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Grzybowski's Generalized Eruptive Keratoacanthomas in a Patient with Terminal Kidney Disease-An Unmet Medical Need Equally Ameliorated by Topical Imiquimod Cream and Lapacho Tea Wraps: A Case Report.

IntroductionDevelopment of singular keratoacanthoma (KA) is generally considered a benign condition as it has a tendency to regress spontaneously in spite of histological similarity to squamous cell carcinoma. Most KAs undergo excision to rule out differential diagnoses. Several alternative treatment modalities (keratinolytic, ablative, immunomodulating, antiproliferative, or targeted therapy) have been described in the past with varying success, underlining the therapeutic challenges associated with large or multiple lesions. Isomorphic response (Koebner phenomenon) may limit the efficacy of

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… The permanent medication consisted of felodipine, bisoprolol, clonidine, ramipril, urapidil, cholecalciferol, acetylsalicylic acid, allopurinol, phenprocoumon, thyroxine, iodine, fluvastatin, calcium acetate, omeprazole, and sevelamer carbonate. …

Strategies to overcome myeloid cell induced immune suppression in the tumor microenvironment.

Cancer progression and metastasis due to tumor immune evasion and drug resistance is strongly associated with immune suppressive cellular responses, particularly in the case of metastatic tumors. The myeloid cell component plays a key role within the tumor microenvironment (TME) and disrupts both adaptive and innate immune cell responses leading to loss of tumor control. Therefore, strategies to eliminate or modulate the myeloid cell compartment of the TME are increasingly attractive to non-specifically increase anti-tumoral immunity and enhance existing immunotherapies. This review covers cur

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… Treatment in Pancreatic Cancer | Recruiting | No Results Available | Pancreatic Ductal Adenocarcinoma | Combination Product: Paricalcitol, Hydroxychloroquine, Losartan|Other: Neoadjuvant therapy and surgery only (Control) | Early Phase 1 | 20 5 | NCT01234922 | Benazepril Hydrochloride, Lisinopril, Ramipril … Hypertension in Patients With Solid Tumors | Terminated | Protocol was closed early due to slow accrual, no SAE observed | Hypertension|Unspecified Adult Solid Tumor, Protocol Specific | Drug: lisinopril|Drug: losartan potassium|Other: laboratory biomarker analysis|Drug: benazepril hydrochloride|Drug: ramipril …

Repurposing drugs for highly prevalent diseases: pentoxifylline, an old drug and a new opportunity for diabetic kidney disease.

Diabetic kidney disease is one of the most frequent complications in patients with diabetes and constitutes a major cause of end-stage kidney disease. The prevalence of diabetic kidney disease continues to increase as a result of the growing epidemic of diabetes and obesity. Therefore, there is mounting urgency to design and optimize novel strategies and drugs that delay the progression of this pathology and contain this trend. The new approaches should go beyond the current therapy focussed on the control of traditional risk factors such as hyperglycaemia and hypertension. In this scenario, d

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… Renal outcomes with telmisartan, ramipril, or both, in people at high vascular risk (The ONTARGET study): a multicentre, randomised, double-blind, controlled trial. Lancet 2008; 372: 547–553 23. Esteras R, Perez-Gomez MV, Rodriguez-Osorio Let al. …

Выявляется высокий уровень использования медицинских услуг после операции на шейном позвоночнике с использованием комплексных методов прогнозирования.

Расходы на медицинское обслуживание пациентов с хроническими заболеваниями позвоночника и пациентов, проходящих хирургическую операцию, продолжают расти заметными темпами. Таким образом, выявление пациентов, подверженных риску в плане более широкого использования послеоперационного медицинского обслуживания, имеет решающее значение для оптимизации результатов медицинского обслуживания и распределения ресурсов. Цель нашего исследования заключается в использовании целого ряда предоперабельных характеристик пациентов, включая всеобъемлющую медицинскую, хирургическую и социальную историю, для разр

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… M5020” | Lumbar disc herniation | “M5126” | Prior FBSS | “M961” | Prior pseudoarthrosis | “M960” Preoperative medication use | ACE inhibitors | Binary Defined by a prescription or order placed for these medications during the 90 day preoperative windoww | “captopril”, “lisinopril”, “enalapril”, “ramipril …

Сердечно-когнитивные ассоциации в период физиологических проблем, связанных с повторным множественным склерозом.

КОЛИЧЕСКАЯ ОСНОВА: Когнитивное нарушение, особенно снижение скорости обработки информации (ИПС), является клинически значимым проявлением множественного склероза (МС). Тест с использованием символических дигитов (SDMT) является чувствительным, проверенным показателем IPS, широко используемым в исследованиях MS. В то время как сосудистые и гемодинамические факторы все чаще признаются в качестве факторов, способствующих когнитивной эффективности в MS, их взаимосвязь с IPS с различными физиологическими проблемами остается неизученной.ЦЕЛЬ: В рамках этого экспериментального исследования были проан

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… One PwMS was also taking several non-DMT medications that could potentially influence hemodynamic or autonomic function, including ramipril, nadolol, silodosin, amitriptyline, and fampridine. One healthy participant was taking amitriptyline. …

Unlocking Novel Therapeutic Potential of Angiotensin II Receptor Blockers.

Pharmaceutical companies keep producing novel drugs and drug treatments for improving the life of every sick individual, most often following a pattern; a specific drug for a specific condition. Evidence suggests that different medications can have a positive effect on different pathological conditions. The full potential of existing therapies can be revealed through drug repurposing-also referred to as drug repositioning, reprofiling, or re-tasking-which involves identifying new therapeutic uses for approved or investigational drugs beyond their original indications. One significant target in

Chronic stress in solid tumor development: from mechanisms to interventions.

Chronic stress results in disturbances of body hormones through the neuroendocrine system. Cancer patients often experience recurrent anxiety and restlessness during disease progression and treatment, which aggravates disease progression and hinders treatment effects. Recent studies have shown that chronic stress-regulated neuroendocrine systems secret hormones to activate many signaling pathways related to tumor development in tumor cells. The activated neuroendocrine system acts not only on tumor cells but also modulates the survival and metabolic changes of surrounding non-cancerous cells.

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… Ramucirumab (IMC-1121B) docetaxel | NCT00703326 BC | 2 | 2 | Completed | Zero AEs have been reported/observed during and at the end of treatment | Propranolol | No | No | NCT02596867 BC | 262 | 3 | Completed | Prevention of LVEF decline and cardiac remodeling related to cancer treatment | Bisoprolol | No | Ramipril … | 2 | Completed | Not reported | Carvedilol | No | Herceptin | NCT02177175 BC | 20 | 1 | Completed | The use of standard-of-care treatments for left ventricular impairment using ACE-I and BBs for trastuzumab therapy-induced left ventricular dysfunction is safe and improves LVEFs | Carvedilol | No | Ramipril …

Cardiotoxicity Induced by Anticancer Therapies: A Call for Integrated Cardio-Oncology Practice.

The introduction of novel oncologic therapies, including targeted agents, immunotherapies, and antibody-drug conjugates, has transformed the therapeutic landscape of cancer care. This evolution has resulted in a dual clinical scenario; while survival outcomes have markedly improved, leading to a growing population of long-term cancer survivors, an increasing incidence of previously unrecognized treatment-related toxicities has emerged. Among these, cardiovascular adverse events represent some of the most prevalent and clinically significant complications observed in both conventional chemother

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… Other studies testing enalapril or ramipril have yielded mixed or negative results, particularly when used in low-risk populations or in short-term follow-up. Beta-blockers (BBs), particularly carvedilol and bisoprolol, have also demonstrated efficacy in preventing CTRCD. … In contrast, a factorial trial using ramipril and bisoprolol showed significant reductions in subclinical cardiac damage, suggesting a possible benefit in early myocardial injury prevention [ 134 ]. …

Heart Failure in Older Patients: An Update.

Heart failure (HF) is a clinical syndrome with high incidence and prevalence and high morbidity and death rate, even in the short term, representing a serious public health issue, mainly in older people. It is a growing cause for hospital admission in this age group, being frequently associated with several comorbidities, further aggravating the disease's course. Moreover, older HF patients are usually affected by clinical conditions, like frailty, malnutrition, and cachexia, which significantly impact the overall management of HF and need to be properly identified and treated. Diagnosing and

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… Regarding older subgroups, in the HOPE study (Heart Outcomes Prevention and Evaluation), ramipril significantly reduced cardiovascular mortality by 26%, all-cause mortality by 16%, stroke by 32%, and heart failure by 23% in high-risk elderly patients (>65 years) with pre-existing cardiovascular disease … Effects of an Angiotensin-Converting–Enzyme Inhibitor, Ramipril, on Cardiovascular Events in High-Risk Patients N. Engl. J. Med. 2000 342 145 153 10.1056/NEJM200001203420301 10639539 72. Aronow W.S. Fleg J.L. Pepine C.J. Artinian N.T. Bakris G. Brown A.S. Ferdinand K.C. Ann Forciea M. …

Exploration and Development of PPAR Modulators in Health and Disease: An Update of Clinical Evidence.

Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors that govern the expression of genes responsible for energy metabolism, cellular development, and differentiation. Their crucial biological roles dictate the significance of PPAR-targeting synthetic ligands in medical research and drug discovery. Clinical implications of PPAR agonists span across a wide range of health conditions, including metabolic diseases, chronic inflammatory diseases, infections, autoimmune diseases, neurological and psychiatric disorders, and malignancies. In this review we aim to consolidate exist

A narrative review on trazodone as a multimodal and multifunctional antidepressant: clinical relevance of formulations, dosing, and pharmacokinetic/pharmacodynamic targets.

BackgroundTrazodone, an antidepressant, has only been approved for use in major depressive disorder (MDD), but has demonstrated potent therapeutic potential in various conditions, such as insomnia and anxiety. It targets multiple serotonergic, adrenergic, and histaminergic receptors. Given this multimodal and multifunctional profile, we aimed to provide a comprehensive overview of the pharmacodynamic and pharmacokinetic properties of trazodone and its clinical applications across various conditions.Main textTrazodone demonstrates sedative and anxiolytic effects even at a low dose (25-75 mg) an

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… She was on ramipril 5 mg and nebivolol 5 mg each morning for hypertension. Given the clinical picture at the initial visit (characterized by late-life adjustment depression with prominent anxiety and insomnia), we initiated trazodone IR oral [10 drops (~ 25 mg)] in the evening. …

Efficacy of Polymer-Based Nanocarriers for Co-Delivery of Curcumin and Selected Anticancer Drugs.

Cancer remains a heavy health burden resulting in a high rate of mortality around the world. The presently used anticancer drugs suffer from several shortcomings, such as drug toxicity, poor biodegradability and bioavailability, and poor water solubility and drug resistance. Cancer is treated effectively by combination therapy whereby two or more anticancer drugs are employed. Most of the combination chemotherapies result in a synergistic effect and overcome drug resistance. Furthermore, the design of polymer-based nanocarriers for combination therapy has been reported by several researchers t

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… Three drugs that target the renin-angiotensin system, Ramipril, Lisinopril, and Valsartan, increased the plasma levels of curcumin and THC in three cancer patients infused with Lipocurc™. …

Животные модели периферической нейропатии, вызванной химиотерапией, для гематологических заболеваний: обзор.

Химиотерапия это one основные виды лечения гематологовых магнестов. Однако периферическая нейропатия, вызванная химиотерапией (CIPN) one Наиболее часто встречающиеся долгосрочные токсичные реакции в химиотерапии, а также случаи CIPN влияют на качество жизни пациентов и могут приводить к прерыванию химиотерапии в тяжелых случаях, снижая тем самым эффективность химиотерапии. В настоящее время мы резюмируем существующие зверские модели CIPN, включая характеристики нескольких общих животных моделей, таких, как периферическая нейропатия, вызванная бортезомибами, периферическая нейропатия, вызванная

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… Ramipril alleviates oxaliplatin‐induced acute pain syndrome in mice. Front Pharmacol. 2021;12:712442. 10.3389/fphar.2021.712442 70. Liu H, Xu R, Huang H. …

Artificial intelligence in drug discovery and development.

Artificial intelligence-integrated drug discovery and development has accelerated the growth of the pharmaceutical sector, leading to a revolutionary change in the pharma industry. Here, we discuss areas of integration, tools, and techniques utilized in enforcing AI, ongoing challenges, and ways to overcome them.

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… A quality by design approach using artificial intelligence techniques to control the critical quality attributes of ramipril tablets manufactured by wet granulation Pharm. Dev. Technol. 18 2013 236 245 22881350 10.3109/10837450.2012.705294 96 Goh W.Y. …

Improving Kidney Disease Care: One Giant Leap for Nephrology.

Nephrology is an ever-evolving field of medicine. The importance of such a discipline is related to the high clinical impact of kidney disease. In fact, abnormalities of kidney function and/or structure are common in the general population, reaching an overall prevalence of about 10%. More importantly, the onset of kidney damage is related to a strikingly high risk of cardiovascular events, mortality, and progression to kidney failure which, in turn, compromises quality and duration of life. Attempts to comprehend the pathogenesis and molecular mechanisms involved in kidney disease occurrence

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… The GISEN Group (Gruppo Italiano di Studi Epidemiologici in Nefrologia) Randomised placebo-controlled trial of effect of ramipril on decline in glomerular filtration rate and risk of terminal renal failure in proteinuric, non-diabetic nephropathy Lancet 1997 349 1857 1863 10.1016/S0140-6736(96)11445- …

Primed for global coronavirus pandemic: Emerging research and clinical outcome.

The global effort to combat and contain the coronavirus disease 2019 (COVID-19) caused by the recently discovered severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is now proceeding on a war footing. The world was slow to react to the developing crisis, but once the contours of the impending calamity became evident, the different state and non-state actors have raced to put their act together. The COVID-19 pandemic has blatantly exposed the shortcomings of our healthcare system and the limitations of medical science, despite considerable advances in recent years. To effectively tack

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… Sceinces, Iran | Phase-II/III IRCT20190727044343N2 (ICTPR) | Used to prevent cardiovascular disease 84 | Almitrine ( 87 ) | Assistance Publique– Hôpitaufx de Paris (AP-HP), France | Phase-III NCT04357457 ( ClinicalTrials.gov ) | Agonist of peripheral chemoreceptors present on the carotid bodies 85 | Ramipril …

Molecular Mechanisms and Biomarkers Associated with Chemotherapy-Induced AKI.

Acute kidney injury (AKI) is a life-threatening condition characterized by a rapid and transient decrease in kidney function. AKI is part of an array of conditions collectively defined as acute kidney diseases (AKD). In AKD, persistent kidney damage and dysfunction lead to chronic kidney disease (CKD) over time. A variety of insults can trigger AKI; however, chemotherapy-associated nephrotoxicity is increasingly recognized as a significant side effect of chemotherapy. New biomarkers are urgently needed to identify patients at high risk of developing chemotherapy-associated nephrotoxicity and s

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… Randomised Placebo-Controlled Trial of Effect of Ramipril on Decline in Glomerular Filtration Rate and Risk of Terminal Renal Failure in Proteinuric, Non-Diabetic Nephropathy The GISEN Group (Gruppo Italiano Di Studi Epidemiologici in Nefrologia) Lancet 1997 349 1857 1863 9217756 212. Tang H. …

Artificial Intelligence and Machine Learning Technology Driven Modern Drug Discovery and Development.

The discovery and advances of medicines may be considered as the ultimate relevant translational science effort that adds to human invulnerability and happiness. But advancing a fresh medication is a quite convoluted, costly, and protracted operation, normally costing USD ~2.6 billion and consuming a mean time span of 12 years. Methods to cut back expenditure and hasten new drug discovery have prompted an arduous and compelling brainstorming exercise in the pharmaceutical industry. The engagement of Artificial Intelligence (AI), including the deep-learning (DL) component in particular, has bee

Epigenetic modification in diabetic kidney disease.

Diabetic kidney disease (DKD) is a common microangiopathy in diabetic patients and the main cause of death in diabetic patients. The main manifestations of DKD are proteinuria and decreased renal filtration capacity. The glomerular filtration rate and urinary albumin level are two of the most important hallmarks of the progression of DKD. The classical treatment of DKD is controlling blood glucose and blood pressure. However, the commonly used clinical therapeutic strategies and the existing biomarkers only partially slow the progression of DKD and roughly predict disease progression. Therefor

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… She started medical therapy (bisoprolol 2.5 mg, ramipril 2,5 mg, furosemide 25 mg, canrenone 50 mg). …