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Identification of factors predicting scar outcome after burn in adults: A prospective case-control study.

This study examined influences on scarring after burn in a prospective study using a defined outcome measure: scar height measured by a modi … ion statistics (odds ratios and 95% confidence intervals) reported will be of practical benefit for clinical decision-making and counselling of patients, and plausible biological explanations for the findings support the validity of the results.

When to Consider Allogeneic Transplantation in CML.

Tyrosine kinase inhibitor (TKI) therapy has radically altered the treatment strategy for chronic myeloid leukemia. Allogeneic transplantation, which over a decade ago was considered the definitive therapy for CML, is now appropriately used in cases where all TKIs are not tolerated, in cases of resistance to TKI therapy, or when the disease progresses from chronic phase to accelerated or blast phase.

Ambulance smartphone tool for field triage of ruptured aortic aneurysms (FILTR): study protocol for a prospective observational validation of diagnostic accuracy.

INTRODUCTION: Rupture of an abdominal aortic aneurysm (rAAA) carries a considerable mortality rate and is often fatal. rAAA can be treated through open or endovascular surgical intervention and it is possible that more rapid access to definitive intervention might be a key aspect of improving mortality for rAAA. Diagnosis is not always straightforward with up to 42% of rAAA initially misdiagnosed, introducing potentially harmful delay. There is a need for an effective clinical decision support tool for accurate prehospital diagnosis and triage to enable transfer to an appropriate centre. METH

Isolating tape method is useful for an early judgment of curability during pancreaticoduodenectomy for pancreatic cancer.

Positive surgical margin of extrapancreatic nerve plexus (ENP) is a major cause of non-curative resection during pancreaticoduodenectomy (PD) for periampullary carcinoma (PC), which is difficult to detect at the early stage of PD. We describe a novel surgical technique using an isolating tape (iTape)-oriented ENP-first dissection (IOEFD) during PD. The iTape is firstly passed through the retroperitoneal space between ENP and inferior vena cava. Then, the iTape is further extracted from major vessels such as the common hepatic and superior mesenteric artery. Consequently, the iTape encircles EN

Development and validation of a risk score for chronic kidney disease in HIV infection using prospective cohort data from the D:A:D study.

BACKGROUND: Chronic kidney disease (CKD) is a major health issue for HIV-positive individuals, associated with increased morbidity and mortality. Development and implementation of a risk score model for CKD would allow comparison of the risks and benefits of adding potentially nephrotoxic antiretrovirals to a treatment regimen and would identify those at greatest risk of CKD. The aims of this study were to develop a simple, externally validated, and widely applicable long-term risk score model for CKD in HIV-positive individuals that can guide decision making in clinical practice. METHODS AND

Strategic threat management: an exploration of nursing strategies in the pediatric intensive care unit.

Part of the work of a critical care nurse is to manage the threats that arise that could impede efficient and effective job performance. Nurses manage threats by employing various strategies to keep performance high and workload manageable. We investigated strategic threat management by using the Threat-Strategy Interview. Threats frequently involved technology, staff, or organizational components. The threats were managed by a toolbox of multifaceted strategies, the most frequent of which involved staff-, treatment- (patient + technology), examination- (patient + clinician), and patient-orien

A research agenda for malaria eradication: vaccines.

Vaccines could be a crucial component of efforts to eradicate malaria. Current attempts to develop malaria vaccines are primarily focused on Plasmodium falciparum and are directed towards reducing morbidity and mortality. Continued support for these efforts is essential, but if malaria vaccines are to be used as part of a repertoire of tools for elimination or eradication of malaria, they will need to have an impact on malaria transmission. We introduce the concept of "vaccines that interrupt malaria transmission" (VIMT), which includes not only "classical" transmission-blocking vaccines that

Barriers to evidence-based decision making in public health: a national survey of chronic disease practitioners.

OBJECTIVE: Existing knowledge of evidence-based chronic disease prevention is not systematically disseminated or applied. This study investigated state and territorial chronic disease practitioners' self-reported barriers to evidence-based decision making (EBDM). METHODS: In a nationwide survey, participants indicated the extent to which they agreed with statements reflecting four personal and five organizational barriers to EBDM. Responses were measured on a Likert scale from 0 to 10, with higher scores indicating a larger barrier to EBDM. We analyzed mean levels of barriers and calculated a

Complex sclerosing lesions of the breast mimicking carcinoma: diagnostic pitfalls and the decisive role of immunohistochemistry.

BACKGROUND: Complex sclerosing lesion (CSL) of the breast is a benign proliferative condition that frequently mimics invasive carcinoma on imaging and in limited biopsy specimens. Radiologic-pathologic discordance may result in diagnostic uncertainty and potentially unnecessary surgical intervention. Accurate pathological assessment, particularly evaluation of myoepithelial cell preservation, is therefore critical to appropriate clinical decision-making. METHODS: A retrospective analysis of three female patients diagnosed with CSL at a single medical institution was conducted, along with a fo…

Epidemiology and Oncologic Patterns of Cervical Spine Metastases and Primary Tumors.

STUDY DESIGN: Narrative review. OBJECTIVE: To summarize the epidemiology and oncologic patterns of metastatic and primary cervical spine tumors and evaluate the classification systems, instability assessments, cord compression frameworks, and prognostic tools used in their management. SUMMARY OF BACKGROUND DATA: Although relatively uncommon, cervical spine tumors carry disproportionate clinical consequences. Epidural spinal cord compression can cause quadriplegia and respiratory failure, while the region's distinctive anatomy and biomechanics complicate oncologic decision-making. METHODS: A

[Selection of restorative strategies for extensive tooth defects in young permanent molars].

Restoration of extensive defects in young permanent molars is more complex than that in mature permanent teeth. Young permanent teeth are ch … computer-aided design and computer-aided manufacturing (CAD/CAM) indirect restorations, proposing a clinical decision-making framework for extensive defects in young permanent molars. The proposed pathway follows a "three-level assessment and integrated decision-making" approach, in which the physiological characteristics of young permanent teeth, the objective condition …

Artificial intelligence and machine learning in sports medicine: mapping clinical tasks and assessing clinical maturity - a scoping review.

BACKGROUND: Artificial intelligence (AI) and machine learning (ML) are rapidly transforming the medical field. The aim of this review was to outline the current scientific state of AI and ML application in sports medicine, evaluate the level of clinical validation and readiness for implementation, and identify key priorities to guide future advancements and implementation into injury risk assessment, diagnosis, rehabilitation and clinical decision-making in sport medicine. METHODS: A scoping review was conducted with a literature search performed on February 5, 2026, using the MEDLINE, EMBASE…

Digital Health in Pediatric Oncology and Hematooncology: A Quasi-Systematic Review of Telehealth, mHealth and Precision Medicine.

Pediatric oncological and hematological diseases remain a significant challenge due to their complexity, the need for personalized treatment, and long-term follow-up. Recent advances in medical technologies, particularly in information technology (IT), telemedicine, mobile health (mHealth), and precision medicine, have opened new possibilities for improving care and supporting clinical decision-making in pediatric patients. This quasi-systematic review examines the current landscape of emerging technologies applied in pediatric oncology and hematology. A structured literature search was conduc…

A Retrospective Case-Control Study of the Visual Outcomes in Patients With Glaucoma Following Cataract Surgery at the Queensland Children's Hospital.

PURPOSE: To better characterize the epidemiology of glaucoma following cataract surgery (GFCS) in an Australian population and to inform clinical decision-making in patients with GFCS. METHODS: This was a single-center retrospective case-control study looking at the incidence, management, and outcomes of glaucoma in a cohort of eyes that underwent lensectomy surgeries for congenital cataract at the Queensland Children's Hospital between January 2014 and December 2020. RESULTS: Ninety-seven eyes underwent lensectomy for congenital cataract. GFCS was diagnosed in 24.7% of eyes, and mean age of…

Sestrin-2: a new biomarker for type 2 Diabetes Mellitus and Insulin resistance.

Multiple myeloma (MM) is the second most common haematological malignancy characterised by clonal proliferation of plasma cells within the bone marrow. Despite advances in treatment options, myeloma remains incurable. Relapsed MM poses significant challenges due to clonal evolution, drug resistance, patient comorbidities and therefore complexities of therapeutic decision-making. A critical question in managing relapsed MM is whether to switch drug classes or retreat with agents within the same class. The question is present with the recent addition of three new drug classes (XPO1 inhibitors, B

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… This has introduced new complexities in clinical decision-making, particularly when determining whether to switch drug classes or retreat with the same class [ 10 ]. This review aims to address the decision to switch drug classes or retreat with the same class in relapsed MM. … Therefore, clinical decision making in early relapse management requires careful consideration. In the pursuit of improving outcomes, especially for these triple exposed/refractory patients, new drugs have been developed with mechanisms of action different from existing ones. …

Evolving the Control-Chaos Continuum: Part 2-Shifting "Attention" to Progress On-Pitch Rehabilitation.

BACKGROUND: On-pitch rehabilitation is key to supporting return to sport in elite soccer (football). The control-chaos continuum (CCC) guides practitioners through the sport-specific components of return to sport. There is a need to update the framework with recent research in injury neurophysiology, soccer performance, and coaching science. CLINICAL QUESTION: How do practitioners integrate the insights from injury neurophysiology, soccer performance, and coaching science discussed in part 1 of this 2-part series into an updated version of the CCC, to enhance the planning and execution of on-p

Medico-legal risk in the emergency department.

PURPOSE: The landscape of the medico-legal risk in emergency medicine in Canada is unknown. The objective of this study was to describe and … peer-expert criticism identified the most common factors contributing to medico-legal risk included clinical decision-making (64%), situational awareness (44%), and issues with provider's documentation (42%). CONCLUSIONS: The most common diagnoses associated with medico-legal risk were injuries, infections, and disorders of the circulatory system. The three most common c …

Timing of pharmacological thromboprophylaxis following traumatic brain injury: a UK-wide survey of clinical practice.

BACKGROUND: Traumatic brain injury (TBI) is associated with an increased risk of venous thromboembolism (VTE), which can complicate recovery from TBI, lead to long-term reductions in quality of life, and occasionally be fatal. There is no high-quality evidence to support recommendations for optimal timing, dosing or type of pharmacological thromboprophylaxis (PTP). This study aimed to characterise current clinical practice among healthcare professionals in the UK and Ireland regarding VTE prophylaxis in patients with TBI, to inform research. METHODS: An online survey was distributed to health

Addressing the false dichotomy between autonomy and preservation of life: Clinical, legal, and ethical considerations in severe and longstanding anorexia nervosa.

Anorexia nervosa (AN) is a serious metabo-psychiatric disorder. Despite a mortality rate approximately five times higher than that of age-matched controls, most deaths result from delayed recognition, fragmented care, and limited access to integrated, evidence-based treatment. Refusal of life-sustaining nutrition in severe or longstanding AN presents profound ethical and legal dilemmas, challenging the balance between autonomy, protection, and the duty to preserve life. This paper provides a critical narrative and normative review of how clinical uncertainty, systemic failure, and legal interp