Результаты поиска

Inflammation and Cancer: Molecular Mechanisms and Therapeutic Targets.

Inflammation is a core pathological factor regulating tumor initiation, progression, and therapeutic resistance, and elucidating its molecular crosstalk with tumors is crucial for developing effective clinical therapies. Internal drivers of inflammation-tumor transformation include genomic disorder, epigenetic memory, mitochondrial stress, and metabolic reprogramming, which synergistically initiate carcinogenesis. External factors amplifying tumor progression cover immune dysfunction, stromal fibrosis, microbial dysbiosis, vascular neoplasia, and neurotoxicity, collectively accelerating tumor

Совпадение в полном тексте источника
… signaling pathways | Janus kinase‐signal transducer and Activator of transcription (JAK‐STAT) pathway | Immune cells, parenchymal cells (hepatocytes/epithelial cells) | JAK2‐STAT3 mediates IL‐6 signaling; JAK1‐STAT1 mediates IFN‐γ signaling | [ 29 , 30 ] | Inflammasome pathways | NOD‐like receptor family pyrin …

" Глаза как окно к нейродегенерации: окисляющий стресс " , " Оптическая уязвимость нерва " и " Стержневой обзор биомаркеров-а " .

Нейродегенеративные заболевания представляют собой серьезное и растущее бремя для здоровья населения мира, характеризующееся постепенной нейронной дисфункцией, аксонной дегенерацией и необратимой потерей нейронных тканей. Все больше фактов указывает на окислительный стресс как на один из нескольких взаимодействующих патогенных механизмов в болезни Альцгеймера, болезни Паркинсона, амиотропического бокового склероза и нескольких оптических нейропот. Все больше внимания уделяется оси мозга и сетчатки, поскольку сетчатка и зрительный нерв делятся структурными, метаболическими и молекулярными харак

Mechanisms and Applications of Manganese-Based Nanomaterials in Tumor Diagnosis and Therapy.

Tumors are the second most common cause of mortality globally, ranking just below heart disease. With continuous advances in diagnostic technology and treatment approaches, the survival rates of some cancers have increased. Nevertheless, due to the complexity of the mechanisms underlying tumors, cancer remains a serious public health issue that threatens the health of the population globally. Manganese (Mn) is an essential trace element for the human body. Its regulatory role in tumor biology has received much attention in recent years. Developments in nanotechnology have led to the emergence

Совпадение в полном тексте источника
… Additionally, with Mn overexposure in Parkinson’s disease rat models, neuroinflammatory biomarkers, such as tumor necrosis factor-α (TNF-α), TLR4, nucleotide-binding oligomerization domain, leucine-rich repeat and pyrin domain-containing 3 (NLRP3), NF-κB, Caspase-1, and interleukin-1β (IL-1β), were increased …

Cancer-Therapy-Related Cardiac Dysfunction: Latest Advances in Prevention and Treatment.

The increasing efficacy of cancer therapies has significantly improved survival rates, but it has also highlighted the prevalence of cancer-therapy-related cardiac dysfunction (CTRCD). This review provides a comprehensive overview of the identification, monitoring, and management of CTRCD, a condition resulting from several treatments, such as anthracyclines, HER2-targeted therapies, target therapies, and radiotherapy. The paper includes a discussion of the mechanisms of CTRCD associated with various cancer treatments. Early detection through serum biomarkers and advanced imaging techniques is

Совпадение в полном тексте источника
… Additionally, flavonoids, like dihydromyrecetin, have shown potential in reducing doxorubicin-induced cardiotoxicity by modulating inflammation through the nucleotide-binding oligomerization domain-like receptor family pyrin domain containing 3 (NLRP3) inflammasome [ 11 , 128 , 129 , 130 ]. …

Нейроинфламмация в нейродегенеративных заболеваниях: сосредоточение внимания на посредничестве лимфоцитов T.

Нейродегенеративные заболевания представляют собой группу заболеваний, характеризующихся постепенным ухудшением центральной нервной системы, что приводит к снижению когнитивных, моторных и эмоциональных способностей пациентов. Нейроинфламмация играет важную роль в развитии этих заболеваний. Вместе с тем исследования терапевтических подходов к целенаправленной борьбе с нейроинфламмацией носят ограниченный характер. Все шире признается роль лимфоцитов, которые являются важнейшими посредниками адаптивной иммунной реакции, в нейродегенеративных заболеваниях. В настоящем обзоре основное внимание уд

Совпадение в полном тексте источника
… colony-stimulating factor; Gra B: granzyme B; ICAM-1: intercellular adhesion molecule 1; IFN-γ: interferon-gamma; IL: interleukin; IL-17R: interleukin-17 receptor; LFA-1: leukocyte function-associated antigen 1; NK: natural killer cell; NLRP3: nucleotide-binding oligomerization domain, leucine-rich repeat and pyrin …

Amyloid Proteins and Peripheral Neuropathy.

Painful peripheral neuropathy affects millions of people worldwide. Peripheral neuropathy develops in patients with various diseases, including rare familial or acquired amyloid polyneuropathies, as well as some common diseases, including type 2 diabetes mellitus and several chronic inflammatory diseases. Intriguingly, these diseases share a histopathological feature-deposits of amyloid-forming proteins in tissues. Amyloid-forming proteins may cause tissue dysregulation and damage, including damage to nerves, and may be a common cause of neuropathy in these, and potentially other, diseases. He

Совпадение в полном тексте источника
… The pyrin domain containing NOD-like receptor (NLRP3) inflammasome is a key component of the innate immune system that induces proinflammatory cytokine production. Protein aggregates from hIAPP and Aβ activate NLRP3 [ 243 ]. …

The Role of Circulating MicroRNAs as Biomarkers and Therapeutic Targets in Venous Thromboembolism: A Systematic Review.

Introduction: Venous thromboembolism (VTE), encompassing deep vein thrombosis (DVT) and pulmonary embolism (PE), is a major cardiovascular disorder and a leading cause of vascular mortality. MicroRNAs (miRNAs) are small endogenous noncoding RNAs that regulate gene expression post-transcriptionally by binding to the target messenger RNAs (mRNAs), inducing mRNA degradation or translational repression. miRNA dysregulation likely contributes to VTE pathogenesis. This review comprehensively summarizes current evidence on miRNAs in VTE, offering a structured overview of the existing literature. Mate

Совпадение в полном тексте источника
… | nuclear paraspeckle assembly transcript 1 long noncoding RNA (non-protein-coding RNA product) CASC2 | 608598 | cancer susceptibility 2 long noncoding RNA (non-protein-coding RNA product) | Nek2 | 604043 | never in mitosis A-related kinase 2 CASP1 | 147678 | caspase-1 | NLRP3 | 606416 | NLR family pyrin …

Infections associated with immunotherapeutic and molecular targeted agents in hematology and oncology. A position paper by the European Conference on Infections in Leukemia (ECIL).

A multitude of new agents for the treatment of hematologic malignancies has been introduced over the past decade. Hematologists, infectious disease specialists, stem cell transplant experts, pulmonologists and radiologists have met within the framework of the European Conference on Infections in Leukemia (ECIL) to provide a critical state-of-the-art on infectious complications associated with immunotherapeutic and molecular targeted agents used in clinical routine. For brentuximab vedotin, blinatumomab, CTLA4- and PD-1/PD-L1-inhibitors as well as for ibrutinib, idelalisib, HDAC inhibitors, mTO

Совпадение в полном тексте источника
… Table 1 Summary of drug characteristics, reported infectious complications and ECIL recommendations for clinical practice NLRP3, NLR (nucleotide-binding domain, leucine-rich repeat) family, pyrin domain containing 3, G-CSF granulocyte-colony stimulating factor, HBV hepatitis B virus, CMV cytomegalovirus …

Abscopal Effects in Metastatic Cancer: Is a Predictive Approach Possible to Improve Individual Outcomes?

Patients with metastatic cancers often require radiotherapy (RT) as a palliative therapy for cancer pain. RT can, however, also induce systemic antitumor effects outside of the irradiated field (abscopal effects) in various cancer entities. The occurrence of the abscopal effect is associated with a specific immunological activation in response to RT-induced cell death, which is mainly seen under concomitant immune checkpoint blockade. Even if the number of reported apscopal effects has increased since the introduction of immune checkpoint inhibition, its occurrence is still considered rare and

Совпадение в полном тексте источника
… Moreover, ATP binds to P2X purinoreceptor 7 (P2X7R) on inflammatory cells, activating the NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammasome, a multiprotein complex that produces active caspase-1 and stimulates the production of interleukin (IL) 1β and IL-18 [ 116 , 117 ]. …

Healthy Effects of Plant Polyphenols: Molecular Mechanisms.

The increasing extension in life expectancy of human beings in developed countries is accompanied by a progressively greater rate of degenerative diseases associated with lifestyle and aging, most of which are still waiting for effective, not merely symptomatic, therapies. Accordingly, at present, the recommendations aimed at reducing the prevalence of these conditions in the population are limited to a safer lifestyle including physical/mental exercise, a reduced caloric intake, and a proper diet in a convivial environment. The claimed health benefits of the Mediterranean and Asian diets have

Совпадение в полном тексте источника
… In particular, the NLR family, pyrin domain-containing-3 (NLRP3) inflammasome has been shown to play a pathogenic role in the development of neuroinflammatory disorders, such as AD [ 125 ] and PD [ 126 ]. …

The Cancer Antioxidant Regulation System in Therapeutic Resistance.

Antioxidants play a pivotal role in neutralizing reactive oxygen species (ROS), which are known to induce oxidative stress. In the context of cancer development, cancer cells adeptly maintain elevated levels of both ROS and antioxidants through a process termed "redox reprogramming". This balance optimizes the proliferative influence of ROS while simultaneously reducing the potential for ROS to cause damage to the cell. In some cases, the adapted antioxidant machinery can hamper the efficacy of treatments for neoplastic diseases, representing a significant facet of the resistance mechanisms ob

Совпадение в полном тексте источника
… RRx-001, an NLR family pyrin domain-containing 3 (NLRP3) inflammasome inhibitor and NO releaser, was found to inhibit G6PD in different cancer cells [ 289 , 290 ]. …

Oxidative Stress: Signaling Pathways, Biological Functions, and Disease.

The dysregulated accumulation of reactive oxygen species (ROS) and reactive nitrogen species disrupts redox homeostasis, triggering oxidative stress (OS) and driving pathophysiological changes across multiple organ systems. OS modulates critical signaling pathways, induces inflammation, impairs mitochondrial function, alters metabolic homeostasis, and dysregulates autophagy, contributing to disease progression. While prior research has largely focused on OS within single-organ diseases (e.g., neurodegenerative, cardiovascular, and oncological disorders), the systemic role of OS in pan-organ di

Совпадение в полном тексте источника
… , ROS drive M1 polarization via ataxia–telangiectasia mutated (ATM)‐cell cycle checkpoint kinase 2 (Chk2)‐mediated pyruvate kinase M2 (PKM2) phosphorylation/glycolysis, MAPK‐nuclear factor kappa‐B p65 (NF‐κB p65)‐dependent cytokine secretion, and hypoxia‐inducible factor 1‐alpha (HIF‐1α)/NLR family pyrin … ROS also upregulate the expression of hypoxia‐inducible factor 1‐alpha (HIF‐1α) [ 33 ] and induce the activation of NLR family pyrin domain‐containing 3 (NLRP3) inflammasome [ 34 ], promoting the M1 polarization of macrophages [35]. …

Posttransplant complications: molecular mechanisms and therapeutic interventions.

Posttransplantation complications pose a major challenge to the long-term survival and quality of life of organ transplant recipients. These complications encompass immune-mediated complications, infectious complications, metabolic complications, and malignancies, with each type influenced by various risk factors and pathological mechanisms. The molecular mechanisms underlying posttransplantation complications involve a complex interplay of immunological, metabolic, and oncogenic processes, including innate and adaptive immune activation, immunosuppressant side effects, and viral reactivation.

Совпадение в полном тексте источника
… glucagon‐like peptide 1 receptor; GVHD, graft‐versus‐host disease; HBV, hepatitis B virus; HCC, hepatocellular carcinoma; IFN‐γ, interferon‐gamma; IL, interleukin; JAK, Janus kinase; MICs, modified immune cells; MSCs, mesenchymal stromal cells; mTOR, mammalian target of rapamycin; NLRP3, NOD‐, LRR‐, and pyrin …

Chemotherapy-induced peripheral neuropathy in children and adolescent cancer patients.

Brain cancer and leukemia are the most common cancers diagnosed in the pediatric population and are often treated with lifesaving chemotherapy. However, chemotherapy causes severe adverse effects and chemotherapy-induced peripheral neuropathy (CIPN) is a major dose-limiting and debilitating side effect. CIPN can greatly impair quality of life and increases morbidity of pediatric patients with cancer, with the accompanying symptoms frequently remaining underdiagnosed. Little is known about the incidence of CIPN, its impact on the pediatric population, and the underlying pathophysiological mecha

Совпадение в полном тексте источника
… receptor potential (TRP) ankyrin 1; TRPM8, transient receptor potential cation channel subfamily melastatin member 8; TRPV1, transient receptor potential vanilloid-type 1; TRPV4, transient receptor potential vanilloid-type 4; ROS, reactive oxygen species; TLR4, toll-like receptor 4; NLRP3, NOD-, LRR- and pyrin …

Natural biomolecules and derivatives as anticancer immunomodulatory agents.

Despite advancements in chemotherapy, the issue of resistance and non-responsiveness to many chemotherapeutic drugs that are currently in clinical use still remains. Recently, cancer immunotherapy has gathered attention as a novel treatment against select cancers. Immunomodulation is also emerging as an effective strategy to improve efficacy. Natural phytochemicals, with known anticancer properties, been reported to mediate their effects by modulating both traditional cancer pathways and immunity. The mechanism of phytochemical mediated-immunomodulatory activity may be attributed to the remode

MSC-EV therapy for bone/cartilage diseases.

Mesenchymal stromal cells (MSCs) have been utilized in cell therapy for various diseases. Recent studies have demonstrated that extracellular vesicles (EVs) released by MSCs play an important role in their therapeutic activities. EVs contain a variety of bioactive molecules such as proteins, messenger RNAs (mRNAs), and micro RNAs (miRNAs) and modify the function of the recipient cells by transferring these molecules. Despite the promising potential of EV therapy as a substitute for MSC therapy, there are challenges that need to be addressed for the clinical success of EV therapy. EV quality ha

Совпадение в полном тексте источника
… MiR-223 in BMSCs-secreted exosomes delays the inflammatory responses by targeting NLR family pyrin domain containing 3 (NLRP3) ( Huang et al., 2022b ). Osteoporosis Bone is an organ exhibiting dynamic metabolic activity. …

Decoding the molecular mechanisms of pyroptosis and its therapeutic development prospects.

Pyroptosis is an emerging form of inflammatory programmed cell death primarily mediated by the gasdermin protein family, characterized by cell swelling, membrane pore formation, and the release of pro-inflammatory cytokines such as IL-1β and IL-18. This mode of cell death has garnered significant attention due to its critical involvement in a variety of diseases, including cancer, cardiovascular disorders, autoimmune diseases, and metabolic syndromes, positioning it as a promising therapeutic target. Despite advances, the complexity of pyroptosis regulation and its dual roles in disease pathog

Myelin Displacement and Revention in the Central Nervous System: Молекулярные механизмы, болезни и перспективные терапевтические цели.

Майлин пластичность имеет основополагающее значение для формирования нейронных сетей и оптимизации нейронных функций, формирования схем, регулирующих эмоции, сознание, сенсацию и управление двигателем. Подкомбинированный олигодендроцитами, миелин подвергается пожизненной реконструкции, которая требует высокой метаболической активности; это делает миелин-олигодендроцитную единицу весьма восприимчивой к метаболическому стрессу, старению и патологическим оскорблениям. Хотя обезвоживание является основной характеристикой различных хронических неврологических расстройств, в настоящем обзоре особо п

Совпадение в полном тексте источника
… EBV infection has been implicated in the demyelination of the CNS [ 116 ], primarily through the activation of the NLR family pyrin domain containing protein 3 (NLRP3) inflammasome pathway [ 117 ], a critical neuroinflammatory pathway in AD [ 118 ]. …

The ambiguous role of obesity in oncology by promoting cancer but boosting antitumor immunotherapy.

Obesity is nowadays considered a pandemic which prevalence's has been steadily increasingly in western countries. It is a dynamic, complex, and multifactorial disease which propitiates the development of several metabolic and cardiovascular diseases, as well as cancer. Excessive adipose tissue has been causally related to cancer progression and is a preventable risk factor for overall and cancer-specific survival, associated with poor prognosis in cancer patients. The onset of obesity features a state of chronic low-grade inflammation and secretion of a diversity of adipocyte-derived molecules

Совпадение в полном тексте источника
… NLR family pyrin domain containing 3 (NLRP3) and absent in melanoma 2 (AIM2) inflammasomes are molecular pattern sensors [ 92 ] that, through processing caspase-1, enable cytokine secretion and maturation of Gasdermin D (GSDMD), the cell death executor [ 90 ]. …

Specific epigenetic regulators serve as potential therapeutic targets in idiopathic pulmonary fibrosis.

Idiopathic pulmonary fibrosis (IPF), a disorder observed mostly in older human beings, is characterised by chronic and progressive lung scarring leading to an irreversible decline in lung function. This health condition has a dismal prognosis and the currently available drugs only delay but fail to reverse the progression of lung damage. Consequently, it becomes imperative to discover improved therapeutic compounds and their cellular targets to cure IPF. In this regard, a number of recent studies have targeted the epigenetic regulation by histone deacetylases (HDACs) to develop and categorise

Совпадение в полном тексте источника
… follows: NACHT, An acronym standing for NAIP (neuronal apoptosis inhibitor protein), C2TA [major histocompatibility complex (MHC) class 2 transcription activator], HET-E (incompatibility locus protein from Podospora anserina ) and TP1 (telomerase-associated protein); LRR, Leucine-rich repeat; PYD, Pyrin …