Результаты поиска

Belatacept Maintenance Immunosuppression for Calcineurin Inhibitor Sparing or Avoidance in Pancreas Transplant Recipients With Progressive Renal or Renal Allograft Dysfunction.

Belatacept may be used to spare or replace calcineurin inhibitors (CNI) to preserve renal function. Use in pancreas transplant (PTx) is limited by increased risk of pancreas rejection. This retrospective analysis included all PTxs performed between 2004 and 2023. A 1:2 case/control analysis was performed to identify predictors of belatacept use and compare allograft and patient survival. Of 731 PTxs, 21 (3%) started belatacept (eight simultaneous pancreas and kidney (SPK), three pancreas after kidney (PAK), and 10 pancreas transplant alone (PTA). At 1 year, Δ estimated glomerular filtration ra

Maintenance of Postoperative Reduction in Trochanteric Fracture Fixation: A Prospective Comparison of Helical Blades and Screws in a Single Cephalomedullary Nailing System.

BACKGROUND: Cephalomedullary nailing systems, such as the trochanteric femoral nail advanced (TFNa), are standard of care for trochanteric fractures. The TFNa system allows for the use of either a helical blade or a lag screw for femoral neck fixation, but there is ongoing debate regarding which component provides superior outcomes. The aim of this study was to compare the performance of these two components in maintaining fracture reduction and preventing mechanical complications. METHODS: A prospective cohort study enrolled 201 patients aged 50 years or older with type 31A1-31A2 (pertrochan

Reliability Between Sarcopenia Diagnosis by EWGSOP 1 and EWGSOP 2 Criteria and Association With Clinical Parameters in Maintenance Hemodialysis Patients.

OBJECTIVES: To analyze the reliability between the sarcopenia criteria proposed by the European Working Group on Sarcopenia in Older People (EWGSOP) 1 and 2 and to verify the association of clinical parameters with sarcopenia diagnosis in patients on maintenance hemodialysis. METHODS: Cross-sectional analysis including adult patients on maintenance hemodialysis. The assessment of lean mass was performed by dual-energy X-ray absorptiometry, and the appendicular lean mass index was calculated. The assessment of muscle strength was performed using a handgrip dynamometer. The cutoff values consid…

Real-world outcomes of PARP inhibitor maintenance in advanced ovarian cancer: a focus on disease patterns and treatment modalities at recurrence.

BACKGROUND: The utilization of poly-ADP-ribose polymerase (PARP) inhibitors (PARPi) as a first-line maintenance therapy for advanced ovarian cancer has increased significantly, with ∼80% of patients potentially eligible. This expansion has led to a rise in the population experiencing platinum-sensitive recurrence, yet data on first recurrence during PARPi are limited. This real-world study from a high-volume referral center aims to elucidate recurrence rates, disease distribution, and treatment modalities at the time of progression in PARPi-treated patients. MATERIALS AND METHODS: We analyzed…

Originator versus biosimilar adalimumab in hidradenitis suppurativa: A multicenter real-world analysis of clinical response, maintenance of response, and switching.

BACKGROUND: Adalimumab is a mainstay treatment for hidradenitis suppurativa (HS); however, high-costs limit accessibility. While biosimilars offer an affordable alternative, concerns remain regarding clinical equivalence and the impact of switching. OBJECTIVE: To evaluate the clinical response of originator versus biosimilar adalimumab in HS and assess outcomes following nonmedical switching. METHODS: This multicenter, real-world study included treatment naïve HS patients initiated on originator or biosimilar adalimumab between April 2021 and December 2024. Outcomes were compared between pat

First report on the enzootic maintenance of Dirofilaria sp. hongkongensis in the canine hosts and mosquito vector Armigeres subalbatus (Coquillet) in Puducherry.

BACKGROUND: Dirofilariasis is a re-emerging zoonosis caused by the nematode Dirofilaria spp., parasitizing canines, felines and humans and transmitted by mosquito vectors of the Culicidae family. Currently, reports of human dirofilariasis are increasing in India and thus we explored the occurrence of Dirofilaria infection among dogs and mosquitoes in Puducherry, India. METHODS: Two millilitres of blood collected from 293 dogs from Puducherry was subjected to microscopy and Dirofilaria screening polymerase chain reaction (PCR) targeting the ITS2 gene. Mosquitoes trapped from areas with filaria

Необычайное представление множественного склероза стероида-реактивного стероида: кризис мозга, урегулированный с помощью плазмы и обслуживания Ocrelizumab.

Трубоактивный множественный склероз (TMS) — редкий вариант множественного склероза, вызывающий серьезные повреждения, часто имитирующие новообразования или инсульт. Мы сообщаем о случае с 32-летним мужчиной, у которого была прогрессивная правая слабость, участие лиц и черепно-нервный дефицит. Нейроимация выявила демиелинирующее повреждение в левых порциях с дополнительными старыми досками. Несмотря на первоначальное лечение высокодозированным кортикостероидом, у пациента не было никаких улучшений. Последующий плазменный обмен привел к значительному неврологическому восстановлению, и для предот

Совпадение в аннотации оригинала
Tumefactive multiple sclerosis (TMS) is a rare variant of multiple sclerosis that presents large demyelinating lesions, often mimicking neop … resenting as a brainstem syndrome and the effective role of plasma exchange followed by ocrelizumab maintenance therapy.

Real-World Treatment Patterns and Clinical Outcomes in Patients With Locally Advanced or Metastatic Urothelial Carcinoma by Eligibility for Maintenance Avelumab.

INTRODUCTION: 1L PBC has historically been recommended for patients with la/mUC. Maintenance avelumab is recommended for patients without disease progression following 1L PBC. Real-world data on the proportion of patients eligible for maintenance avelumab are limited, and outcomes among patients ineligible for maintenance avelumab are uncertain. This study assessed the proportion of patients with la/mUC initiating 1L PBC who were maintenance-avelumab eligible and real-world outcomes following 1L PBC by maintenance-avelumab eligibility. METHODS: A retrospective, observational study was conduct…

Clinical outcomes and risk factors associated with drug-coated balloon treatment for femoropopliteal artery disease in patients on maintenance hemodialysis.

The effect of drug-coated balloons (DCB) on hemodialysis (HD) in patients with femoropopliteal (FP) disease remains uncertain. This study aimed to investigate the outcomes of DCB therapy in patients with FP artery disease on HD. A total of 185 patients with FP lesions (140 HD patients) who underwent DCB treatment were included in the study. The incidence of restenosis and target lesion revascularization (TLR) at 12 months were measured. Risk factors for TLR were also investigated. The mean age was 71.7 years, and diabetes was observed in 82.3% of patients. The mean duration of receiving dialys

Glial cell deficits are a key feature of schizophrenia: implications for neuronal circuit maintenance and histological differentiation from classical neurodegeneration.

Dysfunctional glial cells play a pre-eminent role in schizophrenia pathophysiology. Post-mortem studies have provided evidence for significantly decreased glial cell numbers in different brain regions of individuals with schizophrenia. Reduced glial cell numbers are most pronounced in oligodendroglia, but reduced astrocyte cell densities have also been reported. This review highlights that oligo- and astroglial deficits are a key histopathological feature in schizophrenia, distinct from typical changes seen in neurodegenerative disorders. Significant deficits of oligodendrocytes in schizophren

Воздействие непрерывного лечения леналидомидома на людей, живущих с множественным исследованием по оценке качества услуг в одном центре миэломы.

PMOPSE: Непрерывное лечение линалидомида после аутологической трансплантации стволовых клеток способствует повышению уровня свободного развития и общей выживаемости вновь диагностированных пациентов с множественными миеломами и является стандартом ухода в Соединенном Королевстве с марта 2021. Однако имеется мало информации о ее воздействии на повседневную жизнь пациентов. Эта оценка услуг была направлена на качественную оценку пациентов, проходящих курс лечения линалидомидом в раковом центре в Лондоне, с тем чтобы эта служба могла лучше соответствовать потребностям и ожиданиям пациентов.МЕТОДЫ

Совпадение в аннотации оригинала
PURPOSE: Continuous lenalidomide maintenance treatment after autologous stem cell transplantation delivers improvement in progression free and overall survival among newly diagnosed multiple myeloma patients and has been the standard of care in the UK since March 2021. However, there is scant information about its impact on patients' day-to-day lives. This s…

"This Is Fate! Nothing We Can Do to Change It": Triggers of Learned Helplessness Among Patients in Maintenance Hemodialysis - A Qualitative Study.

As the global population of patients undergoing maintenance hemodialysis continues to grow, more than half are experiencing the psychological distress associated with learned helplessness, a condition potentially linked to adverse outcomes such as depression and suicidal ideation. However, the triggers contributing to learned helplessness in these patients remain poorly understood. This study employs an interpretative phenomenological approach to explore the experiences and triggers of learned helplessness among 26 maintenance hemodialysis patients across five hospitals in China. The analysis …

The polymorphisms of candidate pharmacokinetic and pharmacodynamic genes and their pharmacogenetic impacts on the effectiveness of risperidone maintenance therapy among Saudi children with autism.

BACKGROUND: Antipsychotics, including risperidone (RIS), are frequently indicated for various autism spectrum disorder (ASD) manifestations; however, "actionable" PGx testing in psychiatry regarding antipsychotic dosing and selection has limited applications in routine clinical practice because of the lack of standard guidelines, mostly due to the inconsistency and scarcity of genetic variant data. The current study is aimed at examining the association of RIS effectiveness, according to ABC-CV and CGI indexes, with relevant pharmacokinetics (PK) and pharmacodynamics (PD) genes. METHODS: Eigh

The efficacy of valproate in acute mania, bipolar depression and maintenance therapy for bipolar disorder: an overview of systematic reviews with meta-analyses.

OBJECTIVE: This study aims to conduct an overview on the comparative efficacy of valproate in acute mania, bipolar depression and maintenance treatment of bipolar disorder (BD). METHOD: We performed an overview of systematic reviews with meta-analyses of randomised controlled trials (RCTs), registered in PROSPERO (CRD42024497749). We searched Medline and Cochrane Database of Systematic Reviews. Summary measures comparing valproate with placebo or other active drugs were described. RESULTS: We included 26 systematic reviews. For acute mania (31 RCTs, n=4376), valproate showed a significantly …

ELP1, the Gene Mutated in Familial Dysautonomia, Is Required for Normal Enteric Nervous System Development and Maintenance and for Gut Epithelium Homeostasis.

Familial dysautonomia (FD) is a rare sensory and autonomic neuropathy that results from a mutation in the ELP1 gene. Virtually all patients report gastrointestinal (GI) dysfunction and we have recently shown that FD patients have a dysbiotic gut microbiome and altered metabolome. These findings were recapitulated in an FD mouse model and moreover, the FD mice had reduced intestinal motility, as did patients. To understand the cellular basis for impaired GI function in FD, the enteric nervous system (ENS; both female and male mice) from FD mouse models was analyzed during embryonic development

Detection of pulmonary actinomycosis by metagenomic next-generation sequencing in a cancer patient receiving maintenance olaparib: A review and case report.

A 52-year-old female patient receiving olaparib maintenance treatment was admitted to hospital with a low fever and chest tightness. A CT scan of the patient's chest showed diffuse ground glass shadow or miliary nodular shadow in the bilateral lungs. Her inflammatory biomarkers were almost normal, except the slightly elevated C-reactive protein. Moreover, lymphocytes count obviously decreased. Empirical treatment did not relieve her symptoms, while traditional testing developed negative results. The results of metagenomic next-generation sequencing (mNGS) revealed the presence of a potential p…

[Efficacy of Tyrosine Kinase Inhibitor Combined with Decitabine, Homoharringtonine, Interferon in the Maintenance Therapy of Blast Phase Chronic Myeloid Leukemia].

OBJECTIVE: To explore the efficacy of tyrosine kinase inhibitor (TKI) combined with decitabine, homoharringtonine, and interferon regimen as maintenance therapy for blast phase chronic myeloid leukemia (CML-BP). METHODS: The clinical data of CML-BP patients who received the first major hematological response after induction therapy at The Affiliated Cancer Hospital of Zhengzhou University from June 2015 to December 2021 were analyzed retrospectively. The event-free survival, duration of remission, and overall survival of patients in TKI combined with decitabine, homoharringtonine, interferon …

The risk factors and predictive model for cardiac valve calcification in patients on maintenance peritoneal dialysis: a single-center retrospective study.

BACKGROUND: Cardiovascular calcification includes cardiac valve calcification (CVC) and vascular calcification. We aimed to analyze risk factors for CVC, and construct a predictive model in maintenance peritoneal dialysis (MPD) patients. METHODS: We retrospectively analyzed MPD patients who began peritoneal dialysis between January 2014 and September 2021. Patients were randomly assigned to the derivation cohort and validation cohort in a 7:3 ratio. The patients in the derivation cohort were divided into the CVC group and non-CVC group. Logistic regression was used to analyze risk factors, th…