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Squamous cell carcinoma of the renal pelvis presenting with hypercalcemia.

A case of hypercalcemia associated with documented squamous cell carcinoma of the renal pelvis without bony metastasis is reported. Pseudohyperparathyroidism was suspected strongly because of the radioimmunoassay values of parathormone. This was confirmed by the prompt decrease of serum calcium after removal of the neoplasm. The radiologic findings were non-specific.

Beyond Malignancy: Clinical Insights from Three Cases of Severe Hypercalcemia.

Severe hypercalcemia is a life-threatening condition requiring immediate treatment alongside a systematic evaluation to identify the underlying cause. Although malignancy is a common etiology among hospitalized patients, alternative causes must be considered to guide targeted therapy, as illustrated in these cases. The first case involved a 31-year-old postpartum woman with corrected calcium levels of 14.5 mg/dL and suppressed PTH. Hypercalcemia resolved after tapering and temporary cessation of breastfeeding, consistent with lactation-associated hypercalcemia that is likely PTHrP-mediated. Th…

Hypercalcemia due to PTHrp producing pancreas NET: A case report.

INTRODUCTION: Secretion of parathormone related peptide (PTHrp) is the most common cause of tumor-associated hypercalcemia. This occurs most often in squamous cell carcinomas in the ear nose and throat, bronchial and breast carcinomas. We report a rare case of a PTHrp-producing pancreatic neuroendocrine tumor (pNET) and provide a brief review of the literature. CASE PRESENTATION: A 68-year-old female patient with epigastric pain and weight loss was diagnosed with a 11 × 8 × 9 cm tumor in the pancreatic body with infiltration of the splenic vein and consecutive portal vein thrombosis without e…

Dual-mediated PTH and Osteolytic Hypercalcemia in Metastatic Endometrial Carcinoma.

Hypercalcemia of malignancy (HCM) occurs frequently in advanced stage cancer and can be secondary to many different etiologies. This case illustrates a rare case of dual-mediated PTH and osteolytic HCM in the setting of metastatic endometrial carcinoma. The patient's hypercalcemia was refractory to initial treatment with IV hydration, calcitonin, and zoledronic acid, eventually requiring the addition of denosumab therapy and cinacalcet. After 15 days of treatment, the patient's calcium concentration returned to normal levels. Owing to elevated PTH levels, other etiologies of hypercalcemia were…

Systemic sarcoidosis presenting with hypercalcemia, sinusitis and hypothalamic-pituitary dysfunction.

OBJECTIVES: Sarcoidosis is a multi-system granulomatous disease of unknown origin. It is mainly thought of as a lung disease but it can affect any organ system. Sinus and endocrine dysfunctions are described but are rare and seldomly linked with sarcoidosis. METHODS: Here we describe a case of a young Caucasian man who already visited multiple care givers for sinusitis, erectile dysfunction and anorexia. He presented at the emergency department with fever and emaciation, polyuria and polydipsia. The results of the blood sampling revealed a hypercalcaemia as well as abnormal thyroid function.

Disseminated tuberculosis presented with explicit hypercalcemia: A clinical case report.

KEY CLINICAL MESSAGE: Tuberculosis (TB) is a rare but known reason for hypercalcemia usually in those with underlying conditions such as renal failure, diabetes, or severe anemia. It is essential to consider TB in those with refractory or resistant hypercalcemia. ABSTRACT: Hypercalcemia or a calcium level above 10.5 mg/dL can be a manifestation of TB that only became symptomatic in a small percentage of the patients. Patients with underlying diseases such as renal failure are more prone to poor prognosis. It is essential to use anti-TB drugs besides hypercalcemia standard treatment to maintai…

Prenatal bone abnormalities in three cases of familial hypocalciuric hypercalcemia.

INTRODUCTION: Prenatal diagnosis of bone and mineralization anomalies is associated with a wide range of etiologies and prognoses. The impro … trimester ultrasound of pregnancy. Postnatal follow-up showed transitory hyperparathyroidism, with hypercalcemia and hypocalciuria. METHODS: Sanger sequencing performed after birth in the three newborns revealed a monoallelic pathogenic variant in the CASR gene, encoding the calcium sensing receptor, confirming the diagnosis of familial hypocalciuric hypercal …

Synthol systemic complications: Hypercalcemia and pulmonary granulomatosis. A case report.

INTRODUCTION: Synthol injection for body contouring has been used by bodybuilders for some time. We report two extremely rare systemic complications; pulmonary granulomatosis and hypercalcemia, in a woman who has received Synthol injections for buttocks augmentation. PRESENTATION OF CASE: The case discussed in this report is of a 36-year-old lady who presented for severe hypercalcemia and nephrocalcinosis. Subsequent workup revealed granulomas in the buttocks and in the lungs. Upon questioning, it was discovered that she had received Synthol injection for buttocks augmentation a few months ea…

Hypercalcemia-Leukocytosis syndrome and adenosquamous lung carcinoma: An overlooked conjugation.

Hypercalcaemia and leukocytosis are two paraneoplastic conditions associated with poor prognosis. Adenosquamous carcinoma is a rare and aggressive histological subtype of lung cancer consisting of adenocarcinoma and squamous cell components. We report the case of a 57-year-old male smoker who was admitted to the Emergency Room with skull and neck tumefactions, confusion and deteriorated general condition. The complementary study in the ER revealed severe hypercalcaemia (19.8 mg/dL), leukocytosis (18.7 × 109/L) and extensive osteolytic lesions of the skull on cranioencephalic computer tomograph

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… In the presence of non-PTH-mediated hypercalcemia, PTH levels should be suppressed or low-normal. … Prevalence of hypercalcemia among cancer patients in the United States. Cancer Medicine , 5 ( 8 ), 2091–2100. DOI 10.1002/cam4.749. 12. Stewart, A. F. (2005). Clinical practice. Hypercalcemia associated with cancer. New England Journal of Medicine , 352 ( 4 ), 373–379. …

Autoimmune Hypercalcemia Due to Autoantibodies Against the Calcium-sensing Receptor.

CONTEXT: Autoimmune hypocalciuric hypercalcemia (AHH) is an acquired disorder caused by the presence of blocking autoantibodies against the calcium-sensing receptor (CaSR). Few cases of this condition have been described to date in the literature. OBJECTIVE: The objectives of this study were to describe 2 patients in whom the presence of AHH was suspected and to assess the patients for the presence of CaSR antibodies. METHODS: CaSR antibodies were detected and characterised by immunoprecipitation assays, CaSR peptide ELISAs, and functional assays based on the calcium-stimulated accumulation …

Intrahepatic Cholangiocarcinoma Associated with High Procalcitonin, Hypercalcemia, Polycythemia and Leukocytosis.

Intrahepatic cholangiocarcinomas or bile duct cancers comprise approximately 10-20% of all cholangiocarcinomas and may present with right upper quadrant pain, weight loss, liver enzyme abnormalities or they may be completely asymptomatic and be picked incidentally on routine abdominal imaging. Typically, hepatocellular carcinomas have been associated with various paraneoplastic syndromes such as hypercalcemia, erythrocytosis, hypoglycemia, diarrhea and skin changes though paraneoplastic syndromes in the setting of cholangiocarcinoma do occur as well. Cholangiocarcinomas are usually associated …