Результаты поиска

Gut microbiota interactions with the immunomodulatory role of 25-hydroxyvitamin D in children with infectious mononucleosis.

INTRODUCTION: Infectious mononucleosis (IM) is a childhood infectious disease caused by the Epstein-Barr virus (EBV). Its pathogenesis is associated with immune and gut microbiota disorders. Exploring the regulatory factors of immune function and gut microbiota in IM may provide novel strategies for the prophylaxis and management of this condition. This study explored the association between 25-hydroxyvitamin D (25(OH)D) level and gut microbiota abundance in children with IM. METHODS: Individuals meeting the inclusion criteria for IM were enrolled, and their blood samples were collected. The …

Gut microbiota dysbiosis and the gut-lung axis: links to asthma and its common comorbidities.

INTRODUCTION: Almost from the beginning of the HIV epidemic in 1981, an association with tuberculosis (TB) was recognized. This association between HIV and TB co-infection has been particularly evident amongst prisoners. However, despite this, few studies of TB in prisons have stratified results by HIV status. Given the high prevalence of HIV-positive persons and TB-infected persons in prisons and the documented risk of TB in those infected with HIV, it is of interest to determine how co-infection varies amongst prison populations worldwide. For this reason we have undertaken a systematic revi

Gut Microbiota, Immunity, and Metabolism in the Progression From Chronic Liver Disease to Hepatocellular Carcinoma.

The progression from chronic liver injury to hepatocellular carcinoma (HCC) should be viewed as a heterogeneous continuum of immune, metabol … al model selection influence disease trajectories and therapeutic responses. By focusing on the gut microbiota-metabolism-immunity axis, this review provides a systems-level framework for biomarker discovery, risk stratification, precision nutrition, and rational combination therapies. Targeting the coordinated interplay among diet, microbiota, metabolism, i …

Метагеномическая профайлирование Фекальной и Цекальной микробиоты и их антимикробных генов сопротивления на заднем дворе птицы коренных народов.

Преобладающим видом птицы в развивающихся странах является птица на заднем дворе коренных народов. Сельские мелкие фермеры в этих районах, как правило, используют систему свободного распределения (задние дворы), которая подвергает птицу различным условиям и широкому спектру микроорганизмов, влияющих на их рацион питания и кишечную микробиоту. В этом поперечном исследовании мы провели оценку микробных профилей местных птиц из заднего двора и их антимикробных генов устойчивости (ARGs) с использованием как цекаловых образцов, которые обеспечивают более точное представление кишечника кишечника мик

Совпадение в аннотации оригинала
Indigenous backyard poultry is the predominant type of poultry in developing countries. Rural smallholder farmers in these regions usually adopt the free-range (backyard) production system, which exposes the poultry to diverse environments and a broad spectrum of microorganisms that influence their diet and gut microbiota. In this cross-sectional purposive s…

Association of gut microbiota and inflammation with carotid atherosclerosis in HIV infection with poor immune reconstitution.

BACKGROUND: People living with HIV (PLWH) have an excess risk of cardiovascular disease (CVD), but little is known regarding intrinsic links between gut microbiota profiles, inflammatory factors, and the risk of carotid atherosclerosis in HIV infection with poor immune reconstitution (INR). METHODS: Well-controlled HIV patients were enrolled to analyze risk factors for carotid intima-media thickness (cIMT). Participants were stratified based on CD4+T cell count; fecal samples were collected for 16S rRNA sequencing, and plasma inflammatory markers were assessed. RESULTS: Of 518 participants w…

Pathogenesis and therapeutic strategies in the interaction between gut microbiota and enterohemorrhagic Escherichia coli infection.

Enterohemorrhagic Escherichia coli (EHEC) is a major foodborne pathogen that causes hemorrhagic colitis and hemolytic uremic syndrome. Increasing evidence indicates that the gut microbiota plays a central role in modulating EHEC pathogenesis through complex metabolic and signaling networks. Beneficial commensals, including Bifidobacterium, Lactobacillus, and segmented filamentous bacteria, contribute to colonization resistance by competing for nutrients and adhesion sites, producing antimicrobial metabolites, and enhancing epithelial barrier integrity. In contrast, certain species such as Bact…

Metagenomic Evaluation of Oral Microbiota in Patients Affected by Oral Lichen Planus: A Pilot Study.

OBJECTIVE: To characterize the oral bacterial and fungal microbiota of symptomatic oral lichen planus patients undergoing topical corticosteroid therapy and to explore microbial patterns potentially associated with subsequent oral candidiasis. METHODS: Twelve patients with clinically and histologically confirmed OLP were enrolled. Unstimulated saliva and tongue dorsum swabs were collected at baseline and weekly for three weeks during betamethasone therapy. Bacterial communities were profiled using shallow shotgun metagenomics analyzed with METAnnotatorX2, and fungal communities through ITS se…

Genetic Elements Associated with the Acquired Resistome of the Gut Microbiota in a Broiler Rooster Flock in Hungary.

Antibiotic resistance in Gram-negative bacteria poses a global health threat, and poultry farming provides an important reservoir for multidrug-resistant pathogens. Our study aimed to characterize the faecal microbiota and acquired resistome of Ross-308 roosters in Hungary. Amplicon and shotgun metagenomics revealed a faecal microbiota dominated by the Firmicutes, Bacteroidota, and Proteobacteria and a diverse faecal resistome, including qnrB and an aadA1-bearing integron. Culture-based screening of an antibiotic-free rooster yielded the MDR Escherichia coli strain K1G, displaying resistance a…

The Effects of Smoking on Respiratory Microbiota Diversity and Composition: A Systematic Review with Exploratory Meta-Analysis.

Smoking is a major modifier of respiratory health, but its effects on the respiratory microbiota remain incompletely defined across airway niches and exposure types. We conducted a PRISMA-guided systematic review of PubMed, Web of Science, and Scopus, to identify human studies using culture-independent sequencing to examine associations between smoking and microbiota composition and diversity in anatomically defined upper and lower airway sites. Thirteen studies met the inclusion criteria. The exploratory meta-analysis of bronchoalveolar lavage inverse Simpson diversity from two studies did no…

Co-inoculation of broilers by Campylobacter and Salmonella: effect on colonization, cecal microbiota, and serum metabolome.

Campylobacteriosis and salmonellosis are the leading bacterial zoonoses in Europe, with poultry meat being the primary source of human conta … t the experiment when co-inoculated compared to when inoculated alone. Additionally, changes in the microbiota were associated with each pathogen inoculated alone, but the simultaneous presence of Campylobacter and Salmonella induced specific modulations that could possibly explain this phenomenon. Significant differences were found in the serum metabolome o …

Gut microbiota signatures associated with the development of Salmonella Typhimurium super-shedders in broiler chickens.

Broiler chickens infected with Salmonella Typhimurium (S. Typhimurium) may transition from acute infection to a persistent carrier state, wi … nce, and sustained intestinal inflammation. Full-length 16S rRNA sequencing revealed distinct fecal microbiota configurations among shedding phenotypes, with super-shedders characterized by a significant enrichment of Blautia and depletion of Escherichia and Streptococcus. Correlation analyses indicated that Blautia abundance was positively associated with f …

Gut microbiota dysbiosis in Indian women with PCOS may be linked to metabolic and hormonal dysregulation.

AIM: Polycystic ovary syndrome (PCOS) is a common gynecological and cardiometabolic disorder in reproductive-aged women. Recently gut microbiota alterations have been identified as key contributors to PCOS pathophysiology, but it remains understudied in Indian population. METHODS: 16S rRNA gene amplicon sequencing using Illumina-MiSeq platform was conducted in 57 PCOS and 30 control women. Diversity indices were assessed and significantly altered taxa were identified by differential abundance tests (Wilcoxon-rank-sum test, ANCOMBC2 and LEfSe) in total and hyperandrogenism-based PCOS subgroups…

Gut metabolites: key factors in the cross-talk between the gut microbiota and tumor immunotherapy.

This review synthesizes recent research findings and proposes an integrated "microbiota-metabolite-immune-oncology" framework, highlighting how gut-derived metabolites regulate the dynamics of tumor immunity and informing the development of next-generation immunotherapies. Key metabolites-including short-chain fatty acids (SCFAs), bile acids (BAs), trimethylamine N-oxide (TMAO), indole-3-propionic acid (IPA), and urolithin A-exert bidirectional effects on antitumor immunity through multiple mechanisms. These include histone acetylation-driven epigenetic reprogramming, aryl hydrocarbon receptor…

Impact of a GABA-Producing Lactococcus lactis on Microbiota and Mycobiota During CNS Inflammatory Demyelination.

Gut microbes are key regulators of immune homeostasis. Their composition fluctuates over time and between individuals and is also influenced … nditions. The study also highlights the importance of controlling the mouse source in probiotic and microbiota research within experimental models of immune-mediated diseases.

[Tremella fuciformispolysaccharide retards the progression of colorectal cancer by regulating the gut microbiota-metabolome axis].

Objective: To investigate the anti-colorectal cancer effect of tremella fuciformis polysaccharides (TFP) via the gut microbiota-metabolite axis. Methods: Colorectal cancer was induced in C57BL/6J mice using azoxymethane/dextran sulfate sodium. TFP or distilled water was administered by gavage for 3 weeks. Disease activity index (DAI), colon length, tumor burden, histopathology, gut microbiota (metagenomics), fecal metabolites (untargeted metabolomics), and colonic protein expression (Western blot) were assessed. Pyridoxic acid's effect on HT-29 cells was tested in vitro. Results: TFP significa…

A Comparative Analysis of Tissue and Digestive Microbiota Composition in Patients With Oral Squamous Cell Carcinoma.

IntroductionAs the most prevalent malignant tumor in oral cancer, oral squamous cell carcinoma (OSCC) remains incompletely understood, especially its complex interactions with microbiota. This study investigated microbial signatures across tumor tissue and digestive tract niches in patients with OSCC.MethodsThis retrospective cohort study included 28 patients with OSCC who underwent surgical treatment at a tertiary cancer center between 2019 and 2022, along with 14 healthy controls. 16S rRNA gene sequencing was performed to characterize microbial profiles in tumor tissues, as well as oral and …

Gut microbiota-innate immune crosstalk in the initiation and progression of CRC: mechanisms and therapeutic potential.

Colorectal cancer (CRC) is a common malignancy of the digestive system, and its initiation and progression are associated with multiple factors, including genetic alterations, environmental exposures, changes in the gut microbiota, and disruption of immune homeostasis. In recent years, evidence from human observational studies, animal models, and in vitro experiments has shown that the gut microbiota can influence Toll-like receptor and NOD-like receptor signaling, NF-κB activation, the NLRP3 inflammasome, and immunometabolic pathways through multiple mechanisms, including microbial structural…

The Role of the Gut Microbiota in Female Reproductive and Gynecological Health: Insights into Endometrial Signaling Pathways.

Fertility is a dynamic, multifactorial process governed by hormonal, immune, metabolic, and environmental factors. Recent evidence highlights the gut microbiota as a key systemic regulator of reproductive health, with notable impacts on endometrial function, implantation, pregnancy maintenance, and the timing of birth. This review examines the gut-endometrial axis, focusing on how gut microbial communities influence reproductive biology through molecular signaling pathways. We discuss the modulatory roles of microbial-derived metabolites-including short-chain fatty acids, bile acids, and trypt…

Route of fecal microbiota transplantation delivery determined the dynamics and predictability of donor microbe colonization.

BACKGROUND: Fecal microbiota transplantation (FMT) and the colonization of delivered donor microbes has been reported to improve the negative effects (decrease in body weight, diarrhea, and gut barrier disruption) associated with weaning in pigs. However, delivery of FMT in pigs is still invasive and predicting the colonization or rejection of donor microbes remains challenging. Therefore, this study developed a non-invasive in-feed delivery of FMT and evaluated the effect of FMT mode of delivery on growth performance, gut physiology, microbiota dynamics, and predictability of colonization or …

Gut Microbiota and Metabolite Changes Induced by Tacrolimus: Implications for Skin Transplant Immunology in Mice.

BACKGROUND: Tacrolimus is the most widely used immunosuppressive therapy in solid organ transplantation. However, whether it can inhibit transplant graft rejection by altering the composition and metabolism of gut microbiota remains unclear. METHODS: In this study, a skin transplantation mouse model was established to explore the effects of tacrolimus on gut microbiota and its metabolites. Additionally, we investigated the protective effect and potential mechanism of feces from mice treated with tacrolimus on skin allografts. RESULTS: Tacrolimus did not significantly affect gut microbiota α-…