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Genetic Syndromes, Maternal Diseases and Antenatal Factors Associated with Autism Spectrum Disorders (ASD).

Autism spectrum disorder (ASD) affecting about 1% of all children is associated, in addition to complex genetic factors, with a variety of prenatal, perinatal, and postnatal etiologies. In addition, ASD is often an important clinical presentation of some well-known genetic syndromes in human. We discuss these syndromes as well as the role of the more important prenatal factors affecting the fetus throughout pregnancy which may also be associated with ASD. Among the genetic disorders we find Fragile X, Rett syndrome, tuberous sclerosis, Timothy syndrome, Phelan-McDermid syndrome, Hamartoma tumo

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… Thalidomide is still used in the treatment of leprosy and multiple myeloma (Ito et al., 2010 ). Stromland et al. ( 1994 ) have reported increased number of incidences of autism in children exposed prenatally to thalidomide. …

An Updated Comprehensive Review on Diseases Associated with Nephrotic Syndromes.

There have been exciting advances in our knowledge of primary glomerular diseases and nephrotic syndromes in recent years. Beyond the histological pattern from renal biopsy, more precise phenotyping of the diseases and the use of modern nephrogenetics helps to improve treatment decisions and sometimes also avoid unnecessary exposure to potentially toxic immunosuppression. New biomarkers have led to easier and more accurate diagnoses and more targeted therapeutic decisions. The treatment landscape is becoming wider with a pipeline of promising new therapeutic agents with more sophisticated appr

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… Group | Disease Gastrointestinal and liver diseases | Inflammatory bowel disease, celiac disease, cirrhosis Infection | HBV, HCV, HIV, tuberculosis, leprosy Autoimmune diseases | Ankylosing spondylitis, rheumatoid arthritis, Sjögren syndrome Malignancy | Lung cancer, renal cell carcinoma, non-Hodgkin …

Analgesic Alkaloids Derived From Traditional Chinese Medicine in Pain Management.

Chronic pain is one of the most prevalent health problems. The establishment of chronic pain is complex. Current medication for chronic pain mainly dependent on anticonvulsants, tricyclic antidepressants and opioidergic drugs. However, they have limited therapeutic efficacy, and some even with severe side effects. We turned our interest into alkaloids separated from traditional Chinese medicine (TCM), that usually act on multiple drug targets. In this article, we introduced the best-studied analgesic alkaloids derived from TCM, including tetrahydropalmatine, aloperine, oxysophocarpine, matrine

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… Miers [Menispermaceae; Stephaniae japonicae folium et rhizome] ( Brochmann-Hanssen and Richte, 1975 ), which is traditional used in China for curing asthma, dysmenorrhea, and leprosy ( Desgrouas et al., 2014 ). …

Current and future applications of ultrasound imaging in peripheral nerve disorders.

Neuromuscular ultrasound (NMUS) is a rapidly evolving technique used in neuromuscular medicine to provide complimentary information to standard electrodiagnostic studies. NMUS provides a dynamic, real time assessment of anatomy which can alter both diagnostic and management pathways in peripheral nerve disorders. This review describes the current and future techniques used in NMUS and details the applications and developments in the diagnosis and monitoring of compressive, hereditary, immune-mediated and axonal peripheral nerve disorders, and motor neuron diseases. Technological advances have

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… High-resolution sonography: a new technique to detect nerve damage in leprosy. PLoS Negl Trop Dis. 2009;3:e498. doi: 10.1371/journal.pntd.0000498. 36. Martinoli C, Bianchi S, Gandolfo N, Valle M, Simonetti S, Derchi LE. US of nerve entrapments in osteofibrous tunnels of the upper and lower limbs. …

Coexistence of Autoantibodies against the Golgi Complex and Ro52 Antigen in a Patient with Nonspecific Interstitial Pneumonia.

Nonspecific interstitial pneumonia (NSIP) is often associated with connective tissue diseases (CTD). The diagnosis of NSIP was confirmed in a 63-year-old man by high-resolution computed tomography and an open lung biopsy. Anti-Golgi complex autoantibodies (AGA) and anti-Ro52 antibodies were simultaneously detected at high concentrations. Autoantibodies to aminoacyl-tRNA synthetases (ARS) were negative. The patient was treated with corticosteroids for six months. During the seven-year follow-up, NSIP had a slow progression and patient had not developed the clinical features of CTD. The present

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… Sarcoidosis belongs to a large family of granulomatous disorders, which includes tuberculosis, leprosy, Langerhans cell histiocytosis, and more. All members of the granulomatous disease are characterized by the formation of granulomas within the body system. …

Targeted protein degradation: advances in drug discovery and clinical practice.

Targeted protein degradation (TPD) represents a revolutionary therapeutic strategy in disease management, providing a stark contrast to traditional therapeutic approaches like small molecule inhibitors that primarily focus on inhibiting protein function. This advanced technology capitalizes on the cell's intrinsic proteolytic systems, including the proteasome and lysosomal pathways, to selectively eliminate disease-causing proteins. TPD not only enhances the efficacy of treatments but also expands the scope of protein degradation applications. Despite its considerable potential, TPD faces chal

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… The rediscovery of thalidomide’s benefits in treating leprosy sparked renewed interest, resulting in the development of more potent analogs such as lenalidomide and pomalidomide, which showed promising anti-inflammatory 121 , 122 and anti-angiogenic efficacy. 123 , 124 These new discoveries promoted …

Abstracts - IANCON 2025

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E-Posters

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Unlocking Novel Therapeutic Potential of Angiotensin II Receptor Blockers.

Pharmaceutical companies keep producing novel drugs and drug treatments for improving the life of every sick individual, most often following a pattern; a specific drug for a specific condition. Evidence suggests that different medications can have a positive effect on different pathological conditions. The full potential of existing therapies can be revealed through drug repurposing-also referred to as drug repositioning, reprofiling, or re-tasking-which involves identifying new therapeutic uses for approved or investigational drugs beyond their original indications. One significant target in

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… Cushing’s syndrome [ 106 ] | Approved | Remdesivir | Antiviral [ 107 ] | SARS-CoV-2 [ 107 ] | Approved | Sirolimus | Organ rejection in patients receiving renal transplants [ 108 ] | Malaria [ 109 ] | Investigational | Thalidomide | Morning sickness (withdrawn) [ 67 ] | Erythema nodosum leprosum (Leprosy …

NF-κB: master regulator of cellular responses in health and disease.

The NF-κB transcription control proteins play widespread roles in cellular behavior, regulating immune responses, inflammation, cell survival, proliferation, and development. Here, we attempt to comprehensively review these diverse functions and underlying mechanisms, leading readers to relevant references of both historic and topical importance. Because of the huge number of NF-κB control mechanisms and functions, and the vast literature that describes these, being comprehensive is a daunting task but we hope that readers will find clues to lead them to whatever understanding they may seek. A

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… They are used to treat multiple myeloma, myelodysplastic syndromes, and leprosy (thalidomide). Side effects include teratogenicity (strict contraindication in pregnancy), neuropathy (thalidomide), and immunosuppression (infection risk). …

Rapid health transition in China, 1990-2010: findings from the Global Burden of Disease Study 2010.

BACKGROUND: China has undergone rapid demographic and epidemiological changes in the past few decades, including striking declines in fertility and child mortality and increases in life expectancy at birth. Popular discontent with the health system has led to major reforms. To help inform these reforms, we did a comprehensive assessment of disease burden in China, how it changed between 1990 and 2010, and how China's health burden compares with other nations. METHODS: We used results of the Global Burden of Diseases, Injuries, and Risk Factors Study 2010 (GBD 2010) for 1990 and 2010 for China

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… (739·2–1394·0) | 25·8 | 84·8 (63·8–108·4) | 71·7 (49·5–91·9) | −14·8 | | Acute hepatitis C | 25·9 (15·2–41·4) | 41·8 (28·3–57·1) | 66·0 | 2·6 (1·6–4·2) | 2·8 (1·9–3·8) | 8·1 | | Acute hepatitis E | 281·7 (160·9–461·6) | 138·2 (71·0–240·2) | −51·6 | 21·9 (12·6–35·9) | 10·5 (5·5–18·0) | −53·0 | Leprosy …

Abstracts - IANCON 2024

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2020 CIS Annual Meeting: Immune Deficiency & Dysregulation North American Conference.

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NF-κB in biology and targeted therapy: new insights and translational implications.

NF-κB signaling has been discovered for nearly 40 years. Initially, NF-κB signaling was identified as a pivotal pathway in mediating inflammatory responses. However, with extensive and in-depth investigations, researchers have discovered that its role can be expanded to a variety of signaling mechanisms, biological processes, human diseases, and treatment options. In this review, we first scrutinize the research process of NF-κB signaling, and summarize the composition, activation, and regulatory mechanism of NF-κB signaling. We investigate the interaction of NF-κB signaling with other importa

Global, regional, and national disability-adjusted life-years (DALYs) for 333 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016.

BACKGROUND: Measurement of changes in health across locations is useful to compare and contrast changing epidemiological patterns against health system performance and identify specific needs for resource allocation in research, policy development, and programme decision making. Using the Global Burden of Diseases, Injuries, and Risk Factors Study 2016, we drew from two widely used summary measures to monitor such changes in population health: disability-adjusted life-years (DALYs) and healthy life expectancy (HALE). We used these measures to track trends and benchmark progress compared with e

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… to –39·6) * | –13·5 (–18·2 to –8·5) * Food-borne trematodiases | 1425·0 (591·7 to 2937·7) | 1659·6 (832·5 to 3083·5) | 1771·2 (923·9 to 3158·4) | 24·3 (–3·9 to 71·7) | 6·7 (1·3 to 15·7) * | 27·9 (12·0 to 56·7) | 25·4 (12·9 to 46·8) | 23·7 (12·2 to 42·0) | –15·3 (–34·0 to 13·1) | –7·0 (–11·4 to 0·5) Leprosy …

Proceedings of the 3rd IPLeiria's International Health Congress : Leiria, Portugal. 6-7 May 2016.

S1 Health literacy and health education in adolescence Catarina Cardoso Tomás S2 The effect of a walking program on the quality of life and … Ana Xavier, Marina Cunha, José Pinto-Gouveia O112 Prevalence of physical disability in people with leprosy Liana Alencar, Madalena Cunha, António Madureira O113 Quality of life and self-esteem in type 1 and type 2 diabetes mellitus patients Ilda Cardoso, Ana Galhardo, Fernanda Daniel, Vítor Rodrigues O114 Cross-cultural comparison of gross motor coordina …

Всемирный конгресс по болезням остеопороза, остеоартрита и мускулоскелета 2025).

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C

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Резюме: 31 Европейский конгресс патологии.

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Global, regional, and national disability-adjusted life-years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017.

BACKGROUND: How long one lives, how many years of life are spent in good and poor health, and how the population's state of health and leading causes of disability change over time all have implications for policy, planning, and provision of services. We comparatively assessed the patterns and trends of healthy life expectancy (HALE), which quantifies the number of years of life expected to be lived in good health, and the complementary measure of disability-adjusted life-years (DALYs), a composite measure of disease burden capturing both premature mortality and prevalence and severity of ill