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Notch Effects on the Stress Intensity Factor and on the Fatigue Crack Path for Eccentric Circular Internal Cracks in Elliptically Notched Round Bars under Tensile Loading.

In this paper, stress intensity factor (SIF) solutions are numerically obtained for notched bars subjected to tensile loading containing an … effect being greater as the diameter and eccentricity of the inner crack increase. In addition, the fatigue growth of an eccentric crack induces an increase in such eccentricity, greater as the notch axial semi-axis increases. The cause of these phenomena can be attributed to the constraint loss caused by the notch, which also facilitates bending of the s …

Home-based exercise in patients with refractory fatigue associated with primary biliary cholangitis: a protocol for the EXerCise Intervention in cholesTatic LivEr Disease (EXCITED) feasibility trial.

INTRODUCTION: Fatigue is the most commonly reported symptom of the liver disease primary biliary cholangitis (PBC). It affects 40%-80% of patients, has no effective treatment and is associated with heightened mortality risk. The pathogenesis is unknown, but muscle bioenergetic abnormalities have been proposed to contribute. Directly observed exercise has been shown to attenuate symptoms in small groups; however, due to the rare nature of the disease, home-based interventions need to be evaluated for feasibility, safety and efficacy. METHODS AND ANALYSIS: This is a phase 1/pilot, single-arm, o…

Sense of coherence and its relationship to participation, cancer-related fatigue, symptom burden, and quality of life in women with breast cancer participating in the OptiTrain exercise trial.

Abstract Purpose This study examined the Sense of Coherence (SOC) of patients participating in the randomized controlled ‘Optimal Training for Women with Breast Cancer’ (OptiTrain) study and assessed how patient characteristics were associated with SOC. Secondary aims were to assess the association between SOC and patients’ participation in this study and to determine whether SOC moderates the effect of the 16-week exercise intervention on fatigue, quality of life (QoL), and symptom burden in women with breast cancer undergoing chemotherapy. Methods Modified Poisson regression analyses were co…

Work stress, fatigue and risk behaviors at the wheel: Data to assess the association between psychosocial work factors and risky driving on Bus Rapid Transit drivers.

This Data in Brief (DiB) article presents a hierarchical multiple linear regression model that examine the associations between psychosocial work factors and risk behaviors at the wheel in Bus Rapid Transit (BRT) drivers (n=524). The data were collected using a structured self-administrable questionnaire made of measurements of wok stress (job strain and effort- reward imbalance), fatigue (need for recovery and chronic fatigue), psychological distress and demographics (professional driving experience, hours driven per day and days working per week). The data contains 4 parts: descriptive stati…

Fatigue as Presenting Symptom and a High Burden of Premature Ventricular Contractions Are Independently Associated With Increased Ventricular Wall Stress in Patients With Normal Left Ventricular Function.

BACKGROUND: High idiopathic premature ventricular contractions (PVC) burden has been associated with PVC-induced cardiomyopathy. Patients ma … VCs and normal LV function referred for PVC ablation were included. Type of symptoms (palpitations, fatigue, and [near-]syncope), PVC burden on 24-hour Holter, NT-proBNP levels, and cESS on echocardiography were assessed before and 3 months after ablation. Sustained successful ablation was defined as ≥80% PVC burden reduction during follow-up. Patients we …

The role of mitochondrial dysfunctions due to oxidative and nitrosative stress in the chronic pain or chronic fatigue syndromes and fibromyalgia patients: peripheral and central mechanisms as therapeutic targets?

INTRODUCTION: Chronic fatigue syndrome (CFS) and fibromyalgia (FM) are characterized by persistent pain and fatigue. It is hypothesized that reactive oxygen species (ROS), caused by oxidative and nitrosative stress, by inhibiting mitochondrial function can be involved in muscle pain and central sensitization as typically seen in these patients. AREAS COVERED: The current evidence regarding oxidative and nitrosative stress and mitochondrial dysfunction in CFS and FM is presented in relation to chronic widespread pain. Mitochondrial dysfunction has been shown in leukocytes of CFS patients and i…

Exercise therapy and cognitive behavioural therapy to improve fatigue, daily activity performance and quality of life in postpoliomyelitis syndrome: the protocol of the FACTS-2-PPS trial.

BACKGROUND: Postpoliomyelitis Syndrome (PPS) is a complex of late onset neuromuscular symptoms with new or increased muscle weakness and muscle fatigability as key symptoms. Main clinical complaints are severe fatigue, deterioration in functional abilities and health related quality of life. Rehabilitation management is the mainstay of treatment. Two different therapeutic interventions may be prescribed (1) exercise therapy or (2) cognitive behavioural therapy (CBT). However, the evidence on the effectiveness of both interventions is limited. The primary aim of the FACTS-2-PPS trial is to stud…

Effect of oral melatonin on sleep quality, fatigue, and caregiver sleep perception in patients with head and neck cancer: A randomized double-blind placebo-controlled trial.

BACKGROUND: Sleep disturbances and fatigue are common in patients with head and neck cancer and adversely affect quality of life. Melatonin may improve sleep quality with minimal adverse effects. This study evaluated the effect of oral melatonin on sleep quality, fatigue, and caregiver sleep perception in patients with head and neck cancer. METHODS: In this prospective, randomised, placebo-controlled trial, 70 patients aged 18-65 years with head and neck cancer and sleep disturbances for >1 month were randomised to oral melatonin 3 mg (Group M, n = 35) or multivitamin (placebo) (Group P, n = …

The effect of online physical activity monitoring on physical activity level, psychological health, fatigue, and quality of life in patients with multiple sclerosis: a randomized controlled trial.

BACKGROUND: It is known that individuals with multiple sclerosis (MS) have lower levels of physical activity compared to the healthy population. Encouraging and continuous monitoring ofphysical activity through digital reminders can be beneficial in increasing physical activity levels. OBJECTIVE: The aim of this study was to investigate the effects of continuous monitoring of walking-based physical activity, supported by reminders using a messaging application, on physical activity level, psychological health, and quality of life. METHODS: Forty-two individuals with MS were randomly assigned

Сравнительное воздействие мер, принимаемых на основе пилатесов, на функциональную мобильность, сбалансированность, усталость и качество жизни людей с множественным склерозом: систематический обзор и сетевой метаанализ.

ЦЕЛЬ: Упражнения на основе пилатеса привлекли внимание в качестве нефармакологической стратегии реабилитации лиц с множественным склерозом (МС), однако сравнительная эффективность различных методов пилатесов остается неопределенной. Этот систематический обзор и сетевой метаанализ позволили оценить и ранжировать на основе пилатеса мероприятия, направленные на обеспечение функциональной мобильности, сбалансированности, ходьбы, усталости и качества жизни взрослых с НР. МЕТОДЫ: В период с момента создания и по октябрь проводились обыски PubMed, Scopus, Web of Science и Cochrane Central Register of

Совпадение в аннотации оригинала
PURPOSE: Pilates-based exercise has gained attention as a non-pharmacological rehabilitation strategy for people with multiple sclerosis (MS … uated and ranked Pilates-based interventions for functional mobility, balance, walking performance, fatigue, and health-related quality of life in adults with MS. METHODS: PubMed, Scopus, Web of Science, and Cochrane Central Register of Controlled Trials were searched from inception to October 24, 2025. Eligible studies were randomized controlled trials …

Evaluation of self-reported dominance in upper and lower limbs and its relationship with fatigue onset in dominant limbs using surface electromyography (sEMG) in young adults.

BACKGROUND: "Laterality", or "lateral preference" indicates how differently or rather 'differentially' one tends to use a pair of sense orga … es of the limbs at rest and during sustained contraction using a pre-defined load till the onset of fatigue. On the basis of normality test, the data were expressed as median with interquartile range. Wilcoxon signed rank test was performed to compare the parameters of sEMG. SPSS software version 20.0 (IBM Inc., USA) was used to analyse the data. A two-ta …

Pain Reduction Following Massage After Induced Fatigue Is Not Mediated by Changes in Muscle Stiffness or Intramuscular Fluid Content: A Randomized Controlled Trial With Mediation Analysis.

CONTEXT: Massage therapy is a common intervention for athletic recovery. However, its effects on fatigue, muscle stiffness, and intramuscular fluid content or the mechanism for pain reduction remain uncertain. OBJECTIVES: To evaluate the immediate and subacute effects (24-72 hours) of massage on pain, fatigue, muscle stiffness, and intramuscular fluid content in university athletes after an induced fatigue protocol. Additionally, we investigated whether changes in muscle stiffness and intramuscular fluid content mediate the effects of massage on pain and fatigue. DESIGN: Randomized controlle…

Effect of Continuity of Care on Cancer-Related Fatigue, Self-Care Ability and Fear of Recurrence in Patients with Intravesical Chemotherapy after Transurethral Resection of Bladder Tumors.

BACKGROUND: Patients undergoing intravesical chemotherapy following transurethral resection of bladder tumour (TURBT) frequently face challenges including insufficient disease-related knowledge, inadequate self-management skills during chemotherapy intervals and discontinuity in routine postoperative care. This study aimed to investigate the effects of continuity of care patterns on cancer-related fatigue, self-care ability, fear of recurrence and risk of complications. METHODS: This retrospective study included 105 patients who received intravesical chemotherapy after TURBT in our hospital b…

Mixed-Mode Crack Growth Behavior of Compact Tension Shear (CTS) Specimens: A Study on the Impact of the Fatigue Stress Ratio, Loading Angle, and Geometry Thickness.

The majority of engineering structures are subjected to intricate loading scenarios or possess intricate geometries, resulting in a mixed-mode stress within the component. This study aims to investigate the fracture behavior of these components under mixed-mode loading conditions by examining the relationship among the fatigue stress ratio (R), loading angle, and geometry thicknesses in compact tension shear (CTS) specimens. Using advanced ANSYS simulation techniques, this research explores how these factors affect the fatigue life cycles of engineering materials. To simulate real-world loadin…

Quality of life, pain, depression, fatigue and sleep in patients with remission or mild fibromyalgia: a comparison with remission or low disease activity rheumatoid arthritis and healthy controls.

BACKGROUND: Fibromyalgia is a chronic condition marked by widespread pain and various accompanying symptoms. Compared to healthy individuals … spread Pain Index (WPI), Pain Visual Analogue Scale (VAS), Numerical Rating Scale, Multidimensional Fatigue Inventory (MFI-20), Pittsburgh Sleep Quality Index (PSQI), and Beck Depression Inventory (BDI), and Short Form-36 Health Status Questionnaire (SF-36). RESULTS: The FIQR total score and pain VAS, MFI, and PSQI scores were higher in RFM and RRA patie …

The effects of mask applied aromatherapy on allergic rhinitis symptoms, fatigue, and quality of life related to allergic rhinitis in the COVID-19 era: a randomized controlled trial.

PURPOSE: Even after allergic rhinitis is diagnosed and treated, various symptoms such as runny nose, sneezing, and itchy nose recur periodic … TNSS, F = 15.82, p < .001). The aromatherapy group also showed significantly higher improvements in fatigue (F = 8.28, p < .001), allergic rhinitis-specific quality of life (F = 11.12, p < .001). CONCLUSION: The oils used in this study appeared to be effective in relieving the symptoms of allergic rhinitis. In particular, the mask drop inhalation method …

Eveningness is associated with more severe depressive symptoms independently of sleep quality and fatigue level only in first-episode but not recurrent depression in major depressive disorder.

People with an evening chronotype have an increased risk of experiencing a major depressive disorder (MDD). It is unclear if this effect is … ningness - Eveningness Questionnaire (MEQ), Pittsburgh Sleep Quality Index (PSQI), Multidimensional Fatigue Inventory (MFI20), and Quick Inventory of Depressive Symptomatology (QIDS-SR16) were administered to participants to determine chronotype, sleep quality, fatigue level, and depressive severity, respectively. Multivariate regression models were utili …

Psychological interventions to improve pain, fatigue, anxiety, depression, and quality of life in children and adults with hypermobility spectrum disorders and Ehlers-Danlos syndrome: a systematic review.

Hypermobility spectrum disorders (HSD) affect individuals across physical, psychological and social domains, making assessment and management difficult. Management for this condition primarily focuses on addressing the musculoskeletal complaints using physiotherapy rather than the additional manifestations such as fatigue, anxiety and depression. This systematic review aims to identify psychological interventions and assess whether they improve the lived experiences of individuals with HSD. It also aims to assess which psychological interventions were most effective, which symptoms were most e…