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Detection of circulating immune complexes in feline leishmaniosis: first evidence and diagnostic implications.

Feline leishmaniosis caused by Leishmania infantum is a zoonotic, vector-borne disease. While dogs are the main reservoir and exhibit immune … g. This report describes an eight-year-old spayed European Shorthair cat from Spain with unilateral uveitis as the main clinical manifestation associated with Leishmania infantum infection. Leishmania infection was confirmed by positive immunochromatographic rapid test, high anti-Leishmania enzyme-linked immunosorbent assay and Western Blot reactivity, mo …

Relentless Placoid Chorioretinitis in a Patient with Atopic Dermatitis Treated with Dupilumab.

PURPOSE: Dupilumab is an injectable human IgG4 monoclonal antibody targeting the IL-4 receptor indicated for moderate to severe atopic dermatitis (AD) refractory to standard topical treatments. We report an association of dupilumab with non-infectious posterior uveitis in a 10-year-old boy. METHODS: Case report. RESULTS: A 10-year-old boy was referred for specialty eye examination due to bilateral blurry vision, redness, and light sensitivity unresponsive to topical ocular corticosteroids in the setting of using dupilumab for severe AD. There was iritis and vitreitis and numerous yellow-whit…

Safety and efficacy profile of the fluocinolone acetonide implant in non-infectious uveitic macular edema: 5-year follow-up.

OBJECTIVE: To evaluate the safety and efficacy profile of the fluocinolone acetonide implant (FAI) in patients with non-infectious posterior segment uveitis over a 60-month follow-up period. METHODS: We retrospective conducted a study with a mean follow-up of 47 months (minimum, 18; maximum, 60). The study included 11 eyes (9 patients), with a male-to-female ratio of 8:1. The etiology of uveitis was heterogeneous. Efficacy parameters included visual acuity (VA) and Central macular thickness (CMT), and the ones who needed adjuvant therapy or re-injection. Safety parameters focused on the devel…

Deficiency of Adenosine Deaminase 2 Masquerading as Behçet's Disease: Phenotypic Mimicry with HLA-B*51 Positivity.

PURPOSE: Deficiency of adenosine deaminase 2 (DADA2) is a rare monogenic autoinflammatory disease resulting from biallelic loss-of-function … t to the final diagnosis of DADA2 was 7 years. All patients exhibited BD-like phenotype, except for uveitis, and 8 were HLA-B*51 positive, which likely contributed to the diagnostic confusion. CONCLUSION: These findings highlight the broad clinical spectrum of DADA2, which can resemble BD, and suggest that HLA-B*51 positivity in DADA2 may further complic …

Cytomegalovirus retinitis (CMVR) in an HIV-negative patient with a history of chronic lymphoproliferative disease.

PURPOSE: To report a challenging case of cytomegalovirus retinitis (CMVR) in a Human immunodeficiency virus (HIV) negative patient with diab … rred vision in the right eye. The patient presented with hypertensive anterior CMV-related anterior uveitis. The baseline visual acuities were 6/9 in both eyes with elevated IOP in the right eye (31mmHg). Dilated fundus examination revealed right eye peripheral retinitis accompanied by haemorrhages. The anterior tap confirmed the presence of CMV, and anti …

Efficacy of risankizumab across GRAPPA domains in psoriatic arthritis: a pooled analysis of patients from the phase 3 KEEPsAKE 1 and 2 studies.

OBJECTIVE: To assess the efficacy of long-term treatment with risankizumab across the updated Group for Research and Assessment of Psoriasis … l psoriasis, axial disease) and PsA-related conditions such as inflammatory bowel disease (IBD) and uveitis were assessed over 100 weeks of treatment (~2 years). Statistical approaches included non-responder imputation (as-observed with imputation) for categorical variables and mixed-effect model for repeated measures for continuous variables including as …

Окулярная токсичность целевой терапии и иммунотерапии гематологов.

Целенаправленная терапия и иммунная терапия изменили методы борьбы с гематологическими заболеваниями. Однако эти агенты могут также иметь непреднамеренные окулярные неблагоприятные последствия. Эти токсичные вещества часто недооцениваются, но могут существенно повлиять на качество жизни пациентов и на процесс принятия терапевтических решений. Всеобъемлющее понимание этих последствий имеет важное значение для междисциплинарного управления. В этом обзоре обобщаются имеющиеся в настоящее время данные об окулярной токсичности, связанной с современными целенаправленными и иммунными терапиями, испол

Совпадение в аннотации оригинала
Targeted therapies and immune-based treatments have transformed the management of hematologic malignancies. However, these agents can also r … s. Tyrosine kinase inhibitors were associated with a range of effects, including periorbital edema, uveitis, and retinal vascular complications. Immune checkpoint inhibitors caused inflammatory eye diseases such as uveitis, optic neuritis, and ocular myasthenia, consistent with immune-related adverse events. Certain antibody-drug conjugates, particularly …

Clinical characteristics of Behçet's syndrome in Shanghai database: Baseline data of a cross-sectional cohort study.

OBJECTIVE: Behçet's syndrome (BS) is a variant vessel vasculitis that can involve multiple organs, with highly heterogeneous clinical manife … ificant gender differences were observed in clinical manifestations. Pseudofolliculitis (p < .001), uveitis (p = .003), vascular (p < .001), and cardiovascular involvement (p < .001) were significantly more prevalent in male BS patients, while genital ulcers (p = .011) and erythema nodosum (p = .009) were more common among the female. Furthermore, pseudof …

Ocular Syphilis - Clinical Features and Outcome in HIV Positive and HIV Negative Patients from a Tertiary Eye Center from India - A Comparative Study.

PURPOSE: To study and compare the clinical characteristics and outcome of ocular syphilis between HIV positive and HIV negative patients. METHODS: Retrospective hospital-based case series from a tertiary eye care hospital in India. Patients with uveitis and positive syphilis serology were included. Demographics, clinical features, investigations, imaging and treatment modalities were noted. RESULTS: Hundred and five (105) eyes of 66 patients were analyzed. Males were predominantly affected (n = 57/66, 86.4%). Secondary syphilis was the most common stage of presentation (n = 48/66, 72.7%). Tw…

Characteristics of patients with axial spondyloarthritis by geographic regions: PROOF multicountry observational study baseline results.

OBJECTIVES: To compare demographic and clinical characteristics of patients with axial SpA (axSpA) across geographic regions. METHODS: Pati … was in Latin America, and the lowest was in Canada (9%, 9% and 2%, respectively). The occurrence of uveitis and psoriasis was highest in Canada (18% and 14%, respectively) and lowest in China (6% and <1%, respectively). IBD was highest in Arabia (21%), and no cases were observed in China. In multivariable analysis adjusted for factors potentially affectin …

Long-Term Safety and Effectiveness of Adalimumab in Japanese Patients with Noninfectious Intermediate, Posterior, or Panuveitis: Post-Marketing Surveillance of 251 Patients.

INTRODUCTION: The aim of this nationwide, prospective post-marketing surveillance was to assess the safety and effectiveness of up to 52 weeks of adalimumab treatment in patients with noninfectious intermediate, posterior, or panuveitis in Japanese clinical practice. METHODS: This post-marketing surveillance was conducted at 60 medical facilities in Japan from October 2016 to June 2020. Patients with noninfectious intermediate, posterior, or panuveitis who were administered adalimumab (Humira®, AbbVie Inc.) for the first time were eligible. Subcutaneous adalimumab was initially administered a…

Glued intraocular lens in eyes with deficient capsules: retrospective analysis of long-term effects.

PURPOSE: To assess the long-term (6-12 years) results and complications of glued transscleral-fixated intraocular lens (IOL). SETTING: Dr. … OL luxation (4.4%), retinal detachment (3.2%), macular edema (4.3%), corneal decompensation (3.2%), uveitis (2.1%), and uveitis-glaucoma-hyphema syndrome (1%). Haptic reposition (3.2%), retinal detachment surgery (3.2%) keratoplasty (1%), pupilloplasty (2.1%), and IOL explantation (1%) were the second surgeries performed. CONCLUSIONS: Glued IOL has shown …

Case Report: Significant Complications of Cosmetic Iris Implantation.

SIGNIFICANCE: The complications of cosmetic iris implantation may result in irreversible vision loss. Patients who obtain these implants aga … ndia 16 months prior was referred to our center. He had a history of 4 months of steroid-refractory uveitis and secondary glaucoma, with IOP measurements of more than 50 mmHg in the outpatient setting. Slit-lamp examination revealed ciliary flush, pannus formation, corneal edema, and keratic precipitates. Optical coherence tomography suggested possible re …

Clinical Characteristics of Sarcoidosis in Asian Population: A 14-year Single Center Retrospective Cohort Study from Thailand.

BACKGROUND: Little is known about epidemiology and clinical characteristics of sarcoidosis in Asian population. OBJECTIVES: This study aime … pulmonary sarcoidosis was accompanied by extrathoracic involvement in 53 patients (65.4%). Sarcoid uveitis was the most common extrathoracic disease (35 cases; 39.3%), followed by cutaneous sarcoidosis (24 cases; 26.9%), extrathoracic lymphadenopathy (18 cases; 22.5%) and sarcoid arthropathy (4 cases; 4.5%). CONCLUSION: The current study examined clinic …

Diurnal Spikes of Intraocular Pressure in Uveitic Glaucoma: A 24-hour Intraocular Pressure Monitoring Study.

PURPOSE: The aim of this study was to document diurnal changes in intraocular pressure (IOP) in uveitic glaucoma (UG) and compare it with primary open angle glaucoma (POAG) patients. METHODS: Eight patients with UG and seven patients with POAG were included in this study. The patients were matched for age, gender, and glaucoma medications. None of the patients experienced angle closure, uveitis attack, and ocular surgery, and were not under steroid or immunomodulatory therapy within the last three months. The 24-hour IOP fluctuations were recorded with the help of a contact lens sensor (Sensi…

Outcomes of transplant recipients treated with cidofovir for resistant or refractory cytomegalovirus infection.

BACKGROUND: Treatment of ganciclovir-resistant (GCV-R)/refractory cytomegalovirus (CMV) infections in blood/marrow transplant (BMT) and soli … resistance mutations. While on CDV, six (37.5%) developed nephrotoxicity, and four (25%) developed uveitis (two had both uveitis and nephrotoxicity). Eight (50%) had failure to clear CMV DNAemia despite CDV treatment. Eight (50%) of the patients died; median time to death, after initiation of CDV, was 33.5 days [IQR22-988]. CONCLUSIONS: In the absence o …

Blau Syndrome and Early-Onset Sarcoidosis: A Six Case Series and Review of the Literature.

OBJECTIVES: This study aims to discuss the clinical, laboratory and genetic findings, and treatment options for six patients who were diagnosed with Blau syndrome (BS)/early-onset sarcoidosis (EOS). PATIENTS AND METHODS: The study included four patients (2 males,2 females; mean age 7 years; range 4 to 10 years) with EOS and two siblings (1 male, 1 female; mean age 10 years; range, 9 to 11 years) with BS. Age, age of initial symptoms, age of diagnosis; articular involvement, presence of uveitis, dermatitis, or fever, other organ involvement, laboratory findings, results of metabolic tests for …

Effect of Gut Involvement in Patients with High Probability of Early Spondyloarthritis: Data from the DESIR Cohort.

OBJECTIVE: Inflammatory bowel disease (IBD) is a well-known extraarticular feature of spondyloarthritis (SpA). The aims of this study were t … , 35 had IBD (prevalence 4.94%, CI 95% 3.3-6.5). IBD was associated (multivariable) with history of uveitis, levels of Dickkopf-1, and tumor necrosis factor, but not with phenotypic presentation (peripheral arthritis, enthesitis, dactylitis, uveitis) or baseline serum levels of other cytokines. At 5 years, 480 patients were analyzed, 58 with IBD. IBD was …

Feline Ocular Mycobacteriosis: Clinical Presentation, Histopathological Features, and Outcome.

This study describes clinical and histopathological features, treatment, and outcome of cats diagnosed with ocular mycobacteriosis. Cases di … ilaterally visual (unilateral: n = 3 cats; bilateral: n = 2 cats). The commonest ocular finding was uveitis (87%). The main histopathological features were granulomatous to pyogranulomatous chorioretinitis with retinal detachment, anterior uveitis, optic neuritis, episcleritis, scleritis, and/or retrobulbar cellulitis. Nineteen cats (76%) had systemic sig …

Work Outcome in Patients With Ankylosing Spondylitis: Results From a 12-Year Followup of an International Study.

OBJECTIVE: To understand the impact of ankylosing spondylitis (AS) on work disability (WD) over 12 years compared with the general populatio … HR 1.2 [95% CI 1.0, 1.4]). Time-varying predictors over 12 years were residence in The Netherlands, uveitis, and either BASFI or Bath Ankylosing Spondylitis Disease Activity Index with age and inflammatory bowel disease. CONCLUSION: Although WD was already prevalent at inclusion in the cohort, a substantial proportion of patients incurred further adverse …