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[Foot tumor and diffuse pain: a case of oncogenic osteomalacia].

Oncogenic osteomalacia is a rare clinicopathologic entity, linked to a mesenchymal tumor which overexpresses a hypophosphatemic factor, supp … biochemical defects. Pathologic examination revealed spindle cells associated with osteoclast-like giant cells, embedded within a myxoid matrix which showed floculent calcification. These observations were compatible with the features of PMTMCT (Phosphaturic mesenchymal tumor mixed connective tissue variant).

Rapidly progressed acquired immunodeficiency syndrome dementia complex as an initial manifestation.

We report a patient with acquired immunodeficiency syndrome dementia complex (ADC) that presented human immunodeficiency virus infection as … phylococcus aureus. Autopsy findings in the brain included increased glial cells and multinucleated giant cells in cerebral white matter and subcortical gray matter. These features were compatible with ADC.

Crystal deposition disease of the shoulder (including calcific tendonitis and milwaukee shoulder syndrome).

Calcific tendinitis of the shoulder is a dynamic process. Osteopontin is present in cells surrounding tendon calcifications. Resorption is probably mediated by cathepsin K-containing multinucleated giant cells. Rotator cuff tears are associated with an inflammatory response based on the presence of interleukin-1 and a proliferative synovitis. Metalloproteinases are found in the synovial fluids of patients with rotator cuff tears. Some patients with large rotator cuff tears progress to a severe destructive arthropathy characterized by large joint effusions, which are noninflammatory but contain…

Fine needle aspiration diagnosis of orbital plasmacytoma with amyloidosis. A case report.

Fine needle aspiration (FNA) cytology of the orbit was used to diagnose an unusual case of multiple myeloma with secondary amyloid deposition in a 27-year-old man who presented with bilateral keratoconjunctivitis and left-sided ptosis. The FNA smears revealed immature plasma cells, extracellular eosinophilic material (amyloid) and numerous multinucleate giant cells. Subsequent histologic studies of excised tissue confirmed the cytologic diagnosis of plasmacytoma with secondary amyloidosis. Amyloid was further confirmed by electron microscopy. The patient was subsequently diagnosed as having mu…

Ewing's sarcoma: an autopsy study.

An autopsy study of 26 cases of Ewing's sarcoma treated with radiation to the primary site plus adjuvant chemotherapy has shown metastatic tumor in 23 cases. Metastases were found typically in lungs, pleura, bones and regional lymph nodes. In three cases no tumor could be found at autopsy, and death was due to complications of treatment. Tumor was found in the irradiated primary site in 13 of the 20 cases in which the primary site was examined at autopsy. Histologically, the tumor at autopsy frequently had increased pleomorphism and increased numbers of bizarre giant cells; however, these chan…

[Multicentric reticulohistiocytosis (lipoid dermato-arthritis). Apropos of a case with fatal outcome].

The authors report the case of a 37-year-old man affected by a seronegative polyarthritis associated at first with erythroderma and then with cutaneous and subcutaneous papulo-nodular structures and a xanthomatous eryption. Histological examination of the cutaneous nodules and of the synovial membrane confirmed the diagnosis of multicentred reticulohistiocytosis by showing the presence of lipid infiltrates in the histiocyte cells and of multinucleate giant cells. A study of the ultrastructure of the histiocytes revealed the presence of numerous intracytoplasmic vacuoles. In spite of antimalari…

Congential dyserythropoietic anemia--type IV.

Congenital dyserythropoietic anemia is characterized by ineffective erythropoiesis and increased numbers of multinucleated red cell precursors in the marrow. This syndrome has been subclassified on the basis of morphologic differences in the red cell precursors. Type I is characterized by megaloblastoid erythropoiesis and macrocytosis; Type II, by normoblastic multinuclearity and normocytosis; and Type III, by frequent giant multinucleated erythroblasts and macrocytes. Type II is further distinguished from the other types by serologic and ultrastructural abnormalities. The patient presented in

The Mystery Plaque: Unraveling a Singular Perioral Granulomatous Enigma.

A 34-year-old lactating woman presented with erythematous indurated plaques around the perioral region, extending to the nose and forehead, mimicking granulomatous dermatoses. Dermoscopy showed follicular plugging and dermal inflammation. Histopathology revealed epithelioid cell granulomas with giant cells and nerve infiltration, confirming borderline tuberculoid leprosy. The patient was treated with multidrug therapy and closely monitored for reactions. This case underscores the diagnostic challenge of Hansen's disease with atypical centrofacial presentation and emphasizes the importance of h…

Calvarial Tuberculosis in Patient With Cervical Tuberculous Lymphadenitis: A Case Report.

Calvarial tuberculosis (TB) is an uncommon form of TB reported in patients with mycobacterial infections. We present a case of calvarial TB in a patient with cervical TB lymphadenitis. The patient had a history of headache and swelling of the right parietal region of the skull. CT head showed peripherally enhancing small epidural collection at the right parietal region with overlying destroyed right parietal bone. Histopathology showed giant cells, lymphocytes, and caseous necrosis. We acknowledge that cervical TB lymphadenitis poses the development of calvarial TB in our patient.

Acne agminata: dermoscopic features and a short review.

Acne agminata is a rare idiopathic inflammatory dermatosis. Treatment is variable with no clear consensus. We herein report a case of a 31-year-old man with sudden onset papulonodular eruptions on his face over two months. Histopathological examination revealed superficial granuloma composed of epithelioid histiocytes and scattered multinucleated giant cells, confirming acne agminata. Dermoscopy showed focal orangish structureless areas with follicular openings with white keratotic plugs. He achieved complete clinical resolution with oral prednisolone in 6 weeks. We also reviewed the literatur…

Multiple tuberous xanthomas diagnosed on fine-needle aspiration cytology - Report of a rare case.

Xanthomas are papulonodular skin lesions present in lipoprotein metabolism disorders, which result in cholesterol deposits in subcutaneous tissue, tendons, ligaments, periosteum, etc. A 28-year-old male presented with multiple soft-tissue swellings, prominently over joints. Fine-needle aspiration (FNA) from multiple sites had similar appearance with foamy histocytes and giant cells. We describe an unusual case of tendinous and tuberous xanthoma diagnosed by cytology. Acquaintance with FNA cytology findings in xanthomas can help to avoid the need of surgical biopsy, as xanthomas can regress on …

[Cerebral manifestations of tuberculosis].

Almost two billion people are infected with M. Tuberculosis. The most common manifestation of TB is pulmonary; however, severe manifestations of TB can affect the central nervous system. This case report describes a young refugee with onset of sixth nerve palsy and an MRI consistent with a pontine tumor. Stereotactic biopsy showed giant cells and acid-fast rods, Quantiferon test was positive, thus fulfilling the criteria for tuberculoma. The patient immediately began antituberculous treatment and slowly recovered. The purpose of this article was to elucidate the necessity of screening migrants…

Surgical Management of Giant L2 Adrenal Neuroblastoma in Adult Male.

Neuroblastoma is an embryonal malignancy that arises from neural crest cells. Adult adrenal neuroblastoma is a rare disease, and less than 100 cases were reported in the literature. Adult neuroblastoma commonly presents with abdominal (retroperitoneal) lump and pain. A 35-year-old male patient presented with a giant (20 cm × 17 cm × 12 cm) nonfunctional left adrenal mass. He underwent en-bloc surgical excision of the left adrenal gland along with the left kidney. Histopathological examination revealed adrenal neuroblastoma (stage 2B, L2). We present here the surgical management of the rare adu

Fibrosing Mediastinitis Requiring Multimodality Treatment to Maintain Pulmonary Vein Patency.

Fibrosing mediastinitis is a rare condition with limited epidemiologic data. We detail a case of a 43-year-old female with no past medical history, who presented with chest pain and dyspnea on exertion. Chest computed tomography revealed a large mediastinal mass that was invading into the anterior chest as well as encasing the pulmonary hilum. Surgical pathology returned as dense hyaline fibrosis tissue with focal histiocytic aggregates and giant cells consistent with fibrosing mediastinitis. Treatment with rituximab and steroids showed a reduction in the size of her mass.

[Disseminated osteolytic lesions in a 28-year-old refugee].

A 28-year-old Syrian refugee presented with right-sided knee pain and progressive deterioration of the general condition over the past months. Laboratory diagnostics revealed severe hypercalcemia due to primary hyperparathyroidism, and computed tomography (CT) scanning demonstrated disseminated osteolytic lesions throughout the skeleton. Histologically, these lesions were characterized by multinuclear giant cells (defining these lesions as so-called brown tumors). Finally, surgical removal of a jugular mass allowed the histopathologic diagnosis of a sporadic parathyroid carcinoma. In the patie…

Etanercept-induced sarcoidosis in rheumatoid arthritis: FDG PET findings.

We report the F-FDG PET/CT findings of an etanercept-induced sarcoidosis in a patient with rheumatoid arthritis. A 68-year-old woman with rheumatoid arthritis who had been treated with etanercept and methotrexate showed multiple lung nodules and hilar lymph node swellings on CT. She underwent FDG PET/CT for cancer screening. Intense FDG uptakes were found in the multiple lung nodules, bilateral hilar lymph nodes, a periurethral masslike lesion, and cranial meningeal nodules. A histopathological examination revealed epithelioid granuloma with multinucleated giant cells, which was compatible wit…

Penile and scrotal lymphedema as an unusual presentation of Crohn's disease: case report and review of the literature.

Crohn's disease is an inflammatory intestinal disease that primarily causes abdominal pain and diarrhea. We report a male patient who presented with penile and scrotal lymphedema and inguinal fistulas as the first manifestations of Crohn's disease. Extraintestinal or metastatic Crohn's disease initially presenting as genital lymphedema with fistula formation is rare. Skin lesions in extraintestinal Crohn's disease typically show non-caseating, sarcoidal granulomas with numerous foreign body- and Langhans-type multinucleated giant cells, which are separated from intestinal involvement by normal…

Post-steroid panniculitis in an adult.

Post-steroid panniculitis is an extremely rare phenomenon caused by inappropriate interruption of long-term systemic corticosteroid therapy. It usually occurs in children and is characterized by development of multiple subcutaneous nodules on the cheeks, arms, and trunk. Histologically it is a lobular type of panniculitis with characteristic needle-shaped clefts within adipocytes and numerous foreign-body giant cells. We present a case of post-steroid panniculitis occurring in a 50-year-old female after long-term administration of oral corticosteroids for Sjögren's syndrome accompanied by leuk…

Случай Варичеллы в сочетании с болезнью ручных ступней в здоровом ребенке.

Мы сообщаем здесь о 11-летнем ребенке с извержением пастуловицы на ее теле, включая ее ладони, подошвы и пероральную слизь, и это сопровождалось лихорадкой. Серологический тест был положительным для антител IgM varicella зостера и коксакивируса A16. Гистопатологический анализ с пальмы выявил внутрипайдермальные пуштулы, которые не показали ни интеграционного тела, ни многонуклеарных гигантских клеток. Мы сделали окончательный диагноз, согласно серологическим тестам и гистопатологическим заключениям, как варицелла в сочетании с болезнью ручной ступни, вызванной коксакивирусом А16 у ранее здоров

Совпадение в аннотации оригинала
We report here on an 11-year-old child with a pustulovesicular eruption on her whole body, including her palms, soles and oral mucosa, and t … m the palm revealed intraepidermal pustules that showed neither inclusion bodies nor multinucleated giant cells. We made the final diagnosis, according to the serologic tests and histopathologic findings, as varicella combined with hand-foot-mouth disease caused by coxsackievirus A16 in a previously healthy child.

Granulomatous pericarditis associated with systemic Mucormycosis in a finless porpoise (Neophocaena phocaenoides).

An adult male finless porpoise (Neophocaena phocaenoides) kept in an aquarium in Japan displayed loss of appetite and reduced body weight over several months. Necropsy examination revealed the presence of lesions in the pericardium, lung, and mediastinal and pancreatico-duodenal lymph nodes. Microscopically, these comprised regions of necrotizing granulomatous inflammation with multinucleated giant cells and surrounding fibrosis. Fungal hyphae were identified within macrophages and the extracellular tissue. Immunohistochemical labelling determined that these organisms were of the order Mucoral…