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Intranasal co-administration of 1,8-cineole with influenza vaccine provide cross-protection against influenza virus infection.

BACKGROUND: Vaccination is the most efficient means for protection against influenza. However, the various vaccines have low efficacy to pro … to investigate the potential use of i.n. co-administration of 1,8-cineole, a major component of the Eucalyptus essential oils, with influenza vaccine and whether could provide cross-protection against influenza virus infection in a mouse model. STUDY DESIGN: I.n. co-administration of 1,8-cineole in two doses (6.25 and 12.5 mg/kg) with influenza vaccine was …

Caries inhibition efficacy of an antiplaque/antigingivitis dentifrice.

PURPOSE: To evaluate the efficacy of a fluoride dentifrice containing a fixed combination of essential oils (Thymol, Menthol, Eucalyptol, and Methyl Salicylate) in preventing caries in Sprague Dawley rats. MATERIALS AND METHODS: The dentifrice contains 0.76% sodium monofluorophosphate (SMFP) as the fluoride source and a silica abrasive system. A fluoride-free placebo and a clinically proven USP dentifrice reference standard for SMFP/silica were included as controls. Three groups of 45 SDV-free Sprague Dawley weanlings were infected by a cariogenic strain of Streptococcus sobrinus and fed cari

Subgingival ultrasonic instrumentation of residual pockets irrigated with essential oils: a randomized controlled trial.

AIM: To evaluate the clinical efficacy of subgingival ultrasonic instrumentation irrigated with essential oils (EOs) of residual periodontal pockets. MATERIAL AND METHODS: Sixty-four individuals with chronic periodontitis were invited to participate in this randomized, double-blind, parallel, and placebo-controlled clinical trial. All subjects received non-surgical periodontal therapy. After re-evaluation (baseline), residual pockets (pocket depth ≥5 mm) received test (ultrasonic instrumentation irrigated with EOs) or control therapy (ultrasonic instrumentation irrigated with negative control

Effect of an essential oil-containing dentifrice on dental plaque microbial composition.

PURPOSE: To determine the effect of 6 months use of an essential oil-containing (EO) antiplaque/antigingivitis fluoride dentifrice on the balance of the oral microbial flora and on the emergence of resistant microbial forms by analysis of dental plaque and saliva. MATERIALS AND METHODS: The dentifrice essential oils consisted of a fixed combination of thymol, menthol, methyl salicylate, and eucalyptol. An identical fluoride-containing dentifrice without the essential oils served as the control. A subgroup of 66 subjects from a clinical trial population of 321 was randomly selected for charact

Efficacy of Combined Visual-Olfactory Training With Patient-Preferred Scents as Treatment for Patients With COVID-19 Resultant Olfactory Loss: A Randomized Clinical Trial.

IMPORTANCE: The number of olfactory dysfunction cases has increased dramatically because of the COVID-19 pandemic. Identifying therapies tha … ween odors for 3 months. Participants in the physician-assigned odor arms trained with rose, lemon, eucalyptus, and clove. Participants randomized to the patient-preferred arms chose 4 of 24 available scents. If assigned to the bimodal arm, participants were shown digital images of the essential oil they were smelling. MAIN OUTCOMES AND MEASURES: The primar …

New and Interesting Fungi. 8.

Eight new genera, 28 new species, four epitypes, two lectotypes, and 21 interesting new host and / or geographical records are introduced in … sslia solidaginis (on dead stems of Solidago sp., Germany), Paraacanthostigma eucalypti (on bark of Eucalyptus globulus, Australia), Phaeococcomyces mesembryanthemi (on Mesembryanthemum schultzii, South Africa), Phialemonium parasulfureum (on algae, Germany), Phytophthora caput-medusae (from rhizosphere soil of Citrus × aurantium, Italy), Pleurophragmium fal …

Fungal Planet description sheets: 1478-1549.

Novel species of fungi described in this study include those from various countries as follows: Australia, Aschersonia mackerrasiae on white … borealis from roots of Vitis berlandieri × Vitis rupestris, Sympoventuria eucalyptorum on leaves of Eucalyptus sp., and Tuber conchae from soil. Sweden, Inocybe bidumensis on calcareous soil. Thailand, Cordyceps sandindaengensis on Lepidoptera pupa, buried in soil, Ophiocordyceps kuchinaraiensis on Coleoptera larva, buried in soil, and Samsoniella winandae o …

Anti-Cancer Potential of Cannabinoids, Terpenes, and Flavonoids Present in Cannabis.

In recent years, and even more since its legalization in several jurisdictions, cannabis and the endocannabinoid system have received an increasing amount of interest related to their potential exploitation in clinical settings. Cannabinoids have been suggested and shown to be effective in the treatment of various conditions. In cancer, the endocannabinoid system is altered in numerous types of tumours and can relate to cancer prognosis and disease outcome. Additionally, cannabinoids display anticancer effects in several models by suppressing the proliferation, migration and/or invasion of can

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… Eucalyptol Eucalyptol, also known as 1,8-cineole, gets its name from Eucalyptus, as it is the major constituent of eucalyptus oil. Wormwood, rosemary, and sage also contain this compound. Eucalyptol is a cyclic ether and monoterpenoid with a fresh, minty aroma. … Alpha-Phellandrene α-phellandrene and β-phellandrene are cyclic monoterpenes. α-phellandrene was named after Eucalyptus phellandra , now called Eucalyptus radiata . …

Essential oils and their constituents as anticancer agents: a mechanistic view.

Exploring natural plant products as an option to find new chemical entities as anticancer agents is one of the fastest growing areas of research. Recently, in the last decade, essential oils (EOs) have been under study for their use in cancer therapy and the present review is an attempt to collect and document the available studies indicating EOs and their constituents as anticancer agents. This review enlists nearly 130 studies of EOs from various plant species and their constituents that have been studied so far for their anticancer potential and these studies have been classified as in vitr

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… Patients suffering from such malodour were reported to have improvement in their state on treatment of these ulcers with the mixture of EOs having eucalyptus, melaleuca, lemongrass, lemon, clove leaf, and thyme on a 40% ethanol base [ 110 ]. … sideroxylon and Eucalyptus torquata Cancer Biology and Therapy 2008 7 3 399 403 2-s2.0-45349084126 18075306 10.4161/cbt.7.3.5367 154 Diaz C Quesada S Brenes O Aguilar G Ciccio JF Chemical composition of Schinus molle essential oil and its cytotoxic activity on tumour cell lines Natural Product Research …

Interventions for managing halitosis.

BACKGROUND: Halitosis or bad breath is a symptom in which a noticeably unpleasant breath odour is present due to an underlying oral or syste … ce). No data were reported for patient-reported OLT score or adverse events. Chewing gums: for 0.6% eucalyptus chewing gum versus placebo chewing gum, the evidence was very uncertain for the outcome dentist-reported OLT scores (MD -0.10, 95% CI -0.31 to 0.11; 1 trial, 65 participants; very low-certainty evidence). No data were reported for patient-reported O …

Платеже-Rich Plasma-Derived Exosom Olficy Инъекции для лечения травматического обесценения

Фон: В последнее время для лечения травматической обонятельной дисфункции, связанной с болезнью коронавируса, использовались носовые инъекции плазмы с высоким содержанием тромбоцитов (РРП). 2019. Однако в настоящее время экзосомы, получаемые из плазмы, богатой тромбоцитами, становятся ключевыми факторами, влияющими на активность ПРП, и, по сравнению с ПРП, характеризуются высокой устойчивостью и минимальной иммуногенностью. Представление дела: Мы описали случай 27-year-old женщина, которая потеряла свою обонятельную функцию после того, как ударилась головой 8 июль 2022. Анализ запаха показал п

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… She was treated with zinc gluconate (10mg, three times a day) along with OT, which used 4 separate bottles of PEA, lemon, eucalyptus, and clove oil. Patients were told to sniff each odorant for 10 s, twice a day. Until 5 September 2023, her olfactory function did not improve. …

Targeted phytotherapy: essential oils, multi-target cancer action & nanodelivery.

Biochemical components of essential oils (EOs) are an innovative but largely underexplored type of precision phytotherapy (PT) in oncology owing to their anticancer activity against many types of tumors. This article discusses the important multitargeted molecular mechanisms of EOs (apoptosis, cell cycle arrest, angiogenesis, metastasis, tumor microenvironment) and their role as antitumor agents. In particular, an effort has been made to emphasize on the most notable volatile EOs such as thymol, eugenol, limonene, β-caryophyllene, and their interaction with oncogenic signaling pathways (NF-κB,

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… Moreover Eucalyptus oil inhibits NF-κB in macrophages associated with cancer by releasing cytokines from TNF-α, IL-6, NO, iNOS and COX-2 ( 197 ), which leads to a normalization of the microenvironment. …

Интегрин α4β7:: патогенные роли в заболеваниях метаболики и воспаления и в терапии перевода.

Интегрин α4β7 является ключевым рецептором сцепления, который является посредником лимфоцита, движущегося к кишечной слизи через взаимодействие с MAdCAM-1, VCAM-1, и фибронектин, тем самым играя центральную роль в иммунной слежке и мукозаловом иммунитете. Появляющиеся данные расширили его функциональный охват за пределы кишечного гомеостаза, с тем чтобы охватить различные подстрекательские и метаболические заболевания. В настоящем обзоре систематически резюмируются структурные характеристики, взаимодействия лигандов и положения о соответствии α.4β7, с акцентом на патогенную роль в провокационн

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… action: it inhibits the trafficking of leukocytes to the gut mucosa by blocking the α4β7/MAdCAM-1 interaction, and it reduces the retention of lymphocytes, particularly CD8+ T cells, within the intraepithelial compartment by blocking the αEβ7/E-cadherin interaction. 182 , 185 While a Phase II trial (EUCALYPTUS …

Complexity and clinical significance of drug-drug interactions (DDIs) in oncology: challenging issues in the care of patients regarding cancer-associated thrombosis (CAT).

Cancer patients have an increased risk of developing venous thromboembolic events. Anticoagulation management includes prophylactic or therapeutic doses of low molecular weight heparins (LMWHs) or direct oral anticoagulants (DOACs). However, the management of thrombosis in patients with cancer is complex due to various individual and disease-related factors, including drug-drug interactions (DDIs). Furthermore, DDIs may impact both, cancer and venous thrombosis, treatment effectiveness and safety; their relevance is highlighted by the advances in cancer therapeutics. Given that these new oncol

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… Orange, grapefruit, eucalyptus, garlic, grape juice, licorice, peppermint are the best-known herbs and foods that inhibit CYP3A4 [ 34 ]. Ginkgo biloba, berberine, green tea, grape juice, curcumin are also inhibitors of the P-gp [ 34 ]. …

Nursing Procedures for the Prevention and Treatment of Mucositis Induced by Cancer Therapies: Clinical Practice Guideline Based on an Interdisciplinary Consensus Process and a Systematic Literature Search.

BackgroundPatients with cancer receiving tumor therapy often suffer from oral mucositis.ObjectivesThe aim of this project was to summarize experiences with nursing procedures by experts in integrative oncology and to establish recommendations for nursing interventions that can prevent or cure mucositis.MethodsThe study design was an interdisciplinary consensus process based on a systematic literature search.ResultsThe panel discussed and agreed on 19 nursing procedures, which included mouthwashes, such as teas, supplements, oil applications, and different kinds of ice cubes to suck, as well as

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… acid, xylitol, 9,11-linoleic acid, palmitic acid Saliva Natura oral spray for treating xerostomia | Natural extract of the plant yerba santa ( Eriodictyon crassifolium , “holy herb”) Kamistad STADA | Lidocaine hydrochloride and extracts of chamomile flowers Repha-Os oral spray | Stevia leaves extract, eucalyptus …

New Avenues and Major Achievements in Phytocompounds Research for Glioblastoma Therapy.

Phytocompounds have been evaluated for their anti-glioblastoma actions for decades, with promising results from preclinical studies but only limited translation into clinics. Indeed, by targeting multiple signaling pathways deregulated in cancer, they often show high efficacy in the in vitro studies, but their poor bioavailability, low tumor accumulation, and rapid clearance compromise their efficacy in vivo. Here, we present the new avenues in phytocompound research for the improvement of glioblastoma therapy, including the ways to enhance the response to temozolomide using phytochemicals, th

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… One of the more recent studies assessed the anti-glioma potential of eucalyptal A, a compound with phloroglucinol-terpene skeleton isolated from the fruit of Eucalyptus globulus . Hua et al. tested its anti-GBM activity using in vitro LN229 and U87MG cell lines and in vivo mouse models. …

Piper nigrum Extract: Dietary Supplement for Reducing Mammary Tumor Incidence and Chemotherapy-Induced Toxicity.

A low piperine fractional Piper nigrum extract (PFPE) was prepared by mixing cold-pressed coconut oil and honey in distilled water, namely, PFPE-CH. In this study, PFPE-CH was orally administered as a dietary supplement to decrease the risk of tumor formation and reduce the side effects of chemotherapeutic drugs during breast cancer treatment. The toxicity study demonstrated no mortality or adverse effects after administrating PFPE-CH at 5000 mg/kg during a 14-day observation period. Additionally, PFPE-CH at 86 mg/kg BW/day did not cause any harm to the kidney or liver function of the rats for

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… Correlation between chemical composition and antibacterial activity of essential oils from fifteen Eucalyptus species growing in the Korbous and Jbel Abderrahman arboreta (North East Tunisia) Molecules. 2012;17:3044–3057. doi: 10.3390/molecules17033044. 45. …

Hair Dye Ingredients and Potential Health Risks from Exposure to Hair Dyeing.

Given the worldwide popularity of hair dyeing, there is an urgent need to understand the toxicities and risks associated with exposure to chemicals found in hair dye formulations. Hair dyes are categorized as oxidative and nonoxidative in terms of their chemical composition and ingredients. For several decades, the expert panel's Cosmetic Ingredient Review (CIR) has assessed the safety of many of the chemicals used in hair dyes; however, a comprehensive review of hair dye ingredients and the risk of exposure to hair dyeing has not been documented. Herein, we review the safety of the various ch

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… is associated with inhibition of IL-8, IL-6, and TNF-α secretion from stimulated human mast cells. 49 The resulting color intensity that can be achieved by some plant colorants, such as pure henna, is time dependent. 47 Some darkening substances in proprietary formulas, such as lemon oil, vinegar, eucalyptus …

Resveratrol from Dietary Supplement to a Drug Candidate: An Assessment of Potential.

Resveratrol (RVT) is a well known phyto-chemical and is widely used in dietary supplements and botanical products. It shows a wide range of pharmacological/beneficial effects. Therefore, it can be a potential candidate to be developed as phyto-pharmaceutical. Multiple diseases are reported to be treated by the therapeutic effect of RVT since it has antioxidant, anti-cancer activity and anti-inflammatory activities. It also has a major role in diabetes, arthritis, cardiac disorder and platelet aggregation etc. The major requirements are establishments regarding safety, efficacy profile and phys

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… Additionally, it is also found in plants such as eucalyptus, spruce, and lily, as well as in foods such as mulberries, peanuts, blueberries, strawberries, hops, and their derivatives [ 14 , 15 ]. …

Deciphering the Potentials of Cardamom in Cancer Prevention and Therapy: From Kitchen to Clinic.

Cardamom (cardamum) is a spice produced from the seeds of several Elettaria and Amomum plants of the Zingiberaceae family. Cardamom has been demonstrated to offer numerous benefits, including its antioxidant, antimicrobial, anti-inflammatory, and other metabolic (anti-diabetic) properties, and its potential to reduce cancer risk. Recently, researchers have extracted and tested multiple phytochemicals from cardamom to assess their potential effectiveness against various types of human malignancy. These studies have indicated that cardamom can help overcome drug resistance to standard chemothera

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… Solar energy-based extraction of essential oils from cloves, cinnamon, orange, lemon, eucalyptus, and cardamom: A clean energy technology for green extraction. J. Food Process Eng. 2022;45:e14038. doi: 10.1111/jfpe.14038. 20. Zhang J., Zhang M., Ju R., Chen K., Bhandari B., Wang H. …