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MEWDS-like Presentation Unmasking Sequential Bilateral Multifocal Choroiditis: Insights from Longitudinal Multimodal Imaging.

Background: Multiple evanescent white dot syndrome (MEWDS) is usually acute and self-limited, whereas multifocal choroiditis (MFC)/punctate … ic/neurologic/rheumatologic work-up. Treatment included intravenous methylprednisolone for presumed optic neuritis, followed by topical, periocular, intravitreal, and systemic corticosteroids, later escalated to adalimumab and an intravitreal dexamethasone implant. Because foveal granularity could not be documented, baseline was termed "MEWDS-like". Diagnostic l …

Retinal atrophy in multiple sclerosis is similar with extended versus standard interval natalizumab therapy.

BACKGROUND: Retinal ganglion cell + inner plexiform layer (GCIPL) atrophy reflects global neurodegeneration and disability in multiple scler … . Analyses utilized mixed-effects regression models adjusting for age, sex, race, disease duration, optic neuritis history, and interval between treatment initiation and OCT monitoring, accounting for within-subject, inter-eye correlations. RESULTS: GCIPL and pRNFL atrophy rates were not significantly different between EID (n = 22) and SID (n = 109) natalizumab …

Optical coherence tomography angiography biomarkers in multiple sclerosis and neuromyelitis optica spectrum disorders: a systematic review.

BACKGROUND: Multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) are autoimmune disorders of the central nervous syste … ripapillary capillary (RPC) density, and smaller foveal avascular zone (FAZ) areas, particularly in optic neuritis (ON)-affected eyes. Minimal differences were observed in eyes without ON, suggesting that ON may be crucial when utilizing OCT-A biomarkers for disease discrimination. CONCLUSION: OCT-A metrics demonstrate potential as biomarkers that may help dist …

Нейропзащитная роль высокодозы витамина D в множестве склероза: субанализ испытания EVIDIMS.

Предыдущие данные свидетельствуют о том, что витамин D может помочь в нейродегенерации при множественном склерозе (МС). С учетом этого цель исследования заключается в изучении вопроса о том, может ли увеличение содержания витамина D в более высоких дозах у лиц, имеющих MS, привести к снижению атрофии, измеряемой по результатам оптической последовательности томографии (OCT) и структурным результатам МРТ. Эта цель основывается на сложившемся понимании таламической атрофии и атрофии мозга как надежных индикаторов развития заболеваний и потенциальной связи между адекватными уровнями витамина D и у

Совпадение в аннотации оригинала
BACKGROUND: Previous evidence suggests that vitamin D may help with neurodegeneration in multiple sclerosis (MS). Considering this, the stud … L at 18 months between the low versus high-dose treatment arm attributable to patients who suffered optic neuritis (NO), with no significant differences in neither pRNFL nor GCIPL. CONCLUSION: Vitamin D supplementation did not affect MS imaging parameters. However, future studies should thoroughly evaluate patient histories of attacks and endogenous vitamin D l …

Блокада канала натрия Флекаинида повышает целостность мозгового барьера и способствует нейрозащите при нейроинфламмации.

Множественный склероз (MS), аутоиммунный расстройство, характеризуется сильным нейроинфламмированием, приводящим к обезвоживанию и нейронным повреждениям в CNS, что приводит к значительным клиническим расстройствам. Подвижки MS связаны со сложными патологическими процессами, такими как вторжение в иммунные клетки и набор на службу в ЦНС с помощью цитокина. Экспериментальный аутоиммунный энцефаломиэлит (EAE), широко используемый в качестве модели для MS, несмотря на его ограничения в плане перевода, имеет решающее значение для выявления эффективных методов лечения. Недавние исследования показал

Совпадение в аннотации оригинала
Multiple Sclerosis (MS), an autoimmune disorder, is characterized by severe neuroinflammation, leading to demyelination and neuronal damage … channel (NaV) blockers and monoamine oxidase- (MAO) B inhibitors can alleviate symptoms of EAE and optic neuritis (ON), but their mode of action remains partially unclear. To evaluate the effects and understand the action mechanism of NaV blockers and MAO-B inhibitors (rasagiline, safinamide, flecainide and phenytoin) in neurological conditions, various techniq …

Ангиография, связанная с оптической согласованностью, ассоциируется с деятельностью по заболеваниям, о которой свидетельствует статус NEDA-3 у пациентов с повторным множественным склерозом.

Фон: Микровирусные изменения сетчатки могут служить биомаркерами активности заболеваний при множественном склерозе (МС). В ходе этого исследования была проведена оценка плотности сосудистых связующих и перипиллярных мышц с использованием оптической топографической ангиографии (OCTA) у пациентов с повторной пощечиной MS (RMS) и здоровым контролем (HC) с изучением их связи с деятельностью по болезням на основе концепции NEDA-3. Методы: В ходе перекрестного исследования 117 пациентов РМС и 37 HC прошли съемку OCTA. Анализировались такие параметры, как поверхностная сосудистая слекция (SVP), глубо

Совпадение в аннотации оригинала
Background: Retinal microvascular changes may serve as biomarkers for disease activity in multiple sclerosis (MS). This study evaluated macu … racteristic (ROC) curves assessed predictive capacity. Results: Compared to HCs, MS eyes with prior optic neuritis showed significantly lower SVP density (p < 0.05). DVP and FAZ parameters did not differ between groups. SVP and DVP densities correlated with age, disease duration, relapse history, and MRI volumetrics, including gray matter and whole brain volume. …

Optical coherence tomography angiography helps distinguish multiple sclerosis from AQP4-IgG-seropositive neuromyelitis optica spectrum disorder.

INTRODUCTION: The aim was to characterize the optical coherence tomography (OCT) angiography measures in patients with multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) and to evaluate their disease discrimination capacity. METHODS: Patients with MS (n = 83) and AQP4-IgG-seropositive NMOSD (n = 91) with or without a history of optic neuritis, together with healthy controls (n = 34), were imaged. The main outcome measures were peripapillary retinal nerve fiber layer (pRNFL) thickness, macular ganglion cell-inner plexiform layer (GC-IPL) thickness, macular vessel densit…

Predictors of vision impairment in Multiple Sclerosis.

Visual impairment significantly alters the quality of life of people with Multiple Sclerosis (MS). The objective of this study was to identi … exiform layer (GCIPL). The vision of patients with MS was impaired, particularly in eyes with prior optic neuritis. Retinal atrophy (pRNFL and GCIPL) was closely associated with impaired low contrast vision and color vision, whereas the volume of the GCIPL showed a trend (p = 0.092) to be associated with quality of vision. Multiple regression analysis revealed t …

Non-human Immunodeficiency Virus-related Ocular Syphilis in a Korean Population: Clinical Manifestations and Treatment Outcomes.

PURPOSE: To describe the clinical manifestations and treatment outcomes of ocular syphilis in patients without human immunodeficiency virus … sentation were most frequently related to posterior uveitis (38%), followed by panuveitis (29%) and optic neuritis (11%). Isolated interstitial keratitis and intermediate uveitis were uncommon (4%, both). Twenty-eight eyes (62.2%) were treated with penicillin, and 11 eyes (24.4%) underwent surgical treatment. The mean baseline best corrected visual acuity was 0. …

High-Resolution Spectral Domain-Optical Coherence Tomography in Multiple Sclerosis, Part II - the Total Macular Volume. The First Follow-Up Study over 2 Years.

BACKGROUND: Recent studies investigating the use of optical coherence tomography (OCT) in multiple sclerosis (MS) patients have resulted in … circle scan protocol (with locked reference images and eye-tracking mode). None of the patients had optic neuritis 12 months prior to study entry or during the observation period. PRINCIPAL FINDINGS: The initial TMV pattern differed between study participants, but remained relatively unchanged over the 2-year observation period despite high disease activity or …

Active MS is associated with accelerated retinal ganglion cell/inner plexiform layer thinning.

OBJECTIVE: To determine the effect of clinical and radiologic disease activity on the rate of thinning of the ganglion cell/inner plexiform (GCIP) layer and the retinal nerve fiber layer in patients with multiple sclerosis (MS) using optical coherence tomography (OCT). METHODS: One hundred sixty-four patients with MS and 59 healthy controls underwent spectral-domain OCT scans every 6 months for a mean follow-up period of 21.1 months. Baseline and annual contrast-enhanced brain MRIs were performed. Patients who developed optic neuritis during follow-up were excluded from analysis. RESULTS: Pa…

Longitudinal study of vision and retinal nerve fiber layer thickness in multiple sclerosis.

OBJECTIVE: Cross-sectional studies of optical coherence tomography (OCT) show that retinal nerve fiber layer (RNFL) thickness is reduced in multiple sclerosis (MS) and correlates with visual function. We determined how longitudinal changes in RNFL thickness relate to visual loss. We also examined patterns of RNFL thinning over time in MS eyes with and without a prior history of acute optic neuritis (ON). METHODS: Patients underwent OCT measurement of RNFL thickness at baseline and at 6-month intervals during a mean follow-up of 18 months at 3 centers. Low-contrast letter acuity (2.5%, 1.25% c…

Evaluation of optic nerve and retinal functions in demyelinating diseases using electrophysiological tests.

PURPOSE: The aim of this study was to evaluate pattern visual evoked potential (PVEP) and pattern electroretinography (PERG) parameters during the attack-free period in patients with multiple sclerosis (MS) with and without a history of optic neuritis (ON), as well as in individuals with non-MS demyelinating diseases and healthy controls. MATERIALS AND METHODS: This cross-sectional study included 71 patients with demyelinating diseases (95 eyes) and 44 healthy volunteers (88 eyes). This study was prospectively designed to evaluate clinical and electrophysiological data obtained during the rou…

[Related factors of acute symptomatic seizures and epilepsy in children with myelin oligodendrocyte glycoprotein antibody-associated disease].

Objective: To investigate the risk factors of acute symptomatic seizures (ASS) and epilepsy in children with myelin oligodendrocyte glycopro … se of disease and in 29.3% (70/239) of attacks. The common phenotypes were ADEM (67 times (28.0%)), optic neuritis (37 times (15.4%)) and cerebral cortical encephalitis (31 times (13.0%)) in 239 times acute clinical episodes. The incidence of ASS in ADEM and cerebral cortical encephalitis phenotype was 28.4%(19/67) and 100.0% (31/31), respectively. Multivariate …