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An Amide-Carboxylic Acid Compound as Gel Structure Breaker to Improve the Rheology of Oil-Based Drilling Fluids.

High-density oil-based drilling fluids (OBDFs) are widely used in drilling operations, but during their application, the viscosity of the fl … stability were also tested. Finally, the mechanism of OCD was analyzed through contact angle tests, particle size analysis, and microstructural observations. The experimental results demonstrated that OCD could effectively reduce the viscosity of various high-density OBDFs. Adding 2 wt% of OCD reduced the apparent viscosity of laboratory-prepared OBDFs by 20.4% …

Use of a scattered light sensor for monitoring the dispersed surface in multimodal system.

The article presented here deals with the quality parameter dispersed surface in material systems like suspensions or dispersions in which several phases are present simultaneously such as solids in continuous solution. Here, other quality parameters are relevant for the quality of the products than, for example, in pure solutions or gases. The dispersed surface is relevant for reaction rates, absorption capacity, and many other properties of the suspension. In contrast to the common method of measuring particle size distributions and solid concentrations in a complex manner, the article shows…

Повышение терапевтической эффективности финголимода за счет внутриназальных поставок в модели множественного склероза, вызванной этимидиумом.

Множественный склероз (MS) — хроническая аутоиммунная неврология, характеризующаяся мышечной слабостью, онеменностью, покалыванием, проблемами зрения и трудностями в координации и равновесии, вызванными повреждением содержания миелина в нервных волокнах. Недавняя литература свидетельствует о том, что наряду с их механизмом предотвращения приступов лимфоцитов финголимод (ФПГ) может также служить нейрозащитой, обеспечивая их более широкий доступ к мозгу. Таким образом, в рамках этого проекта наличие мозга у ФПГ было увеличено за счет доставки ППГ в виде наночастиц.НОВЫЕ МЕТОДЫ: Твердые наночасти

Совпадение в аннотации оригинала
BACKGROUND: Multiple sclerosis (MS) is a chronic inflammatory autoimmune neurological characterized by muscle weakness, numbness, tingling, … ncentration; X3) and response were established by factorial design. FNG-SLNs were characterized for particle size, entrapment efficiency and in-vitro drug release. Optimized formulations were characterized for in-vivo efficacy study in ethidium bromide-induced MS rat model. RESULT: Obtained data revealed that the particle size and entrapment efficiency of FNG- …

ROS-responsive nanomicelles encapsulating celastrol ameliorate pressure overload-induced cardiac hypertrophy by regulating the NF-κB signaling pathway.

Celastrol (CEL) belongs to the group of non-steroidal immunosuppressants with the potential to improve cardiac hypertrophy (CH). However, th … olymer encapsulating CEL (DBD@CEL), was synthesized using chemical synthesis. Then, the morphology, particle size, drug-loaded content, and ROS-responsive release behavior of DBD@CEL were studied. Pharmacokinetics and biocompatibility were evaluated using healthy mice. Finally, the ability and mechanism of DBD@CEL in improving CH in vivo were investigated using …

Preparation of pH-responsive polyurethane nano micelles and their antibacterial application.

Considering the differences in pH between bacterial infection microenvironment and normal tissues, a series of pH-responsive drug-release am … ). We loaded a model drug called triclosan onto DPU-g-PEG micelles and studied how pH affects their particle size, Zeta potential, and drug release performance. The results revealed that when exposed to acidic conditions, the surface potential of DPU-g-PEG micelles changed, the micelles' particle size increased, and the drug release performance was significantl …

Utilization of response surface design for development and optimization of rosuvastatin calcium-loaded nano-squarticles for hair growth stimulating VEGF and IGF production: in-vitro and in-vivo evaluation.

INTRODUCTION: Countless individuals experience negative emotions as hair loss pattern affects their self-esteem and well-being. Rosuvastatin … onic® F68 (PF68) and the percentage of liquid lipids within the core of the SQRs and the effects of particle size, entrapment efficiency, and drug released percentage after 24 h (%Q24) were assessed. The optimized formula was subjected to DSC, XRD, and in-vivo evaluation in rats. RESULTS: SQRs stabilized by 0.8% PF68 and contained 37.5% liquid lipids showed an …

Bolus Texture Testing as a Clinical Method for Evaluating Food Oral Processing and Choking Risk: A Pilot Study.

PURPOSE: Choking on food is a leading cause of accidental death in several populations, including children, people with intellectual/developmental disability, and older adults in residential care facilities. One contributor to choking risk is incomplete oral processing and failure to convert food to a cohesive, nonsticky bolus with a maximum particle size that will not block the airway. Clinical tests of mastication do not evaluate properties of chewed food boluses. We characterized expectorated boluses, after oral processing, using methods developed by the International Dysphagia Diet Standar…

Mechanical behavior and corrosion resistance of sol-gel derived 45S5 bioactive glass coating on Ti6Al4V synthesized by electrophoretic deposition.

The purpose of this work is the synthesis and the characterization of sol-gel derived 45S5 bioactive glass coatings deposited onto Ti6Al4V alloy substrates. This coating aims the improvement of the biocompatibility of metallic implants for use in dentistry and orthopedy. The 45S5 bioactive glass powder was synthetized by the sol-gel process and the coatings were produced by the electrophoretic deposition technique (EPD). A grinding protocol was developed to reduce the particle size distribution of the sol-gel powder in order to obtain a stable suspension needed for the electrophoretic depositi…

Targeted Therapy of Non-Small Cell Lung Cancer and Liver Cancer: Functional Nanocarriers for the Delivery of Cisplatin and Tissue Factor Pathway Inhibitor-2.

INTRODUCTION: The aim of the study was to construct folic acid-modified PEGylated paramagnetic nanoparticles (MNPs) co-carrying tissue facto … ion spectrum, and dynamic light scattering were employed to characterize the morphology, structure, particle size, and zeta potential of the nanocomposite. The phenylenediamine method was used to detect the loading of CDDP, and the CCK-8 assay was used to detect the toxic effect of the nanocomposite on HUVECs, A549, and NCI-H460 cells. In tumor-bearing mice mod …

Micronization of Thebaine Extracted from Papaver bracteatum Lindl. Using Supercritical Fluid Technology.

BACKGROUND: Thebaine, as a main opiate alkaloid extracted from Papaveraceae plants, is widely used in the synthesis of many pharmaceutical ingredients such as buprenorphine, naltrexone, naloxone, and hydrocodone. Nevertheless, thebaine and related derivatives are often insoluble in aqueous media and have low bioavailability in digestive systems. OBJECTIVE: Reducing particle size and changing the morphology can mitigate the mentioned problem. In this study, extraction of thebaine from the capsule, stem, and root of Papaver bracteatum L. was optimized and micronization of extract components was…

Distance dilution of antibiotic resistance genes of sediments in an estuary system in relation to coastal cities.

Coastal tourist and industrial cities are most likely to have differential effects on the distance dilution of antibiotic resistance genes ( … abundance and number of ARGs and mobile genetic elements (MGEs) were positively correlated with the particle size and total organic carbon (TOC) contents of sediments, whereas they were negatively associated with the oxidation and reduction potential (Eh) and pH of sediments, as well as the seawater salinity. The sediment particle size (SPZ) was the dominant ph …

Development of Perphenazine-Loaded Solid Lipid Nanoparticles: Statistical Optimization and Cytotoxicity Studies.

OBJECTIVE: Perphenazine (PPZ), as a typical antipsychotic medical substance, has the same effectiveness compared to atypical antipsychotic m … stical optimization was done by the Box-Behnken design method to achieve formulation with optimized particle size, entrapment efficiency, and zeta potential. Also, transmission electron microscopy, in vitro release behavior, differential scanning calorimetry (DSC), and powder X-ray diffractometry (P-XRD) studies and cytotoxicity studies were assessed. RESULTS: …

Formulation, optimization, and nephrotoxicity evaluation of an antifungal in situ nasal gel loaded with voriconazole‒clove oil transferosomal nanoparticles.

Fungal infections of the paranasal cavity are among the most widely spread illnesses nowadays. The aim of the current study was to estimate the effectiveness of an in situ gel loaded with voriconazole‒clove oil nano-transferosomes (VRC-CO-NT) in enhancing the activity of voriconazole against Aspergillus flavus, which causes rhinosinusitis. The nephrotoxic side effects of voriconazole may be reduced through the incorporation of the clove oil, which has antioxidant activity that protects tissue. The Box‒Behnken design was applied to formulate the VRC-CO-NT. The particle size, entrapment efficien…

Formulation of Aceclofenac Tablets Using Nanosuspension as Granulating Agent: An Attempt to Enhance Dissolution Rate and Oral Bioavailability.

PURPOSE: The aim of the studies was to fabricate aceclofenac (AC) tablets using nanosuspension as granulating fluid to boost its rate of in vitro dissolution and eventually its oral bioavailability. METHODS: The optimized nanosuspension with particle size of 112±2.01 nm was fabricated using HPMC 1% (w/v), PVP-K30 1% (w/v) and SLS 0.12% (w/v) at 400 watts of ultrasonication energy for 15 min duration and 3 sec pause. Then, the optimized aceclofenac nanosuspension was used as granulating fluid for aceclofenac tablets formulation. The characterization was performed using Malvern zetasizer, SEM, …

Roles of Relative Humidity in Aerosol Pollution Aggravation over Central China during Wintertime.

Aerosol pollution elicits considerable public concern due to the adverse influence on air quality, climate change, and human health. Outside … measurements. The results show that, aerosol pollution in Wuhan is dominated by PM2.5 (aerodynamic particle size not larger than 2.5 μm) on wet days (RH ≥ 60%), with the averaged mass fraction of 0.62 for PM10. Based on the RH dependence of aerosol light scattering (f (RH)), aerosol hygroscopicity was evaluated and shows the high dependence on the particle siz …

Risk Assessment Integrated QbD Approach for Development of Optimized Bicontinuous Mucoadhesive Limicubes for Oral Delivery of Rosuvastatin.

Statins are widely prescribed for hyperlipidemia, cancer, and Alzheimer's disease but are facing some inherent challenges such as low solubi … t to modulate and improve the biopharmaceutical performance affecting key attributes, viz., average particle size (Y1 = 1.40-2.70 μ), entrapment efficiency (Y2 = 62.60-88.80%), and drug loading (Y3 = 0.817-1.15%), in QbD-enabled process. The optimal performance of developed Limicubes exhibited an average particle size of 1.8 ± 0.2 μ, entrapment efficiency 80.32 …

Enhanced Both in vitro and in vivo Kinetics by SLNs Induced Transdermal System of Furosemide: A Novel Approach.

BACKGROUND: Furosemide is a potent diuretic agent used to treat pulmonary arterial hypertension. Variable dosage regimen and poor pharmacoki … omogenization and ultra-sonication method; optimization was done based on entrapment efficiency and particle size. Optimized SLNs were incorporated in to transdermal patches by solvent casting method. In vitro and in vivo studies were carried out for characterization of transdermal patches. RESULTS: SLNs of F9 (GMS: Span 60: Pluronic F 68 in 6:2.5:0.2) were op …

Co-instillation of nano-solid magnesium hydroxide enhances corneal permeability of dissolved timolol.

We prepared magnesium hydroxide (MH) nanoparticles by a bead mill method, and investigated whether the co-instillation of MH nanoparticles improves the low transcorneal penetration of water-soluble drugs, such as the anti-glaucoma eye drug timolol maleate (TM). MH particle size was decreased by the bead mill treatment to a mean particle size of 71 nm. In addition, the MH nanoparticles were highly stable. Next, we demonstrated the effect of MH nanoparticles on the corneal surface. MH shows only slight solubility in lacrimal fluid, and the instillation of MH nanoparticles for 14 days did not aff…

Antioxidative Protection of Squalene Adjuvant and Rabies Vaccine with Adjuvant.

The authors verified the possibility of antioxidative protection of squalene adjuvant emulsions by the antioxidants α-tocopherol and β-carot … the emulsions. The stability of the emulsions was evaluated by the determination of the emulsion's particle size. The level of rabies antibodies (RAB) in mice sera until day 90 after vaccination, was determined by the rapid fluorescent focus inhibition test. In the in vitro system of squalene adjuvant, α-tocopherol acted as a prooxidant, while β-carotene effec …

Influence of magnesium stearate on the physicochemical and pharmacodynamic characteristics of insulin-loaded Eudragit entrapped mucoadhesive microspheres.

Effective oral insulin delivery has remained a challenge to the pharmaceutical industry. This study was designed to evaluate the effect of magnesium stearate on the properties of insulin-loaded Eudragit® RL 100 entrapped mucoadhesive microspheres. Microspheres containing Eudragit® RL 100, insulin, and varying concentrations of magnesium stearate (agglomeration-preventing agent) were prepared by emulsification-coacervation method and characterized with respect to differential scanning calorimetry (DSC), morphology, particle size, loading efficiency, mucoadhesive and micromeritics properties. Th…