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Treatment with spesolimab in patients with generalized pustular psoriasis: a review of real-world experience.

Generalized pustular psoriasis (GPP) is a potentially life-threatening rare immune-mediated disease characterized by rapid onset of erythematous plaques, sterile pustules and systemic inflammation. Spesolimab, a monoclonal antibody targeting the interleukin-36 receptor, is a novel treatment for GPP. However, GPP's low incidence and limited evidence relating to treatment with spesolimab represents a challenge in determining its real-world efficacy. This review explores the clinical use of spesolimab in a real-world setting. We conducted a review on PubMed, SCOPUS, Embase, and ScienceDirect of c…

Combination therapy with spesolimab and apremilast for refractory generalized pustular psoriasis: a case report.

Generalized pustular psoriasis (GPP) is a rare, life-threatening neutrophilic dermatosis characterized by recurrent episodes of widespread sterile pustules, systemic inflammation, and potential multi-organ failure. We present a 75-year-old woman with a 10-year history of GPP refractory to conventional therapies, including cyclosporine, tripterygium glycosides, and acitretin. Following initial spesolimab infusions that controlled acute flares but failed to prevent relapse, a sequential therapeutic strategy was initiated: a single 900-mg intravenous dose of spesolimab followed by adjunctive apre…

Advancements in understanding and treating psoriasis: a comprehensive review of pathophysiology, diagnosis, and therapeutic approaches.

Psoriasis is a chronic autoimmune disease affecting millions worldwide. This condition is characterized by scaly, red patches of skin that can be painful, itchy, and disfiguring. This non-contagious illness forms plaques and accelerates the dermal cell's life cycle. This review provides a comprehensive overview of the current knowledge on psoriasis, covering its definition, prevalence, causes, pathogenesis, clinical features, diagnosis, and treatment options. The psychosocial impact of psoriasis on patients and their coping mechanisms is also explored. Biologic agents, which target specific cy…

Biological activity study of a pine pollen extract rich in dihydroquercetin for the treatment of psoriasis.

BACKGROUND: Psoriasis is a chronic inflammatory skin disease often referred to as the "incurable cancer," characterized by a long disease course, high recurrence rate, and inability to achieve complete cure. It not only severely impacts patients' quality of life but also faces challenges such as high treatment costs and side effects with current therapeutic approaches. The primary active component of pine pollen (PP) extract (PPE) is dihydroquercetin (DHQ), which possesses various pharmacological activities, including anti-inflammatory, antioxidant, and immune-modulating effects. To date, howe…

Французские руководящие принципы системного лечения от умеренного до сильного псориаза у взрослых: обновленный вариант 2025 года.

Нынешние французские руководящие принципы обращения с псориазом датируются 2019 годом и не включают в себя самые современные меры. Исследовательская группа < < Псориаз > > Французского общества дерматологии разработала новые руководящие принципы, предусматривающие обновление алгоритмов принятия решений для системного лечения взрослых пациентов с умеренным и сильным псориазом. Эти алгоритмы были разработаны после тщательного обзора существующих руководящих принципов лечения псориазом и недавних публикаций по новым системным методам лечения, не включенным в предыдущие рекомендации. О

Совпадение в аннотации оригинала
The current French guidelines for the treatment of psoriasis date from 2019 and do not include the most up-to-date interventions. The Psoriasis Research Group of the French Society of Dermatology has developed new guidelines to provide updated decision-making algorithms for the systemic treatment of adult patients with moderate-to-severe psoriasis. The algor…

Real-world outcomes in patients with malignancy and moderate-to-severe psoriasis treated with guselkumab.

BACKGROUND: The treatment of psoriasis in patients with a personal history of cancer is a matter of debate and limited evidence is available to guide clinicians. OBJECTIVES: To report a multicenter real-life experience of a group of patients with psoriasis undergoing treatment with guselkumab and a history of cancer. METHODS: We conducted a multicenter retrospective Spanish study enrolling patients with moderate-to-severe plaque psoriasis and neoplasia being treated with guselkumab for their psoriasis. RESULTS: Twenty patients with moderate-to-severe psoriasis and at least 12 weeks of ongoi…

Genetic insights into the gut microbiota and risk of psoriasis: a bidirectional mendelian randomization study.

BACKGROUND: Growing evidence indicates a potential association between the gut microbiome and psoriasis. Nevertheless, the precise nature of these associations and whether they constitute causal relationships remain unclear. METHODS: A rigorous bidirectional two-sample Mendelian randomization study was undertaken to establish a putative causal link between gut microbiota and psoriasis. We drew upon publicly available datasets containing summary statistics from GWAS to accomplish this. Utilizing various analytical techniques, including inverse variance weighting, MR-Egger, weighted median, wei…

Secukinumab in the Treatment of Psoriasis: A Narrative Review on Early Treatment and Real-World Evidence.

Psoriasis is a chronic, immune-mediated, inflammatory skin disease, associated with multiple comorbidities and psychological and psychiatric disorders. The quality of life of patients with this disease is severely compromised, especially in moderate-to-severe plaque psoriasis. Secukinumab, a fully humanized monoclonal antibody, was the first anti-interleukin (IL)-17 biologic approved for treating psoriasis. Secukinumab demonstrated long-lasting efficacy and a good safety profile in individuals with plaque psoriasis, and it is associated with an improvement in health-related quality of life. Wh…

Psychosocial impact of climatotherapy in young patients with psoriasis: a 3-month cohort study.

Ultraviolet rays are known to have positive effect on psoriasis, but the cold climate and latitude in Northern Europe reduce access to the sun. Climatotherapy is a treatment modality where the patient is relocated to a warmer region with a high ultraviolet (UV) index. Young patients with psoriasis can be particularly burdened by the disease, and studies have shown an association between psoriasis and mood disorders. Patients who have undergone climatotherapy often report beneficial psychological effects after treatment, but this has not yet been studied. To explore the psychosocial impact of c…

Co-Occurrence of Psoriasis and Asthma in the Pediatric Population: A Systematic Review and Meta-Analysis.

Introduction: The risk of asthma in patients with psoriasis and that of psoriasis in patients with asthma have increased, but relevant data for the pediatric population are lacking. Therefore, we performed a meta-analysis to assess the pooled association between psoriasis and asthma in children and adolescents. Methods: We conducted an extensive search of the medical literature databases through to July 2024. The estimated risk ratios (RRs) and corresponding 95% confidence intervals (CIs) were computed. Results: Three studies, involving 5310 children with psoriasis and 1,539,029 control partic…

Helicobacter pylori infection and its impact on psoriasis: a systematic review and meta-analysis.

INTRODUCTION: Psoriasis is a chronic skin condition characterized by immune-mediated inflammation. Recent research suggests a possible interaction between Helicobacter pylori infection and the immunopathogenesis of psoriasis. However, over the past 5 years, no significant new evidence has clarified the relationship between H. pylori and skin diseases. This study aimed to determine the relationship between H. pylori infection and psoriasis through a systematic review and meta-analysis. METHODS: We searched for articles published in databases including PubMed, Embase, the China National Knowled…

Ten-Year Persistence of Biologic Drugs in Psoriasis and Its Relationship with Pharmacogenetic Biomarkers.

Background: Psoriasis is a skin disease characterized by the presence of erythematous, scaly plaques on the extensor surfaces of the body. Treatment varies according to the stage of the disease, with the most severe cases being treated with biologic treatments that differ in efficacy and persistence over time. This study aimed to evaluate the 10-year persistence of biologic drugs (adalimumab, etanercept, infliximab and ustekinumab) in the treatment of moderate-to-severe plaque psoriasis. Methods: A total of 143 patients (61 women and 82 men) were evaluated; data were collected from the electro…

From Traditional Medicine to Advanced Therapeutics: The Renaissance of Phyto-nano Interventions in Psoriasis.

Psoriasis is an autoimmune systemic chronic inflammatory disease that exhibits characteristic detrimental effects on the skin, often leading to infections or comorbid conditions. The multifaceted nature of psoriasis has made it very challenging to treat, especially with current chemotherapy options. Therefore, it is essential to consider phytoconstituents as novel alternatives. However, despite demonstrating higher anti-inflammatory, anti-psoriasis, and immunomodulatory potential, their clinical usage is hindered due to their poor physicochemical properties. To address these drawbacks, nanopar…

Exploring the Effectiveness of Biological Therapy in Patients with Psoriasis: Body Image and Quality of Life.

Background and Objectives: Psoriasis is a chronic, long-term, incurable skin inflammatory disease characterized by the excessive proliferation of epidermal keratinocytes, dilation of blood vessels, thickening of the skin, and the formation of visible red patches of variable sizes. The impact on patients differs with the severity of the disease, leading to physiological discomfort and psychological distress, which significantly affect the quality of life. The etiology of psoriasis is not completely clear, but immune cells, including type 1 and type 17 cytokine-producing cells modulated by regul…