Результаты поиска

Editorial: The Role of Complement in Health and Disease.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… The C1q serum concentrations were significantly higher in TB patients, compared not only with healthy controls but also with individuals with latent M. tuberculosis infection, leprosy, pneumonia, or sarcoidosis. …

The penumbra of thalidomide, the litigation culture and the licensing of pharmaceuticals.

Fifty years ago several thousand children were born with severe limb defects after their mothers had been given thalidomide in pregnancy. This tragedy caused procedures for licensing new medicines to become much stricter. Where, nevertheless, significant side effects were found it became common to sue for damages. These consequences have caused possibly an even greater disaster damaging many more people and threatening ruin to health services everywhere. The huge increase in both time and cost in bringing medicines to market is increasing their price to unsupportable levels; and only wealthy c

Совпадение в полном тексте источника
… It has been proved of considerable value in treating erythema nodosum leprosum, a form of cutaneous leprosy, and also in treating blood cancer and multiple myeloma. …

Uncovering the knowledge about systemic amyloidosis relevant to the rheumatologists.

Amyloidosis is a localized or systemic disease caused by deposition of proteins in the extracellular space of various organs and tissues. As part of the disease, proteins that were originally soluble misfold and acquire a fibrillar conformation that renders them insoluble and resistant to proteolysis. Systemic amyloidosis is a rare, often underdiagnosed condition. In recent years, the incidence of newly diagnosed cases of amyloidosis has been increasing in association with the aging of the population and greater access to diagnostic tests. From a clinical perspective, systemic amyloidosis is f

Совпадение в полном тексте источника
… In addition, chronic infections like tuberculosis, leprosy, chronic osteomyelitis, and bronchiectasis are still an important etiology of AA amyloidosis in developing countries and an emerging cause in developed countries. [ 8 , 9 ] Independent from the underlying disease, patients with AA amyloidosis …

Disability Weights Measurement for 228 Causes of Disease in the Korean Burden of Disease Study 2012.

Disability weight for each disease plays a key role in combining years lived with disability and years of life lost in disability adjusted life year. For the Korean Burden of Disease 2012 study, we have conducted a re-estimation of disability weights for causes of disease by adapting the methodology of a recent Global Burden of Disease study. Our study was conducted through a self-administered web-based survey using a paired comparison (PC) as the main valuation method. A total of 496 physicians and medical college students who were attending in third or fourth grade of a regular course conduc

Совпадение в полном тексте источника
… 0.413 | 0.317-0.516 Gonococcal infection | 0.345 | 0.252-0.448 Trichomoniasis | 0.346 | 0.253-0.448 Herpes genitalia | 0.442 | 0.344-0.545 Acute hepatitis A | 0.346 | 0.254-0.448 Acute hepatitis B | 0.483 | 0.384-0.583 Acute hepatitis C | 0.646 | 0.548-0.738 Acute hepatitis E | 0.462 | 0.369-0.558 Leprosy …

Plantar Pressure Changes and Correlating Risk Factors in Chinese Patients with Type 2 Diabetes: Preliminary 2-year Results of a Prospective Study.

BackgroundPlantar pressure serves as a key factor for predicting ulceration in the feet of diabetes patients. We designed this study to analyze plantar pressure changes and correlating risk factors in Chinese patients with type 2 diabetes.MethodsWe recruited 65 patients with type 2 diabetes. They were invited to participate in the second wave 2 years later. The patients completed identical examinations at the baseline point and 2 years later. We obtained maximum force, maximum pressure, impulse, pressure-time integral, and loading rate values from 10 foot regions. We collected data on six hist

Совпадение в полном тексте источника
… Association of limited joint mobility and high plantar pressure in diabetic foot ulceration in Asian Indians Diabetes Res Clin Pract 2003 60 57 61 12639766 10.1016/s0168-8227(02)00272-3 6 van Schie CH Slim FJ Keukenkamp R Faber WR Nollet F Plantar pressure and daily cumulative stress in persons affected by leprosy …

The Mushroom Agaricus blazei Murill Elicits Medicinal Effects on Tumor, Infection, Allergy, and Inflammation through Its Modulation of Innate Immunity and Amelioration of Th1/Th2 Imbalance and Inflammation.

The medicinal mushroom Agaricus blazei Murill from the Brazilian rain forest has been used in traditional medicine and as health food for the prevention of a range of diseases, including infection, allergy, and cancer. Other scientists and we have examined whether there is scientific evidence behind such postulations. Agaricus blazei M is rich in the immunomodulating polysaccharides, β-glucans, and has been shown to have antitumor, anti-infection, and antiallergic/-asthmatic properties in mouse models, in addition to anti-inflammatory effects in inflammatory bowel disease patients. These effec

Совпадение в полном тексте источника
… Allergic sensitisation in tuberculosis and leprosy patients. International Archives of Allergy and Immunology. 2005;138(3):217–224. doi: 10.1159/000088722. 22. Hetland G, Løvik M, Wiker HG. Protective effect of β-glucan against Mycobacterium bovis, BCG infection in BALB/c mice. …

Co-Encapsulation of Multiple Antineoplastic Agents in Liposomes by Exploring Microfluidics.

The inherent complexity of cancer proliferation and malignancy cannot be addressed by the conventional approach of relying on high doses of a single powerful anticancer agent, which is associated with poor efficacy, higher toxicity, and the development of drug resistance. Multiple drug therapy (MDT) rationally designed to target tumor heterogeneity, block alternative survival pathways, modulate the tumor microenvironment, and reduce toxicities would be a viable solution against cancer. Liposomes are the most suitable carrier for anticancer MDT due to their ability to encapsulate both hydrophil

Совпадение в полном тексте источника
… of cancer [ 2 , 3 ], heart diseases [ 4 , 5 ], metabolic disorders [ 6 , 7 ], renal malfunctions [ 8 ], neurological diseases [ 9 , 10 ], inflammatory diseases [ 11 , 12 ], and fatal infections like malaria [ 13 ], acquired immunodeficiency syndrome (AIDS) [ 14 , 15 ], tuberculosis [ 16 , 17 ], and leprosy … Multidrug therapy for leprosy: A game changer on the path to elimination. Lancet Infect. Dis. 2017;17:e293–e297. doi: 10.1016/S1473-3099(17)30418-8. 19. Sun W., Sanderson P.E., Zheng W. Drug combination therapy increases successful drug repositioning. Drug Discov. …

Abstracts from the 8th Drug Hypersensitivity Meeting (DHM)

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… A previous publication showed that HLA-B*1301 allele is a genetic marker for dapsone-induced hypersensitivity syndrome of leprosy patients in China, and another report showed that HLA-B*1301 is associated with SASP-induced DRESS in the Han Chinese population. … It has been reported that HLA - B*13:01 is strongly associated with dapsone-induced hypersensitivity reactions among leprosy patients. However, the phenotype specificity and detailed immune mechanism of HLA-B*13:01 remains unclear. …

Azoximer Bromide: Mystery, Serendipity, and Promise.

Azoximer bromide (AZB) was identified as an immunomodulator, and was initially developed and currently successfully indicated as one of several natural polyelectrolytes, a vaccine adjuvant, and an effective agent for the treatment of infectious and inflammatory diseases of viral, bacterial, and fungal origin. AZB has the potential to increase an individual's resistance to local and general infection and is indicated for the treatment of viral infections, and has also demonstrated clinical efficacy in the treatment of a variety of secondary immunodeficiencies. However, AZB may offer long-term p

Совпадение в полном тексте источника
… Around the same time that AZB was being used in its first patients, thalidomide was approved by the United States (US) Food and Drug Administration (FDA) for use in the US for the treatment of erythema nodosum leprosum, an inflammatory condition associated with leprosy. …

Neuropathic cancer pain: What we are dealing with? How to manage it?

Cancer pain is a serious health problem, and imposes a great burden on the lives of patients and their families. Pain can be associated with delay in treatment, denial of treatment, or failure of treatment. If the pain is not treated properly it may impair the quality of life. Neuropathic cancer pain (NCP) is one of the most complex phenomena among cancer pain syndromes. NCP may result from direct damage to nerves due to acute diagnostic/therapeutic interventions. Chronic NCP is the result of treatment complications or malignancy itself. Although the reason for pain is different in NCP and non

Совпадение в полном тексте источника
… syndromes like carpel tunnel syndrome, direct tumor compression, especially in tumor metastasis Ischemia | Pain in diabetic food ulcers, vasculitis-associated neuropathy, Buerger’s disease Infection | Postherpetic neuralgia, human immunodeficiency virus-associated neuropathy, herpes zoster-associated leprosy … Infectious neuropathies are a group of disorders mainly encountered with leprosy, hepatitis C virus, and human immunodeficiency virus (HIV) infections, Lyme disease, and varicella zoster virus (VZV) infections. …

Disability Weights Measurement for 289 Causes of Disease Considering Disease Severity in Korea.

BackgroundFor the Korean Burden of Disease (KBD) 2015 study, we have amended disability weights for causes of disease adapting the methodology of the KBD disability weight 2012 study.MethodsWe conducted a self-administered web-based survey in Korea using ranking five causes of disease. A total of 605 physicians and medical college students who were attending in third or fourth grade of a regular course performed the survey. We converted the ranked data into paired comparison data and ran a probit regression. The predicted probabilities for each cause of disease were calculated from the coeffic

Совпадение в полном тексте источника
… | 0.255 | 0.364 66 | Trichomoniasis | 0.316 | 0.259 | 0.377 67 | Herpes genitalia | 0.286 | 0.231 | 0.345 68 | Acute hepatitis A | 0.364 | 0.307 | 0.424 69 | Acute hepatitis B | 0.431 | 0.372 | 0.491 70 | Acute hepatitis C | 0.501 | 0.441 | 0.561 71 | Acute hepatitis E | 0.467 | 0.407 | 0.526 72 | Leprosy …

[Tuberculosis in Asia].

1. Philippines: The development, expansion and maintenance of pilot area activities: Cristina B. Giango (Technical Division, Cebu Provincial … . Cambodia: HIV/TB and the health sector reform: Tan Eang Mao (National Center for Tuberculosis and Leprosy Control, Cambodia) Cambodia is one of the 23 high burden countries of tuberculosis in the world. Moreover, HIV/AIDS has been spreading rapidly since 1990s, which is worsening the tuberculosis epidemics. To cope with the burden, Cambodia has started …

Revolutionary drug repositioning: the preventive and therapeutic potential of metformin and other antidiabetic drugs in age-related macular degeneration.

Age-related macular degeneration (AMD) is a leading cause of blindness among the elderly worldwide. Anti-vascular endothelial growth factor (anti-VEGF) injections remain the first-line therapy for AMD. However, their high cost and the need for frequent administration pose challenges to long-term adherence, highlighting the need for accessible and cost-effective preventive strategies. Emerging evidence suggests that traditional antidiabetic drugs, such as metformin, sulfonylureas, and thiazolidinediones, may offer neuroprotective benefits, opening new avenues for AMD prevention. Among these, me

Совпадение в полном тексте источника
… Classic examples include Viagra (originally developed for cardiovascular conditions but later used for erectile dysfunction and pulmonary hypertension) ( Ghofrani et al., 2006 ), and Thalidomide (repurposed from a morning sickness treatment to a therapy for leprosy and multiple myeloma) ( Wang et al. …

Mechanisms to medicines: navigating drug repurposing strategies in Alzheimer's disease.

Alzheimer's disease (AD) represents a continuously advancing neurodegenerative condition distinguished by the unremitting deterioration of cognitive abilities and memory impairment, which significantly hampers daily functioning of life. In the absence of disease modifying treatments, it continues to pose a significant global challenge. Though symptomatic treatment exists, the inherent complexity involved with AD pathogenesis related to Aβ plaques, neurofibrillary tangles, neuroinflammation, oxidative stress, etc. poses a tremendous challenge to developing drugs. With the incidence of AD increa

Совпадение в полном тексте источника
… For instance, thalidomide, which was globally banned in 1960s due to its teratogenic properties, was approved for treating leprosy in 1998 and for multiple myeloma as well in 2006. … However, it has shown significant efficacy in treating erythema nodosum leprosum, an autoimmune consequence of leprosy ( Okafor, 2003 ; Kim and Scialli, 2011 ). …

Thalidomide attenuates radiation-induced apoptosis and pro-inflammatory cytokine secretion in oral epithelial cells by promoting LZTS3 expression.

Radiation-induced oral mucositis (RIOM) is a prevalent oral complication that occurs in individuals undergoing radiotherapy or radiation treatment for head and neck tumors. The presence of oral mucosal rupture and ulcerative lesions, which are the defining features of this condition, can significantly affect the quality of life of patients. Additionally, it can interfere with tumor therapy and contribute to an unfavorable prognosis. Current evidence suggests that cellular inflammation and programmed cell death are important factors in disease development. Moreover, thalidomide (THD) has been r

Совпадение в полном тексте источника
… Owing to its anti-inflammatory properties, this synthetic derivative is used for leprosy treatment [ 12 ]. Recently, research has revealed the role of THD in treating various inflammatory and infectious conditions and other ailments, including multiple myeloma. …

Updating Disability Weights for Measurement of Healthy Life Expectancy and Disability-adjusted Life Year in Korea.

BackgroundThe present study aimed to update the methodology to estimate cause-specific disability weight (DW) for the calculation of disability adjusted life year (DALY) and health-adjusted life expectancy (HALE) based on the opinion of medical professional experts. Furthermore, the study also aimed to compare and assess the size of DW according to two analytical methods and estimate the most valid DW from the perspective of years lost due to disability and HALE estimation.MethodsA self-administered web-based survey was conducted ranking five causes of disease. A total of 901 participants star

Совпадение в полном тексте источника
… fever | 0.512 | 0.366 | 0.463 | 0.416 39 | Rabies | 0.685 | 0.455 | 0.656 | 0.518 40 | Ascariasis | 0.231 | 0.272 | 0.306 | 0.355 41 | Trichuriasis | 0.332 | 0.301 | 0.377 | 0.381 42 | Hookworm disease | 0.222 | 0.269 | 0.330 | 0.363 43 | Food-borne trematodiases | 0.309 | 0.294 | 0.398 | 0.389 44 | Leprosy …

10th Trends in Medical Mycology Held on 8 to 11 October 2021, Aberdeen, Scotland, Organized by the European Confederation of Medical Mycology (ECMM).

Plenary Sessions: [...].

Rational treatment of chemotherapy-induced peripheral neuropathy with capsaicin 8% patch: from pain relief towards disease modification.

PurposeChemotherapy-induced peripheral neuropathy (CIPN) with associated chronic pain is a common and disabling condition. Current treatments for neuropathic pain in CIPN are largely ineffective, with unfavorable side-effects. The capsaicin 8% patch (capsaicin 179 mg patch) is approved for the treatment of neuropathic pain: a single topical cutaneous application can produce effective pain relief for up to 12 weeks. We assessed the therapeutic potential of capsaicin 8% patch in patients with painful CIPN, and its mechanism of action.Patients and methods16 patients with chronic painful CIPN (mea

Совпадение в полном тексте источника
… Correlation of quantitative tests of nerve and target organ dysfunction with skin immunohistology in leprosy. Brain . 1998;121(Pt 12):2239–2247. doi: 10.1093/brain/121.12.2239 77. Narayanaswamy H, Facer P, Misra VP, et al. …

Some Aspects and Convergence of Human and Veterinary Drug Repositioning.

Drug innovation traditionally follows a de novo approach with new molecules through a complex preclinical and clinical pathway. In addition to this strategy, drug repositioning has also become an important complementary approach, which can be shorter, cheaper, and less risky. This review provides an overview of drug innovation in both human and veterinary medicine, with a focus on drug repositioning. The evolution of drug repositioning and the effectiveness of this approach are presented, including the growing role of data science and computational modeling methods in identifying drugs with po

Совпадение в полном тексте источника
… By a serendipitous observation, thalidomide was approved for the treatment of leprosy in 1998, then, through a systematic path, for multiple myeloma in 2006. Notably, it is also used for the treatment of various cancers in dogs. … Following the approval of thalidomide for a second therapeutic use for the treatment of leprosy (see above), in an independent repositioning, it was also registered for the treatment of multiple myeloma. …

Relevance Index Regional Variation by Each Disease and Its Essential Medical Field: A Retrospective Data Analysis From 2016-2020 in Korea.

BackgroundTo precisely build a healthcare delivery system at regional levels, local patients' healthcare service utilization patterns must be examined. Hence, this study utilized trend analysis of the relevance index of each disease of each essential medical service field at the municipal and provincial levels.MethodsThis study analyzed customized databases released by the National Health Insurance Service from 2016-2020. Diseases defined in the Korean National Burden of Disease (KNBD) study were categorized into the following essential medical service fields: trauma care, cardiocerebrovascula

Совпадение в полном тексте источника
… 79.5 75 | Herpes genitalia | 83.3 | 100.0 | 90.9 | 85.7 | 85.7 76 | Acute hepatitis A | 83.5 | 84.4 | 82.0 | 83.8 | 83.3 77 | Acute hepatitis B | 77.3 | 80.0 | 83.3 | 81.3 | 90.9 78 | Acute hepatitis C | 83.3 | 72.7 | 75.0 | 85.7 | 87.5 79 | Acute hepatitis E | 0.0 | 40.0 | 30.0 | 93.3 | 25.0 80 | Leprosy …