миокардит в геморрагической лихорадке денге: описание клинического случая и анализ сердечных осложнений у больных, страдающих денге.

Мы сообщаем о случае геморрагической лихорадки денге, вызванной острым миокардитом, и анализируем литературу. У 65-летней женщины ДГФ из-за серотипа 3 вируса денге, сложного с острым миокардитом и острым отёком легких. Клинически это маскировалось как острый инфаркт миокарда, с электрокардиографическим депрессивным сегментом ST в пикиальных векторах и повышенным сыворотным сердечным тропонином I уровня. 3 дня спустя пациент, получивший поддержку со стороны руководства, выздоровел. В ходе обыска в Пубмеде было обнаружено в общей сложности 18 соответствующих статей с участием 339 больных, страда

Совпадение в аннотации оригинала
We report a case of dengue hemorrhagic fever (DHF) complicated by acute myocarditis and review the literature. A 65-year-old woman experienced DHF due to dengue virus serotype 3, complicated with acute myocarditis and acute pulmonary edema. Clinically this masqueraded as acute myocardial infarction, with an electrocardiographically depressed ST segment in pr…

Concurrent infections by all four dengue virus serotypes during an outbreak of dengue in 2006 in Delhi, India.

BACKGROUND: Co-circulation of multiple dengue virus serotypes has been reported from many parts of the world including India, however concurrent infection with more than one serotype of dengue viruses in the same individual is rarely documented. An outbreak of dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS) occurred in and around Delhi in 2006. This is the first report from India with high percentage of concurrent infections with different dengue virus serotypes circulating during one outbreak. RESULTS: Acute phase sera from patients were tested for the presence of dengue virus RNA b…

Knowledge, attitude and practices related to dengue in rural and slum areas of Delhi after the dengue epidemic of 1996.

To assess the knowledge and attitudes about dengue and practice of prevention followed by the residents of a rural area and an urban resettlement colony of East Delhi, an interview based cross sectional KAP study was undertaken in Jan 97 to Feb 97, a few months after the dengue epidemic in rural area and urban areas of East Delhi. A pre-structured and pre-tested format containing the relevant questions was administered to the subjects. A total of 687 subjects (334 rural and 353 urban) were interviewed. Nearly four fifth (82.3%) of these were aware of Dengue. Audiovisual media was the most comm…

Preventing dengue/dengue haemorrhagic fever outbreaks in the National Capital Territory of Delhi--the role of entomological surveillance.

Outbreaks of Dengue/Dengue Haemorrhagic Fever have been occurring in the National Capital Territory (NCT) Delhi from time to time. A massive outbreak of Dengue/DHF causing considerable mortality occurred in 1996 in the NCT, Delhi. Since this outbreak regular entomological surveillance has been instituted, for timely preventive action against Dengue/DHF. The Central Cross Checking Organisation (CCO) of the National Malaria Eradication Programme cross-checks Aedes surveillance activities in Delhi. In this paper we present our experiences in entomological surveillance in relation Dengue, to share…

Protective Role of Vitamins C, D, and K in the Management of Dengue: A Narrative Review to Combat the Dengue Outbreak.

BACKGROUND AND AIMS: Dengue fever is mostly found in tropical and subtropical regions and is spread by mosquitoes. Still now, no specific antiviral medication is available against the disease. However, several vitamins have been identified as potential dengue therapy supplements. Therefore, this study aimed to comprehensively gather data on the protective role of vitamins C, D, and K in the treatment of dengue fever. METHODS: To conduct the present narrative review, we retrieved data from Google Scholar, Web of Science, PubMed, Cochrane Library, BanglaJOL, Embase, and Scopus regarding the inf…

Prospective Evaluation of the FUJIFILM SILVAMP Dengue NS1 Ag for Early Dengue Detection: A Multicenter Study in Thailand.

Early detection of dengue is crucial to prevent severe outcomes. This multicenter prospective cohort study evaluated the performance of the FUJIFILM SILVAMP Dengue NS1 rapid test (SILVAMP NS1) compared to a commercially available rapid NS1 test (non-SILVAMP NS1) and NS1 enzyme-linked immunosorbent assay (ELISA), using real-time reverse transcription polymerase chain reaction (rRT-PCR) as the primary reference standard. A total of 402 patients with acute febrile illness were enrolled across four hospitals in Thailand between March 2023 and September 2024. Clinical features and baseline laborato…

The impact of blood pressure indicators and shock indices on hazard of complicated dengue in hospitalized adults with dengue infection.

Blood pressure monitoring is crucial for early detection of complicated dengue. We investigated the association between blood pressure indicators and complicated dengue hazard over the course of dengue hospitalization in a well-characterized dengue cohort. This study involved 4789 adult dengue patients hospitalized between 2005 and 2008 who did not have complicated dengue (defined as dengue haemorrhagic fever and/or severe dengue) initially. Cases (n = 689) included patients who progressed to complicated dengue during hospitalization, while controls were patients who did not (n = 4100). We use…

Impact of tetravalent dengue vaccination with screening, ADE, and altered infectivity on single-serotype dengue and Zika transmission.

Acquired immunity to a dengue virus serotype (whether by infection or the only licensed dengue vaccine) can produce antibody-dependent enhancement (ADE) in later infections with another dengue serotype, resulting in higher viral loads and more severe symptoms such as dengue hemorrhagic fever, unless the person already has immunity to multiple dengue serotypes. Screening to confirm dengue seropositivity is therefore recommended before vaccination. Recent studies suggest that the closely-related Zika virus may also interact with dengue through ADE. This study uses a mathematical model to evaluat…