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Oral infection with periodontal pathogens induced chronic obstructive pulmonary disease-like lung changes in mice.

BACKGROUND: Epidemiological studies have demonstrated that periodontitis is an independent risk factor for chronic obstructive pulmonary dis … models with oral infection by typical periodontal pathogens, porphyromonas gingivalis (Pg group) or fusobacterium nucleatum (Fn group), over a three-month period. Mice that did not receive oral infection were set as the control group (C group). We assessed the level of alveolar bone resorption, lung function, and histological changes in the lungs of the mice. Additionall …

[Brain abscess in retroperitoneal perforated colonic diverticulitis].

The most frequent complications in diverticular disease are local abscess, perforation with peritoneal sepsis, fistula and ileus. Extraabdominal manifestation is an actual rarity. A haematogenous bacterial spread via portal vein with formation of liver abscess has seldom been described. But a complicated diverticular disease as a cause for a brain abscess is an absolute rarity. Our case presents a patient with brain abscess caused by asymptomatic, retroperitoneal perforated colonic diverticulosis. We discuss diagnostic steps both in diverticular disease and brain abscess and different surgical

Engineering bio-selectivity: Novel denture coatings for targeted inhibition of denture-associated pathogens.

The increasing prevalence of denture use, particularly among the elderly population, necessitates effective strategies against Candida-containing polymicrobial biofilms. This study investigated novel temporary (biocompatible hydrogel) and permanent (sealant) denture coatings designed to selectively inhibit associated pathogens. Seven biomaterials were screened using minimum inhibitory concentration (MIC) assays against Candida albicans, Fusobacterium nucleatum, and Streptococcus mutans. Coatings were applied to acrylic surfaces and evaluated for physicochemical properties and antimicrobial eff…

A synergistic strategy of AIE and electron asymmetry anchored in covalent organic frameworks for enhanced periodontitis photodynamic therapy.

Periodontitis, a widespread inflammatory disease, is difficult to treat effectively due to incomplete mechanical cleaning and increasing ant … cies (ROS) generation. It showed strong antibacterial activity against Porphyromonas gingivalis and Fusobacterium nucleatum in vitro and demonstrated effective periodontitis treatment with decreased inflammatory responses in vivo. This work pioneered the integration of AIE and LAED in COFs, providing a promising antibiotic-free strategy for periodontal therapy.

Influence of magnesium oxide nanoparticles on in vitro mechanical and antibacterial performance of self-curing dental polymethyl-methacrylate.

Self-curing polymethyl methacrylate is widely used for provisional restorations, retainers and denture repairs, but its lack of antibacteria … is, Prevotella intermedia, Streptococcus sanguinis, Streptococcus sobrinus, Eikenella corrodens and Fusobacterium nucleatum sensu stricto. Nanoparticles (1, 3 and 5 wt%) were incorporated into the polymer powder and polymerized. Flexural strength, elastic modulus, water sorption and solubility were determined. Antibacterial activity was assessed in broth cultures and qua …

Множественные пациенты, страдающие склерозом, имеют оральный дисбиоз с уменьшением числа колонизаторов и более низким уровнем гипотаурина.

Хотя дисбиоз кишечного микробиома связан с патобиологией множественного склероза (MS), роль перорального микробиома (OM), второго по величине микробиома, по-прежнему недостаточно понятна. Кроме того, в то время как слюнный метаболом связан с другими нейродегенеративными заболеваниями, его роль в людях с релапсирующими-излучающими MS (pwRRMS), наиболее распространенной формой MS, неизвестна. Комбинируя метагеномику дробовика с нецелевой метаболомией, мы выявили уменьшение изобилия нескольких ранних колонизирующих видов, включая Стрептококококку и Актиномику в ПВИРМС, и обогащение бактерий с пат

Совпадение в аннотации оригинала
Although gut microbiome dysbiosis is implicated in the pathobiology of multiple sclerosis (MS), the role of the oral microbiome (OM), the se … ococcus and Actinomyces in pwRRMS and an enrichment of bacteria with pathogenic potential including Fusobacterium nucleatum, Porphyromonas gingivalis, and several Prevotella species. pwRRMS had an altered metabolite profile including a decreased hypotaurine compared to healthy controls. Thus we report altered oral microbiome and metabolome in pwRRMS which might contribut …

A case of Lemierre's syndrome with double vision as the first symptom.

Lemierre's syndrome is a serious disease that typically causes oropharyngeal infection with internal jugular vein thrombosis, followed by distant infection focus, such as septic pulmonary embolism. The main causative organisms are anaerobic bacteria in the oral cavity, namely Fusobacterium necrophorum. We encountered an extremely rare case of Lemierre's syndrome, where double vision was found to be the first symptom. The patient's blood culture results showed the presence of F. nucleatum, which spread from the sphenoid sinus to the skull base because of chronic sinusitis; the patient presented

NOD1 and NOD2 mediate sensing of periodontal pathogens.

In bacterial infection, Nucleotide-binding Oligomerization Domain (NOD) 1 and NOD2 induce innate immune responses by recognizing fragments of the bacterial component peptidoglycan (PGN). To determine the roles of these receptors in detection of periodontal pathogens, we stimulated human embryonic kidney cells expressing NOD1 or NOD2 with heat-killed Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, and Fusobacterium nucleatum or their soluble PGNs (sPGNs). All bacteria and their sPGNs could stimulate activation of NF-kappaB. However, there were differences in NOD1- and NOD2-stim…

TGF-beta1 Inhibits TLR-mediated odontoblast responses to oral bacteria.

TGF-beta1 exerts diverse functions in tooth development and tissue repair, but its role in microbial defenses of the tooth is not well-under … n receptors TLR2 and TLR4 on the cell surface. Porphyromonas gingivalis, Prevotella intermedia, and Fusobacterium nucleatum activated both TLRs, but TLR4 played a greater role. Lack of cell-surface TLR2 was associated with poor response to Streptococcus mutans, Enterococcus faecalis, and Lactobacillus casei. TGF-beta1 inhibited TLR2 and TLR4 expression and attenuated odo …

The association of anaerobic bacteria with infectious mononucleosis.

This review summarizes the information that supports the potential importance of anaerobic bacteria in the pharyngo-tonsillitis (PT) associa … in-Barr virus. This explanation is supported by the increased recovery of Prevotella intermedia and Fusobacterium nucleatum from the tonsillar surfaces during the acute phases of IM and an immune response against these organisms by patients with IM. Although more studies are needed, these findings support the possible pathogenicity of Gram-negative anaerobic bacteria in …

Molecular and immunological characterization of a 64-kDa protein of Actinobacillus actinomycetemcomitans.

The 64-kDa protein to which about half the sera from patients with localized juvenile periodontitis and rapidly progressive periodontitis re … corrodens but not with any cellular proteins of Porphyromonas gingivalis, Prevotella intermedia and Fusobacterium nucleatum. It is possible that antibodies reactive to the 64-kDa protein in periodontitis patients are induced by the cross-reactivity with the hsp60 proteins of other bacteria.

Correlation between thermal sensitivity and microorganisms isolated from deep carious dentin.

The correlation between thermal sensitivity and the microorganisms present in 29 deep carious lesions was studied. The numbers of lactobacilli and total Gram-positive rods in the carious lesions were found to be negatively related to the length of pain triggered by cold and heat stimulants. The presence of Gram-positive cocci and non-black-pigmented Bacteroides were positively associated with both cold and heat sensitivities. Black-pigmented Bacteroides, Streptococcus mutans, and total anaerobic colony counts were positively related to the heat sensitivity. Recovery of Fusobacterium nucleatum,…

Peritonsillar abscess, retropharyngeal abscess, mediastinitis, and nonclostridial anaerobic myonecrosis: a case report.

Peritonsillar abscess is a potentially life-threatening complication of acute tonsillitis. On occasion, peritonsillar abscess can extend to … and group F streptococci, and Citrobacter diversus. Culture of the retropharyngeal abscess yielded Fusobacterium nucleatum and Actinomyces odontolyticus in addition to most of the aforementioned organisms. The patient underwent repeated drainage and debridement procedures and was treated with various antimicrobial agents and ultimately recovered. This case highlights th …

Antimicrobial Efficacy of Rhamnolipid Biosurfactant Against Multi-Species Endodontic Biofilm: A Comparative In Vitro Study.

OBJECTIVE: Persistent root canal infections are driven by resilient multi-species biofilms that withstand conventional irrigants. This in vitro study aimed to compare the antimicrobial efficacy of rhamnolipid (RHL) with NaOCl against a multi-species endodontic biofilm. METHODS: A 4-species biofilm (Enterococcus faecalis, Streptococcus mutans, Fusobacterium nucleatum, Staphylococcus aureus) was developed on human dentine discs over 21 days under anaerobic conditions to simulate infected root canals. Biofilm-laden specimens were treated for 10 minutes with RHL at 1×, 2× and 4× the minimum inhib…

Cytokine responses of CD4+ T cells and NKT cells to periodontitis-associated bacteria in individuals with or without periodontitis.

AIM: Periodontitis is an inflammatory disease driven by opportunistic bacteria including Porphyromonas gingivalis and Fusobacterium nucleatum, where T-cell and NKT-cell responses to these bacteria in patients with periodontitis grade B or C are not fully elucidated. The objective is to determine if exaggerated proinflammatory Th-cell responses to periodontitis-associated bacteria, but not commensal bacteria, is a characteristic of increased periodontitis grade. METHODS: Mononuclear cells from patients with periodontitis grade C (n = 26) or grade B (n = 33) and healthy controls (HCs; n = 26) w…

The influence of periodontal disease and periodontal treatment on colorectal cancer.

BACKGROUND: Periodontal disease (PD) is associated with more than 50 diseases and conditions, including colorectal cancer. The study aimed to investigate if periodontal treatment influences the blood levels of C-reactive protein (CRP) in colorectal cancer patients. In addition, the aim was to isolate periodontal pathogenic bacteria Fusobacterium nucleatum (FN) and Porphyromonas gingivalis (PG), which are most linked to colorectal cancer (CRC), from the mucosa of the cancer-affected intestine. PATIENTS AND METHODS: To assess the effect of periodontal treatment on colorectal cancer, we measured…

Antibiotic Resistance in Patients with Peri-Implantitis: A Systematic Scoping Review.

The implementation of adjunctive antibiotics has been recommended for the therapy of peri-implantitis (PI). In this review, antibiotic resis … ection criteria. These studies evaluated 214 implants in 168 patients. Porphyromonas gingivalis and Fusobacterium nucleatum mainly presented high resistance to tetracycline, metronidazole, and erythromycin in PI patients. Similarly, Aggregatibacter actinomycetemcomitans was also highly resistant to clindamycin and doxycycline. Other microorganisms such as Tannerella …

Prevalence of six periodontal pathogens in subgingival samples of Italian patients with chronic periodontitis.

The aim of this study was to investigate the subgingival prevalence of six periodontal pathogens in 352 Italian patients with chronic period … s gingivalis (Pg), Treponema denticola (Td), Tannerella forsythia (Tf), Prevotella intermedia (Pi), Fusobacterium nucleatum (Fn) and Aggregatibacter actinomycetemcomitans (Aa) were investigated. Fn resulted the most frequently detected (95%) while Tf showed the highest load (12x105 cells/plaque sample). Aa was the less represented bacteria for load and presence. Bacteria …

Ferumoxytol nanozymes effectively target chronic biofilm infections in apical periodontitis.

Bacterial biofilms are pervasive and recalcitrant to current antimicrobials, causing numerous infections. Iron oxide nanozymes, including an … without adverse effects. FMX binds efficiently to the bacterial pathogens Enterococcus faecalis and Fusobacterium nucleatum and remains catalytically active without being affected by dental tissues. This allows for effective eradication of endodontic biofilms via on-site free radical generation without inducing cytotoxicity. Unexpectedly, FMX promotes growth of stem cell …