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Оказание помощи лицам, страдающим множественным склерозом, в Италии: восходящий подход проекта < < Континхом > > .

ЦЕЛЬ: В Италии, вокруг 137,000 Люди живут с множественным склерозом, сталкиваясь с организационными сложностями из-за того, что нынешняя модель уделяет ограниченное внимание уходу в непосредственной близости. Этот проект направлен на определение модели близости в соответствии с последними изменениями в итальянской системе здравоохранения, которая включает в себя: 150 Заинтересованные стороны в области здравоохранения, которые могут оказать 14,000 Пациенты. МЕТОДЫ: Был проведен анализ с целью картирования многоразового склерозового пути, после чего были проведены собеседования для выявления фак

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… IQVIA Italy’s Implementation Science Team (hereinafter operative team) led the development of the project’s phases, drawing on their specialized expertise in optimizing clinical pathways and healthcare processes. …

Impact of the National Health Insurance Coverage Policy on the Utilisation and Accessibility of Innovative Anti-cancer Medicines in China: An Interrupted Time-Series Study.

Objective: The study aimed to evaluate the impact of the National Health Insurance Coverage (NHIC) policy on the utilisation and accessibility of innovative anti-cancer medicines in Nanjing, China. Methods: We used the adjusted World Health Organisation and Health Action International methodology to calculate the price and availability of 15 innovative anti-cancer medicines included in the National Health Insurance drug list in 20 tertiary hospitals and six secondary hospitals in Nanjing before and after NHIC policy implementation. Interrupted time-series regression was used to analyse the cha

Using the Computer-based Health Evaluation System (CHES) to Support Self-management of Symptoms and Functional Health: Evaluation of Hematological Patient Use of a Web-Based Patient Portal.

BACKGROUND: Patient portals offer the possibility to assess patient-reported outcome measures (PROMs) remotely, and first evidence has demonstrated their potential benefits. OBJECTIVE: In this study, we evaluated patient use of a web-based patient portal that provides patient information and allows online completion of PROMs. A particular focus was on patient motivation for (not) using the portal. The portal was developed to supplement routine monitoring at the Department of Internal Medicine V in Innsbruck. METHODS: We included patients with multiple myeloma and chronic lymphocytic leukemia

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… Finally, the literature shows that in order to provide a sound theoretical basis for sustainable PRO solutions in routine care settings, an implementation science approach can be followed [ 33 ]. … Science Work Group Using an implementation science approach to implement and evaluate patient-reported outcome measures (PROM) initiatives in routine care settings Qual Life Res 2020 7 10 1 10.1007/s11136-020-02564-9 32651805 PMC8528754 32651805 34 Lubberding S van Uden-Kraan CF Te Velde EA Cuijpers …

The Challenges of Outcomes-Based Contract Implementation for Medicines in Europe.

ObjectivesThe aim was to outline the challenges of implementing outcomes-based contracts (OBCs) in Europe.MethodsA scoping review was conducted, building on the searches of a previous systematic review and updating them for December 2017 until May 2021. The combined results were screened, based on inclusion and exclusion criteria. All identified studies published in the English language that described specific OBC schemes for medicines in European countries were included. Insights into the challenges of OBCs were extracted and analysed to develop a conceptual framework.ResultsTen articles from

An Interdisciplinary Perspective on Improving Cancer Care in the State of Mississippi as an Example of Cancer Care Improvements in the Global South.

Cancer disparities, a critical public health issue, particularly in states such as Mississippi, where socioeconomic factors significantly influence health outcomes, require our collective attention. This paper delves into the multifaceted nature of cancer disparities through a macro-level analysis of cancer data, specifically focusing on Mississippi as a microcosm of broader national and global trends. Two key indices, the Socio-Demographic Index (SDI) and the Social Deprivation Index (SDeI), provide valuable insights. The former offers a macro-level understanding of the socioeconomic factors

Practical Guidance for the Expanded Implementation and Provision of Bispecific Antibodies for Diffuse Large B-Cell Lymphoma (DLBCL) Across Canada.

(1) Background: Bispecific antibodies (BsAbs) for the treatment of relapsed/refractory diffuse large B-cell lymphoma (R/R DLBCL) can be delivered in ambulatory healthcare settings; however, the safe and effective management of potential side effects, such as cytokine release syndrome (CRS), requires protocolized monitoring and management. (2) Methods: An Expert Working Group (EWG) of nine hematologists from across Canada, with experience in leading BsAb program implementation, combined a review of published literature, a comparison of national/provincial/regional guidance documents and protoco

Chronotherapy in Hematological Malignancies: Evaluating the Rationale and Evidence.

Hematological malignancies remain one of the leading causes of morbidity and mortality despite advances in targeted therapies, immunotherapy, and stem cell transplantation. Emerging evidence indicates that treatment efficacy and toxicity depend not only on the choice of therapy but also on its timing relative to the patient's internal circadian rhythm. The circadian clock orchestrates fundamental processes in hematopoiesis and immunity, such as stem-cell proliferation, leukocyte trafficking, DNA repair, and drug metabolism, while its disruption promotes malignant transformation, therapeutic re

Global burden of 292 causes of death in 204 countries and territories and 660 subnational locations, 1990-2023: a systematic analysis for the Global Burden of Disease Study 2023.

BACKGROUND: Timely and comprehensive analyses of causes of death stratified by age, sex, and location are essential for shaping effective health policies aimed at reducing global mortality. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2023 provides cause-specific mortality estimates measured in counts, rates, and years of life lost (YLLs). GBD 2023 aimed to enhance our understanding of the relationship between age and cause of death by quantifying the probability of dying before age 70 years (70q0) and the mean age at death by cause and sex. This study enables comparis

Impact of integrated teaching-learning method on oncology clinical decision-making ability and cognitive learning of nursing students.

BackgroundInnovative and student-centered teaching methods are required to improve critical thinking and clinical reasoning skills. The objective of this study was to determine the impact of an oncology internship training on learning outcomes of nursing students using an integrated teaching-learning method.MethodsA pre- and post-test quasi-experimental study was conducted among 107 undergraduate nursing students in fourth year who were allocated to two groups (intervention group = 51 and control group = 55) to receive an integrated teaching-learning method and routine method respectively. Dat

User experiences on implementation of patient reported outcome measures (PROMs)in a Haematological outpatient clinic.

BackgroundPROMs can help healthcare professionals gain an improved understanding of patients' physical burdens, functional levels, and (health-related) quality of life throughout disease and medical treatment. The aim of this study was to investigate the barriers and potential opportunities PROMs may present in a haematological outpatient clinic from three different perspectives: patients, nurses and haematologists.MethodsThe present study synthesizes three previously published studies that separately explored the experiences of patients, nurses and haematologists when implementing PROMs. The

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… Implementation Science. 2013;8:28. doi: 10.1186/1748-5908-8-28. 59. Nilsen P. Making sense of implementation theories, models and frameworks. Implementation Science. 2015;10:53. doi: 10.1186/s13012-015-0242-0. 60. Grol R, et al. …

Расовая неравноправие, множественный склероз и внедрение нового лечения алгоритма на уровне системы здравоохранения.

СПРАВОЧНАЯ ИНФОРМАЦИЯ И ЗАДАЧИ: Достижения в области множественного склероза (МС) не привели к справедливому улучшению лечения НР или результатов среди миниатюризированных людей. Наша цель заключалась в том, чтобы определить, осуществляются ли меры системы здравоохранения, направленные на расширение использования высокоэффективных методов лечения, на справедливой основе и привели ли они к аналогичным улучшениям в показателях НР среди расовых и этнических групп.МЕТОДЫ: Мы разработали и внедрили алгоритм лечения MS, который увязывает риск инвалидности человека с надлежащим образом эффективными м

Artificial Intelligence and Machine Learning Technology Driven Modern Drug Discovery and Development.

The discovery and advances of medicines may be considered as the ultimate relevant translational science effort that adds to human invulnerability and happiness. But advancing a fresh medication is a quite convoluted, costly, and protracted operation, normally costing USD ~2.6 billion and consuming a mean time span of 12 years. Methods to cut back expenditure and hasten new drug discovery have prompted an arduous and compelling brainstorming exercise in the pharmaceutical industry. The engagement of Artificial Intelligence (AI), including the deep-learning (DL) component in particular, has bee

Адаптация программы психического здоровья для людей с множественной миеломой и миеломой: технико-экономическое обоснование с учетом интересов потребителей.

Участие потребителей в мероприятиях по охране психического здоровья признается в качестве важнейшего элемента проведения исследований, которые являются актуальными, приемлемыми и в конечном счете более эффективными. Здесь мы сообщаем о смешанном экспериментальном исследовании по оценке пригодности существующей программы в области психического здоровья для людей, страдающих неизлечимым раком крови, множественной миеломой и формой прекурсора, в результате чего у них возникает множественный миелома. Цель этого исследования состояла в том, чтобы определить рекомендации с учетом интересов потребите

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… This study also has relevance to implementation science, particularly in relation to identifying factors that may influence future implementation and sustainable scale-up [ 17 ]. … science. …

A SITC vision: adapting clinical trials to accelerate drug development in cancer immunotherapy.

Clinical trials of cancer immunotherapy (IO) were historically based on a drug development paradigm built for chemotherapies. The remarkable clinical activity of programmed cell death protein 1/programmed death ligand 1 blockade, chimeric antigen receptor-T cells, and T cell engagers yielded new insights into how the mechanistic underpinnings of IO are reflected in the clinic. These insights and the sheer number of novel immunotherapies currently in the pipeline have made it clear that our strategies and tools for IO drug development must adapt. Recent innovations like engineered T cells and t

Gene therapy: principles, challenges and use in clinical practice.

INTRODUCTION: Gene therapy is an emerging topic in medicine. The first products have already been licensed in the European Union for the treatment of immune deficiency, spinal muscular atrophy, hemophilia, retinal dystrophy, a rare neurotransmitter disorder and some hematological cancers, while many more are being assessed in preclinical and clinical trials. OBJECTIVE: The purpose of this review is to provide an overview of the core principles of gene therapy along with information on challenges and risks. Benefits, adverse effects and potential risks are illustrated based on the examples of

Effect of counseling intervention on symptoms, pain acceptance and psychological wellbeing among patients with fibromyalgia.

BACKGROUND: Nurses to assist patients make the best choices in challenging circumstances, counseling is crucial. Patients' health and quality of life can be enhanced by healthcare providers, particularly nurses, through counseling and educational initiatives. Fibromyalgia is characterized by widespread pain that negatively impacts an individual's ability to work. People may be able to improve their physical and mental health and accept suffering with the use of nursing counseling methods. AIM: This study aimed to investigate the effect of counselling intervention on symptoms, pain acceptance,

Психологические исследования в области расстройств питания/безпорядкового питания по типу 1 диабет: систематический обзор с использованием модели НГП для разработки поведенческих мер.

АИСЮ: расстройства питания по типу 1 диабет 2.4 Временами больше, чем у тех, у кого нет диабета. Цель заключалась в проведении систематического обзора психологического вмешательства в IRDEB (поведение, связанное с расстройствами питания, связанными с инулином)/поглощающих расстройства у взрослых, имеющих тип 1 диабет. В обзоре описываются тип и качество исследований с группами контроля/сопоставимости, а также качественные исследования и обобщаются результаты исследований в соответствии с моделью развития поведенческих мер, разработанной на этапе НГП. Классификация в соответствии с моделью позв

ESCP Spring Workshop 2023: Advancing clinical pharmacy and care in diabetes and cardiovascular comorbidities-Antwerp, 20-21 April 2023.

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Geriatric assessment for the practicing clinician: The why, what, and how.

Older adults with cancer heterogeneously experience health care, treatment, and symptoms. Geriatric assessment (GA) offers a comprehensive evaluation of an older individual's health status and can predict cancer-related outcomes in individuals with solid tumors and those with hematologic malignancies. In the last decade, randomized controlled trials have demonstrated the benefits of GA and GA management (GAM), which uses GA information to provide tailored intervention strategies to address GA impairments (e.g., implementing physical therapy for impaired physical function). Multiple phase 3 cli

Implementation of a model integrating primary and oncology pharmacists' care for patients taking oral anticancer agents (OAA).

Improvements in chronic myeloid leukemia (CML), chronic lymphocytic leukemia (CLL), and multiple myeloma (MM) treatment options have increased the 5-year survival rates for patients with these hematologic malignancies. In addition to cancer management, these patients may need help to manage multiple chronic conditions (MCC). The overall objective of this study is to examine the impact and implementation of a model that coordinates care between oncology and primary care pharmacists for people taking an oral anti-cancer agent (OAAs) and medications for comorbid chronic conditions. This is a mult