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3D Virtual reality assessment of right ventricle-pulmonary artery conduit dilation and coronary compression risk: a retrospective bi-center feasibility study.

BACKGROUND: Right ventricle-to-pulmonary artery (RV-PA) conduits are crucial to establishing or restoring RV-PA continuity in children with … ion for RV-PA conduit dilation and stenting was conducted at the Sheba and Wolfson Medical Centers, Israel, between January 2018 and September 2022. For 19 eligible patients, cardiac CT datasets were processed to generate high-fidelity 3D VR models. Two independent cardiologists assessed the models, quantified the distances between the conduit and the ma …

Public Dental Expenditure and Dental Visits in Europe and Japan.

BACKGROUND: Dental care is important for oral health, but access to dental services is subject to social inequalities and varies between countries. Despite this, few cross-national studies have examined how public dental expenditure relates to dental service use among older adults. This study aimed to investigate the associations between public dental expenditure and dental visits among older adults using an international comparative design. METHODS: Data were obtained from the Survey of Health, Ageing and Retirement in Europe (SHARE, Wave 8, 2019), covering 25 European countries and Israel, …

Evolution and Emerging Trends in Liposomal Bupivacaine Research: A Comprehensive Bibliometric Study (1993-2024).

BACKGROUND: Liposomal bupivacaine has become a significant advancement in postsurgical pain management. OBJECTIVES: Our study aimed to desc … h 457 publications and 8,880 citations, followed by the People's Republic of China and the State of Israel. The Mayo Clinic, Harvard University, and the University of Texas System were the top institutions. The Journal of Arthroplasty published the most articles-33-and garnered the highest citations-957. Key authors such as Daniel S. Kohane and Michael A …

Cannabis use and anaesthetic agent dosing in patients undergoing surgery or interventional procedures: a single-centre retrospective cohort study.

BACKGROUND: There is limited evidence that habitual cannabis consumption increases anaesthetic requirements. We hypothesised that cannabis use affects anaesthetic dosing among patients undergoing surgery or interventional procedures. METHODS: A total of 341 199 adult patients undergoing propofol sedation or volatile-based general anaesthesia at Beth Israel Deaconess Medical Center, Boston, USA, between 2008 and 2024 were included. The primary exposure was cannabis use, differentiated into medical or non-medical use (recreational use or cannabis use disorder). Primary outcomes were propofol do…

Systemic and Intracranial Efficacy and Safety of Trastuzumab Deruxtecan in Patients With HER2-Mutant NSCLC Across Treatment Lines: Evidence From the TRACER/HERTras Real-World Cohort.

INTRODUCTION: HER2 mutations define a distinct, therapeutically actionable subset of NSCLC. Trastuzumab deruxtecan (T-DXd) has demonstrated strong activity in clinical trials, but real-world data are limited. METHODS: We conducted a retrospective, multinational cohort study of patients with advanced HER2-mutant NSCLC treated with T-DXd outside clinical trials between August 2021 and January 2025 across 68 centers in Europe and Israel. The primary end point was objective response rate (ORR). Secondary end points included progression-free survival (PFS), overall survival (OS), intracranial effi…

Sex Differences in Documented Multimorbidity and Selected Healthcare-Use Indicators Among Deceased Patients Meeting an Operational Definition of Advanced COPD: A Retrospective Population-Based Cohort Study.

BACKGROUND: Advanced chronic obstructive pulmonary disease (COPD) is associated with multimorbidity and substantial healthcare use. However, sex differences in documented multimorbidity and healthcare use near the end of life remain insufficiently understood. METHODS: This retrospective population-based cohort study used routinely collected administrative and clinical data from Clalit Health Services, Israel. The study included deceased patients with advanced COPD during 2016-2020 and 2022-2023. The year 2021 was excluded a priori as the period designated in the study protocol to minimize dis…

Early biomarker prognostic signals for 30-day mortality in acute poisoning: exploratory analysis of a complete-case subgroup from a derived MIMIC-IV dataset.

Reliable early prognostic tools for acute poisoning remain limited. This study examined whether four first-measured routine biomarkers - glucose, lactate, bicarbonate, and white blood cell count (WBC) - carry prognostic signal for 30-day mortality in emergency department (ED) patients with acute poisoning, using a pre-processed, de-identified electronic health records dataset derived from MIMIC-IV (Medical Information Mart for Intensive Care, version 3.1; a publicly available critical care database from Beth Israel Deaconess Medical Center, Boston, USA, hosted on PhysioNet; n=12,039 ED visits;…

Headache and Dizziness Provoked by Mental Imagery in Patients With Persistent Postconcussive Symptoms: A Case Series.

OBJECTIVE: To document and characterize headache and dizziness provocation during mental imagery of real-life symptom-provoking movements in patients with persistent postconcussive symptoms (PPCS). SETTING: Outpatient rehabilitation department at Reuth Rehabilitation Hospital, Tel Aviv, Israel. PARTICIPANTS: Thirteen adults (7 females; mean age 34.3 ± 12.6 years) undergoing multidisciplinary rehabilitation for PPCS with functional decline after mild traumatic brain injury. All were ≥3 months postinjury, reported both headache and dizziness, and had a known real-life symptom trigger (eg, move…

Evaluation of a Novel Technique for a 3D-Printed Temporal Bone Analog for Mastoidectomy Training.

INTRODUCTION: Cadaveric temporal bones (CTBs) for otologic instruction have become increasingly expensive and scarce. Simulators offer a pot … created from multiple materials using a Stratasys J750 inkjet 3D printer (Stratasys Ltd., Rehovot, Israel). Surveys using a customized version of the Michigan Standard Simulation Scale Experience (MiSSES) were administered to otolaryngology trainees, otologists, and pediatric otolaryngologists to evaluate AM temporal bone (AMTB) analogs and a CTB. Kenda …

Descriptive analysis of the causes and outcomes of patients admitted to intensive care unit in Gaza during June 2024: A prospective cohort study.

Since the onset of the 2023 Israel-Gaza war, the healthcare system in the Gaza Strip has nearly collapsed. More than 70,937 casualties and 171,192 injuries have been reported, yet limited data exist on injury types and outcomes. Critical care services are essential during conflicts. This study aimed to determine causes of intensive care unit (ICU) admissions, associated injuries, complications, and outcomes in the Gaza Strip. We conducted a prospective cohort study of all adult and pediatric patients admitted to the ICUs at European Gaza Hospital and Shuhada Al-Aqsa Hospital between May 29 and…

Mortality and survival in patients with systemic lupus erythematosus in the Middle East and North Africa: a systematic review and meta-analysis.

Systemic lupus erythematosus (SLE) is associated with increased mortality compared with the general population, with outcomes influenced by … lve cohort studies, including 3,478 adults with SLE from five MENA countries (Türkiye, Iran, Egypt, Israel, and Tunisia), were analyzed. The pooled all-cause mortality rate was 9.9% (95% CI: 7.2%-14.0%; I² = 89.7%). Survival remained high at 5 years (93.9%) and 10 years (90.0%), but declined at 15 years (85.5%) and 20 years (71.7%), with long-term estima …

Vertical Gas Breakthrough Complicating Femtosecond LASIK: Incidence, Management, and Visual Outcomes in a Retrospective Case Series.

PURPOSE: To characterize vertical gas breakthrough (VGB) during femtosecond LASIK (FS-LASIK) by frequency, location, management, and early visual outcomes. SETTING: Care-Vision Laser Center, Tel Aviv, Israel. DESIGN: Retrospective consecutive case series. METHODS: All FS-LASIK procedures (June 2020-January 2023) were reviewed. Cases with an uncut area during flap creation were identified; VGB was confirmed on intraoperative video as gas breaching the lamellar plane with subepithelial accumulation. Management was classified as proceed, manual completion (crescent/keratome), conversion to PRK…

Bronchiectasis in Italy: an analysis of the EMBARC registry.

BACKGROUND: Bronchiectasis is a complex disease with geographical variability in its presentation and management. Despite the growing contri … laboration (EMBARC) registry, with comparisons made to patients in Spain, Greece, Portugal, Turkey, Israel and Malta (Southern European countries). Demographics, comorbidities, exacerbation history, spirometry, microbiology and treatment patterns were evaluated. RESULTS: Among 1657 Italian patients, the majority were female (70.5%) with a median age of …

Использование машинного обучения с помощью краткого перечня симптомов для просмотра Comorbid Disabilities: A account of Principle Study.

ВВЕДЕНИЕ: Психические расстройства являются основными причинами заболеваемости во всем мире и часто связаны с потреблением психоактивных веществ и другими видами наркотического поведения. Однако многие лица, находящиеся в психиатрических учреждениях, не проходят проверку на наличие зависимости. Общие психопатологические меры, такие, как краткий список симптомов (BSI), могут дать ценное представление о риске наркомании. В этом исследовании рассматривается вопрос о том, могут ли модели машинного обучения использовать реакцию БСИ для прогнозирования проблемного потребления веществ (алкоголь, нарк

Совпадение в аннотации оригинала
INTRODUCTION: Mental health disorders are leading causes of morbidity worldwide and often co-occur with substance use and other addictive be … ming, hypersexual behavior, and pornography use). METHODS: A population sample of Jewish adults in Israel (N = 2,451) was assessed for mental health, including the BSI, problematic substance use (alcohol, drugs), and potentially addictive behaviors: gambling, gaming, compulsive sexual behavior, and pornography use. Machine learning models - including de …

Visual Outcomes Following Cataract Surgery With Custom-Made Toric IOLs for the Correction of High Corneal Astigmatism.

PURPOSE: To describe the refractive results of cataract surgery in patients with high corneal astigmatism treated with implantation of custom-made toric intraocular lenses (IOLs). METHODS: This retrospective cohort analysis of eyes implanted with high-cylinder (≥6.75 diopters [D]) custom-made toric IOLs was conducted at Rabin Medical Center, Petach Tikva, Israel. A control group of eyes implanted with standard toric IOLs (1.50 to 3.75 D) was also included. Postoperative IOL misalignment, uncorrected distance visual acuity (UDVA), residual refractive astigmatism (RA), and the prediction error …

Low Match Between the Emerging 'Mayotte-like' Strain and the 919-Strain Bovine Ephemeral Fever Vaccine.

Background/Objectives: Bovine ephemeral fever virus (BEFV) causes an economically important arthropod-borne cattle disease. In 2023, a lineage I "Mayotte-like" (ML) strain emerged in Israel during an outbreak in vaccinated herds, raising concerns about its antigenic match with the live-attenuated vaccine based on Australian strain 919. We compared G-protein neutralizing sites and cross-neutralization among the vaccine strain, Israeli lineage IIIa strains from 2000 and 2021, and ML. Methods: G1-G3 neutralizing-site sequences were compared. Serum-neutralization assays tested all four viruses usi…

COVID-19 pandemic and thyroid diseases.

BACKGROUND: The COVID-19 pandemic has been associated with various autoimmune manifestations. Several studies have suggested a potential ass … upted time series analysis of adults (≥16 years) in the Clalit Health Services southern district of Israel from January 2018 to December 2022. New cases of TDs were identified using either ICD-9 codes, laboratory results, medication dispensing data or a combination of them. Monthly disease-specific incidence rates were compared between pre-pandemic (Janu …

From Rapid Progression to Long-Lasting Complete Response: A Wide Range of Ripretinib Activity for Metastatic GIST-A Real-World Cohort.

Background: Ripretinib, a switch-control kinase inhibitor approved for advanced gastrointestinal stromal tumor (GIST), inhibits primary and secondary KIT and PDGFRA mutations. Real-world data from Western and Middle Eastern populations remain limited. We report outcomes from a molecularly characterized Israeli multicenter cohort. Methods: We conducted a multicenter retrospective cohort study across seven university-affiliated medical centers in Israel. Patients with advanced GIST receiving Ripretinib at any treatment line were eligible. Progression-free survival (PFS) and overall survival (OS)…

Rehabilitation resource planning for mass casualty incidents: A retrospective analysis of blast and ballistic injuries.

INTRODUCTION: Mass casualty incidents (MCIs) involving extensive ballistic and explosive injuries place considerable pressure on healthcare resources. This study aimed to evaluate the rehabilitation resources required for individuals who sustained blast and ballistic injuries during an MCI. METHODS: A retrospective review was conducted using Electronic Medical Records (EMRs) of patients admitted to Sheba Medical Center (SMC), Israel, following an MCI on 7 October 2023. Patients diagnosed with gunshot wounds (GSW), or blast injuries (BI) were included. Data were collected over an almost 7-mont…

The Effects of Age on the Human Tear Film Assessed with a Novel Imaging Device.

Purpose: We aimed to analyze the effects of age on human tear film (TF) using a novel nanometer resolution TF imaging device (Tear Film Imager, TFI, AdOM, Israel). Methods: 44 healthy adult subjects (≥18 years of age) without ocular or systemic diseases or prior eye treatments with ages spanning seven decades were enrolled in this prospective cross-sectional study. Subjects underwent a comprehensive ophthalmic examination and completed the Ocular Surface Disease Index questionnaire (OSDI). All study participants underwent TF imaging using the TFI, including assessment of muco-aqueous layer thi…