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Proceedings of the 3rd IPLeiria's International Health Congress : Leiria, Portugal. 6-7 May 2016.

S1 Health literacy and health education in adolescence Catarina Cardoso Tomás S2 The effect of a walking program on the quality of life and well-being of people with schizophrenia Emanuel Oliveira, D. Sousa, M. Uba-Chupel, G. Furtado, C. Rocha, A. Teixeira, P. Ferreira S3 Diagnosis and innovative treatments - the way to a better medical practice Celeste Alves S4 Simulation-based learning and how it is a high contribution Stefan Gisin S5 Formative research about acceptability, utilization and promotion of a home fortification programme with micronutrient powders (MNP) in the Autonomous Region o

Common Non-Rheumatic Medical Conditions Mimicking Fibromyalgia: A Simple Framework for Differential Diagnosis.

Fibromyalgia (FM) is a chronic non-inflammatory disorder mainly characterized by widespread musculoskeletal pain, fatigue, sleep disturbances, and a constellation of other symptoms. For this reason, delineating a clear distinction between pure FM and FM-like picture attributable to other common diseases can be extremely challenging. Physicians must identify the most significant confounders in individual patients and implement an appropriate diagnostic workflow, carefully choosing a minimal (but sufficient) set of tests to be used for identifying the most plausible diseases in the specific case

The Burden of Cancer, Government Strategic Policies, and Challenges in Pakistan: A Comprehensive Review.

Cancer is a severe condition characterized by uncontrolled cell division and increasing reported mortality and diagnostic cases. In 2040, an estimated 28.4 million cancer cases are expected to happen globally. In 2020, an estimated 19.3 million new cancer cases (18.1 million excluding non-melanoma skin cancer) had been diagnosed worldwide, with around 10.0 million cancer deaths. Breast cancer cases have increased by 2.26 million, lung cancer by 2.21 million, stomach by 1.089 million, liver by 0.96 million, and colon cancer by 1.93 million. Cancer is becoming more prevalent in Pakistan, with 19

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… Micronutrient deficiency disorders in Pakistan are likely to be caused by fluctuations in the availability of these essential foods ( 52 ). Figure 2 shows the link between dietary consumption and cancer. Figure 2 Nutrient intake and cancer prognosis. … A deficiency of macronutrients and micronutrients, such as iron ( 207 ), vitamin A ( 208 ), vitamin C ( 209 ), and vitamin D ( 210 ), causes cancer ( 207 ). The major causes of such deficiencies are insufficient bioavailability and insufficient food intake. …

Humanistic Health Management and Cancer: Associations of Psychology, Nutrition, and Exercise with Cancer Progression and Pathogenesis.

The incidence rate of cancer is increasing year by year due to the aging of the population, unhealthy living, and eating habits. At present, surgery and medication are still the main treatments for cancer, without paying attention to the impact of individual differences in health management on cancer. However, increasing evidence suggests that individual psychological status, dietary habits, and exercise frequency are closely related to the risk and prognosis of cancer. The reminder to humanity is that the medical concept of the unified treatment plan is insufficient in cancer treatment, and a

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… might be beneficial to men with PSA‐defined prostate cancer recurrence. [ 77 ] In addition, the ACS guidelines for nutrition and physical activity for cancer survivors recommend that prostate cancer survivors should emphasize vegetables and fruits rich in micronutrients and phytochemicals, low amounts … Many diets and natural products have shown a potential role in preventing cancer. [ 55 ] Such as polyphenols are naturally occurring micronutrients found in many food sources such as vegetables, red fruits, grains, spices, and green tea, etc. polyphenolic compounds such as flavonoids, curcumin, anthocyanins …

European Cancer Organisation Essential Requirements for Quality Cancer Care: Hematological malignancies.

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… Includes access to oral nutritional supplements and, if necessary, tube or intravenous feeding, ensuring provision of adequate amounts of energy and nutrients, particularly protein and micronutrients, according to international guidelines. …

Гомоцитистейн, питание и Гут Микробиота: всеобъемлющий обзор текущих данных и понимания.

Гомоциштейн, содержащий серную аминокислоту, является промежуточным продуктом во время метаболизма метатонина, жизненно важной аминокислоты. Возвышенная концентрация гомоцистайна в плазме, названной гипергомоцистистемией, в значительной степени связана с возникновением нескольких заболеваний, включая диабет, множественный склероз, остеопороз, рак и нейродегенеративные расстройства, такие как слабоумие, болезни Альцгеймера и Паркинсона. Сообщалось о взаимодействии между метаболическими путями гомоциштейна и кишечной микробиотой, а также о конкретных микробных сигнатурах у лиц, страдающих гиперг

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… ) and the progression of atherosclerosis, Apolipoprotein-E-deficient (apoE −/− ) mice—an established pre-clinical model for this human pathology—were assigned to either a hyperhomocysteinemic diet (HHD) deficient in methyl donors and B vitamins or a control diet (CD) containing sufficient levels of micronutrients …

От ожирения до митохондриальной дисфункции в периферальных тканях и в центральной нервной системе.

Ожирение - это состояние хронического низкосортного воспаления, затрагивающего периферийные органы тела, а также центральную нервную систему. Дефункция жировой ткани, возникающая в условиях ожирения, является ключевым фактором возникновения и развития различных заболеваний, включая нейродегенеративные расстройства. Митохондрия, ключевые органеллы в производстве клеточной энергии, играет важную роль в этой дисфункции тканей. В многочисленных исследованиях подчеркивается тесная связь между ожирением и дисфункцией митохондриалов адипоцита, что приводит к чрезмерному производству ROS и воспалению

Воздействие кетогенного рациона питания на качество жизни взрослых людей с хроническими заболеваниями: систематический обзор случайных контролируемых испытаний.

СПРАВОЧНАЯ ИНФОРМАЦИЯ: Хронические заболевания отрицательно сказываются на качестве жизни (КОЛ). Кетогенное питание (КД) может улучшить КОЛ. ЦЕЛЬ: Цель этого систематического обзора заключалась в обобщении имеющихся данных о выборочных контролируемых испытаниях (РСТ) для определения воздействия KD на QOL у взрослых, страдающих хроническими заболеваниями. МЕТОДЫ: Представление докладов осуществлялось в соответствии с руководящими принципами ПРИСМА. Мы включали в себя выборочные контролируемые испытания (РСТ), проведенные на взрослых с хроническими заболеваниями, включая группу вмешательства, ко

Metformin-induced vitamin B12 deficiency: An underdiagnosed cause of diabetic neuropathy.

Metformin-induced vitamin B12 deficiency is a prevalent condition among patients with type 2 diabetes mellitus. In recent years, a growing body of evidence has demonstrated the association between vitamin B12 deficiency and the onset, progression, and worsening of diabetic neuropathy (DNP) as well as its improvement with supplementation in cases of deficiency. Major clinical guidelines for diabetes and DNP remain vague in their recommendations for B12 measurement and supplementation, and some guidelines do not address it at all. Given that vitamin B12 therapy is an economical, safe, and widely

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… Improving neuropathy scores in type 2 diabetic patients using micronutrients supplementation. Diabetes Res Clin Pract. 2011;93:86–94. doi: 10.1016/j.diabres.2011.03.016. 29. Li S, Chen X, Li Q, Du J, Liu Z, Peng Y, Xu M, Li Q, Lei M, Wang C, Zheng S, Zhang X, Yu H, Shi J, Tao S, Feng P, Tian H. …

A case-control study of prevalence of anemia among patients with type 2 diabetes.

BackgroundAnemia is defined as a reduction in the hemoglobin concentration of blood, which consequently reduces the oxygen-carrying capacity of red blood cells such that they are unable to meet the body's physiological needs. Several reports have indicated that anemia mostly occurs in patients with diabetes with renal insufficiency while limited studies have reported the incidence of anemia in people with diabetes prior to evidence of renal impairment. Other studies have also identified anemia as a risk factor for the need for renal replacement therapy in diabetes. Understanding the pathogenes

Evaluation and Treatment of Obesity and Its Comorbidities: 2022 Update of Clinical Practice Guidelines for Obesity by the Korean Society for the Study of Obesity.

The goal of the 8th edition of the Clinical Practice Guidelines for Obesity is to help primary care physician provide safe, effective care to patients with obesity by offering evidence-based recommendations to improve the quality of treatment. The Committee for Clinical Practice Guidelines comprised individuals with multidisciplinary expertise in obesity management. A steering board of seven experts oversaw the entire project. Recommendations were developed as the answers to key questions formulated in patient/problem, intervention, comparison, outcomes (PICO) format. Guidelines underwent mult

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… It is recommended to supplement micronutrients and conduct regular follow-up examinations according to the surgical procedure after bariatric/metabolic surgery (I, B). 76 , 81 , 84 8. Obesity in the elderly Q8-1. What should be considered when evaluating obesity in the elderly? R8-1. … , Roux-en-Y gastric bypass, adjustable gastric banding, or biliopancreatic diversion/duodenal switch, is recommended based on patient condition (I, A). 40 , 47 After bariatric/metabolic surgery, multidisciplinary follow-up management should be scheduled for all patients (I, B). 47 - 50 In addition, micronutrient …

Является ли изменение миелинодегенеративное изменение, связанное с возрастом, первоначальным фактором риска нейродегенеративных заболеваний?

Myelination, непрерывное покрытие нейронных аксонов, является пожизненным процессом в нервной системе, который необходим для точного, темпорального пространственного проведения потенциалов действий между нейронами. Myelin также оказывает межклеточную метаболическую поддержку аксонам. Даже незначительные нарушения целостности миелина могут ухудшить нейронные характеристики и повысить подверженность неврологическим заболеваниям. На самом деле, дегенерация миелина — это хорошо известное нейропологическое заболевание, связанное с нормальным старением и несколькими нейродегенеративными заболеваниям

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… Nourishing myelin: Role of nutritional interventions The synthesis and maintenance of myelin, a complex and substantial membrane structure, depend on the adequate delivery of proteins, lipids, fatty acids, and micronutrients to oligodendrocytes. …

Скрытые расходы PEG-rhG-CSF на аутлогическую трансплантацию стволовых клеток для недавно диагностированной множественной миеломы.

Оценить клиническую ценность полиэтилен-гликолизированного рекомбинированного человеческого гранулоцита-стимулирующего фактора (PEG-rhG-CSF) для гематопоэтического восстановления после аутологической трансплантации стволовых клеток (ASCT) у недавно диагностированных пациентов с множественными миеломами (NDMM). В настоящем исследовании анализируются данные, полученные от 70 Пациенты NDMM, проходящие ACCT, с 33 получение PEG-rhG-CSF и 37 Принимаю RG-CSF. Среднее время нейтрофильного и тромбоцитного оплодотворения, медианное переливание продуктов крови, неблагоприятные реакции, связанные с лечени

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… In cases of oral mucosal ulcers, the treatment regimen included a combination of oral gel and supplementation with multivitamins and micronutrients. …

Obesity Disease and Surgery.

Obesity is a medical disease that is increasing significantly nowadays. Worldwide obesity prevalence doubled since 1980. Obese patients are at great risk for complications with physical and psychological burdens, thus affecting their quality of life. Obesity is well known to have higher risk for cardiovascular diseases, diabetes mellitus, musculoskeletal diseases and shorter life expectancy. In addition, obesity has a great impact on surgical diseases, and elective surgeries in comparison to general population. There is higher risk for wound infection, longer operative time, poorer outcome, an

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… require subsequent surgical intervention, device-related complications with the gastric band which include malfunction of the band, tubing, or reservoir component, hypoglycemia steatorrhea, diarrhea, and bacterial overgrowth that are more common with malabsorptive procedures, nutritional deficiencies of micronutrients …

Feeding the critically ill obese patient: a systematic review protocol.

REVIEW QUESTION/OBJECTIVE: The objective of this review is to identify effective enteral nutritional regimens targeting protein and calorie delivery for the critically ill obese patient on morbidity and mortality.More specifically, the review question is:In the critically ill obese patient, what is the optimal enteral protein and calorie target that improves mortality and morbidity? BACKGROUND: The World Health Organization (WHO) defines obesity as abnormal or excessive fat accumulation that may impair health, or, empirically, as a body mass index (BMI) ≥ 30 kg/m. Twenty-eight percent of the

Exploring the Influence of Oral and Gut Microbiota on Ulcerative Mucositis: A Pilot Cohort Study.

AIM: Comparing oral and gut microbiome profiles between patients with and without ulcerative mucositis during allogeneic stem cell transplantation (aSCT). MATERIALS AND METHODS: Specimens from oral mucosa, saliva, and stool were collected pre-(T0) and post- (T0 +28d ± 14d) aSCT (T1). Microbiome structure differences were analyzed by 16S-rRNA-gene sequencing, and associations to patients' clinical characteristics were investigated. RESULTS: Ten of 25 included patients developed ulcerations. The α-diversity decreased between T0 and T1, independent of ulcerations. PERMANOVA revealed differences

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… Hence the effect of a possible malnutrition (high intake of sugar and industrially fermented carbohydrates, saturated fatty acids, trans fatty acids, low intake of dietary fiber, micronutrients, polyunsaturated fatty acids, and phytochemicals) could not be assessed. (7) Data regarding the history of …

Paediatric intestinal pseudo-obstruction: a scoping review.

Paediatric intestinal pseudo-obstruction (PIPO) encompasses a group of rare disorders in which patients present with the clinical features of bowel obstruction in the absence of mechanical occlusion. The management of PIPO presents a challenge as evidence remains limited on available medical and surgical therapy. Parenteral nutrition is often the mainstay of therapy. Long-term therapy may culminate in life-threatening complications including intestinal failure-related liver disease, central line thrombosis and sepsis. Intestinal transplantation remains the only definitive cure in PIPO but is a

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… IFALD arises from a combination of SIBO bacterial translocation, recurrent line sepsis, release of endotoxins and synthetic concentrations of PN solutions with excessive glucose and lipids and inadequate micronutrients and amino acids [ 16 , 57 ]. …

Secondary antibody deficiencies: what's around the corner?

Secondary antibody deficiencies (SADs) are characterized by impaired humoral immunity, which can cause recurrent and severe infections. Several factors may contribute to SAD development, making it difficult to establish a clear etiological classification. This heterogeneity also leads to clinical variability, further complicating patient management and treatment strategies. Various diagnostic and therapeutic algorithms are often adapted from those used in primary antibody deficiencies, potentially resulting in under- or over-treatment. Key points include the decision to initiate Immunoglobulin

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… Even if hypogammaglobulinemia is not a common feature ( 36 ), several studies have demonstrated a poor antibody response following vaccination in children with an inadequate intake of essential micronutrients ( 155 ). … Macronutrients, micronutrients, and malnutrition: effects of nutrition on immune function in infants and young children. Nutrients. (2025) 17. doi: 10.3390/nu17091469, PMID: 155. Migliore E, Amaitsa VK, Mutuku FM, Malhotra IJ, Mukoko D, Sharma A, et al. …

Sarcopenia Diagnosis and Management in Hematological Malignancies and Differences with Cachexia and Frailty.

Sarcopenia is a geriatric syndrome characterized by a progressive loss of systemic muscle mass and decreased muscle strength or physical function. Several conditions have a role in its pathogenesis, significantly impacting adverse outcomes such as falls, functional decline, frailty, disability, multiple hospitalizations, and mortality. In the oncological setting, sarcopenia is associated with an increased risk of treatment toxicity, postoperative complications, and a higher mortality rate related to other causes (e.g., pneumonia). In the hematological field, even more so, sarcopenia predicts t

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… Regarding nutrition, the general recommendations for optimal intake of macro- and micronutrients for sarcopenia are 24–36 kcal per kg of body weight and 1.2–1.5 gr per kg of protein, distributed over the three main meals, while ensuring vitamin D intake is sufficient to maintain adequate serum blood …

High-intensity interval training and strength conditioning in patients with chronic lymphocytic leukemia: a systematic review.

BackgroundThis systematic review explores the impact of physical exercise on chronic lymphocytic leukemia (CLL) patients' physical fitness, immunologic, and quality of life outcomes.MethodsEligible studies were searched in PubMed and Web of Science up to February 2024 and were included if they involved participants in adult age, with confirmed CLL diagnose, using physical activity protocols with study design helding intervention protocols, clinical trials, or quantitative data reporting. Bias was assessed with ROBINS-I and RoB2 tools from Cochrane. The results are presented in tables and figur

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… Padilha, Micronutrients deficiency in children and adolescents with sickle cell anemia: a systematic review. Rev. Bras. Hematol. Hemoter., 2010. 32(3): p. 247–256. 39. Sterne JA, et al. ROBINS-I: a tool for assessing risk of bias in non-randomised studies of interventions. …