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Design and Validation of an AI-Assisted Sequential Screening Framework for Psychological Distress in Glaucoma.

PURPOSE: Psychological distress is highly prevalent in glaucoma and is associated with worse adherence, reduced quality of life, and faster disease progression. However, distress is rarely assessed in ophthalmology settings due to time, workflow, and staffing constraints. We evaluated two artificial intelligence (AI)-based screening strategies, designed to efficiently identify distressed primary open angle glaucoma (POAG) patients during routine care, aiming to achieve effective, resource conscious, low burden clinical screening. DESIGN: Hybrid retrospective cohort and prospective cross-secti…

Environmental Triggers and Ocular Disease Networks: Analyzing the Impact of Air Pollutants and Meteorological Factors Using Fuzzy Cognitive Maps.

Growing evidence suggests that climate change and air pollution significantly contribute to the rising incidence of ocular morbidity; however, quantifying the complex interplay of these factors presents significant methodological challenges. This study aimed to investigate the impact of multiple air pollutants and meteorological conditions on common ocular diseases utilizing Fuzzy Cognitive Maps (FCMs) and to delineate the pathogenic relationships among them. We analyzed data from 28,981 hospitalizations in ophthalmology (2019-2024) at a tertiary hospital in Wuhan, China, coupled with daily en…

Explainable multimodal AI and neuro-symbolic clinical decision support system for chronic eye disease management: a digital health implementation study.

INTRODUCTION: Administrative burden and documentation workload are increasingly recognized as major contributors to healthcare costs and cli … umentation in AMD care. METHODS: A longitudinal proof-of-concept study was conducted in a tertiary ophthalmology network. A hybrid Neuro-Symbolic and Large Language Model (LLM) framework was developed to automate information extraction, clinical documentation structuring, and billing code validation. The system was applied to 24 de-identified unstructured clin …

Evolution of the Criteria to Diagnose Idiopathic Intracranial Hypertension: An Algorithm.

BACKGROUND: Idiopathic intracranial hypertension (IIH) is a condition characterized by elevated intracranial pressure that can cause a varie … etrospective chart review was conducted on 100 consecutive patients diagnosed with IIH in our neuro-ophthalmology clinic over 9 years (2016-present). Inclusion criteria required a high clinical suspicion of IIH with no alternative etiology, a complete neuro-ophthalmologic examination before LP, and no prior history of IIH or LP. Ninety-six patients underwent LP …

Semaglutide and non-arteritic anterior ischaemic optic neuropathy: Review and interpretation of reported association.

This review covers a seminal study of the relation between exposure to the glucagon-like peptide 1 (GLP-1) agonist semaglutide and incident non-arteritic anterior ischaemic optic neuropathy (NAION) in a neuro-ophthalmology clinic setting, subsequent studies in unselected populations, a meta-analysis of clinical trials and pathophysiology studies of the optic disc and retina that may help elucidate the relation between semaglutide and NAION in patients with diabetes or obesity. In the matched cohort study of neuro-ophthalmology patients, those treated using agents other than semaglutide had NAI…

Benchmarking large multimodal models for ophthalmic visual question answering with OphthalWeChat.

PURPOSE: To develop a bilingual multimodal visual question answering (VQA) benchmark for evaluating Vision-language models (VLMs) in ophthalmology. METHODS: In this cross-sectional study, ophthalmic image posts and associated captions published between Jan 1, 2016, and Dec 31, 2024, were collected from WeChat Official Accounts. Based on these captions, bilingual question-answer (QA) pairs in Chinese and English were generated using GPT-4o-mini. QA pairs were categorized into six subsets by question type and language: binary (Binary_CN, Binary_EN), single-choice (Single-choice_CN, Single-choic…

Assessing the possibility of using large language models in ocular surface diseases.

AIM: To assess the possibility of using different large language models (LLMs) in ocular surface diseases by selecting five different LLMS to test their accuracy in answering specialized questions related to ocular surface diseases: ChatGPT-4, ChatGPT-3.5, Claude 2, PaLM2, and SenseNova. METHODS: A group of experienced ophthalmology professors were asked to develop a 100-question single-choice question on ocular surface diseases designed to assess the performance of LLMs and human participants in answering ophthalmology specialty exam questions. The exam includes questions on the following to…

Связь Визуальной функции, толщиной ретинальной мышцы с оптической согласованностью, Томография, и МРТ Мозговой объем в педиатрическом многоразовом склерозе.

В то время как сокращение томографии оптической согласованности (OCT) PRNFL и толщины плексифного слоя в клетках и ганглионах, как было установлено, связано с атрофией мозга у взрослых групп MS (AOMS), взаимосвязь между показателями OCT и MRI головного мозга в педиатрическом диапазоне MS (POMS). Наша цель состояла в том, чтобы изучить связи мер по ОКТ с объемным МРТ в группе пациентов с ПОМС, с тем чтобы определить, отражают ли меры по ОКТ нейродегенерацию CNS в этой популяции пациентов, как это видно из групп АОМС.МЕТОДЫ: Это было перекрестное исследование с ретроспективным выявлением пациент

Совпадение в аннотации оригинала
BACKGROUND AND OBJECTIVES: While reductions in optical coherence tomography (OCT) pRNFL and ganglion cell-inner plexiform layer thicknesses … e ascertainment of patients with POMS evaluated at a single center with expertise in POMS and neuro-ophthalmology. As part of routine clinical care, patients with POMS are evaluated by a POMS expert and undergo volumetric brain MRI, including whole-brain (WB), subregional, and gray matter (GM) volume analyses. Patients with POMS are routinely referred to neuro- …

Cost consequences of task-shifting intravitreal injections from physicians to nurses in a tertiary hospital in Norway.

BACKGROUND: Anti-vascular endothelial growth factor is a medicine administered intravitreally by an injection to maintain visual acuity in p … lated as the sum of hospital costs, transport costs for patients, caregivers' use of time, costs of ophthalmology consultations and community-based homecare. RESULTS: The hospital costs per injection were 5.5 € higher for physicians compared to nurses (281.6 € versus 276.1 €). Cost projections estimated an annual hospital saving of task-shifting of 48 921 € fo …

Validation of Deep Convolutional Neural Network-based algorithm for detection of diabetic retinopathy - Artificial intelligence versus clinician for screening.

PURPOSE: Deep learning is a newer and advanced subfield in artificial intelligence (AI). The aim of our study is to validate a machine-based algorithm developed based on deep convolutional neural networks as a tool for screening to detect referable diabetic retinopathy (DR). METHODS: An AI algorithm to detect DR was validated at our hospital using an internal dataset consisting of 1,533 macula-centered fundus images collected retrospectively and an external validation set using Methods to Evaluate Segmentation and Indexing Techniques in the field of Retinal Ophthalmology (MESSIDOR) dataset. I…

Developing Therapies for Age-related Macular Degeneration: The Art and Science of Problem-solving: The 2018 Charles L. Schepens, MD, Lecture.

PURPOSE: To review the roles of analytic and innovative thought in advancing knowledge, using past examples in ophthalmology, and to explore potential strategies to improve our understanding of age-related macular degeneration (AMD) and develop new therapies. DESIGN: Presented as the 2018 Charles L. Schepens, MD, Lecture at the American Academy of Ophthalmology Retina Subspecialty Day, Chicago, Illinois, on October 26, 2018. PARTICIPANTS: None. METHODS: Review of published literature and sources on creativity and innovation. MAIN OUTCOME MEASURES: Recommendations for future AMD research. …

Real-world data in retinal diseases treated with anti-vascular endothelial growth factor (anti-VEGF) therapy - a systematic approach to identify and characterize data sources.

BACKGROUND: Real-world data (RWD) has been a valuable addition to the scientific literature regarding treatment pathways, clinical outcomes … all of the areas of interest; these sources are considered to be robust data sources for performing ophthalmology real-world studies. CONCLUSIONS: The study provides a comprehensive list of RWD sources for patients with retinal disease, many of which will be useful for conducting real-world studies in the field of ophthalmology.

Diagnostic Errors in Initial Misdiagnosis of Optic Nerve Sheath Meningiomas.

IMPORTANCE: Diagnostic errors can lead to the initial misdiagnosis of optic nerve sheath meningiomas (ONSM), which can lead to vision loss. OBJECTIVE: To identify factors contributing to the initial misdiagnosis of ONSM. DESIGN, SETTING, AND PARTICIPANTS: We retrospectively reviewed 35 of 39 patients with unilateral ONSM (89.7%) who were seen in the tertiary neuro-ophthalmology practice at Emory University School of Medicine between January 2002 and March 2017. The Diagnosis Error Evaluation and Research taxonomy tool was applied to cases with missed/delayed diagnoses. EXPOSURES: Evaluation…

Endophthalmitis after Cataract Surgery in the United States: A Report from the Intelligent Research in Sight Registry, 2013-2017.

PURPOSE: To determine recent incidence and visual outcomes for acute-onset endophthalmitis after cataract surgery performed in the United States. DESIGN: Retrospective cohort study. PARTICIPANTS: United States cataract surgery patients, 2013-2017 (5 401 686 patients). METHODS: Cases of acute-onset postoperative endophthalmitis occurring within 30 days after cataract surgery were identified using diagnosis codes in the American Academy of Ophthalmology IRIS (Intelligent Research in Sight) Registry database, drawn from electronic health records in ophthalmology practices across the nation. An…

Goldenhar syndrome with blepharophimosis and limb deformities: a case report.

BACKGROUND: Goldenhar syndrome has variable presentations and can affect multiple regions of the body. Diagnoses are based on clinical manifestations. The association of Goldenhar syndrome with blepharophimosis and limb deformities has not previously been reported. Here, we describe a patient who was diagnosed with Goldenhar syndrome in association with blepharophimosis, ocular hypertelorism, hearing loss and limb deformities. CASE PRESENTATION: A 10-year-old male was first referred to our ophthalmology clinic on 2009-2-11 for ocular hypertelorism and microphthalmia when he had chin-up positi…