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Абстрактный сборник ISEV2022.

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… ISEV2022 International Organizing Committee IOC Chairs: Lorraine O'Driscoll (Ireland), Sophie Rome (France) IOC Members: Yu Fujita (Japan), Bernd Giebel (Germany), David Greening (Australia), Soazig Le Lay (France), Metka Lenassi (Slovenia), and Ken Witwer (USA) Journal of Extracellular Vesicles: … James's Cancer Institute, Trinity College Dublin, Dublin 2, Ireland Chair: Bernd Giebel – Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg‐Essen, Essen, Germany EV‐Tag: A novel synthetic reporter system to understand in vivo extracellular vesicle‐mediated intercellular …

Pooled analysis of Day 100 survival for defibrotide-treated patients with hepatic veno-occlusive disease/sinusoidal obstruction syndrome and ventilator or dialysis dependence following haematopoietic cell transplantation.

For patients with untreated hepatic veno-occlusive disease (VOD)/sinusoidal obstruction syndrome (SOS) with multi-organ dysfunction (MOD), mortality is >80%. We conducted a pooled analysis of three studies that assessed Day 100 survival in relationship to MOD severity, with dialysis and/or ventilator dependence representing the most severe organ dysfunction. All patients in the analysis were diagnosed using Baltimore criteria/biopsy. This analysis of patients with VOD/SOS and MOD after haematopoietic cell transplantation (HCT; n = 651) demonstrated higher Day 100 survival rates amongst defibro

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… Jazz Pharmaceuticals Ireland, Limited , Dublin, Ireland Available at: http://pp.jazzpharma.com/pi/defitelio.ca.PM‐en.pdf Defitelio (defibrotide) ( 2018 ) Summary of Product Characteristics . …

Минимальная информация для исследований внеклеточной везиклетки (MISEV2023): от базовых до передовых подходов.

Внеклеточные везиклолы (ЭМ) с помощью своего сложного груза могут отражать состояние клетки их происхождения и изменять функции и фенотипы других ячеек. Эти особенности свидетельствуют о значительном биомаркировании и терапевтическом потенциале и вызывают широкий интерес, о чем свидетельствует постоянное увеличение числа научных публикаций об ЭМ за год. Значительные успехи были достигнуты в области ЭВМ, а также в понимании и применении биологии ЭМ. Вместе с тем сохраняются препятствия на пути реализации потенциала ЭМ в различных областях - от базовой биологии до клинического применения - в свя

Occupational exposure to ionizing radiation and risk of lymphoma subtypes: results of the Epilymph European case-control study.

BackgroundEvidence linking risk of lymphoma and B-cell lymphoma subtypes to ionizing radiation is inconclusive, particularly at low exposure levels.MethodsWe investigated risk of lymphoma (all subtypes), B-cell lymphomas, and its major subtypes, associated with low-level occupational exposure to ionizing radiation, in 2346 lymphoma cases and 2463 controls, who participated in the multicenter EpiLymph case-control study. We developed a job-exposure matrix to estimate exposure to ionizing radiation, distinguishing between internal and external radiation, and we applied it to the lifetime occupat

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… Materials and methods Study population The EpiLymph study is a multicenter case-control study on lymphoma etiology, which was conducted in 1998–2004 in six European Countries, namely Czech Republic, France, Germany, Ireland, Italy, and Spain. … exposure to external and internal sources of ionizing radiation Cases (N = 2346) Controls (N = 2463) N % N % Gender Male 1313 55.97 1321 53.63 Females 1033 44.03 1142 46.37 Area of recruitment Spain 591 25.19 631 25.62 France 298 12.70 276 11.21 Germany 703 29.97 710 28.83 Italy 262 11.17 336 13.64 Ireland …

Novel diagnostic options for endometriosis - Based on the glycome and microbiome.

BackgroundEndometriosis is a chronic gynaecological disease whose aetiology is still unknown. Despite its prevalence among women of reproductive age, the pathology of the disease has not yet been elucidated and only symptomatic treatment is available. Endometriosis has high latency and diagnostic methods are both limited and invasive.Aim of reviewThe aim of this review is to summarise minimally invasive or non-invasive diagnostic methods for endometriosis and their diagnostic efficiencies. Furthermore, we discuss the identification and diagnostic potential of novel disease biomarkers of microb

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… She is also an adjunct Assistant Professor at both Trinity College Dublin and University College Dublin, two of Ireland’s leading academic research institutions. Dr. … She is a member of the European Society of Human Reproduction and Embryology (ESHRE) and the Health Research Board Clinical Research Coordination Ireland (CRCI). Dr. …

Management of bone health in patients with cancer: a survey of specialist nurses.

BackgroundPatients with cancer can experience bone metastases and/or cancer treatment-induced bone loss (CTIBL), and the resulting bone complications place burdens on patients and healthcare provision. Management of bone complications is becoming increasingly important as cancer survival rates improve. Advances in specialist oncology nursing practice benefit patients through better management of their bone health, which may improve quality of life and survival.MethodsAn anonymised online quantitative survey asked specialist oncology nurses about factors affecting their provision of support in

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… Among responding participants, nurses were from 17 countries, including Switzerland, Ireland, Spain, the UK and Australia (Table 1 ). … The second, third and fourth most common geographical locations of institutes were in countries where nurses were directly contacted by email (Ireland, Spain and Australia, respectively); therefore, it is likely that this direct contact led to increased responses. …

The global prevalence of peripheral neuropathy following chemotherapy in cancer patients: a systematic review and meta-analysis.

BACKGROUND: Chemotherapy-induced peripheral neuropathy (CIPN) is a major cause of dose reduction, drug modification, or drug discontinuation in cancer patients which negatively impacts the overall well-being of cancer patients and medication procedures. This systematic review and meta-analysis investigation aimed to determine the global prevalence of CIPN in cancer patients. METHODS: Various scientific databases (PubMed, Scopus, Web of Science, Embase, ScienceDirect, and Google Scholar) were systematically searched (by July 2023) for published studies reporting the CIPN prevalence. Meta-analys

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… - 29 mTNS (93%) - - 29 Jain et al. [ 38 ] 2014 India 5–18 80 rTNS (33.75%) - - 30 Vasquez et al. [ 39 ] 2013 Ireland median : 62, 31–74 29 mTNS (100%) - - 31 Liew et al. [ 40 ] 2013 Canada median 41.0, 21.5–71.9 29 SPNS (43%) - - 32 Burnette et al. [ 41 ] 2013 USA 18- >80y 736 researcher made (27%) … | - | 29 | mTNS (93%) | - | - 29 | Jain et al. [ 38 ] | 2014 | India | 5–18 | 80 | rTNS (33.75%) | - | - 30 | Vasquez et al. [ 39 ] | 2013 | Ireland | median : 62, 31–74 | 29 | mTNS (100%) | - | - 31 | Liew et al. [ 40 ] | 2013 | Canada | median 41.0, 21.5–71.9 | 29 | SPNS (43%) | - | - 32 | Burnette …

Secondary antibody deficiencies in the modern era: emerging trends, diagnostic pitfalls, and advances in personalised management.

Secondary antibody deficiencies (SADs) are a significant but frequently under-recognised group of acquired immunodeficiencies. They may arise in various clinical settings, including haematological malignancies, immunosuppressive therapies, and protein-losing conditions. SADs are associated with an increased risk of recurrent and severe infections, hospitalisation, and impaired quality of life. Despite this, diagnostic and treatment pathways remain inconsistent across healthcare settings and regions. Recent advances in the use of structured clinical data, including electronic health records and

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… Prescribing immunoglobulin replacement therapy for patients with non-classical and secondary antibody deficiency: an analysis of the practice of clinical immunologists in the UK and republic of Ireland . … Ireland : Health Service Executive ( 2026 ). 31 Boqué C Sánchez-Ramón S Córdoba R Moreno C Cabezudo E . Current approach in the management of secondary immunodeficiency in patients with hematological Malignancies: spanish expert consensus recommendations . …

Elective freezing of embryos versus fresh embryo transfer in IVF: a multicentre randomized controlled trial in the UK (E-Freeze).

STUDY QUESTION: Does a policy of elective freezing of embryos, followed by frozen embryo transfer result in a higher healthy baby rate, afte … ir of two), membership of six Trial Steering Committees (Chair of four), membership of the Northern Ireland Clinical Trials Unit Advisory Group and Chair of the board of Oxford Brain Health Clinical Trials Unit. R.M. reports consulting fees from Gedeon Richter, honorarium from Merck, support fees for attendance at educational events and conferences for Me …

Estimating complete cancer prevalence in Europe: validity of alternative vs standard completeness indexes.

IntroductionComparable indicators on complete cancer prevalence are increasingly needed in Europe to support survivorship care planning. Direct measures can be biased by limited registration time and estimates are needed to recover long term survivors. The completeness index method, based on incidence and survival modelling, is the standard most validated approach.MethodsWithin this framework, we consider two alternative approaches that do not require any direct modelling activity: i) empirical indices derived from long established European registries; ii) pre-calculated indices derived from U

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… Birgisson (National CR) ; Ireland: D. Murray; P.M. Walsh (National CR) ; Italy: G. Mazzoleni; F. Vittadello (Alto Adige CR) ; F. Cuccaro (Barletta-Andria-Trani CR) ; R. Galasso (Basilicata CR) ; G. Sampietro (Bergamo CR) ; S. Rosso (Biella CR) ; C. Gasparotti; G. Maifredi (Brescia CR) ; M. … Broggio (National CR) ; UK-Northern Ireland: A. Gavin* (National CR) ; UK-Scotland: D. Morrison (National CR) ; UK-Wales: D. W. Huws* (National CR). *EUROCARE Steering Committee. Acknowledgments The authors would like to thank Tonino Sofia for the English-language revision. …

The European Gaucher Alliance: a survey of member patient organisations' activities, healthcare environments and concerns.

BackgroundThe European Gaucher Alliance (EGA) was established in 1994 and constituted in 2008 as an umbrella group supporting patient organisations for Gaucher disease. Every two years, the EGA conducts a questionnaire survey of member associations to help develop its priorities and annual work programme. Results of the latest survey are presented.MethodsBetween June 2012 and April 2013, the 36 members and associate members of the EGA were asked to complete a questionnaire detailing membership numbers, disease specific treatments used by patients, means of access to treatment, availability of

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… A second ERT, velaglucerase alfa (VPRIV®; Shire Human Genetic Therapies, Dublin, Ireland) became available in 2010 and a third, taliglucerase alfa (Elelyso®; Protalix, Carmiel, Israel) has become available in the USA (approved by the FDA in 2012), Israel (in 2012) and Brazil (in 2013). … Republic, Denmark, Estonia, Finland, France, Germany, Greece, India, Israel, Italy, Jordan, Latvia, Lithuania, Macedonia, Mexico (2 organisations), the Netherlands, Norway, Poland, Romania, Russia, Serbia, Slovakia, Slovenia, South Africa, Spain, Sweden, Switzerland, United Kingdom [UK] & Republic of Ireland …

Midwife continuity of care models versus other models of care for childbearing women.

BACKGROUND: Midwives are primary providers of care for childbearing women globally and there is a need to establish whether there are differ … scientific integrity/trustworthiness concerns. Studies were conducted in Australia, Canada, China, Ireland, and the United Kingdom. The majority of the included studies did not include women at high risk of complications. There are three ongoing studies targeting disadvantaged women. Primary outcomes Based on control group risks observed in the studies, …

Interventions to improve adherence to pharmacological therapy for chronic obstructive pulmonary disease (COPD).

BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a chronic lung condition characterised by persistent respiratory symptoms and li … from mild to very severe. Trials were conducted in the USA, Spain, Germany, Japan, Jordan, Northern Ireland, Iran, South Korea, China and Belgium. Risk of bias was high due to lack of blinding. Evidence certainty was downgraded due to imprecision and small participant numbers. Single component interventions Six studies (55 to 212 participants) reported si …

Galantamine for Alzheimer's disease.

BACKGROUND: Galantamine (also called galanthamine, marketed as Reminyl (Janssen)) was isolated from several plants, including daffodil bulbs … E (BL database of Conference Proceedings and Journals): to June 2000; Aslib Index to Theses (UK and Ireland theses): 1970 to June 2001; Dissertation Abstract (USA): 1861 to June 2001; ADEAR (Alzheimer's Disease Clinical Trials Database): to June 2001; National Research Register (including the MRC Clinical Trials Directory): April 2001 (issue 2) Alzheimers …

Abstract

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Прогрессивная многофукальная лейкоэнцефалопатия в реуматоидном артрите и биологической терапии: доклад по делу и обзор литературы.

Прогрессивная многофукальная лейкоэнцефалопатия - это редкое, но потенциально смертельное заболевание, вызванное инфекцией центральной нервной системы с полиомавирусом Джона Каннингема. Прогрессивная многофукальная лейкоэнцефалопатия встречается главным образом у иммунокомпромиссированных пациентов, включая пациентов с биологическими и адресными синтетическими препаратами, такими, как множественный склероз и ревматоидный артрит. Ранняя диагностика прогрессивной многофукальной лейкоэнцефалопатии имеет решающее значение для выживания пациента. Мы описываем случай прогрессивной многофукальной лей

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… malaise, loss of appetite, disorientation, incontinence, deterioration of verbal communication Encephalomeningitis 3 MRI Survived with disability Yamamoto et al . [ 26 ] Japan Female 72 No Tocilizumab 3.33 Dementia, abnormal behavior Infection MRI Survived with disability Kobayashi et al . [ 27 ] Ireland … malaise, loss of appetite, disorientation, incontinence, deterioration of verbal communication Encephalomeningitis 3 MRI Survived with disability Yamamoto et al . [ 26 ] Japan Female 72 No Tocilizumab 3.33 Dementia, abnormal behavior Infection MRI Survived with disability Kobayashi et al . [ 27 ] Ireland …

Clinical Evidence Linkage From the American Society of Clinical Oncology 2024 Conference Poster Images Using Generative AI: Exploratory Observational Study.

BACKGROUND: Early-stage clinical findings often appear only as conference posters circulated on social media. Because posters rarely carry structured metadata, their citations are invisible to bibliometric and alternative metric tools, limiting real-time research discovery. OBJECTIVE: This study aimed to determine whether a large language model can accurately extract citation data from clinical conference poster images shared on X (formerly known as Twitter) and link those data to the Dimensions and Altmetric databases. METHODS: Poster images associated with the 2024 American Society of Clin

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… | Journal of Clinical Oncology | “First-line systemic therapy following adjuvant immunotherapy in renal cell carcinoma (RCC): an international multi-center study” | 2 | [ 16 ] 2024 | Journal of Clinical Oncology | “Self-expressed needs and gaps in our care of metastatic breast cancer (MBC): an all-Ireland … Self-expressed needs and gaps in our care of metastatic breast cancer (MBC): an all-Ireland patient-led online survey (CTRIAL-IE 23-05) J Clin Oncol. 2024 Jun 01;42(16_suppl):12058. doi: 10.1200/JCO.2024.42.16_suppl.12058. 18. …

Многодисциплинарное групповое вмешательство для лиц, живущих с множественной миеломой: технико-экономическое обоснование.

Несмотря на то, что множественные миеломы по-прежнему являются неизлечимым раком, прогресс в их понимании и управлении ими привел к значительному повышению показателей выживаемости. По-прежнему мало случаев оказания помощи лицам, живущим с множественными миеломами, несмотря на рост числа случаев неудовлетворенных потребностей в поддержке среди многих выживших жертв миэломы. Нынешнее исследование направлено на оценку осуществимости и предварительной эффективности новаторского многодисциплинарного группового мероприятия по оказанию помощи лицам, пережившим миэлому. МЕТОДЫ: В рамках обычной служб

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… Setting The study was set in a not-for-profit, voluntary, community-based cancer support service, dedicated to providing professional, evidence-based, holistic support services (including psychological, exercise-based and nursing inputs) to cancer patients and their families in the West of Ireland. … The study was conducted in conjunction with Galway University Hospital, one of nine designated cancer centres in Ireland, covering haemato-oncology services in West and North-West Ireland. …

CIRSE 2022 Book of Abstracts

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… correction of incorrect entry on page 692: Approach to management of malignant superior vena cava obstruction (SVCO) Greene L1, Cooper P, Allen G, Francis A, Hayden R, Irvine I, Ryan A, Cullen A 1Division of Interventional Radiology, Department of Radiology, University Hospital Waterford, Waterford, Ireland …