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Peripheral Nerves in Cancer: Regulatory Roles and Therapeutic Strategies.

Cancer neuroscience has emerged as a transformative frontier in oncology research, focusing on the interplay between cancer cells and the nervous system. Cancer cells establish tumorspecific neural networks within tumor tissues via neurotrophic hijacking. The nervous system regulates tumor initiation, progression, and metastasis either directly by regulating signal transduction in tumor cells or indirectly by modulating the tumor microenvironment (TME). The positive feedback loop between cancer cells and nerves promotes tumor progression. Deciphering the regulatory role of nerves in tumor prog

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… FIGURE 2 Neurogenesis in tumor. … Factors Contributing to Neurogenesis Emerging evidence indicates that cancer cells can induce axon formation by secreting NTFs, axon guidance molecules, and EVs. …

The mutual impacts of stem cells and sleep: opportunities for improved stem cell therapy.

Sleep is an indispensable physiological function regulated by circadian rhythms, which influence the biological pathways and overall health of the body. Sleep is crucial for the maintenance and restoration of bodily systems, and disturbances can lead to various sleep disorders, which can impair both mental and physical health. Treatment options for these disorders encompass lifestyle modifications, psychotherapy, medications, and therapies such as light therapy and surgery. Not only sleep deprivation has a significant impact on essential organs, but it also influences various types of stem cel

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… Malik A Development of circadian oscillators in neurosphere cultures during adult neurogenesis PLoS ONE 2015 10 3 e0122937 25826427 10.1371/journal.pone.0122937 PMC4380296 Malik A, et al. Development of circadian oscillators in neurosphere cultures during adult neurogenesis. … Adult neurogenesis under control of the circadian system. Cells, 2022;11(5). 10.3390/cells11050764 PMC8909047 35269386 74. …

Иммунитет в нейромодуляции: исследование нейронных и иммунных путей в расстройствах мозга.

Иммунитет четко регулирует функцию мозга. Она непосредственно участвует в патологических процессах таких нейродегенеративных заболеваний, как болезнь Паркинсона и Альцгеймера, посттравматические заболевания, множественный склероз, травма головного мозга и психические расстройства (большое расстройство организма, серьезное депрессивное расстройство (МДС), расстройства тревожности, расстройства психоза и шизофрения, а также расстройства нервного развития (НРД). Нейромодулирование в настоящее время является одной из ведущих терапевтических стратегий лечения этих расстройств, однако пока мало что

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… Levels of pro-inflammatory, anti-inflammatory, and trophic factors increased, as well as those of neurotrophic and neurogenesis factors. In addition, SIR may occur through induction of the NFκB pathway. … Preclinical studies show that rTMS and VNS facilitate microglial phenotypic switching and astrocytic polarization, effectively reducing inflammation and oxidative stress while promoting neurogenesis. …

Мелатонин улучшает астроглиоз и микроглиоз в мышечной модели купризоны.

СПРАВОЧНАЯ ИНФОРМАЦИЯ И ЦЕЛЬ: В ряде исследований сообщалось, что мелатонин участвует в совершенствовании подстрекательского процесса, совершенствовании функции миелина и регенерации центральной нервной системы (ЦНС). Нынешнее исследование направлено на оценку защитного воздействия мелатонина в кустарной зоне (КХЗ) в результате повреждения миелина в корпусе каллосум (КЦ) и изучение вероятных основополагающих механизмов способности к ремиелинации и/или нейрозащиты.Мы управляли кухонной зоной в чау в одиночестве каждый день. 6 Мы изучали демиэлизацию с помощью пятна LFB, пятна олигодендроцита с

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… Kim et al. reported, (6 mg/L in water) melatonin for 6 weeks reduces cuprizone's effects on hippocampus neurogenesis (NeuN and MBP,BDNF protein expression). … There is evidence that the activation of Notch1 signaling may restore neurogenesis and cognitive functioning in AD animal models [ 47 ]. …

Нацеливание на природные полифенолы антиоксидантов в целях защиты от нейроинфламмации и нейродегенеративных заболеваний: всеобъемлющий обзор.

Полифенолы, природные фитонутриенты, встречающиеся в растительных продуктах питания, привлекли значительное внимание к их потенциальному терапевтическому воздействию в неврологических заболеваниях и нейроинфламмации. Эти соединения обладают различными возможностями нейрозащиты, включая антиоксидантные, антивоспалительные и антиамильоидные свойства, которые способствуют смягчению развития таких нейродегенеративных заболеваний, как болезнь Альцгеймера (AD), болезнь Паркинсона (PD), деменция, множественный склероз (MS), Строк и болезнь Хантингтона (HD). Полифенолы были тщательно изучены на предме

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… , modulates PI3K/Akt pathway, enhances autophagy de Oliveira (2016) Silymarin Milk thistle 10–100 µM Antioxidant, anti-inflammatory, inhibits NF-κB, promotes neuroprotection Surai (2015) Apigenin Chamomile, parsley 1–20 µM Antioxidant, anti-inflammatory, modulates MAPK/ERK pathway, promotes neurogenesis … Simmilarly, the involvement of ERK and PKC pathways in the neurogenesis phase in PC12 cells also leads to a curcurrination response. The ERK and P38MAPK also inhibit Artepillin C-induced neutric outgrowth of PC12m3 cells ( Motoda et al., 2019 ). …

The influence of neuro-tumor interactions on tumorigenesis and therapeutic response.

The intricate crosstalk between the nervous system and tumors has emerged as a pivotal determinant of tumorigenesis, progression, and therapeutic response. This review synthesizes current insights into neuro-tumor interactions, highlighting how neuronal networks within the tumor microenvironment (TME) modulate cancer cell proliferation, invasion, and angiogenesis by releasing neurotransmitters, growth factors, etc. The neuro-immune axis, a critical interface linking neural signaling to immune regulation, is explored in depth, elucidating how neuronal-derived molecules influence the phenotype a

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… NOTCH-dependent signal regulates the development and differentiation of many organ systems, including cell differentiation and neurogenesis [ 261 ]. … Single-cell mapping links neurogenesis and angiogenesis in aggressive breast cancer. bioRxiv; 2024. 133. Gomez K, Duran P, Tonello R, Allen HN, Boinon L, Calderon-Rivera A, Loya-López S, Nelson TS, Ran D, Moutal A, et al. …

Интерпретируемая скорость и возможные выгоды от ожирения, диабета и множественного склероза: систематический обзор случайных клинических испытаний.

В последние годы популярна практика интермитирования скорости, которая в споре представляется в качестве возможного терапевтического адъюнктора. Был проведен библиографический обзор литературы по вопросам периодического быстрого роста и ожирения, диабета и множественного склероза. Научное качество методологии и полученные результаты оценивались по парам. Промежуточный пост оказывает благоприятное воздействие на профиль липидов, и он связан с потерей веса и модификацией распределения брюшного жира у людей с ожирением и типом 2 диабет, а также улучшение контроля за глицемическими уровнями. У пац

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… In rodents, IF has a positive impact on adult hippocampal neurogenesis (AHN). IF cannot only improve AHN in healthy mice but also protect against neuronal loss caused by excitotoxic damage in the hippocampus, with a greater survival of neurons than observed in mice fed ad libitum. … Energy restriction can affect the expression of genes involved in neurogenesis and increase the proliferation of neural cells. Low-energy diets during adolescence increase cell proliferation and the number of neurons in the hippocampus and can result in better cognition in adulthood. …

Blood Vessels and Peripheral Nerves as Key Players in Cancer Progression and Therapy Resistance.

Cancer cells continuously interact with the tumor microenvironment (TME), a heterogeneous milieu that surrounds the tumor mass and impinges on its phenotype. Among the components of the TME, blood vessels and peripheral nerves have been extensively studied in recent years for their prominent role in tumor development from tumor initiation. Cancer cells were shown to actively promote their own vascularization and innervation through the processes of angiogenesis and axonogenesis. Indeed, sprouting vessels and axons deliver several factors needed by cancer cells to survive and proliferate, inclu

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… Notably, the upregulation of semaphorin 4F in PC cells was shown to be sufficient to induce both neurogenesis and axonogenesis [ 79 ]. … Neurogenesis in colorectal cancer is a marker of aggressive tumor behavior and poor outcomes. Cancer. 2011;117:4834–4845. doi: 10.1002/cncr.26117. 144. Zhao Q., Yang Y., Liang X., Du G., Liu L., Lu L., Dong J., Han H., Zhang G. The clinicopathological significance of neurogenesis in breast cancer. …

The evolving roles of Wnt signaling in stem cell proliferation and differentiation, the development of human diseases, and therapeutic opportunities.

The evolutionarily conserved Wnt signaling pathway plays a central role in development and adult tissue homeostasis across species. Wnt proteins are secreted, lipid-modified signaling molecules that activate the canonical (β-catenin dependent) and non-canonical (β-catenin independent) Wnt signaling pathways. Cellular behaviors such as proliferation, differentiation, maturation, and proper body-axis specification are carried out by the canonical pathway, which is the best characterized of the known Wnt signaling paths. Wnt signaling has emerged as an important factor in stem cell biology and is

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… Moreover, Wnt5a has been shown to play a role in adult hippocampal neurogenesis by activating the non-canonical Wnt pathway. … The overexpression of Wnt3 caused an increase in AHP neurogenesis in vitro and in vivo . …

Метформин репурируется в неврологических расстройствах: клинический экспериментальный ландшафт.

КОЛИЧЕСТВО: Неврологические расстройства, такие, как болезнь Альцгеймера (AD) и множественный склероз (MS), предполагают постепенную потерю нервных клеток, а текущее лечение в основном обеспечивает симптоматическое облегчение без остановки развития болезни. Для устранения этого пробела перспективным подходом является перерасчет лекарств. Метформин, широко используемый пероральный антидиабетический препарат, изучается в случае расстройств центральной нервной системы (СНС) в силу его множественных последствий, включая активацию аденосинового монофосфата, активирующего белковую киназу (АМПК), под

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… activates several processes in the central nervous system (CNS), such as neuroprotection, neuronal regeneration and anti-inflammation. 1 Through the activation of the atypical protein kinase C (aPKC)–CREB-Binding Protein (CBP) pathway, it increases the generation of spatial memory and supports adult neurogenesis … Using advanced biomarkers such as DTI and molecular assays to measure biological efficacy, these trials are well-organised to explore certain neuroprotective pathways, such as remyelination, neurogenesis and anti-neuroinflammation. 14 Large-scale RCTs are still required to overcome methodological …

Identification of GLI Mutations in Patients With Hirschsprung Disease That Disrupt Enteric Nervous System Development in Mice.

BACKGROUND & AIMS: Hirschsprung disease is characterized by a deficit in enteric neurons, which are derived from neural crest cells (NCCs). Aberrant hedgehog signaling disrupts NCC differentiation and might cause Hirschsprung disease. We performed genetic analyses to determine whether hedgehog signaling is involved in pathogenesis. METHODS: We performed deep-target sequencing of DNA from 20 patients with Hirschsprung disease (16 men, 4 women), and 20 individuals without (controls), and searched for mutation(s) in GLI1, GLI2, GLI3, SUFU, and SOX10. Biological effects of GLI mutations were test

α2-3-sialylated Гликосфинголипиды при нейроинфламмации, иммунитете и запрограммированной смерти клеток: механистические доказательства и регулирование в зависимости от контекста: всеобъемлющий обзор.

α2-3-sialylated glycosphingolids (α2)3-GSLs) являются основными составляющими нейронных мембран и липидных плотов, где они формируют сепарацию рецепторов, комплекс сигналов и связь с клетками. Однако их биологическое воздействие варьируется в зависимости от молекулярного подтипа, типа клеток, стадии заболевания, концентрации и местной микроокружающей среды. В настоящем обзоре обобщены данные о перепончатых изменениях в α2-3-GSL профили и их связи с нейроинфламмацией, иммунной реакцией, протеостазом и запрограммированной клеточной смертностью через болезнь Паркинсона, болезнь Альцгеймера, болез

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… Regulation of neurogenesis: established developmental functions and limitations of extrapolation to PD. … To date, GD3 has been shown to improve neurogenesis only in the olfactory bulb of A53T α-Syn-transgenic mice; evidence that it induces functional dopaminergic neurogenesis and circuit integration in the nigrostriatal pathway remains insufficient ( 44 ). …

Neuroscience in peripheral cancers: tumors hijacking nerves and neuroimmune crosstalk.

Cancer neuroscience is an emerging field that investigates the intricate relationship between the nervous system and cancer, gaining increasing recognition for its importance. The central nervous system governs the development of the nervous system and directly affects brain tumors, and the peripheral nervous system (PNS) shapes the tumor microenvironment (TME) of peripheral tumors. Both systems are crucial in cancer initiation and progression, with recent studies revealing a more intricate role of the PNS within the TME. Tumors not only invade nerves but also persuade them through remodeling

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… For instance, in Alzheimer's disease, conditioned media from T cells treated with photobiomodulation therapy has been found to promote neural stem cell differentiation. 312 Macrophages have a complex role in neurogenesis. … Cancer‐related axonogenesis and neurogenesis in prostate cancer. Clin Cancer Res. 2008;14(23):7593‐7603. 10. Albo D, Akay CL, Marshall CL, et al. Neurogenesis in colorectal cancer is a marker of aggressive tumor behavior and poor outcomes. Cancer. 2011;117(21):4834‐4845. 11. Park H, Lee CH. …

Mechanisms of Chemotherapy-Induced Neurotoxicity.

Since the first clinical trials conducted after World War II, chemotherapeutic drugs have been extensively used in the clinic as the main cancer treatment either alone or as an adjuvant therapy before and after surgery. Although the use of chemotherapeutic drugs improved the survival of cancer patients, these drugs are notorious for causing many severe side effects that significantly reduce the efficacy of anti-cancer treatment and patients' quality of life. Many widely used chemotherapy drugs including platinum-based agents, taxanes, vinca alkaloids, proteasome inhibitors, and thalidomide ana

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… and Neural Network Dynamics Reduced neurogenesis is the most commonly studied mechanism for chemobrain. … Therefore, suppression of neurogenesis was directly related to chronic neurotoxic effects, including hippocampus-dependent cognitive functions ( Christie et al., 2012 ; Monje and Dietrich, 2012 ; Lomeli et al., 2017 ). …

Neuroimmune crosstalk and its impact on cancer therapy and research.

Cancer is a major health problem as it is the first or second leading cause of death worldwide. The global cancer burden is expected to rise 47% relative to 2020 cancer incidence. Recently, the fields of neuroscience, neuroimmunology and oncology have elaborated the neuroimmune crosstalk role in tumor initiation, invasion, progression, and metastases. The nervous system exerts a broad impact on the tumor microenvironment by interacting with a complex network of cells such as stromal, endothelial, malignant cells and immune cells. This communication modulates cancer proliferation, invasion, met

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… neural reprogramming, and promotes sensory neurogenesis [ 29 ]. … Mauffrey P Tchitchek N Barroca V Bemelmans AP Firlej V Allory Y Roméo P Magnon C Progenitors from the central nervous system drive neurogenesis in cancer Nature 2019 569 672 678 10.1038/s41586-019-1219-y 31092925 11. …

Deciphering transcriptomic changes in chemobrain: a comprehensive review.

Chemotherapy-induced cognitive impairments (CICI), colloquially known as "chemobrain," represents a profound and debilitating side effect experienced by a significant number of cancer survivors, impacting their memory, multitasking, and quality of life. This review critically evaluates the molecular mechanisms underlying CICI, with a particular focus on the insights gained from transcriptomic analyses. As cancer incidence rises globally, understanding the complex interplay between chemotherapy agents and their cognitive repercussions becomes increasingly vital. Key mechanisms implicated in CIC

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… Specifically, cisplatin-induced neurogenesis defects are considerably mitigated by KW-6002-mediated A2ar antagonism [ 62 ]. … Genes related to the oxidative phosphorylation pathway and dopaminergic neurogenesis were found to be downregulated in the PFC of females that were administered MMC [ 68 ]. …

Возрастающая роль адропина в неврологическом здоровье: систематический обзор.

Адропин, гормон пептида играет роль в различных физиологических процессах, включая метаболическое регулирование и сердечно-сосудистое здоровье. Цель этого систематического обзора заключалась в обобщении результатов наблюдений по вопросу об участии адропина в неврологических расстройствах и когнитивных характеристиках. Были отобраны и проанализированы исследования, опубликованные в период с 2020 по 2024 год. Процесс поиска и отбора соответствовал Руководящим принципам по предпочтительным элементам отчетности для системных обзоров и мета-анализов (PRISMA). Из 127 отобранных статей 5 удовлетворяю

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… The Notch1 pathway has been found to be one of the major players in cell fate during development and still relevant in the adult brain by modulating neurogenesis and neuronal plasticity. … However, potential pathways include modulation of synaptic plasticity, neurogenesis, and neurotransmitter regulation. …

Neurobiology of Cancer: Introduction of New Drugs in the Treatment and Prevention of Cancer.

Research on the neurobiology of cancer, which lies at the border of neuroscience and oncology, has elucidated the mechanisms and pathways that enable the nervous system to modulate processes associated with cancer initiation and progression. This research has also shown that several drugs which modulate interactions between the nervous system and the tumor micro- and macroenvironments significantly reduced the progression of cancer in animal models. Encouraging results were also provided by prospective clinical trials investigating the effect of drugs that reduce adrenergic signaling on the co

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… Cancer-related axonogenesis and neurogenesis in prostate cancer Clin. Cancer Res. 2008 14 7593 7603 10.1158/1078-0432.CCR-08-1164 19047084 116. Albo D. Akay C.L. Marshall C.L. Wilks J.A. Verstovsek G. Liu H. Agarwal N. Berger D.H. Ayala G.E. … Biologic effect of neurogenesis in pancreatic cancer Hum. Pathol. 2016 52 182 189 10.1016/j.humpath.2016.02.001 26980040 129. Coarfa C. Florentin D. Putluri N. Ding Y. Au J. He D. Ragheb A. Frolov A. Michailidis G. Lee M. …

Unveiling the role of histone deacetylases in neurological diseases: focus on epilepsy.

Epilepsy remains a prevalent chronic neurological disease that is featured by aberrant, recurrent and hypersynchronous discharge of neurons and poses a great challenge to healthcare systems. Although several therapeutic interventions are successfully utilized for treating epilepsy, they can merely provide symptom relief but cannot exert disease-modifying effect. Therefore, it is of urgent need to explore other potential mechanism to develop a novel approach to delay the epileptic progression. Since approximately 30 years ago, histone deacetylases (HDACs), the versatile epigenetic regulators re

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… Additionally, the inhibitory effect of seizure-induced neurogenesis by VPA is also closely linked with the epigenetic mechanisms deriving from HDAC inhibition [ 130 ]. … Aberrant hippocampal neurogenesis contributes to epilepsy and associated cognitive decline. Nat Commun. 2015;6:6606. 25808087 10.1038/ncomms7606 PMC4375780 13. …

Effect of physical exercise on cognitive function after chemotherapy in patients with breast cancer: a randomized controlled trial (PAM study).

BACKGROUND: Up to 60% of breast cancer patients treated with chemotherapy is confronted with cognitive problems, which can have a significant impact on daily activities and quality of life (QoL). We investigated whether exercise training improves cognition in chemotherapy-exposed breast cancer patients 2-4 years after diagnosis. METHODS: Chemotherapy-exposed breast cancer patients, with both self-reported cognitive problems and lower than expected performance on neuropsychological tests, were randomized to an exercise or control group. The 6-month exercise intervention consisted of supervised

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… Rodent studies have shown that several biological processes affected by chemotherapy improved after exercise training, in particular hippocampal neurogenesis, which is important for learning and memory functioning [ 9 ]. … Our exercise intervention aimed at improving tested cognitive problems in patients who self-report cognitive complaints, by targeting one of the presumed causes of these problems, i.e., impaired hippocampal neurogenesis [ 9 ]. …