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Five Cases of Corneal Graft Rejection After Recent COVID-19 Vaccinations and a Review of the Literature.

PURPOSE: The purpose of this study was to report 5 cases of acute corneal graft rejection after COVID-19 vaccination and perform a review of the literature. METHODS: This was a case series and review of literature dated on the October 10, 2021. RESULTS: We describe 5 cases-2 patients with Descemet stripping automated endothelial keratoplasty (for Fuchs endothelial dystrophy) who presented with acute corneal graft rejection after their first dose of mRNA (BNT162) vaccine. The other 3 patients who had penetrating keratoplasty performed more than 10 years ago for keratoconus presented with acut…

Review of the literature on the currently available evidence for the management of infectious keratitis with PACK-CXL.

Infectious keratitis (IK) is one of the most common causes of monocular blindness worldwide, especially in developing countries and may acco … of IK has been proposed. It must be differentiated from CXL used for the management of progressive keratoconus (KC). The objective of this review is to update the available evidence on the efficacy and safety of PACK-CXL in IKs.

Etiology of corneal blindness in patients attending a tertiary care center in Kashmir.

PURPOSE: To study the etiology of corneal blindness in patients attending the cornea clinic of a tertiary care center of Kashmir. MATERIALS … 14.2%), followed by trauma 10.26% with mechanical trauma 6.29% and chemical trauma 3.46%. Advanced keratoconus accounted for 7.5% of cases and failed graft for 4.72%. Corneal dystrophies and degenerations accounted for 1.9% of cases. CONCLUSION: Majority of the causes of corneal blindness are preventable if addressed appropriately and timely with good healt …

Acute Corneal Transplant Rejection After Severe Acute Respiratory Syndrome Coronavirus 2 mRNA-1273 Vaccination.

PURPOSE: The purpose of this article was to report a case of full-thickness corneal transplant rejection 3 days after immunization with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Moderna mRNA-1273 vaccine. METHODS: Case Report. RESULTS: A 51-year-old man with a history of keratoconus and penetrating keratoplasty underwent repeat penetrating keratoplasty for graft failure. The patient had an uncomplicated intraoperative and postoperative course with improved vision and a healthy graft. The patient received the SARS-CoV-2 Moderna vaccine on postoperative week 3, and withi…

Demographic and clinical characteristics of childhood and adult onset Vernal Keratoconjunctivitis in a tertiary care center during Covid pandemic: A prospective study.

Objective: To study the demographic and clinical characteristics of childhood and adult onset vernal keratoconjunctivitis in a tertiary care … d change in treatment regime, followed by shield ulcer in 2.96% and limbal stem cell deficiency and Keratoconus in 1.48%. Conclusion: This study represents the nature of Vernal Keratoconjunctivitis and its presentation in North India, showing regional variations in the presentation of the disease due to different environmental conditions and the variations in …

Обзор корнеальной слепоты: причины и управление.

Корнеальная слепота означает группу нарушений зрения, которые изменяют транспарентность кукурузы, вызывая роговицу и слепоту. К основным причинам кукурузной слепоты относятся инфекционные причины, то есть бактерии, вирусы, грибы и протозоа. Наиболее распространенными предрасположенными факторами являются травма, использование контактных линз или применение стероидных препаратов. К числу других заболеваний относятся трахома, сухие глаза, кератокон, офтальмия новорожденных и неинфекционный увейт. Для лечения кукурузной слепоты используются различные методы лечения, включая трансплантацию органов

Совпадение в аннотации оригинала
Corneal blindness refers to a group of eye disorders that change the corneal transparency, causing corneal scarring and blindness. The leadi … the use of steroid medications. The various other diseases included are trachoma, dry eye disease, keratoconus, ophthalmia neonatorum, and non-infectious uveitis. Various clinical modalities are used for treating corneal blindness, including organ transplantation. Organ donation is cumbersome as various ethical and other factors are involved. Hence the conce …

EyeDiseases: an integrated resource for dedicating to genetic variants, gene expression and epigenetic factors of human eye diseases.

Eye diseases are remarkably common and encompass a large and diverse range of morbidities that affect different components of the visual sys … and found that the SARS-CoV-2 entry factors, ACE2 and TMPRSS2 are highly correlated with cornea and keratoconus, suggest that ocular surface cells are susceptible to infection by SARS-CoV-2. Additionally, integrating analysis of Age-related macular degeneration (AMD) GWAS loci and co-expression data revealed 9 associated genes involved in HIF-1 signaling path …

Structural Changes in Thin Keratoconic Corneas Following Crosslinking with Hypotonic Riboflavin: Findings on In Vivo Confocal Microscopy.

PURPOSE: To report structural changes observable in in vivo confocal microscopy (IVCM) in keratoconic corneas < 400 μm treated with hypotonic riboflavin and collagen crosslinking (CXL). METHODS: Ten eyes of ten patients with progressive keratoconus and corneal thickness between 350 and 399 μm underwent CXL with hypotonic riboflavin. IVCM was performed preoperatively and at one month, three months, and six months after the procedure. RESULTS: IVCM analysis one month postoperatively showed complete absence of the subepithelial nerve plexus with gradual regeneration over six months in 8 of the …

Pregnancy and the eye.

PURPOSE OF REVIEW: The aim of this study was to summarize common eye changes that may occur during pregnancy, and how pregnancy may affect preexisting eye conditions such as glaucoma and diabetic retinopathy. Challenges and complexities surrounding the treatment of these eye conditions during pregnancy are also highlighted. RECENT FINDINGS: Refractive changes are common and may persist in the postpartum in patients with keratoconus. Although new medical and surgical glaucoma treatments are available, their safety in pregnancy is unknown. Limited use of topical and systemic glaucoma therapies …

Changes in Anterior and Posterior Corneal Elevation in Patients With Allergic Conjunctivitis.

Purpose: To evaluate corneal elevation changes in patients with allergic conjunctivitis (AC) and to analyze their correlations with ocular a … of corneal ectasia. Posterior corneal elevation parameters are sensitive and reliable predictors of keratoconus (KC) risk in AC patients. Clinical Trial Registration: https://clinicaltrials.gov/ct2/show/NCT04299399, identifier [NCT04299399].

Survey report on keratoplasty in China: A 5-year review from 2014 to 2018.

To provide the general information on corneal transplantation (CT) in China, China Cornea Society designed a questionnaire on CT from 2014 t … (7683, 20.98%), followed by bacterial keratitis (4209, 11.49%), corneal dystrophies (4189, 11.44%), keratoconus (3578, 9.77%) and corneal perforation (2839, 7.75%). The main surgical techniques were penetrating keratoplasty (PK) (19,896, 54.34%), anterior lamellar keratoplasty (ALK) (13,869, 37.88%). The proportion of PK decreased from 57.97% in 2014 to 52.88 …

Fitting Scleral Lenses Less Than 15 mm in Diameter: A Review of the Literature.

OBJECTIVE: To perform a comprehensive review of the current and historical scientific literature on fitting small scleral lenses (diameter <15 mm) and clarifying their advantages and disadvantages, in addition to their clinical applications. METHODS: The literature search was performed through PubMed from MEDLINE. RESULTS: Eleven studies of case series (258 eyes) were found. Indications were similar to those of larger scleral lenses, 74% for corneal irregularities (mainly keratoconus), whereas 26% for ocular surface diseases. In the studies on cases of irregular corneas, visual acuity improv…

Heritability of pachymetric indices using Pentacam Scheimflug imaging.

AIM: To investigate the heritability of corneal thickness at the apex, entrance pupil centre, thinnest point, pachymetric progression index … find related genes and to understand the aetiology of associated diseases, especially glaucoma and keratoconus.

A novel method in correcting aberropia using pin hole soft contact lenses: A case report.

Aberropia leads to decrease in image quality due to higher order aberrations (HOA). Correction of these HOA poses a great challenge to clini … atism as the posterior float was more than 25 μm in the right eye which led to a diagnosis of early keratoconus. As the decrease in pupil size reduces HOA, a pin hole (2.5 mm pupil) soft contact lens was tried which reduced the symptoms. Hence a novel method is proposed to eliminate HOA which corrects aberropia by using pin hole soft contact lenses.

Obstructive sleep apnoea.

Obstructive sleep apnoea (OSA) is increasing in prevalence due to rising obesity. While OSA is a disorder primarily of the upper airway duri … o diabetic retinopathy, glaucoma, floppy eyelid syndrome, non-arteritic ischaemic optic neuropathy, keratoconus and AMD. Associations with OSA have been found, but robust prospective studies using multi-channel sleep studies to diagnose OSA are lacking. Gaps remain in the evidence and in our knowledge. It is hoped that this review will highlight the need for …

[Update Minimally Invasive Lamellar Keratoplasty: DMEK, DSAEK and DALK].

BACKGROUND: The spectrum of operative interventions in corneal disorders requiring keratoplasty has been expanded considerably in recent yea … Endothelial Dystrophy. The DALK technique for lamellar replacement of the anterior stroma, i.e. in keratoconus, needs further standardisation, so that DALK can in future be performed more often even in less specialised departments. Major advantages of lamellar keratoplasties are the very good results in visual outcome and fewer immune reactions or graft reje …

Water-dilutable microemulsions for transepithelial ocular delivery of riboflavin phosphate.

Riboflavin phosphate (RFP) is an essential compound in the treatment of keratoconus - a degenerative, non-inflammatory disease of the cornea. Currently, the quantitative and efficient transport of riboflavin to the cornea is possible after mechanical removal of the epithelium. To avoid surgical intervention, it is therefore important to develop a method for quantitatively transporting riboflavin across the intact epithelium. In the present study, an RFP-loaded microemulsion was prepared, which could potentially function as an ocular drug delivery system crossing the eye epithelium. The special…

Central corneal thickness in patients with atopic keratoconjunctivitis.

BACKGROUND: The aim of this study was to evaluate central corneal thickness in patients with atopic keratoconjunctivitis. MATERIAL AND METH … lens use, and is an essential parameter in a wide range of ocular disorders, including glaucoma and keratoconus. Therefore, ophthalmologists should be aware of the low central corneal thickness in patients with atopic keratoconjunctivitis.

Corneal thickness measured by Scheimpflug imaging in children with Down syndrome.

PURPOSE: To measure corneal thickness via the use of a Scheimpflug imaging system (OCULUS Optikgeräte GmbH, Wetzlar, Germany) in children wi … ubjects. Decreased corneal thickness may be an early sign of a degenerative corneal disease such as keratoconus in children with Down syndrome.

Corneal crosslinking with riboflavin and ultraviolet A. Part II. Clinical indications and results.

Changes in the biomechanical properties of the human cornea play an important role in the pathogenesis of corneal ectatic diseases. A variety of conditions in primary acquired (keratoconus and pellucid marginal degeneration) or secondary induced (iatrogenic keratectasia after excimer refractive laser surgery) corneal ectatic disorders lead to reduced biomechanical resistance. Corneal collagen crosslinking (CXL) has emerged as a promising technique to slow or even to stop the progression of these corneal ectatic pathologies. In this procedure, riboflavin (vitamin B2) is administered in conjunct…