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Unilateral hypoglossal nerve palsy: as the only presentation of tuberculosis.

INTRODUCTION: Older age has been associated to serious adverse events (AE) following yellow fever (YF) vaccination in passive surveillance studies, but few prospective studies involving seniors have been published. RESULTS: A total of 906 persons were evaluated; 78 were not vaccinated and 828 received the vaccine; 700 (84.7%) were interviewed after vaccination: 593 (84.7%) did not report any symptoms or signs following YF vaccine; 107 (15.3%) reported at least one AE temporally associated to YF vaccination: 97 (13.9%) had systemic AE and 17 (2.4%) reported AE at the injection site (7 had both…

Vaccination and risk of type 1 diabetes mellitus in active component U.S. Military, 2002-2008.

AIMS/HYPOTHESIS: To evaluate whether vaccination increases the risk of type 1 diabetes mellitus in active component U.S. military personnel. … =0.83; 95% CI (0.72, 0.95)], measles mumps rubella vaccine (MMR) [RR=0.71, 95% CI (0.61, 0.83)], or yellow fever vaccine [RR=0.70; 95% CI (0.59, 0.82)]. CONCLUSIONS: We did not find an increased risk of diagnosed type 1 diabetes and any of the study vaccines. We recommend that follow-up studies using medical record review to confirm case status should be cons …

Antiviral activity of geneticin against bovine viral diarrhoea virus.

BACKGROUND: Aminoglycoside G418 is commonly used to generate stable replicons for RNA viruses, such as hepatitis C virus, West Nile virus, a … of viral diseases associated with the Flaviviridae family, such as hepatitis C virus, dengue virus, yellow fever virus, West Nile virus and others.

Dengue virus-specific, human CD4+ cytotoxic T lymphocytes generated in short-term culture.

We previously reported cytotoxic activity of dengue virus-specific CD4+ CD8- T cell clones established in long-term in vitro culture. In the … ious dengue 1 Ag, but did not lyse LCL pulsed with Ag of other dengue serotype, West Nile virus, or yellow fever virus, or control Ag. Treatment of cultured PBMC with monoclonal antibody to CD3 or CD4 and complement abrogated the cytotoxic activity but treatment with a monoclonal antibody to CD8 and complement did not. A time course study showed that dengue 1 …

Hemorrhagic fever with renal syndrome in Yugoslavia: epidemiologic and epizootiologic features of a nationwide outbreak in 1989.

A nationwide epidemic of hemorrhagic fever with renal syndrome (HFRS) occurred in Yugoslavia in 1989. Sera from 609 hospitalized patients, from all six Republics (Bosnia and Hercegovina, Croatia, Macedonia, Montenegro Serbia, Slovenia) and two Provinces (Kosovo and Vojvodina), who had signs and symptoms suggestive of HFRS, and sera and lung tissues from 544 small mammals belonging to 13 species were studied for evidence of hantavirus infection. Of the 226 patients with serologically confirmed HFRS, 182 resided in Bosnia and Hercegovina or in Serbia. The severity of disease differed from region

Green synthesis of silver nanoparticles using Sida acuta (Malvaceae) leaf extract against Culex quinquefasciatus, Anopheles stephensi, and Aedes aegypti (Diptera: Culicidae).

Mosquitoes act as a vector for most of the life-threatening diseases like malaria, yellow fever, dengue fever, chikungunya fever, filariasis, encephalitis, West Nile Virus infection, etc. Under the Integrated Mosquito Management, emphasis was given on the application of alternative strategies in mosquito control. The continuous application of synthetic insecticides causes development of resistance in vector species, biological magnification of toxic substances through the food chain, and adverse effects on environmental quality and nontarget organisms including human health. Application of act…

A Replication-Competent Flavivirus Genome with a Stable GFP Insertion at the NS1-NS2A Junction.

The flavivirus NS1 protein is a component of the viral replication complex and plays diverse, yet poorly understood, roles in the viral life cycle. To enable real-time visualization of the developing replication organelle and biochemical analysis of tagged NS1 and its interacting partners, we engineered a replication-competent yellow fever virus (YFV) replicon encoding a C-terminal fusion of NS1 with green fluorescent protein (NS1-GFP). The initial variant was non-viable in the absence of trans-complementation with wild-type NS1; however, viability was partially restored through the introducti…

Clashing in Murky Waters: On Amphibian Mosquito Suppression.

Mosquito-borne diseases are on the rise globally due to the shifting distribution of key disease vector species. Due to increased global trade and travel and increasing temperatures and changing precipitation patterns, the spread of mosquitoes and the increasing burden of their accompanying diseases like malaria, yellow fever, and dengue persist. Seeking sustainable control measures, there's growing interest in natural control, particularly through predators like amphibians, a globally threatened vertebrate group. However, the effectiveness of different natural predators and their role in an e…

Agent-Based Modeling Approach for Population Dynamics of the Biological Vector Aedes Aegypti.

BACKGROUND: The invasive mosquito Aedes aegypti is a major vector of arboviruses, such as Dengue, Zika, Chikungunya and Yellow Fever. OBJECTIVE: As a first step toward a transmission model for vector-borne diseases, a weather-dependent population dynamic simulation for Ae. aegypti was developed, suitable for high weather short-term variability in the Austrian region. METHODS: We developed an agent-based model, incorporating temperature- and precipitation-dependent development, mortality, movement, feeding behavior, and egg-laying. Species-specific parameters were derived from published exper…

Lethal and sublethal effects of toxic sugar baits differ among insecticide resistant and insecticide susceptible populations of Aedes aegypti.

Widespread insecticide resistance and the potential for sublethal exposures to alter mosquito fitness have increased interest in alternative … eptible Aedes aegypti. Aedes aegypti is the primary global vector of dengue, Zika, chikungunya, and yellow fever viruses, placing billions at risk and underscoring the need for sustainable vector control strategies. ATSB affected ingestion, mortality, and reproductive traits in a resistance-dependent manner. Susceptible mosquitoes exhibited reduced ATSB ingest …

A case of complicated parapneumonic pleural effusion caused by paragonimus infection in a child was successfully treated by intrapleural injection of urokinase: a case report and literature review.

OBJECTIVE: The clinical data of a child with complex parapneumonic effusion (PPE) caused by pneumofluke infection were analyzed, and the diagnosis and treatment of the disease were discussed through literature review. The effectiveness and safety of urokinase in the treatment of complex PPE and empyema caused by multiple pathogens were emphasized. METHODS: A 3-year-old male child with pneumofluke infection was admitted to the pediatric department of Mianyang Central Hospital. Chest CT and chest ultrasound showed a right pleural effusion with dense septum formation. The condition was relieved

Карта данных о стратегиях профилактики и борьбы с инфекциями и связанными с ними вирусными инфекциями Aedes aegypti.

ЦЕЛЬ: Цель данного исследования заключалась в разработке фактологической карты стратегий профилактики и борьбы с инфекциями и связанными с ними вирусными инфекциями Aedes aegypti. МЕТОДЫ: Карта доказательств была составлена в соответствии с методологией Латиноамериканского и Карибского центра информации о медицинских науках (БИРЕМЕ). Поиски публикаций проводились в MedLINE/PubMed и Виртуальной библиотеке здравоохранения, фильтруемой только для систематического обзора (SR). Методологическое качество СР было доступно с помощью инструмента AMSTAR2, а программное обеспечение Tableau использовалось

Совпадение в аннотации оригинала
OBJECTIVE: The objective of this study was to develop an evidence map on the strategies for preventing and controlling Aedes aegypti infesta … and control of A. aegypti infestation and related viral infections (dengue, chikungunya, Zika, and yellow fever viruses) were included in the map. The evidence map indicates 130 associations between 59 interventions and 18 outcomes. The reported interventions were categorized into 10 groups, including community/educational actions, use of repellents, immuniza …

Extralobar pulmonary sequestration presenting with torsion in an elderly patient: A case report.

INTRODUCTION AND IMPORTANCE: Extralobar pulmonary sequestration with torsion is an exceptionally rare condition, especially in adults, and can present with nonspecific symptoms such as abdominal pain, making diagnosis challenging. Timely recognition is critical, as delayed treatment may lead to infarction and serious complications. This report describes the case of a patient with extralobar pulmonary sequestration who presented with abdominal pain. CASE PRESENTATION: An 83-year-old healthy female presented with increasing severe abdominal pain and mild fever that had developed for the past th

Acute intestinal obstruction caused by endoscopic submucosal dissection: A case report.

BACKGROUND: Endoscopic submucosal dissection (ESD) is considered one of the effective and minimally invasive methods for managing lateral spreading tumors of the intestine. However, with the widespread adoption of this technique, the incidence of complications is expected to increase. The most common complications of ESD are hemorrhage and perforation. Rare cases of obstruction after colorectal ESD have been reported, which are often easily misdiagnosed. Therefore, clinicians should maintain heightened awareness of this complication. CASE SUMMARY: We report the case of a 50-year-old male who

Vertical transmission of mosquito microbiota and its effects on offspring development.

BACKGROUND: The mosquito's gut microbiota plays a crucial role in determining its capacity to transmit harmful viruses and parasites. Accordingly, manipulating mosquito gut microbiota is a promising avenue towards reducing mosquito-borne human pathogen transmission. A successful microbial control campaign will require a thorough understanding of how bacteria are transmitted through mosquito populations. Through two parallel but complementary studies using the yellow fever mosquito Aedes aegypti as a focal host species, we surveyed vertical transmission of bacteria from individual mothers to co…

Dengue-mediated changes in the vectorial capacity of Aedes aegypti (Diptera: Culicidae): manipulation of transmission or infection by-product?

An arthropod's vectorial capacity summarizes its disease transmission potential. Life-history traits, such as fecundity or survival, and behavioral traits, such as locomotor activity, host-seeking and feeding behavior, are important components of vectorial capacity. Studies have shown that mosquito-borne pathogens may alter important vectorial capacity traits of their mosquito vectors, thus directly impacting their transmission and epidemic potential. Here, we compile and discuss the evidence supporting dengue-mediated changes in the yellow fever mosquito Aedes aegypti (L.), its primary vector…

Larvicidal efficacy of Varronia curassavica leaf phytochemicals against Aedes aegypti: anatomical, histological and cytotoxic analyses.

Aedes aegypti, the primary vector of diseases like Dengue, Zika, Yellow Fever, and Chikungunya, presents a significant public health challenge, particularly in tropical regions. With rising resistance to conventional insecticides, plant-derived bioinsecticides have emerged as a promising alternative. This study assessed the larvicidal potential of phytochemicals from Varronia curassavica, a species native to the Atlantic Forest. Microscopic analyses revealed various trichome types on V. curassavica leaves, including glandular trichomes containing essential oils, phenolic substances, lipids, al…

A Complex Case of Obstructive Jaundice in a Septuagenarian: Diagnostic Challenges and Therapeutic Strategies.

Obstructive jaundice occurs when an obstruction in the bile duct system prevents bile from flowing from the liver into the intestine, accumulating bilirubin in the blood. This condition can result from various causes, including gallstones, tumors, or inflammation of the bile ducts. The management of obstructive jaundice depends on the underlying cause (malignant obstructions such as cholangiocarcinoma or pancreatic cancer), indicating the need for surgical intervention. The Whipple procedure (pancreaticoduodenectomy) is the standard curative approach for resectable distal common bile duct (CBD

Exposure to low-concentration fipronil impairs survival, behavior, midgut morphology and physiology of Aedes aegypti larvae.

The Aedes aegypti mosquito is a vector for various arboviruses, including dengue and yellow fever. Insecticides, such as pyrethroids and organophosphates, are widely used to manage and control these insects. However, mosquitoes have developed resistance to these chemicals. Therefore, this study aimed to investigate the effects of the commercial formulation of fipronil (Tuit® Florestal; 80% purity) on the survival, behavior, morphology, and proteins related to signaling pathways of the midgut in A. aegypti larvae under controlled laboratory conditions. Significant reductions in immature surviva…

Virtue ethics and the unsettled ethical questions in controlled human infection studies.

Controlled human infection studies (CHIs) involve the intentional infection of human subjects for a scientific aim. Though some past challen … n types of controlled human infection studies. We use the historical example of Walter Reed and the Yellow Fever Commission to illustrate this claim, and we also highlight some contemporary examples. We end by sketching some practical implications of our view, such as ensuring that investigators with experience running CHIs are involved in novel CHI models.