Результаты поиска

Choroidal Metastasis as the Initial Presentation of Rectal Adenocarcinoma.

UNLABELLED: Choroidal metastasis from rectal cancer is a rare occurrence with limited literature on appropriate evidence-based treatment options. We describe the case of 44-year-old man who presented with left-sided painful vision loss who was found to have left choroidal and multiple lung metastasis from an unknown primary which was later found to be rectal adenocarcinoma. LEARNING POINTS: Ocular metastasis from colorectal cancer is rare with choroid being the most common site of involvement if it occurs.Ocular metastasis usually occurs as a part of generalized metastasis to multiple organ s

Retrospective Audit: Does Prior Assessment by Oral and Maxillofacial Surgeons Reduce the Risk of Osteonecrosis of The Jaw in Patients Receiving Bone-Targeted Therapies for Metastatic Cancers to the Skeleton?--Part II.

Men who receive bone-targeted therapy for metastatic prostate cancer are at increased risk of osteonecrosis of the jaw (ONJ). Development of ONJ has been associated with the administration of bone-targeted therapies in association with other risk factors. ONJ can be distressing for a patient because it can cause pain, risk of jaw fracture, body image disturbance, difficultly eating, and difficulty maintaining good oral hygiene. The aim of this article is to report results of an audit of prior assessment by oral and maxillofacial surgeons (OMFS) before initiation of bone-targeted therapies and

[A case of thymic cancer with pericardial tamponade as initial manifestation].

We report a case of thymic cancer with pericardial tamponade in a 70-year-old woman. The patient complained of chest pain and was carried to our hospital. CT scan showed a mediastinal mass and massive pericardial effusion. The effusion was serous fluid, not bloody, and no malignant cells were found. The patient underwent a tumor resection, and the final pathological diagnosis was squamous cell carcinoma of the thymus. In a review of 14 cases of thymic tumor with pericardial tamponade as initial manifestations in the Japanese literature,there were only three cases of thymic cancer. The prognosi

[Neoplastic lumbosacral plexopathy and "hot foot"].

Neoplastic lumbosacral plexopathy is a frequent and disabling complication in subjects with cancer. Its clinical presentation is characterized by pain, muscle weakness, sensory complaints in one or occasionally both limbs associated with the tumoral symptoms. The presence of autonomic symptoms is less frequent; one of these is the "hot and dry foot". We present two patients, one with prostatic cancer and the other with myxoid liposarcoma, who developed a lumbosacral plexopathy as a manifestation of the extension of the neoplastic process; in both cases there was in addition a clear difference

Symposium. ENT for nonspecialists. Supraglottic.

Because supraglottic cancer usually is diagnosed late and metastasizes early, the cure rate is poorer than for glottic cancer. Supraglottic lesions can spread in any direction. The main method of diagnosis is either indirect or direct laryngoscopy, and the main symptoms are vague throat pain, otalgia, hemoptysis, hoarseness, and enlarged cervical lymph nodes. Roentgenographic examination is useful only as a supplement to other diagnostic measures. Staging of the disease is important in determining the most effective therapy and in predicting the results of treatment. Treatment should be indivi

Prevalence of Moderate to Severe Joint Pain Among Adults With Diagnosed Arthritis: United States, 2023.

OBJECTIVE: To estimate the prevalence of moderate to severe joint pain among US adults with arthritis overall and by sociodemographic and health factors. Additionally, to assess progress toward the Healthy People 2030 goal of reducing the percentage of US adults with arthritis reporting moderate to severe joint pain to 52.4%. METHODS: This cross-sectional study used National Health Interview Survey (NHIS) data to estimate the unadjusted and age-standardized prevalence of moderate to severe joint pain. Differences by sociodemographic and health characteristics and survey year (2019 and 2023) w

The impact of nurse education and training on palliative pain management outcomes in radiotherapy patients.

BACKGROUND: Cancer-related pain remains a pervasive challenge, significantly impacting the quality of life for patients undergoing radiotherapy. Despite advancements in treatment, effective pain management continues to be a critical unmet need in oncology care. AIM: of study was to evaluate the effectiveness of the educational program about palliative pain management on nursing care quality for patients undergoing radiotherapy. METHODS: A quasi-experimental research design was utilized in the current study (one group, pre and post-test). This study was conducted at the oncology department and

Effectiveness of Long-Term Opioid Therapy for Chronic Pain in an Outpatient Palliative Medicine Clinic.

Background: Despite widespread use of opioid therapy in outpatient palliative medicine, there is limited evidence supporting its efficacy and safety in the long term. Objectives: We sought to improve overdose risk scores, maintain pain reduction, and preserve patient function in a cohort with severe chronic pain as we managed opioid therapy for a duration of four years in an outpatient palliative care clinic. Design: Over four years, we provided ongoing goal-concordant outpatient palliative care, including opioid therapy, using quarterly clinical encounters for a patient cohort with chronic pa

Chronic adverse effects after an axillary lymphadenectomy in breast cancer patients after administering weaker and stronger postoperative analgesia: results of a prospective double-blind randomized study.

PURPOSE: The aim of this study was to compare the rate of chronic adverse effects after a weaker and stronger postoperative analgesia. METHODS: A prospective double-blind randomized study included 117 breast cancer patients receiving tramadol for pain relief for 4 weeks after an axillary lymphadenectomy from 2015 to 2018. Patients with a larger dose received 75/650 mg of tramadol with paracetamol every 8 h and a group with a lower dose received 37.5/325 mg of tramadol with paracetamol every 8 h from the 2nd to the 29th postoperative day. 1 year after surgery, patients were evaluated for the p

Neuropathic Pain Related with Spinal Disorders: A Systematic Review.

Systematic literature review. To review the evidence from high-quality studies regarding the treatment of neuropathic pain originating specifically from spinal disorders. In general, treatment guidelines for neuropathic pain cover all its various causes, including medical disease, peripheral neuropathy, and cancer. However, the natural history of neuropathic pain originating from spinal disorders may differ from that of the pain originating from other causes or lesions. An expert research librarian used terms related to neuropathic pain and spinal disorders, disc herniation, stenosis, and spin

[One year follow-up of patients discharged from the emergency department with non-specific abdominal pain].

OBJECTIVE: Non-specific abdominal pain (NSAP) is the most common diagnosis of patients presenting to emergency departments (ED) with abdominal pain. The aim of this retrospective study was to investigate how many NSAP patients were re-admitted within 1 year to the ED with abdominal pain. MATERIAL AND METHODS: Included were all patients discharged with NSAP from adult EDs of Landspítali University Hospital (gynecology and pediatric EDs excluded), from January 1, 2005 to December 31, 2005. Hospital records for patients re-admitted within 12 months with abdominal pain were reviewed. Symptoms, pa

Does a perioperative belladonna and opium suppository improve postoperative pain following robotic assisted laparoscopic radical prostatectomy? Results of a single institution randomized study.

INTRODUCTION: Robotic assisted laparoscopic radical prostatectomy (RALP) is a common treatment for localized prostate cancer. Despite a primary advantage of improved postoperative pain, patients undergoing RALP still experience discomfort. Belladonna, containing the muscarinic receptor antagonists atropine and scopolamine, in combination with opium as a rectal suppository (B & O) may improve post-RALP pain. This study evaluates whether a single preoperative B & O results in decreased postoperative patient-reported pain and analgesic requirements. MATERIALS AND METHODS: Patients undergoing RAL

Retrospective evaluation of bone pain palliation after samarium-153-EDTMP therapy.

PURPOSE: The aim of this study was to evaluate the degree of metastatic bone pain palliation and medullar toxicity associated with samarium-153-EDTMP treatment. METHODS: Seventy-three patients with metastatic bone pain having previously undergone therapy with samarium-153-EDTMP (1 mCi/kg) were retrospectively evaluated. Routine follow-up included pain evaluation and blood counts for 2 months after treatment. Pain was evaluated using a subjective scale (from 0 to 10) before and for 8 weeks after the treatment. Blood counts were obtained before treatment and once a week for 2 months during foll

Treatment of gallstones.

PURPOSE: To critically review the risks and benefits of therapy for asymptomatic and symptomatic persons with gallstones who are considering therapy to prevent future episodes of biliary pain or complications including acute cholecystitis, pancreatitis, or gallbladder cancer. DATA SOURCES: Review of English-language literature regarding the natural history of persons with gallstones and the operative mortality rates for open cholecystectomy and laparoscopic cholecystectomy. Mathematical simulation modeling was used to derive estimates of lifetime risks for gallstone-related mortality and for

TMR and RPNI Sustainably Reduce Long-Term Pain and Opioid Use after Oncologic Amputation: A Comparison With Untreated Amputees.

INTRODUCTION: Chronic postamputation pain, driven by residual limb pain (RLP) and phantom limb pain (PLP), is a major source of long-term disability after limb loss. The long-term effectiveness of targeted muscle reinnervation (TMR) and regenerative peripheral nerve interface (RPNI), particularly compared with untreated patients, remains unclear. METHODS: A retrospective cohort study was performed at a single quaternary cancer center. Adult oncologic amputees who received TMR and/or RPNI were compared with a historic cohort without nerve reconstruction, with outcomes assessed at least 10 mont

Quality of life and pain-response after stereotactic ablative radiotherapy of oligometastatic bone metastases in the phase 2 BONY-M trial.

PURPOSE: The Bony-M phase 2 multicentre trial included patients with oligometastatic disease (OMD) for stereotactic ablative radiotherapy (SABR) of bone metastases (clinicaltrials.gov ID-no.NTC05101824). We report the secondary endpoint analyses of longitudinal health-related quality of life (HRQoL) outcomes and pain response. METHODS: Patients with ≥ 1 bone metastasis were eligible for inclusion. Prescription doses were 37.5 or 30 Gy in three fractions. EuroQol EQ-5D-5L and numeric pain rating scale (NPRS) responses were collected at baseline and weeks 12, 24, 36, and 52 (pain also at week 2

Frailty-Informed Pain Management: A Clinical Imperative Beyond Chronological Age.

BACKGROUND: Chronic pain is a prevalent and disabling condition whose management becomes increasingly complex with aging and frailty. While chronological age often guides clinical decisions, frailty offers a more biologically grounded approach. AIMS: We sought to examine the independent associations of chronological age, frailty, and sex with pain management variables in a community-based adult population. METHODS: A cross-sectional study was conducted in 455 adults with chronic non-cancer pain. Frailty was assessed using a 31-item frailty index (FI) on the basis of the deficit accumulation …

Каннабиноиды в условиях хронической боли: обзор истории, эффективности, применения и рисков.

Справочная информация/цели: Хроническая боль по-прежнему является широко распространенной и сложной проблемой в области здравоохранения, которая зачастую является устойчивой к обычным методам лечения, таким, как опиоиды, которые сопряжены со значительным риском зависимости и неблагоприятных последствий. Каннабиноиды, биоактивные соединения, полученные на заводе Cannabis Sativa, и их синтетические аналоги стали потенциальной альтернативой обезболиванию, используя их взаимодействие с эндоканнабиноидной системой для модуляции боли и воспаления. Методы: Были рассмотрены и обобщены нынешняя, развив

Совпадение в полном тексте источника
… Given a lack of strong evidence for their use in cancer pain, guidelines do not currently recommend cannabinoids for treating cancer pain, leaving many oncologists uncertain about offering specific guidance on their use [ 79 ]. … cancer pain), aside from the context of a clinical trial [ 81 ]. 7.6. …

Role of honey in preventing radiation-induced oral mucositis: a meta-analysis of randomized controlled trials.

BACKGROUND: Radiotherapy-induced mucositis easily arouses oral ulceration, pain and xerostomia. Intense pain, difficulty swallowing and speaking greatly affect the quality of life and the treatment process. OBJECTIVE: This study aimed to examine the effects of honey in preventing and treating radiotherapy-induced mucositis in patients with head and neck cancer using a different analytical strategy. METHODS: Articles published until July 2020 were searched across PubMed, Embase, and Cochrane Library databases. Randomized controlled trials that evaluated honey were assessed by two reviewers. T

Transperineal gold marker implantation for image-guided external beam radiotherapy of prostate cancer : A single institution, prospective study.

PURPOSE: To present the feasibility and complications of transperineal fiducial marker implantation in prostate cancer patients undergoing image-guided radiotherapy (IGRT) METHODS AND MATERIALS: Between November 2011 and April 2016, three radiopaque, gold-plated markers were transperineally implanted into the prostate of 300 patients under transrectal ultrasound guidance and with local anaesthesia. A week after the procedure patients filled in a questionnaire regarding pain, dysuria, urinary frequency, nocturia, rectal bleeding, hematuria, hematospermia or fever symptoms caused by the implanta