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Strategies and manoeuvres for severe rigid scoliosis.

Severe rigid scoliosis presents formidable surgical challenges, even for the most seasoned spine surgeons. Patients with idiopathic scoliosi … lease to alleviate the apex and posterior instrumentation, including osteotomies if necessary. Halo traction, temporary internal distraction, releases, osteotomies, and apical vertebral resection are frequently employed concurrently to attain optimal outcomes. Intraoperative strategies include apical translation, rod derotation, cantilever, direct vertebra …

Potential Markers for Thyroid Neoplasms in the Upstream Analysis of the Plasma Proteome.

The reliability of existing diagnostic methods for thyroid neoplasms remains questionable, which necessitates the search for alternative approaches. The use of nontarget proteomic analysis for diagnosing oncological diseases is gaining traction and represents an efficient method for multiplex analysis. This study analyzed 372 blood plasma samples collected from patients with histologically confirmed thyroid pathologies treated at the National Medical Research Center for Endocrinology in 2019-2021. The samples were obtained prior to surgical intervention. Sample preparation involved the reducti…

Обзор патентов модуляторов CXCR7 (2019 год - по настоящее время).

ВВЕДЕНИЕ: Атипичный хемокиновый рецептор 3 (ACKR3) (бывший CXCR7) регулирует различные биологические процессы с помощью своих лигандов и тесно связан с многочисленными заболеваниями, включая воспаление, рак, сердечно-сосудистые заболевания (CVD), боль и неврологические расстройства. Таким образом, ACKR3 стал потенциальной целью лечения болезней. ОБЛОЖКА: В настоящем обзоре резюмируются модули ACKR3, опубликованные в патентах с 2019 по 2024 год с использованием данных из Google Patents, Европейского патентного бюро и онлайновых баз данных Всемирной организации интеллектуальной собственности. Эт

Совпадение в аннотации оригинала
INTRODUCTION: Atypical chemokine receptor 3 (ACKR3) (formerly CXCR7) regulates various biological processes through its ligands and is close … structures, syntheses, activities, and developmental stages. EXPERT OPINION: ACKR3 agonists gained traction as a treatment for cardiovascular and pain conditions. WW-12, which was derived from the chemical modifications of conolidine, became a novel small-molecule pain modulator by activating ACKR3, which in turn boosted endogenous opioid peptides for the …

Orienteering as a Tool for Cognitive Research: An Implementation Guide.

The sport of orienteering combines physical activity with spatial navigation. Using only a map and a compass, the orienteer must locate a se … afflicted by early impairments in wayfinding and spatial cognition. Though orienteering has gained traction in recent literature, certain barriers exist for researchers who are unfamiliar with the sport and wish to implement an intervention. Specifically, a lack of research-based resources for creating orienteering maps and courses may prevent those wishi …

Imaging in the diagnosis and management of fibrosing interstitial lung diseases.

High-resolution computed tomography (HRCT) plays a pivotal role in the diagnosis and management of interstitial lung diseases (ILDs), particularly given the approval of antifibrotic agents for conditions like idiopathic pulmonary fibrosis and progressive pulmonary fibrosis. Diagnosing fibrotic pulmonary disorders through HRCT involves a detailed and methodical examination. The identification of specific lung tissue changes, including ground-glass opacities and reticulation, along with signs of fibrosis like honeycombing, traction bronchiectasis and lung volume loss, establishes clear HRCT patt…

[Expert consensus on the diagnosis and management of IgE mediated food allergy in children].

The prevalence of food allergy in children is increasing, which seriously affects the quality of life of children and their families. Among children and adolescents, IgE-mediated food allergy is the most common type. In recent years, allergen specific IgE (sIgE) and skin prick testing (SPT) have been widely used in clinical practice, with component resolved diagnosis (CRD) also gaining traction for precise diagnosis of IgE-mediated food allergy. However, a challenge persists in clinical practice due to the tendency to over-interpret food allergen test results without considering the patient's …

Acute rejection post lung transplant.

PURPOSE OF REVIEW: To review what is currently known about the pathogenesis, diagnosis, treatment, and prevention of acute rejection (AR) in lung transplantation. RECENT FINDINGS: Epigenomic and transcriptomic methods are gaining traction as tools for earlier detection of AR, which still remains primarily a histopathologic diagnosis. SUMMARY: Acute rejection is a common cause of early posttransplant lung graft dysfunction and increases the risk of chronic rejection. Detection and diagnosis of AR is primarily based on histopathology, but noninvasive molecular methods are undergoing investigat…

Trifluridine and Tipiracil Hydrochloride Combination-Induced Interstitial Pneumonia: A Case Report.

We report a case of a 62-year-old male who was diagnosed with advanced rectal cancer. The attending gastro-enterologist initiated chemothera … solution computed tomography showed bilateral diffuse ground glass opacities in all lung lobes with traction bronchiectasis. At this time, the gastro-enterologist consulted our department. The patient was put on non-invasive positive pressure ventilation due to worsening respiratory symptoms. The patient was suspected to develop TAS-102-induced interstitia …

Oral intake of bucillamine, carvedilol, metformin, or phenformin does not protect against UVR-induced squamous cell carcinomas in hairless mice.

Squamous cell carcinoma represents the second most common type of keratinocyte carcinoma with ultraviolet radiation (UVR) making up the primary risk factor. Oral photoprotection aims to reduce incidence rates through oral intake of photoprotective compounds. Recently, drug repurposing has gained traction as an interesting source of chemoprevention. Because of their reported photoprotective properties, we investigated the potential of bucillamine, carvedilol, metformin, and phenformin as photoprotective compounds following oral intake in UVR-exposed hairless mice. Tumour development was observe…

Recent Progress on Layered Sn and Pb-Based Mono Chalcogenides: Synthesis, Structure, Optical, and Thermoelectric Properties and Related Applications.

The research on two-dimensional materials has gained significant traction due to their potential for thermoelectric, optical, and other properties. The development of two-dimensional (2D) nanostructured-based TE generators and photodetectors has shown promising results. Over the years, researchers have played a crucial role in advancing this field, enhancing the properties of 2D materials through techniques such as doping, alloying, and various growth methods. Among these materials, black phosphorus, transition metal dichalcogenides, graphene, and IVA-VIA compounds stand out for their remarkab…

[Microsurgical vascular suture].

OBJECTIVE: Anastomosis of two vessels by end-to-end or end-to-side suturing to create an uninterrupted blood flow between the two vessels. … lood flow and examination of the anastomosis. POSTOPERATIVE MANAGEMENT: Postoperative avoidance of traction, tension, pressure and shear forces on the anastomosis; regular blood flow checks of the revascularized tissue or flap; sufficient anticoagulation. RESULTS: An atraumatic and gentle suturing technique is a basic requirement for a successful anastom …

Combined Median, Ulnar, and Radial Nerve Injury after a Spiral Humeral Shaft Fracture.

We report the case of a 43-year-old woman who presented with combined radial, median, and ulnar nerve palsies and a spiral humeral shaft fracture after falling down stairs. Postinjury, the patient did not recover full median, ulnar, and radial nerve function despite aggressive hand therapy. Electrodiagnostic studies and imaging findings were concerning for traction neuropraxia or transection, radial nerve neuroma, and scar encasement of the radial, median, and ulnar nerves. The patient underwent radial, median, ulnar, and musculocutaneous nerve neuroplasty, nerve wrap application, nerve stimul…

Palatal root endodontic microsurgery in maxillary molars using the palatal approach: a case study.

BACKGROUND: In clinical practice, the buccal approach is typically the primary choice for endodontic microsurgery. Owing to the thickness of the buccal bone plate, the distance between the buccal bone plate and palatal lesion location, and soft tissue traction, the palatal approach may be more suitable for microsurgery for apical periodontitis of the palatal roots of the maxillary molars. However, the length of the palatal root, location of the greater palatine artery (GPA) and foramen (GPF), and surgical field of observation make palatal surgery challenging. CASE PRESENTATION: With the aid o…

Femoral Nerve Injury After Prone-Position Lumbar Discectomy: A Case Report Highlighting the Role of Ultrasound in Recovery Monitoring.

Postoperative peripheral nerve injuries are well-recognized complications of surgical positioning. In prone spinal surgeries, lateral femora … er the rectus femoris near the inguinal ligament. Ultrasound showed no hematoma but suggested nerve traction or compression. Targeted rehabilitation significantly improved pain, muscle strength, and function within two weeks. Ultrasound imaging confirmed enhanced femoral nerve mobility, which correlated with symptom resolution. This case highlights the imp …

Imaging of the Pediatric Knee.

During normal development, imaging findings in the immature knee joint may mimic pathology or indicate transient sites of weakness, prone to … variants of the femoral condyles, distal femoral metaphyseal cortical irregularity from periosteal traction, and the metaphyseal subperiosteal stripe, which should be distinguished from pathologic mimickers such as endochondral ossification dysfunction, osteochondritis dissecans (OCD), fibroosseous lesion, periosteal and subcortical pathologies. The patel …

Invisalign Treatment of a Three-Year-Old Child with Bilateral Posterior Scissor Bite and Multisite Upper Airway Obstruction: A Case Report.

BACKGROUND: Scissor bites have been reported in relatively few epidemiological studies because of their extremely low prevalence rate (below … igners functioned as occlusion pads to unlock the scissor bite relationship and combined with cross-traction to narrow the maxillary arch and enlarge the mandibular arch simultaneously. RESULTS: The duration of orthodontic therapy was 28 weeks. A multidisciplinary consultation (orthodontics department, ENT department, and spinal surgery) was conducted and …

Endoscopic, "Scarless" Composite Flap Face and Neck Lift.

Deep-plane or composite flap facelift techniques allow deep structural rejuvenation of the face by release of retaining ligaments in the sub … ic dissection and ligament release. Verticalization of fixation vectors and modified concho-mastoid traction sutures are used to minimize preauricular skin redundancy. The surgical procedure is described in detail. Clinical experience in 41 consecutive cases and comparison to other techniques with respect to relevant anatomy are also presented. This endosc …

Epidemiology of Plasmodium malariae and Plasmodium ovale spp. in Kinshasa Province, Democratic Republic of Congo.

Reports suggest non-falciparum species are an underappreciated cause of malaria in sub-Saharan Africa but their epidemiology is ill-defined, … DRC, though non-falciparum species also pose an infection risk. As P. falciparum interventions gain traction in high-burden settings, continued surveillance and improved understanding of non-falciparum infections are warranted.

How to fail with paired VNS therapy.

Vagus nerve stimulation (VNS) has gained enormous traction as a promising bioelectronic therapy. In particular, the delivery of VNS paired with training to promote neural changes has demonstrated clinical success for stroke recovery and found far-reaching application in other domains, from autism to psychiatric disorders to normal learning. The success of paired VNS has been extensively documented. Here, we consider a more unusual question: why does VNS have such broad utility, and perhaps more importantly, when does VNS not work? We present a discussion of the concepts that underlie VNS thera…

Pulmonary fibrosis in sarcoidosis.

Sarcoidosis may progress to pulmonary fibrosis in 5% of patients with significantly increased mortality. Histopathology shows fibrosis in a … progression of disease. CT imaging shows fibrosis along bronchovascular bundles with reticulations, traction bronchiectasis and honeycombing predominantly in the upper and central distribution. Complications include sarcoidosis-associated pulmonary hypertension (SAPH) and chronic pulmonary aspergillosis. Treatment involves glucocorticoids and steroid-spari …