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Which needs do children, adolescents, and young adults with ME/CFS and their parents express and feel? - Qualitative study in Germany.

BACKGROUND: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex, multi-system disease that significantly deteriorates the quality of life for those affected. There is no established effective treatment, and a lack of research on what is needed by severely affected young people with ME/CFS and their caring parents to cope with the disease. The aim of this study was to investigate the needs of young people affected and their parents in order to subsequently build a tailored treatment model for this age group upon this basis. METHODS: Needs were explored using topic-guided f…

Cross-modality network phenotyping: a multivariate MRI biomarker signature predicts spatial pathology and clinical severity in EAE.

INTRODUCTION: Evaluating novel therapies for multiple sclerosis requires robust, non-invasive biomarkers. In the experimental autoimmune encephalomyelitis (EAE) model, standard disease evaluations rely heavily on subjective clinical motor scoring and terminal histology, which frequently suffer from a mathematical dilution effect. To address this, we developed an automated, spatially targeted multiparametric magnetic resonance imaging (MRI) pipeline to extract highly specific in vivo biophysical markers and benchmarked its performance against a potent positive control immunomodulator, fingolimo…

Postural orthostatic tachycardia syndrome in adolescents with ME/CFS - a case control study.

INTRODUCTION: Postural orthostatic tachycardia syndrome (PoTS) can be associated with myalgic encephalomyelitis/ chronic fatigue syndrome (ME/CFS). Pediatric PoTS requires a "sustained" rise in orthostatic heart rate ≥40 bpm above supine heart rate (relative limit), often >120 bpm (absolute limit). However, the diagnostic criteria for PoTS in adolescents remain underexplored, particularly regarding the definition of "sustained" tachycardia, which poses challenges in clinical and research settings. This study examined orthostatic intolerance criteria, including PoTS, in adolescents with ME/CFS …

Evaluation of Selected Brain Damage Biomarkers in the Determination of Brain Damage in Dogs With Neurological Distemper.

BACKGROUND: Canine distemper is a disease with high morbidity and mortality in domestic and wild carnivores caused by Canine distemper virus (CDV). Respiratory, gastrointestinal, dermatological, ophthalmic, or neurological disorders occur in dogs with canine distemper. CDV replicates in the central nervous system and causes non-purulent encephalomyelitis. This causes damage to the brain and spinal cord. OBJECTIVES: The aim of the study was to reveal brain damage caused by the canine distemper virus in dogs using selected brain damage biomarkers and to determine which of these biomarkers are d…

Serum and CSF cytokine profile impact clinical phenotype in pediatric MOGAD.

BACKGROUND: Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) has a broad spectrum of clinical phenotypes, including acute disseminated encephalomyelitis (ADEM), optic neuritis (ON), transverse myelitis (TM), and cerebral cortical encephalitis (CCE). Although these conditions exhibit diverse outcomes and require different treatment options for relapse prevention, no biomarkers have been identified to distinguish the clinical phenotypes. This study aimed to investigate the properties of cytokines and chemokines in the serum and cerebrospinal fluid (CSF) of patients with MO…

Live-Cell-Based Assay Outperforms Fixed Assay in MOGAD Diagnosis: A Retrospective Validation Against the 2023 International Criteria.

Background and Objective: Myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease (MOGAD) is a significant component of demyel … patients studied, 16 presented with optic neuritis (ON), 5 with myelitis, 8 with acute disseminated encephalomyelitis (ADEM), and 7 with cortical encephalitis. Sixteen patients could not be classified by clinical phenotype. The highest MOG-Ab positivity rate was among patients with cortical encephalitis [85.7% (Live-CBA)/71.4% (Fixed-CBA)]. Both assays identified 2 …

Modulating the Gut Microbiome as a Therapeutic Approach in Multiple Sclerosis: Implications for Gut-Brain Interactions and Immune Pathways: A Narrative Review.

PURPOSE: Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system characterized by progressive disability. Emer … anguage articles were included, comprising human MS cohorts and preclinical experimental autoimmune encephalomyelitis models. Of these, approximately 95 human and preclinical studies fulfilled the inclusion criteria. Evidence synthesis was narrative, without meta-analysis. FINDING: There has been a consistent depletion of beneficial genera such as Faecalibacterium …

Central nervous system-penetrant anti-C1q therapy reduces neuroinflammation and preserves neurological function in a model of progressive multiple sclerosis.

Multiple sclerosis (MS) is a chronic, immune-mediated disease of the central nervous system (CNS) characterized by both neuroinflammation an … ment-mediated injury within the CNS. To investigate this mechanistic link, we used Theiler's murine encephalomyelitis virus-induced demyelinating disease (TMEV-IDD), a well-established murine model of PMS that features chronic demyelination, neurodegeneration, neuroinflammation, and robust IIgS. We tested the therapeutic potential of CNS-targeted C1q inhibition usi …

Rare adverse events after COVID-19 vaccination among Swedish older adults-evidence from a nationwide register-based study.

INTRODUCTION: COVID-19 vaccinations have saved millions of lives, particularly among older adults. Rare potential adverse events have been reported in case reports, but risks among older adults remain unclear. This study assessed risks of selected potential adverse events in this population. METHODS: We included more than 2 million Swedish adults ≥65y in a nationwide register-based cohort. Post-vaccination risks were assessed for herpes zoster (HZ), encephalitis, myelitis and encephalomyelitis, multiple sclerosis (MS), myasthenia gravis, cranial nerve palsy, sudden sensorineural hearing loss …

Applicability and adaptation of cognitive behavior therapy for long COVID neuropsychiatric symptoms: a review with insights from ME/CFS.

BACKGROUND: Long COVID presents a spectrum of persistent symptoms that substantially overlap with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), including debilitating fatigue, post-exertional malaise, cognitive dysfunction, and neuropsychiatric manifestations. Despite growing evidence of shared pathophysiological mechanisms, neither condition has established diagnostic biomarkers or disease-modifying treatments. Cognitive behavior therapy (CBT), when appropriately implemented, may serve as one component of comprehensive care. This review examines the neuropsychiatric manifestati…

Anti-central fatigue effects of myelophil in 5-HTergic hyperactivity mice model.

BACKGROUND: Myelophil is a standardized ethanol extract of Astragali Radix and Salviae Miltiorrhizae Radix, which has been developed based on clinical experience in traditional Korean medicine practices for patients with unexplained chronic fatigue, including myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Our previous studies demonstrated Myelophil's clinical efficacy in ME/CFS, as well as its brain-related activities in animal models. However, the underlying pharmacological mechanisms remain unclear. Recently, we identified serotonergic hyperactivity as a key pathophysiological …

Genomic and transcriptomic analyses reveal the genetic basis of leg diseases in laying hens.

In recent years, while monitoring commercial laying hens during the brooding period, we noticed that some chicks exhibited an abnormal lameness phenomenon. Systematic tests were carried out for pathogens including, but not limited to, common diseases such as viral arthritis, mycoplasma synoviae, Marek's disease and encephalomyelitis. However, the absence of these pathogens in these chicks rules out these common diseases as a direct cause of limping and points to genetic factors. Leg disorders in laying hens pose significant welfare challenges and result in considerable economic losses within t…

Complex Genetics and Regulatory Drivers of Hypermobile Ehlers-Danlos Syndrome: Insights from Genome-Wide Association Study Meta-analysis.

BACKGROUND: Hypermobile Ehlers-Danlos syndrome (hEDS) is the most common subtype of EDS, a group of heritable connective tissue disorders. C … regression revealed significant genetic correlations between hEDS and joint hypermobility, myalgic encephalomyelitis/chronic fatigue syndrome, fibromyalgia, depression, anxiety, autism spectrum disorder, migraine, and gastrointestinal diseases. CONCLUSIONS: These results establish the first evidence of common variant contributions to hEDS, supporting a complex, m …

Risk of neurologic or immune-mediated adverse events after COVID-19 diagnosis in the United States.

INTRODUCTION: Neurologic or immune-mediated conditions have been evaluated as potential adverse events (AEs) in coronavirus disease 2019 (CO … vice data (ages ≥ 65 years). AEs included Guillain-Barré syndrome (GBS), Bell's palsy, encephalitis/encephalomyelitis, narcolepsy, immune thrombocytopenia (ITP), and transverse myelitis. The cohort (study period, 1 April 2020-10 December 2020) included adults with COVID-19 diagnoses and matched comparators. Inverse probability of treatment-weighted hazard ratios (H …

Novel Meningoencephalomyelitis Associated With Vimentin IgG Autoantibodies.

IMPORTANCE: Autoantibodies targeting astrocytes, such as those against glial fibrillary acidic protein (GFAP) or aquaporin protein 4, are crucial diagnostic markers for autoimmune astrocytopathy among central nervous system (CNS) autoimmune disorders. However, diagnosis remains challenging for patients lacking specific autoantibodies. OBJECTIVE: To characterize a syndrome of unknown meningoencephalomyelitis associated with an astrocytic autoantibody. DESIGN, SETTING, AND PARTICIPANTS: This retrospective case series study included samples collected from April 2021 to May 2024 at a tertiary re…

Microglia-specific Ido2 deficiency attenuates ictogenesis in the TMEV model of viral encephalitis.

Viral encephalitis is a serious condition that causes acute neuroinflammation, neurodegeneration, cognitive deficits and behavioral changes, while putting patients at risk of developing seizures (ictogenesis) and post-encephalitis epilepsy. Intracerebral injection of C57BL/6 mice with Theiler's murine encephalomyelitis virus (TMEV) is a model of viral encephalitis that causes behavioral seizures along with substantial neurodegeneration and neuroinflammation. This model is considered a benchmark preclinical paradigm for the investigation of hippocampal-dependent viral ictogenesis and temporal l…

PBMC-Humanized Mouse Model for Multical Sclerosis: Изучение неуменные изменения и участие CNS.

Гуманизированная иммунная система (HIS) мыши являются мощными инструментами для изучения функций и дисфункций иммунной системы человека и разработки иммунотерапевтической системы человека. Наличие изощренных штаммов супериммунодефицитной мыши позволило гуманизировать иммунную систему, используя трансплантацию человеческих периферийных моноядерных клеток крови (PBMC) или гематополиетических стволовых клеток. Его мыши широко используются в иммунной онкологии, в то время как проводится меньше исследований в области автономного иммунитета, особенно в области множественного склероза (MS). Используя

Совпадение в аннотации оригинала
Humanized immune system (HIS) mice are powerful tools for studying human immune system function and dysfunction and developing human-specifi … d with hCD4 and hCD8 T and B lymphocytes and developed both spontaneous and experimental autoimmune encephalomyelitis (EAE)-enhanced T-cell lesions in the central nervous system. B-cell engraftment was highest in mice receiving cells from MS patients with serological evidence for Epstein-Barr virus (EBV) reactivation. This humanized MS model shows advantages over E …

COVID-19 vaccines and adverse events of special interest: A multinational Global Vaccine Data Network (GVDN) cohort study of 99 million vaccinated individuals.

BACKGROUND: The Global COVID Vaccine Safety (GCoVS) Project, established in 2021 under the multinational Global Vaccine Data Network™ (GVDN® … ombosis (3.23, 95 % CI: 2.51, 4.09) following the first dose of ChAdOx1 vaccine. Acute disseminated encephalomyelitis showed an OE ratio of 3.78 (95 % CI: 1.52, 7.78) following the first dose of mRNA-1273 vaccine. The OE ratios for myocarditis and pericarditis following BNT162b2, mRNA-1273, and ChAdOx1 were significantly increased with LBCIs > 1.5. CONCLUSION: Thi …

The molecular fingerprint of neuroinflammation in COVID-19: A comprehensive discussion on molecular mechanisms of neuroinflammation due to SARS-COV2 antigens.

BACKGROUND AND OBJECTIVE: Severe acute respiratory syndrome coronavirus 2 attacks the neural system directly and indirectly via various syst … ering from Coronavirus disease 2019, approximately half of the patients reported developing Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. Long Coronavirus disease 2019 imaging reports illustrated the hypometabolism in various parts of the brain, such as olfactory bulbs, limbic/paralimbic domains, the brainstem, and the cerebellum. Ninety imaging and neuropath …

Changes in the Incidence of Optic Neuritis before and after the Coronavirus Disease 2019 Outbreak: A Nationwide Study 2017-2022.

PURPOSE: To determine the risk of optic neuritis (ON) during nonpharmaceutical interventions (NPI), vaccination, and infection phases of the … tions of diagnosis with multiple sclerosis (MS), neuromyelitis optica (NMO), and acute disseminated encephalomyelitis (ADEM) among patients in whom ON developed increased significantly in 2021 in comparison with levels before COVID-19 (10.93% vs. 6.43%; P = 0.0002). CONCLUSIONS: The risks of ON development during the NPI, vaccination, and infection phases of COVID …