Результаты поиска

Lenalidomide use in multiple myeloma (Review).

Lenalidomide is a second-generation new immunomodulatory medication used to treat multiple myeloma (MM). Its mechanism of action involves affecting the expression of vascular endothelial growth factor, interleukin-6, cytochrome c, caspase-8, as well as other factors including immunological modulation and the direct killing of cells, among others, rendering it a fundamental medication, useful for the treatment of MM. Combining lenalidomide with other medications such dexamethasone, bortezomib, ixazomib, carfilzomib and daratumumab can markedly alleviate MM. When autologous-hematopoietic stem ce

Совпадение в полном тексте источника
… patients with newly diagnosed myeloma without intent for immediate autologous stem-cell transplant (SWOG S0777): A randomised, open-label, phase 3 trial Lancet 389 519 527 2017 10.1016/S0140-6736(16)31594-X 28017406 PMC5546834 40 Mohammad NS Nazli R Zafar H Fatima S Effects of lipid based Multiple Micronutrients …

Epigenetic and Transcriptomic Regulation Landscape in HPV+ Cancers: Biological and Clinical Implications.

Human Papillomavirus (HPV) is an oncogenic virus that causes the highest number of viral-associated cancer cases and deaths worldwide, with more than 690,000 new cases per year and 342,000 deaths only for cervical cancer (CC). Although the incidence and mortality rates for CC are declining in countries where screening and vaccination programs have been implemented, other types of cancer in which HPV is involved, such as oropharyngeal cancer, are increasing, particularly in men. Mutational and transcriptional profiles of various HPV-associated neoplasms have been described, and accumulated evid

Совпадение в полном тексте источника
… That is, two of the most important methyl donor micronutrients are associated with site-specific methylation of the promoter (position 31, 37, 43, 43, 52, and 58) and enhancer (7862) regions of the E6 gene, which is associated with a low probability of CIN2+ diagnosis ( Piyathilake et al., 2014 ) ( Figure … Methyl Donor Micronutrients that Modify DNA Methylation and Cancer Outcome. Nutrients 11, 608. 10.3390/nu11030608 Mani E., Medina L. A., Isaac-Olive K., Duenas-Gonzalez A. (2014). Radiosensitization of Cervical Cancer Cells with Epigenetic Drugs Hydralazine and Valproate. Eur. J. Gynaecol. …

Cardiac Cachexia: Unaddressed Aspect in Cancer Patients.

Tumor-derived cachectic factors such as proinflammatory cytokines and neuromodulators not only affect skeletal muscle but also affect other organs, including the heart, in the form of cardiac muscle atrophy, fibrosis, and eventual cardiac dysfunction, resulting in poor quality of life and reduced survival. This article reviews the holistic approaches of existing diagnostic, pathophysiological, and multimodal therapeutic interventions targeting the molecular mechanisms that are responsible for cancer-induced cardiac cachexia. The major drivers of cardiac muscle wasting in cancer patients are au

Совпадение в полном тексте источника
… Nonpharmacological Therapy Several reports indicate that deficiency of vitamins and other micronutrients may contribute to the pathophysiology of various cardiovascular disorders [ 107 ]. …

Личная профилактика нейродегенеративных заболеваний: обзор аналитического исследования и карта пробелов в данных.

Нейродегенеративные заболевания представляют собой серьезную проблему в области общественного здравоохранения в связи с их высокой распространенностью и низким прогнозом. Определение биомаркеров для стратификации людей в силу их риска развития этих заболеваний может помочь в определении новых индивидуализированных профилактических мер. Цель этого исследования заключалась в проведении аналитического обзора биомаркеров для первичной и вторичной индивидуализированной профилактики нейродегенеративных заболеваний. Поиск был нацелен на биомаркеры среди взрослых или групп повышенного риска в клиничес

Совпадение в полном тексте источника
… Genetically Predicted Circulating Concentrations of Micronutrients and Risk of Amyotrophic Lateral Sclerosis: a Mendelian Randomization Study . Front Genet . 2022 ; 12 : 811699 . doi: 10.3389/fgene.2021.811699 35111203 PMC8801789 53 Salvatore C , Castiglioni I , Cerasa A . …

Gene Therapy for Pancreatic Diseases: Current Status.

The pancreas is a key organ involved in digestion and endocrine functions in the body. The major diseases of the pancreas include pancreatitis, pancreatic cancer, cystic diseases, pancreatic divisum, islet cell tumors, endocrine tumors, diabetes mellitus, and pancreatic pain induced by these diseases. While various therapeutic methodologies have been established to date, however, the improvement of conventional treatments and establishment of novel therapies are essential to improve the efficacy. For example, conventional therapeutic options, including chemotherapy, are not effective against p

Совпадение в полном тексте источника
… The currently available management methods include analgesics, antioxidant micronutrients, drugs interfering with neural transmission, pancreatic enzymes, celiac plexus blockade, and surgery [ 67 ]. …

The Association Between Social Support and Psychosomatic Status in Cancer Patients During Mid-Course Radiotherapy: The Chain Mediating Roles of Psychological Capital and Coping Styles.

Background: Cancer patients undergoing mid-course radiotherapy frequently experience psychosomatic distress, yet the psychosocial correlates and indirect pathways associated with this phenomenon remain insufficiently understood. Objective: To examine the direct and indirect associations between social support and psychosomatic status through psychological capital and coping styles in cancer patients undergoing mid-course radiotherapy. Methods: A cross-sectional study was conducted among 327 cancer patients recruited from the radiotherapy center of a tertiary-level general hospital between Augu

Совпадение в полном тексте источника
… Protective role of key micronutrients in chemotherapy-induced organ toxicity: A comprehensive review of mechanistic insights and clinical implications. Nutrients. 2025;17:2838. doi: 10.3390/nu17172838. 45. Astrup G.L., Rustøen T., Miaskowski C., Paul S.M., Bjordal K. …

Естественные модули вкуса и микробиомеозная поддержка в области питания для иммунотерапии-ассоциированной дисгеусии: перевод для оказания помощи в лечении рака.

Дисгейсия является клинической, но по-прежнему недостаточно стандартизированной токсичностью для лечения рака. В эпоху иммунотерапии расстройства вкуса становятся все более актуальными для пациентов, получающих ингибиторы на иммунных контрольно-пропускных пунктах, химерик антигенные рецепторы (CAR) T-клеток и T-перенаправленные антитела, с группой G-белковых рецепторов C 5 - лечение в множестве миэлома, осуществляемое под руководством члена D (GPRC5D), представляет собой особенно поучительную модель с высокой нагрузкой. Мы провели структурированный критический обзор с картированием доказательс

Optimizing Cancer Treatment: A Comprehensive Review of Active and Passive Drug Delivery Strategies.

Nanocarriers as powerful tools for delivering drugs to tumors provide new strategies for cancer treatment. These delivery systems encompass a diverse variety of structures, including polymeric nanoparticles (NPs), liposomes, dendrimers, micelles, and inorganic NPs such as gold and silica. Each type exhibits distinct physicochemical advantages that contribute to stability, drug-loading capacity, and targeting efficacy. Engineered nanocarriers can be utilized for the active targeting of tumor-specific receptors or for passive targeting of tumors via the enhanced permeability (EPR) and retention

Совпадение в полном тексте источника
… Folate Vitamins are essential micronutrients that are necessary for cell survival and maintenance of optimal physiological functions. Due to rapid growth and proliferation, cancer cells require high levels of certain vitamins, particularly folate and biotin [ 69 ] . …

Global cancer statistics 2024: GLOBOCAN estimates of incidence and mortality worldwide for 34 cancers in 186 countries.

This article provides updated global cancer statistics for the year 2024 based on the GLOBOCAN estimates of the International Agency for Research on Cancer. The authors describe national cancer incidence and mortality by world region and the Human Development Index and predict the burden in 2050 based on demographic trends. In 2024, an estimated 20.6 million new cancer cases (19.5 million excluding nonmelanoma skin cancer) and 9.8 million deaths (9.7 million excluding nonmelanoma skin cancer) occurred worldwide, equivalent to one in five people developing cancer during their lifetime and one i

Совпадение в полном тексте источника
… 144 Nonetheless, only a small fraction of infected individuals develop cancer, likely because of differences in bacterial strain virulence, host genetic susceptibility, timing and duration of infection, and other factors that may synergize with H. pylori to promote carcinogenesis, such as smoking and micronutrient … 13 of 118 known HPV types classified as group 1 carcinogens by the IARC Monographs. 212 Other important cofactors include sexually transmitted infections (HIV and Chlamydia trachomatis ), smoking, high parity, immunosuppressive drug use (e.g., transplantation recipients), and low intake of certain micronutrients …

Antiaging Strategies and Remedies: A Landscape of Research Progress and Promise.

Aging is typified by a gradual loss of physiological fitness and accumulation of cellular damage, leading to deteriorated functions and enhanced vulnerability to diseases. Antiaging research has a long history throughout civilization, with many efforts put forth to understand and prevent the effects of aging. Multiple strategies aiming to promote healthy aging and extend the lifespan have been developed including lifestyle adjustments, medical treatments, and social programs. A multitude of antiaging medicines and remedies have also been explored. Here, we use data from the CAS Content Collect

Совпадение в полном тексте источника
… The discovery of such differences among foods is the first step toward personalized nutrition. 264 Further, adequate nutrient levels are important for mitochondrial function as certain particular micronutrients play essential roles in energy metabolism and ATP production. 265 Stem cell therapies strongly … Vital nutrients such as certain vitamins, minerals (as micronutrients), amino acids, polyunsaturated fatty acids, probiotics, and plant metabolites, such as polyphenols and terpenoids, are recognized for their ability to prevent aging and promote healthy aging. …

Метаболизм триптофана в области диагностических и внегигиенических заболеваний: механизмы, клинические последствия и терапевтические перспективы.

Метаболизм триптофана (Trp) лежит на пересечении питания, микробиотики кишечника, мукосовой иммунологии и системных процессов воспаления, которые играют ключевую роль во многих желудочно-кишечных и внекишечных заболеваниях. Трап представляет собой важнейшую аминокислоту, получаемую с помощью рациона питания. Помимо своей роли в синтезе белка, он метаболизируется по трем основным направлениям: кинуреньиновый путь, серотонин/мелатонин, и микробный метаболизм в кишечнике, ведущий к индолу и связанным с ним производным. Кинуренинский путь представляет собой основной путь деградации Trp и тесно свя

Personalized Lifestyle Interventions for Prevention and Treatment of Obesity-Related Cancers: A Call to Action.

The increasing global burden of cancer necessitates innovative approaches to prevention and treatment. Lifestyle factors such as diet, physical activity, and smoking significantly contribute to cancer. At the same time, current guidelines are based on a one-size-fits-all approach, which limits their effectiveness across diverse populations. Obesity is a well-documented risk factor for cancer, directly affecting 13 types of cancer. The complex interplay of genetic, metabolic, hormonal, and environmental factors in obesity's etiology highlights the need for more tailored approaches to obesity-re

Совпадение в полном тексте источника
… For example, international guidelines from the World Cancer Research Fund (WCRF) and the American Institute for Cancer Research (AICR) emphasize dietary patterns for cancer prevention, recommending increased intake of whole plant-based foods rich in micronutrients and antioxidants while limiting red …

Влияние ПГПР на структуру микробиологической сообщества ризосферы и урожайность солончаковых зерновых культур.

Растворяющиеся в почве бактерии, способствующие росту растений (PGPR), могут защищать растения от почвенных заболеваний и абиотических стрессовых условий. Основная цель данного исследования заключалась в оценке влияния различных PGPR (TF1, TF2, TF3 и TF4) на микробную сообщество ризосферы зерна для корма в солончаково-щелочной поле с использованием высокопроизводительной технологии последовательного секвенирования Illumina MiSeq. Результаты показали, что различные PGPRs значительно увеличили плотность уборки (на 21,31–45,16%), высоту растения (на 9,12–19,98%), диаметр стебля (на 30,07–45,78%)

Immunodeficiencies in Adults: Key Considerations for Diagnosis and Management.

Immunodeficiencies in adults are increasingly recognized yet often remain underdiagnosed, leading to significant morbidity from recurrent infections, autoimmunity, and malignancy. Both primary immunodeficiencies (PIDs), now known as inborn errors of immunity (IEI), and secondary immunodeficiencies (SIDs) contribute to immune dysfunction in adults. Although SIDs are more common in adults due to factors like medications, malignancies, metabolic disorders, chronic conditions, and protein-losing conditions, IEI-particularly common variable immunodeficiency (CVID)-can also manifest in adulthood wit

Health-related quality of life in patients with iron deficiency anemia: impact of treatment with intravenous iron.

Most physicians appear to be aware of the health consequences of advanced anemia, especially in the acute setting, frequently responding with a not inconsequential therapeutic default of transfusion. In contrast, the profound impact that chronic anemia, of any degree, may have on a patient's performance is underappreciated. The focus of this review is to 1) delineate the consistent and broad impact of anemia on patient quality of life as documented by multiple well-validated patient-reported outcome instruments and 2) demonstrate the essential normalization of the debilitation as assessed by t

Совпадение в полном тексте источника
… References 1 World Health Organization Iron deficiency anaemia: assessment, prevention and control Geneva World Health Organization 2001 Available from: http://www.who.int/nutrition/publications/micronutrients/anaemia_iron_deficiency/WHO_NHD_01.3/en/ Accessed August 3, 2018 2 Weiss G Goodnough LT Anemia …

Bone fragility and osteoporosis in children and young adults.

Osteoporosis is a metabolic bone disorder which increases fragility fracture risk. Elderly individuals, especially postmenopausal women, are particularly susceptible to osteoporosis. Although rare, osteoporosis in children and young adults is becoming increasingly evident, highlighting the need for timely diagnosis, management and follow-up. Early-onset osteoporosis is defined as the presence of a low BMD (Z-score of ≤ -2.0 in individuals aged < 20 years; T-score of ≤ -2.5 in those aged between 20 to 50 years) accompanied by a clinically significant fracture history, or the presence of low-ene

Effects of Obesity and Calorie Restriction on Cancer Development.

The risk of malignant tumor development is increasing in the world. Obesity is an established risk factor for various malignancies. There are many metabolic alterations associated with obesity which promote cancerogenesis. Excessive body weight leads to increased levels of estrogens, chronic inflammation and hypoxia, which can play an important role in the development of malignancies. It is proved that calorie restriction can improve the state of patients with various diseases. Decreased calorie uptake influences lipid, carbohydrate and protein metabolism, hormone levels and cell processes. Ma

Совпадение в полном тексте источника
… Effect of Long-Term Calorie Restriction with Adequate Protein and Micronutrients on Thyroid Hormones J. Clin. Endocrinol. Metab. 2006 91 3232 3235 10.1210/jc.2006-0328 16720655 90. Cangemi R. Friedmann A.J. Holloszy J.O. Fontana L. …

Insights Into the Role of Vitamin D as a Biomarker in Stem Cell Transplantation.

Vitamin D was discovered 100 years ago and since then multiple studies have consistently proved its effect on bone health and mineral metabolism. Further research has also explored its so-called "non-classical" biological effects, encompassing immune regulation and control of cell proliferation and differentiation. Vitamin D downregulates pro-inflammatory immune cells and subsequently their cytokine production, while enhancing the anti-inflammatory subsets, thus mediating inflammation and fostering a more tolerogenic environment. Its biological action is exerted through the vitamin D receptor,

Совпадение в полном тексте источника
… The role of micronutrients in graft-vs.-host disease: immunomodulatory effects of vitamins A and D. Front Immunol. (2018) 9:2853. 10.3389/fimmu.2018.02853 131. Ghimire S, Weber D, Mavin E, Wang XN, Dickinson AM, Holler E. Pathophysiology of GvHD and other HSCT-related major complications. …

The Power of Phytochemicals Combination in Cancer Chemoprevention.

Conventional therapies for cancer treatment have posed many challenges, including toxicity, multidrug resistance and economic expenses. In contrast, complementary alternative medicine (CAM), employing phytochemicals have recently received increased attention owing to their capability to modulate a myriad of molecular mechanisms with a less toxic effect. Increasing evidence from preclinical and clinical studies suggest that phytochemicals can favorably modulate several signaling pathways involved in cancer development and progression. Combinations of phytochemicals promote cell death, inhibit c

Совпадение в полном тексте источника
… The role of phytochemicals as micronutrients in health and disease. Curr Opin Clin Nutr Metab Care. 2014;17:558–66. doi: 10.1097/MCO.0000000000000115. 5. Surh Y-J. Cancer chemoprevention with dietary phytochemicals. Nature Reviews Cancer. 2003;3:768. doi: 10.1038/nrc1189. 6. …

Modulation of Oxidative Stress by Ozone Therapy in the Prevention and Treatment of Chemotherapy-Induced Toxicity: Review and Prospects.

(1) Background: Cancer is one of the leading causes of mortality worldwide. Radiotherapy and chemotherapy attempt to kill tumor cells by different mechanisms mediated by an intracellular increase of free radicals. However, free radicals can also increase in healthy cells and lead to oxidative stress, resulting in further damage to healthy tissues. Approaches to prevent or treat many of these side effects are limited. Ozone therapy can induce a controlled oxidative stress able to stimulate an adaptive antioxidant response in healthy tissue. This review describes the studies using ozone therapy

Совпадение в полном тексте источника
… Serum micronutrients and prealbumin during development and recovery of chemotherapy-induced peripheral neuropathy. J. Peripher. Nerv. Syst. 2016;21:134–141. doi: 10.1111/jns.12177. 67. Starobova H., Vetter I. Pathophysiology of Chemotherapy-Induced Peripheral Neuropathy. Front. Mol. …